SG10201908987VA - Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein - Google Patents

Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein

Info

Publication number
SG10201908987VA
SG10201908987VA SG10201908987VA SG10201908987VA SG 10201908987V A SG10201908987V A SG 10201908987VA SG 10201908987V A SG10201908987V A SG 10201908987VA SG 10201908987V A SG10201908987V A SG 10201908987VA
Authority
SG
Singapore
Prior art keywords
cancer
human animal
nog
human
searching
Prior art date
Application number
Other languages
English (en)
Inventor
Masami Suzuki
Koichi Matsubara
Atsuhiko Kato
Chie Kato
Shinta Kobayashi
Yu Jau Chen
Masaki Yamazaki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of SG10201908987VA publication Critical patent/SG10201908987VA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Environmental Sciences (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG10201908987V 2009-12-25 2010-12-24 Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein SG10201908987VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009295426 2009-12-25

Publications (1)

Publication Number Publication Date
SG10201908987VA true SG10201908987VA (en) 2019-11-28

Family

ID=44195826

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012047213A SG181938A1 (en) 2009-12-25 2010-12-24 Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein
SG10201908987V SG10201908987VA (en) 2009-12-25 2010-12-24 Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012047213A SG181938A1 (en) 2009-12-25 2010-12-24 Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein

Country Status (7)

Country Link
US (2) US11536713B2 (zh)
EP (2) EP2517555A4 (zh)
JP (1) JP5808054B2 (zh)
CN (1) CN102821600B (zh)
HK (1) HK1177664A1 (zh)
SG (2) SG181938A1 (zh)
WO (1) WO2011078301A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2517555A4 (en) 2009-12-25 2014-09-24 Chugai Pharmaceutical Co Ltd METHOD OF SEARCHING AND SCREENING AN ANTICANCER AGENT TARGET USING A NON-HUMAN ANIMAL MODEL HAVING BEEN TRANSPORTED A LINE OF CANCER CELLS ESTABLISHED ON NOG
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
US9945842B2 (en) 2010-09-03 2018-04-17 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
SG196836A1 (en) 2010-10-06 2014-02-13 Pharmalogicals Res Pte Ltd Cancer stem cell population and method for production thereof
EP2749641B1 (en) * 2011-09-07 2021-06-02 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
JP6291254B2 (ja) 2011-10-28 2018-03-14 中外製薬株式会社 癌幹細胞特異的分子
JP2014033626A (ja) * 2012-08-08 2014-02-24 Juntendo ヒト癌上皮細胞の遠隔転移のモデルマウス作出方法
JP2015057974A (ja) * 2013-09-18 2015-03-30 学校法人順天堂 患者原発性大腸癌の個別化転移モデルマウスの作製方法
WO2016205523A1 (en) * 2015-06-16 2016-12-22 The Jackson Laboratory Genetically modified non-human animals and methods relating to complement dependent cytotoxicity
EP3332814A4 (en) * 2015-08-03 2018-07-25 FUJIFILM Corporation Cell structure, non-human model animal, method for producing non-human model animal, and method for evaluating test substance
CN105296430B (zh) * 2015-09-29 2018-08-17 浙江大学 一种人类结肠癌细胞系dxh-1及其应用
CN110998320B (zh) * 2017-08-21 2024-04-09 凸版印刷株式会社 抗癌效果的评价方法及癌症免疫疗法的有效性预测方法
CN111670247B (zh) * 2017-12-08 2024-01-05 京诊断株式会社 制备癌球状体的方法和选择结直肠癌患者的方法
CN108977410B (zh) * 2018-08-02 2023-04-25 郭世伟 中国人胰腺癌原位癌细胞系
CN112544567B (zh) * 2019-09-10 2022-11-01 上海交通大学医学院附属仁济医院 髓母细胞瘤动物模型及其建立与应用

