CN102917730A - 修饰的脑膜炎球菌fHBP多肽 - Google Patents

修饰的脑膜炎球菌fHBP多肽 Download PDF

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Publication number
CN102917730A
CN102917730A CN201080060450XA CN201080060450A CN102917730A CN 102917730 A CN102917730 A CN 102917730A CN 201080060450X A CN201080060450X A CN 201080060450XA CN 201080060450 A CN201080060450 A CN 201080060450A CN 102917730 A CN102917730 A CN 102917730A
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China
Prior art keywords
seq
polypeptide
sequence
amino acid
fhbp
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Pending
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CN201080060450XA
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Chinese (zh)
Inventor
L·班西
F·坎蒂尼
S·德拉戈内蒂
M·A·简蒂莱
D·维吉
M·斯卡塞利
M·皮萨
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080060450XA 2009-10-27 2010-10-27 修饰的脑膜炎球菌fHBP多肽 Pending CN102917730A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27997709P 2009-10-27 2009-10-27
US61/279,977 2009-10-27
PCT/IB2010/054865 WO2011051893A1 (en) 2009-10-27 2010-10-27 Modified meningococcal fhbp polypeptides

Publications (1)

Publication Number Publication Date
CN102917730A true CN102917730A (zh) 2013-02-06

Family

ID=43431124

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080060450XA Pending CN102917730A (zh) 2009-10-27 2010-10-27 修饰的脑膜炎球菌fHBP多肽

Country Status (9)

Country Link
US (2) US20130022633A1 (https=)
EP (1) EP2493499A1 (https=)
JP (2) JP5960055B2 (https=)
CN (1) CN102917730A (https=)
AU (1) AU2010310985B2 (https=)
BR (1) BR112012010531A2 (https=)
CA (1) CA2779816A1 (https=)
MX (1) MX2012004850A (https=)
WO (1) WO2011051893A1 (https=)

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CN105431167A (zh) * 2013-08-02 2016-03-23 奥克兰儿童医院及研究中心 非天然发生因子h结合蛋白(fhbp)及其使用方法
CN106795208A (zh) * 2014-07-17 2017-05-31 葛兰素史密丝克莱恩生物有限公司 修饰的脑膜炎球菌fHbp多肽
CN112851768A (zh) * 2014-07-23 2021-05-28 奥克兰儿童医院及研究中心 因子h结合蛋白变体及其使用方法
US11147866B2 (en) 2016-09-02 2021-10-19 Sanofi Pasteur Inc. Neisseria meningitidis vaccine
CN120241991A (zh) * 2025-06-05 2025-07-04 北京绿竹生物技术股份有限公司 一种新型的b群流脑外膜蛋白双功能载体
US12485164B2 (en) 2014-07-17 2025-12-02 Glaxosmithkline Biologicals Sa Meningococcus vaccines
US12611451B2 (en) 2023-06-07 2026-04-28 Sanofi Vaccines US Inc. Neisseria meningitidis vaccine

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HUE049695T2 (hu) 2009-03-24 2020-10-28 Glaxosmithkline Biologicals Sa Adjuváló H meningococcus faktort kötõ fehérje
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KR101594228B1 (ko) 2010-08-23 2016-02-15 와이어쓰 엘엘씨 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제
NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
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US9764027B2 (en) * 2012-09-18 2017-09-19 Glaxosmithkline Biologicals Sa Outer membrane vesicles
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US20160030544A1 (en) * 2013-03-14 2016-02-04 Isis Innovation Limited Immunogenic composition to neisseria
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
JP6786394B2 (ja) 2014-02-28 2020-11-18 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 改変髄膜炎菌ｆＨｂｐポリペプチド
US10232029B2 (en) 2014-12-09 2019-03-19 Sanofi Pasteur Compositions comprising N. meningitidis proteins
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
GB201614687D0 (en) * 2016-08-31 2016-10-12 Univ Oxford Innovation Ltd fHbp scaffold
EP3312192B1 (en) * 2016-10-24 2023-02-22 BiOMVis Srl Immunogenic compositions containing bacterial outer membrane vesicles
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
EP3607967A1 (en) 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Modified meningococcal fhbp polypeptides
EP4034157A1 (en) 2019-09-27 2022-08-03 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
US12053516B2 (en) 2021-02-19 2024-08-06 Sanofi Pasteur Inc. Meningococcal B recombinant vaccine
TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物

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WO2007060548A2 (en) * 2005-11-25 2007-05-31 Novartis Vaccines And Diagnostics Srl Chimeric, hybrid and tandem polypeptides of meningococcal nmb1870
WO2009104097A2 (en) * 2008-02-21 2009-08-27 Novartis Ag Meningococcal fhbp polypeptides
WO2010046715A1 (en) * 2008-10-25 2010-04-29 Imperial Innovations Limited Vaccine compositions comprising a mutated factor h binding protein

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