CN102918156B - 用于控制基因表达的单链核酸分子 - Google Patents

用于控制基因表达的单链核酸分子 Download PDF

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Publication number
CN102918156B
CN102918156B CN201180027223.1A CN201180027223A CN102918156B CN 102918156 B CN102918156 B CN 102918156B CN 201180027223 A CN201180027223 A CN 201180027223A CN 102918156 B CN102918156 B CN 102918156B
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nucleic acid
expression
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CN102918156A (zh
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大木忠明
林宏刚
白水久男
滨崎智洋
伊藤彰浩
铃木宽
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Bonac Corp
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180027223.1A 2010-07-08 2011-07-08 用于控制基因表达的单链核酸分子 Expired - Fee Related CN102918156B (zh)

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JP2010156122 2010-07-08
JP2010-156122 2010-07-08
JP2010174915 2010-08-03
JP2010-174915 2010-08-03
JP2010230806 2010-10-13
JP2010-230806 2010-10-13
JP2010230808 2010-10-13
JP2010-230808 2010-10-13
JP2010-269824 2010-12-02
JP2010269824 2010-12-02
JP2010-269823 2010-12-02
JP2010269823 2010-12-02
PCT/JP2011/065737 WO2012005368A1 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子

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CN105899663B (zh) 2013-12-26 2019-07-26 学校法人东京医科大学 用于基因表达控制的人工模拟miRNA及其用途
CN106068324B (zh) 2013-12-27 2020-12-29 株式会社博纳克 控制基因表达的人工匹配型miRNA及其用途
HK1244035A1 (en) 2014-12-15 2018-07-27 Bonac Corporation Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression
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JP6634095B2 (ja) 2015-12-29 2020-01-22 国立大学法人北海道大学 プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途
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JPWO2018182008A1 (ja) 2017-03-31 2020-02-06 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
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JP7405086B2 (ja) * 2018-10-02 2023-12-26 東レ株式会社 ヘアピン型一本鎖ｒｎａ分子の製造方法
JP7241098B2 (ja) 2019-01-25 2023-03-16 杏林製薬株式会社 線維症治療剤
JP7640461B2 (ja) 2019-10-11 2025-03-05 住友化学株式会社 核酸オリゴマーの製造方法
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DK2933333T3 (en) 2018-04-30
CA2804511C (en) 2021-07-06
EP2933333B1 (en) 2018-02-21
EP2431466A4 (en) 2012-04-25
NZ606232A (en) 2015-06-26
BR112013000481A2 (pt) 2019-10-15
ES2550487T3 (es) 2015-11-10
CA2804511A1 (en) 2012-01-12
JP2012130342A (ja) 2012-07-12
HK1181423A1 (zh) 2013-11-08
WO2012005368A1 (ja) 2012-01-12
KR20130090792A (ko) 2013-08-14
MX352568B (es) 2017-11-29
CN104818276A (zh) 2015-08-05
TWI573870B (zh) 2017-03-11
SG196779A1 (en) 2014-02-13
PT2431466E (pt) 2016-01-08
EP2431466B1 (en) 2015-10-07
JP6162182B2 (ja) 2017-07-12
PT2933333T (pt) 2018-04-24
JP5804642B2 (ja) 2015-11-04
SG186899A1 (en) 2013-02-28
TW201217523A (en) 2012-05-01
HUE026520T2 (en) 2016-06-28
TW201627500A (zh) 2016-08-01
DK2431466T3 (en) 2016-01-11
TWI527901B (zh) 2016-04-01
NZ704812A (en) 2017-01-27
RU2628311C2 (ru) 2017-08-15
EP2431466A1 (en) 2012-03-21
CN104818276B (zh) 2020-12-11
MX2013000315A (es) 2013-05-01
CN102918156A (zh) 2013-02-06
HUE037500T2 (hu) 2018-08-28
JP4968811B2 (ja) 2012-07-04
RU2013105329A (ru) 2014-08-20
JPWO2012005368A1 (ja) 2013-09-05
KR101849798B1 (ko) 2018-04-17
AU2011274854B2 (en) 2015-04-16
JP2015231381A (ja) 2015-12-24
EP2933333A1 (en) 2015-10-21
ES2670017T3 (es) 2018-05-29
AU2011274854A1 (en) 2013-02-14

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