AU2010310985B2 - Modified meningococcal fHBP polypeptides - Google Patents

Info

Publication number

AU2010310985B2

AU2010310985B2 AU2010310985A AU2010310985A AU2010310985B2 AU 2010310985 B2 AU2010310985 B2 AU 2010310985B2 AU 2010310985 A AU2010310985 A AU 2010310985A AU 2010310985 A AU2010310985 A AU 2010310985A AU 2010310985 B2 AU2010310985 B2 AU 2010310985B2

Authority

AU

Australia

Prior art keywords

gly

ala

lys

leu

ser

Prior art date

2009-10-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

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• 108090000765 processed proteins & peptides Proteins 0.000 title claims description 143
• 102000004196 processed proteins & peptides Human genes 0.000 title claims description 140
• 229920001184 polypeptide Polymers 0.000 title claims description 136
• 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 30
• 125000000539 amino acid group Chemical group 0.000 claims abstract description 20
• 239000000203 mixture Substances 0.000 claims description 102
• 235000001014 amino acid Nutrition 0.000 claims description 67
• 150000001413 amino acids Chemical class 0.000 claims description 66
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 64
• 108090000623 proteins and genes Proteins 0.000 claims description 60
• 238000000034 method Methods 0.000 claims description 43
• 239000012634 fragment Substances 0.000 claims description 42
• 241000588650 Neisseria meningitidis Species 0.000 claims description 41
• 150000001720 carbohydrates Chemical class 0.000 claims description 38
• 102000004169 proteins and genes Human genes 0.000 claims description 38
• 239000002671 adjuvant Substances 0.000 claims description 37
• 235000018102 proteins Nutrition 0.000 claims description 37
• 230000002163 immunogen Effects 0.000 claims description 33
• 241000894006 Bacteria Species 0.000 claims description 25
• 230000004048 modification Effects 0.000 claims description 22
• 238000012986 modification Methods 0.000 claims description 22
• 108020004707 nucleic acids Proteins 0.000 claims description 18
• 102000039446 nucleic acids Human genes 0.000 claims description 18
• 150000007523 nucleic acids Chemical class 0.000 claims description 18
• 239000012528 membrane Substances 0.000 claims description 16
• 241001212279 Neisseriales Species 0.000 claims description 14
• 239000013612 plasmid Substances 0.000 claims description 13
• 241000124008 Mammalia Species 0.000 claims description 12
• 230000005875 antibody response Effects 0.000 claims description 11
• 108091034117 Oligonucleotide Proteins 0.000 claims description 10
• 208000015181 infectious disease Diseases 0.000 claims description 10
• 241001465754 Metazoa Species 0.000 claims description 9
• 235000004279 alanine Nutrition 0.000 claims description 9
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 8
• 201000010099 disease Diseases 0.000 claims description 8
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
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• 238000004519 manufacturing process Methods 0.000 claims description 8
• 239000002773 nucleotide Substances 0.000 claims description 8
• 125000003729 nucleotide group Chemical group 0.000 claims description 8
• 101000737574 Homo sapiens Complement factor H Proteins 0.000 claims description 7
• 239000003795 chemical substances by application Substances 0.000 claims description 7
• 102000045512 human CFH Human genes 0.000 claims description 7
• 230000003308 immunostimulating effect Effects 0.000 claims description 6
• 238000011282 treatment Methods 0.000 claims description 6
• 201000009906 Meningitis Diseases 0.000 claims description 3
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• 241001174901 Neisseria meningitidis alpha275 Species 0.000 claims description 2
• 241000921898 Neisseria meningitidis serogroup A Species 0.000 claims description 2
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• MUJQWSAWLLRJCE-KATARQTJSA-N Ser-Leu-Thr Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O MUJQWSAWLLRJCE-KATARQTJSA-N 0.000 claims 25
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• PAWIVEIWWYGBAM-YUMQZZPRSA-N Gly-Leu-Ala Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O PAWIVEIWWYGBAM-YUMQZZPRSA-N 0.000 claims 23
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• 108010015792 glycyllysine Proteins 0.000 claims 23
• BUANFPRKJKJSRR-ACZMJKKPSA-N Ala-Ala-Gln Chemical compound C[C@H]([NH3+])C(=O)N[C@@H](C)C(=O)N[C@H](C([O-])=O)CCC(N)=O BUANFPRKJKJSRR-ACZMJKKPSA-N 0.000 claims 21
