SG10201908987VA - Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein - Google Patents

Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein

Info

Publication number
SG10201908987VA
SG10201908987VA SG10201908987VA SG10201908987VA SG 10201908987V A SG10201908987V A SG 10201908987VA SG 10201908987V A SG10201908987V A SG 10201908987VA SG 10201908987V A SG10201908987V A SG 10201908987VA
Authority
SG
Singapore
Prior art keywords
cancer
human animal
nog
human
searching
Prior art date
Application number
Inventor
Masami Suzuki
Koichi Matsubara
Atsuhiko Kato
Chie Kato
Shinta Kobayashi
Yu Jau Chen
Masaki Yamazaki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of SG10201908987VA publication Critical patent/SG10201908987VA/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

METHODFOR SEARCHING AND SCREENING FOR TARGET OF ANTI-CANCER AGENT USING NON-HUMAN ANIMAL MODEL HAVING NOG ESTABLISHED CANCER CELL LINE TRANSPLANTED THEREIN An objective of the present invention is to provide non-human animal models of cancer pathology, which mimic the hierarchical organization, cancer progression process, or biological property of human cancer tissues, and uses thereof. To achieve the objective described above, first, the present inventors transplanted cells of NOG-established cancer lines into NOG mice and morphologically observed the resulting tissue organization. As a result, the non-human animal models were demonstrated to exhibit pathologies (the hierarchical organization, cancer progression process, or biological properties of the cancer cells) similar to that of human cancer. Specifically, the present inventors succeeded in preparing non-human animal models exhibiting pathologies more similar to a human cancer, and cell culture systems using NOG-established cancer cell lines where the in vitro cell morphology is more similar to that of human cancer.
SG10201908987V 2009-12-25 2010-12-24 Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein SG10201908987VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009295426 2009-12-25

Publications (1)

Publication Number Publication Date
SG10201908987VA true SG10201908987VA (en) 2019-11-28

Family

ID=44195826

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012047213A SG181938A1 (en) 2009-12-25 2010-12-24 Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein
SG10201908987V SG10201908987VA (en) 2009-12-25 2010-12-24 Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012047213A SG181938A1 (en) 2009-12-25 2010-12-24 Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein

Country Status (7)

Country Link
US (2) US11536713B2 (en)
EP (2) EP4190149A1 (en)
JP (1) JP5808054B2 (en)
CN (1) CN102821600B (en)
HK (1) HK1177664A1 (en)
SG (2) SG181938A1 (en)
WO (1) WO2011078301A1 (en)

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CN111670247B (en) * 2017-12-08 2024-01-05 京诊断株式会社 Method for preparing cancer spheroids and method for selecting colorectal cancer patients
CN108977410B (en) * 2018-08-02 2023-04-25 郭世伟 Pancreatic cancer in-situ cancer cell line of Chinese people
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Also Published As

Publication number Publication date
WO2011078301A1 (en) 2011-06-30
CN102821600B (en) 2016-01-20
US20230085803A1 (en) 2023-03-23
EP2517555A1 (en) 2012-10-31
JP5808054B2 (en) 2015-11-10
JPWO2011078301A1 (en) 2013-05-09
EP4190149A1 (en) 2023-06-07
SG181938A1 (en) 2012-07-30
HK1177664A1 (en) 2013-08-30
CN102821600A (en) 2012-12-12
US11536713B2 (en) 2022-12-27
EP2517555A4 (en) 2014-09-24
US20130019327A1 (en) 2013-01-17

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