CN102821600A - 使用移植了nog确立癌细胞株的非人动物模型进行的抗癌药靶探索以及筛选方法 - Google Patents
使用移植了nog确立癌细胞株的非人动物模型进行的抗癌药靶探索以及筛选方法 Download PDFInfo
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- CN102821600A CN102821600A CN2010800647647A CN201080064764A CN102821600A CN 102821600 A CN102821600 A CN 102821600A CN 2010800647647 A CN2010800647647 A CN 2010800647647A CN 201080064764 A CN201080064764 A CN 201080064764A CN 102821600 A CN102821600 A CN 102821600A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
Abstract
Description
Claims (18)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009-295426 | 2009-12-25 | ||
JP2009295426 | 2009-12-25 | ||
PCT/JP2010/073266 WO2011078301A1 (ja) | 2009-12-25 | 2010-12-24 | Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法 |
Publications (2)
Publication Number | Publication Date |
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CN102821600A true CN102821600A (zh) | 2012-12-12 |
CN102821600B CN102821600B (zh) | 2016-01-20 |
Family
ID=44195826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080064764.7A Active CN102821600B (zh) | 2009-12-25 | 2010-12-24 | 使用移植了nog确立癌细胞株的非人动物模型进行的抗癌药靶探索以及筛选方法 |
Country Status (7)
Country | Link |
---|---|
US (2) | US11536713B2 (zh) |
EP (2) | EP4190149A1 (zh) |
JP (1) | JP5808054B2 (zh) |
CN (1) | CN102821600B (zh) |
HK (1) | HK1177664A1 (zh) |
SG (2) | SG10201908987VA (zh) |
WO (1) | WO2011078301A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108135150A (zh) * | 2015-06-16 | 2018-06-08 | 杰克逊实验室 | 经遗传修饰的非人类动物和涉及补体依赖性细胞毒性的方法 |
CN110998320A (zh) * | 2017-08-21 | 2020-04-10 | 凸版印刷株式会社 | 抗癌效果的评价方法及癌症免疫疗法的有效性预测方法 |
CN112544567A (zh) * | 2019-09-10 | 2021-03-26 | 上海交通大学医学院附属仁济医院 | 髓母细胞瘤动物模型及其建立与应用 |
CN111670247B (zh) * | 2017-12-08 | 2024-01-05 | 京诊断株式会社 | 制备癌球状体的方法和选择结直肠癌患者的方法 |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5808054B2 (ja) | 2009-12-25 | 2015-11-10 | 中外製薬株式会社 | Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法 |
US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
EP2611463A2 (en) | 2010-09-03 | 2013-07-10 | Stem Centrx, Inc. | Identification and enrichment of cell subpopulations |
CN103328626B (zh) * | 2010-10-06 | 2017-02-08 | 中外制药株式会社 | 癌干细胞群及其制备方法 |
WO2013035824A1 (ja) * | 2011-09-07 | 2013-03-14 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞の分離 |
EP3603671A3 (en) | 2011-10-28 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
JP2014033626A (ja) * | 2012-08-08 | 2014-02-24 | Juntendo | ヒト癌上皮細胞の遠隔転移のモデルマウス作出方法 |
JP2015057974A (ja) * | 2013-09-18 | 2015-03-30 | 学校法人順天堂 | 患者原発性大腸癌の個別化転移モデルマウスの作製方法 |
CN107921173B (zh) * | 2015-08-03 | 2021-07-06 | 富士胶片株式会社 | 细胞结构体、非人模型动物、非人模型动物的制造方法及被检验物质的评价方法 |
CN105296430B (zh) * | 2015-09-29 | 2018-08-17 | 浙江大学 | 一种人类结肠癌细胞系dxh-1及其应用 |
CN108977410B (zh) * | 2018-08-02 | 2023-04-25 | 郭世伟 | 中国人胰腺癌原位癌细胞系 |
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2010
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- 2010-12-24 EP EP23152521.3A patent/EP4190149A1/en active Pending
- 2010-12-24 WO PCT/JP2010/073266 patent/WO2011078301A1/ja active Application Filing
- 2010-12-24 EP EP10839531.0A patent/EP2517555A4/en active Pending
- 2010-12-24 SG SG10201908987V patent/SG10201908987VA/en unknown
- 2010-12-24 SG SG2012047213A patent/SG181938A1/en unknown
- 2010-12-24 CN CN201080064764.7A patent/CN102821600B/zh active Active
- 2010-12-24 US US13/519,059 patent/US11536713B2/en active Active
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2013
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2022
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108135150A (zh) * | 2015-06-16 | 2018-06-08 | 杰克逊实验室 | 经遗传修饰的非人类动物和涉及补体依赖性细胞毒性的方法 |
CN108135150B (zh) * | 2015-06-16 | 2022-08-23 | 杰克逊实验室 | 经遗传修饰的非人类动物和涉及补体依赖性细胞毒性的方法 |
US11785923B2 (en) | 2015-06-16 | 2023-10-17 | The Jackson Laboratory | Genetically modified non-human animals and methods relating to complement dependent cytotoxicity |
CN110998320A (zh) * | 2017-08-21 | 2020-04-10 | 凸版印刷株式会社 | 抗癌效果的评价方法及癌症免疫疗法的有效性预测方法 |
CN110998320B (zh) * | 2017-08-21 | 2024-04-09 | 凸版印刷株式会社 | 抗癌效果的评价方法及癌症免疫疗法的有效性预测方法 |
CN111670247B (zh) * | 2017-12-08 | 2024-01-05 | 京诊断株式会社 | 制备癌球状体的方法和选择结直肠癌患者的方法 |
CN112544567A (zh) * | 2019-09-10 | 2021-03-26 | 上海交通大学医学院附属仁济医院 | 髓母细胞瘤动物模型及其建立与应用 |
Also Published As
Publication number | Publication date |
---|---|
HK1177664A1 (zh) | 2013-08-30 |
EP2517555A4 (en) | 2014-09-24 |
JP5808054B2 (ja) | 2015-11-10 |
US20130019327A1 (en) | 2013-01-17 |
WO2011078301A1 (ja) | 2011-06-30 |
SG10201908987VA (en) | 2019-11-28 |
SG181938A1 (en) | 2012-07-30 |
US20230085803A1 (en) | 2023-03-23 |
CN102821600B (zh) | 2016-01-20 |
US11536713B2 (en) | 2022-12-27 |
EP4190149A1 (en) | 2023-06-07 |
JPWO2011078301A1 (ja) | 2013-05-09 |
EP2517555A1 (en) | 2012-10-31 |
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