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573924A (en) 1992-09-08 1996-11-12 Immunex Corporation CD27 ligand
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
EP1338198B1 (en) 2000-12-01 2007-11-28 Central Institute For Experimental Animals Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
WO2003104401A2 (en) 2002-06-05 2003-12-18 Avalon Pharmaceuticals, Inc. Cancer-linked gene as target for chemotherapy
US20070053884A1 (en) 2003-05-16 2007-03-08 Kyowa Hakko Kogyo Co., Ltd Novel adult tissue-derived stem cell and use thereof
CA2447400A1 (en) 2003-09-12 2005-03-12 The Hospital For Sick Children Brain tumor stem cells
AU2004280064A1 (en) 2003-10-09 2005-04-21 Kyowa Hakko Kirin Co., Ltd. Genomically modified cell neutralized to serum-free system
JP2005206508A (ja) 2004-01-22 2005-08-04 Chemo Sero Therapeut Res Inst 悪性腫瘍細胞増殖抑制抗体
CN1980957A (zh) 2004-03-23 2007-06-13 比奥根艾迪克Ma公司 受体偶联剂及其治疗用途
US20080268476A1 (en) 2004-05-12 2008-10-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nectin 4 (N4) as a Marker for Cancer Prognosis
US20080152700A1 (en) * 2004-06-01 2008-06-26 Reza Sheikhnejad Methods and compositions for the inhibition of gene expression
US20090214517A1 (en) 2004-07-27 2009-08-27 Justin Wong Compositions and methods of use for modulators of nectin 4, semaphorin 4b, igsf9, and kiaa0152 in treating disease
JP2008514205A (ja) 2004-09-29 2008-05-08 財団法人実験動物中央研究所 Ｎｏｇマウスを用いた高転移性細胞株の樹立
WO2006051405A2 (en) 2004-11-12 2006-05-18 Cambridge University Technical Services Ltd. Methods and means related to cancer stem cells
JPWO2006051984A1 (ja) 2004-11-15 2008-05-29 キリンファーマ株式会社 癌細胞の転移抑制方法およびそのために使用する医薬組成物
CA2605507C (en) 2005-04-19 2016-06-28 Seattle Genetics, Inc. Humanized anti-cd70 binding agents and uses thereof
AU2006259583A1 (en) 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2657886A1 (en) 2005-07-26 2007-02-01 Procure Therapeutics Limited Stem cell markers
JP2009509510A (ja) 2005-09-26 2009-03-12 メダレックス インコーポレーティッド Ｃｄ７０に対するヒトモノクローナル抗体
AU2006308847C1 (en) 2005-10-31 2012-05-10 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
US20070220621A1 (en) 2005-10-31 2007-09-20 Clarke Michael F Genetic characterization and prognostic significance of cancer stem cells in cancer
CA2631931C (en) 2005-12-01 2014-04-29 Pronai Therapeutics, Inc. Cancer therapies and pharmaceutical compositions used therein
EP1792979A1 (en) 2005-12-01 2007-06-06 Stiftung Caesar Center of Advanced European Studies and Research Cell culture system for the enrichment and expansion of stem cells
WO2007132883A1 (ja) * 2006-05-17 2007-11-22 Yokohama City University 肝臓癌の鑑別、疾患ステージの判定又は予後の予測方法及びキット
JP2009539374A (ja) 2006-06-06 2009-11-19 ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション 腫瘍性幹細胞が富化された組成物及びそれを含む方法
US8557584B2 (en) 2006-08-11 2013-10-15 Ao-Forschungsinstitut Davos Preparing a homogenous population of stem cells committed to differentiated to a specific cell type
EP2074144A4 (en) 2006-09-05 2011-03-16 Medarex Inc ANTIBODIES TO BONE MORPHOGENIC PROTEINS AND RECEPTORS THEREFOR AND METHOD FOR THEIR USE
WO2008033393A2 (en) 2006-09-11 2008-03-20 University Of Florida Isolation, expansion and uses of tumor stem cells
GB2442059A (en) 2006-09-19 2008-03-26 Ist Superiore Sanita Test for cancer of the gastrointestinal tract
AU2007312367B2 (en) 2006-10-12 2012-09-06 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-EREG antibody
JP2008102012A (ja) 2006-10-19 2008-05-01 Kanazawa Univ 癌幹細胞の同定および単離方法
EP2109668A4 (en) 2007-01-22 2011-10-05 Macrogenics West Inc HUMAN CANCER STEM CELLS
