CN102766142A - 有效作为蛋白激酶抑制剂的内酰胺化合物 - Google Patents

有效作为蛋白激酶抑制剂的内酰胺化合物 Download PDF

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Publication number
CN102766142A
CN102766142A CN2012102393383A CN201210239338A CN102766142A CN 102766142 A CN102766142 A CN 102766142A CN 2012102393383 A CN2012102393383 A CN 2012102393383A CN 201210239338 A CN201210239338 A CN 201210239338A CN 102766142 A CN102766142 A CN 102766142A
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CN
China
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aliphatic group
ring
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benzo
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CN2012102393383A
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English (en)
Chinese (zh)
Inventor
克里斯托弗·布莱克伯恩
克里斯托弗·F·克莱鲍恩
科特妮·A·卡立斯
娜塔利·A·戴尔斯
迈克·A·佩特恩
马修·斯蒂尔林
奥玛·G·斯维戴拉
加布里埃尔·S·外泽黑德
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of CN102766142A publication Critical patent/CN102766142A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2012102393383A 2004-10-04 2005-10-03 有效作为蛋白激酶抑制剂的内酰胺化合物 Pending CN102766142A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61576104P 2004-10-04 2004-10-04
US60/615,761 2004-10-04

Related Parent Applications (1)

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CN2005800414294A Division CN101068815B (zh) 2004-10-04 2005-10-03 有效作为蛋白激酶抑制剂的内酰胺化合物

Publications (1)

Publication Number Publication Date
CN102766142A true CN102766142A (zh) 2012-11-07

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CN2012102393383A Pending CN102766142A (zh) 2004-10-04 2005-10-03 有效作为蛋白激酶抑制剂的内酰胺化合物
CN2005800414294A Expired - Fee Related CN101068815B (zh) 2004-10-04 2005-10-03 有效作为蛋白激酶抑制剂的内酰胺化合物

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Country Status (7)

Country Link
US (4) US7459448B2 (enExample)
EP (2) EP1799684B1 (enExample)
JP (2) JP5002460B2 (enExample)
CN (2) CN102766142A (enExample)
AU (1) AU2005294575B2 (enExample)
CA (1) CA2582235A1 (enExample)
WO (1) WO2006041773A2 (enExample)

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CN101878216B (zh) * 2007-09-28 2013-07-10 西克拉塞尔有限公司 作为蛋白激酶抑制剂的嘧啶衍生物
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US7998952B2 (en) * 2008-12-05 2011-08-16 Millennium Pharmaceuticals, Inc. Thiolactams and uses thereof
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RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
EP2668177B1 (en) 2011-01-28 2014-10-22 Boehringer Ingelheim International GmbH Substituted pyridinyl-pyrimidines and their use as medicaments
CN102174016A (zh) * 2011-03-02 2011-09-07 宁波人健药业集团有限公司 一种制备7-氯-2,3,4,5-四氢-1h-1-苯并氮杂卓-2,5-二酮的方法
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2013033093A1 (en) * 2011-08-29 2013-03-07 Biocryst Pharmaceuticals, Inc. Heterocyclic compounds as janus kinase inhibitors
MX364895B (es) 2013-03-13 2019-05-10 Forma Therapeutics Inc Nuevos compuestos y composiciones para la inhibicion de fasn.
HUE038820T2 (hu) 2013-11-13 2018-11-28 Vertex Pharma Eljárás influenzavírusok replikációjának inhibitorai elõállítására
PT3068776T (pt) 2013-11-13 2019-08-26 Vertex Pharma Inibidores da replicação de vírus da gripe
CN103601678B (zh) * 2013-11-21 2015-02-11 爱斯特(成都)医药技术有限公司 7-氯-1,2,3,4-四氢苯并[b]氮杂卓-5-酮的合成方法
KR102061390B1 (ko) 2014-04-17 2019-12-31 이뮤노메트테라퓨틱스 인코포레이티드 구아니딘 화합물 및 그의 용도
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
WO2017070235A1 (en) * 2015-10-19 2017-04-27 Attenua, Inc. Antitussive compositions and methods
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Also Published As

Publication number Publication date
CN101068815A (zh) 2007-11-07
CN101068815B (zh) 2012-09-05
JP5002460B2 (ja) 2012-08-15
EP1799684B1 (en) 2014-12-03
US20090105213A1 (en) 2009-04-23
US20060100194A1 (en) 2006-05-11
JP2008515798A (ja) 2008-05-15
US20120178739A1 (en) 2012-07-12
WO2006041773A3 (en) 2006-05-18
CA2582235A1 (en) 2006-04-20
JP2012092143A (ja) 2012-05-17
AU2005294575A1 (en) 2006-04-20
AU2005294575B2 (en) 2011-11-24
US7935694B2 (en) 2011-05-03
US7459448B2 (en) 2008-12-02
EP2439207A1 (en) 2012-04-11
EP1799684A2 (en) 2007-06-27
US20110039820A1 (en) 2011-02-17
WO2006041773A2 (en) 2006-04-20

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Legal Events

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20121107