• MFVQGXGQRIXBPK-WDSKDSINSA-N Gly-Ala-Glu Chemical compound NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O MFVQGXGQRIXBPK-WDSKDSINSA-N 0.000 claims 21
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• 108010051110 tyrosyl-lysine Proteins 0.000 claims 20
• FJVAQLJNTSUQPY-CIUDSAMLSA-N Ala-Ala-Lys Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCCCN FJVAQLJNTSUQPY-CIUDSAMLSA-N 0.000 claims 19
• WXUOJXIGOPMDJM-SRVKXCTJSA-N Leu-Lys-Asn Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O WXUOJXIGOPMDJM-SRVKXCTJSA-N 0.000 claims 19
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• QITBQGJOXQYMOA-ZETCQYMHSA-N Gly-Gly-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)CNC(=O)CN QITBQGJOXQYMOA-ZETCQYMHSA-N 0.000 claims 18
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• PJYSOYLLTJKZHC-GUBZILKMSA-N Leu-Asp-Gln Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CCC(N)=O PJYSOYLLTJKZHC-GUBZILKMSA-N 0.000 claims 18
• ZJZNLRVCZWUONM-JXUBOQSCSA-N Leu-Thr-Ala Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O ZJZNLRVCZWUONM-JXUBOQSCSA-N 0.000 claims 18
• 108010089804 glycyl-threonine Proteins 0.000 claims 18
• 108010057821 leucylproline Proteins 0.000 claims 18
• 108010048818 seryl-histidine Proteins 0.000 claims 18
• PBVLJOIPOGUQQP-CIUDSAMLSA-N Asp-Ala-Leu Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O PBVLJOIPOGUQQP-CIUDSAMLSA-N 0.000 claims 17
• NZOCIWKZUVUNDW-ZKWXMUAHSA-N Ile-Gly-Ala Chemical compound CC[C@H](C)[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(O)=O NZOCIWKZUVUNDW-ZKWXMUAHSA-N 0.000 claims 17
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• LGBVMDMZZFYSFW-HJWJTTGWSA-N Phe-Arg-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC1=CC=CC=C1)N LGBVMDMZZFYSFW-HJWJTTGWSA-N 0.000 claims 17
• 108010008355 arginyl-glutamine Proteins 0.000 claims 17
• 108010073969 valyllysine Proteins 0.000 claims 17
• BRRPVTUFESPTCP-ACZMJKKPSA-N Asp-Ser-Glu Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCC(O)=O BRRPVTUFESPTCP-ACZMJKKPSA-N 0.000 claims 16
• RZSLYUUFFVHFRQ-FXQIFTODSA-N Gln-Ala-Glu Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O RZSLYUUFFVHFRQ-FXQIFTODSA-N 0.000 claims 16
• GQZDDFRXSDGUNG-YVNDNENWSA-N Gln-Ile-Gln Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(O)=O GQZDDFRXSDGUNG-YVNDNENWSA-N 0.000 claims 16
• CSMHMEATMDCQNY-DZKIICNBSA-N Gln-Val-Tyr Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O CSMHMEATMDCQNY-DZKIICNBSA-N 0.000 claims 16
• MHXKHKWHPNETGG-QWRGUYRKSA-N Gly-Lys-Leu Chemical compound [H]NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O MHXKHKWHPNETGG-QWRGUYRKSA-N 0.000 claims 16
• NNCDAORZCMPZPX-GUBZILKMSA-N Lys-Gln-Ser Chemical compound C(CCN)C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)O)N NNCDAORZCMPZPX-GUBZILKMSA-N 0.000 claims 16
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• 108010070409 phenylalanyl-glycyl-glycine Proteins 0.000 claims 16
• PIXQDIGKDNNOOV-GUBZILKMSA-N Ala-Lys-Gln Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O PIXQDIGKDNNOOV-GUBZILKMSA-N 0.000 claims 15
• PBSQFBAJKPLRJY-BYULHYEWSA-N Asn-Gly-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)CNC(=O)[C@H](CC(=O)N)N PBSQFBAJKPLRJY-BYULHYEWSA-N 0.000 claims 15
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• 241000880493 Leptailurus serval Species 0.000 claims 14
• NMELOOXSGDRBRU-YUMQZZPRSA-N Pro-Glu-Gly Chemical compound OC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1 NMELOOXSGDRBRU-YUMQZZPRSA-N 0.000 claims 14
• KCNSGAMPBPYUAI-CIUDSAMLSA-N Ser-Leu-Asn Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O KCNSGAMPBPYUAI-CIUDSAMLSA-N 0.000 claims 14
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• 108010087924 alanylproline Proteins 0.000 claims 14
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• ZDSNOSQHMJBRQN-SRVKXCTJSA-N Leu-Asp-His Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)N ZDSNOSQHMJBRQN-SRVKXCTJSA-N 0.000 claims 13
• BGZCJDGBBUUBHA-KKUMJFAQSA-N Leu-Lys-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O BGZCJDGBBUUBHA-KKUMJFAQSA-N 0.000 claims 13
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• VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 claims 13
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• 108010001064 glycyl-glycyl-glycyl-glycine Proteins 0.000 claims 12
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• LIINDKYIGYTDLG-PPCPHDFISA-N Leu-Ile-Thr Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(O)=O LIINDKYIGYTDLG-PPCPHDFISA-N 0.000 claims 11
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