JP2008182912A (ja) 2007-01-29 2008-08-14 Nippon Kayaku Co Ltd 癌幹細胞の培養方法、および癌幹細胞
BRPI0811857A2 (pt) 2007-05-14 2014-10-21 Biogen Idec Inc Regiões fc (scfc) de cadeia simples, polipeptídeos de aglutinação que as compreendem e métodos relacionados.
WO2008149803A1 (ja) 2007-06-06 2008-12-11 The University Of Tokyo 表面抗原マーカーを用いた急性リンパ性白血病における癌幹細胞の分離同定方法
ES2553169T5 (es) 2007-07-02 2023-11-30 Oncomed Pharm Inc Composiciones y métodos para el tratamiento y el diagnóstico del cáncer
WO2009023194A2 (en) 2007-08-10 2009-02-19 Whitehead Institute For Biomedical Research Hormone responsive tissue culture system and uses thereof
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
GB2465940A (en) 2007-10-01 2010-06-09 Hospital For Sick Children Neural tumor stem cells and methods of use thereof
WO2009064301A1 (en) 2007-11-15 2009-05-22 The Johns Hopkins University Methods for detecting and monitoring circulating cancer stem cells
EP2271941B1 (en) * 2008-03-07 2012-08-08 OSI Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
CN102076865B (zh) 2008-05-02 2016-03-16 西雅图基因公司 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物
WO2010009121A2 (en) 2008-07-15 2010-01-21 University Of Florida Research Foundation, Inc. Colon stem cells associated with colitis and colorectal cancer and methods of use
WO2010016766A2 (en) 2008-08-08 2010-02-11 Koninklijke Nederlandse Akademie Van Wetenschappen Antibodies recognizing endogenous human lgr5 and/or lgr6
EP2373794A4 (en) 2008-12-12 2012-09-05 Oncotherapy Science Inc NECTINE-4 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS OF CANCER
EA201101241A1 (ru) 2009-03-06 2012-04-30 Калобайос Фармасьютиклз, Инк. Лечение лейкозов и хронических миелопролиферативных болезней антителами к ерна3
AU2010231575B2 (en) 2009-03-30 2013-09-12 Edimer Biotech S.A. Preparation of isolated agonist anti-EDAR monoclonal antibodies
MA33323B1 (fr) 2009-04-20 2012-06-01 Genentech Inc Thérapie adjuvante de cancer
TW201105347A (en) 2009-04-28 2011-02-16 Chugai Pharmaceutical Co Ltd Pharmaceutical compositions for maintenance therapy containing HLA class I-recognizing antibody as the active ingredient
EP2436397B1 (en) 2009-05-29 2017-05-10 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition containing antagonist of egf family ligand as component
WO2011027308A1 (en) 2009-09-03 2011-03-10 Koninklijke Philips Electronics N.V. Novel tumor markers
EP2517555A4 (en) 2009-12-25 2014-09-24 Chugai Pharmaceutical Co Ltd METHOD OF SEARCHING AND SCREENING AN ANTICANCER AGENT TARGET USING A NON-HUMAN ANIMAL MODEL HAVING BEEN TRANSPORTED A LINE OF CANCER CELLS ESTABLISHED ON NOG
US9217032B2 (en) 2010-01-08 2015-12-22 Les Laboratoires Servier Methods for treating colorectal cancer
SG196836A1 (en) 2010-10-06 2014-02-13 Pharmalogicals Res Pte Ltd Cancer stem cell population and method for production thereof
EP2749641B1 (en) 2011-09-07 2021-06-02 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
JP6291254B2 (ja) 2011-10-28 2018-03-14 中外製薬株式会社 癌幹細胞特異的分子

Also Published As

Publication number Publication date
EP4190149A1 (en) 2023-06-07
EP2517555A1 (en) 2012-10-31
EP2517555A4 (en) 2014-09-24
US20230085803A1 (en) 2023-03-23
US11536713B2 (en) 2022-12-27
WO2011078301A1 (ja) 2011-06-30
CN102821600B (zh) 2016-01-20
SG181938A1 (en) 2012-07-30
US20130019327A1 (en) 2013-01-17
CN102821600A (zh) 2012-12-12
JP5808054B2 (ja) 2015-11-10
JPWO2011078301A1 (ja) 2013-05-09
HK1177664A1 (zh) 2013-08-30

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