CN102766142A - 有效作为蛋白激酶抑制剂的内酰胺化合物 - Google Patents
有效作为蛋白激酶抑制剂的内酰胺化合物 Download PDFInfo
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- CN102766142A CN102766142A CN2012102393383A CN201210239338A CN102766142A CN 102766142 A CN102766142 A CN 102766142A CN 2012102393383 A CN2012102393383 A CN 2012102393383A CN 201210239338 A CN201210239338 A CN 201210239338A CN 102766142 A CN102766142 A CN 102766142A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US61576104P | 2004-10-04 | 2004-10-04 | |
| US60/615,761 | 2004-10-04 |
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| CN102766142A true CN102766142A (zh) | 2012-11-07 |
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| CN2005800414294A Expired - Fee Related CN101068815B (zh) | 2004-10-04 | 2005-10-03 | 有效作为蛋白激酶抑制剂的内酰胺化合物 |
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| CN2005800414294A Expired - Fee Related CN101068815B (zh) | 2004-10-04 | 2005-10-03 | 有效作为蛋白激酶抑制剂的内酰胺化合物 |
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| EP (2) | EP1799684B1 (enExample) |
| JP (2) | JP5002460B2 (enExample) |
| CN (2) | CN102766142A (enExample) |
| AU (1) | AU2005294575B2 (enExample) |
| CA (1) | CA2582235A1 (enExample) |
| WO (1) | WO2006041773A2 (enExample) |
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| EP1799684B1 (en) * | 2004-10-04 | 2014-12-03 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
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| US7998952B2 (en) * | 2008-12-05 | 2011-08-16 | Millennium Pharmaceuticals, Inc. | Thiolactams and uses thereof |
-
2005
- 2005-10-03 EP EP05812472.8A patent/EP1799684B1/en not_active Expired - Lifetime
- 2005-10-03 CN CN2012102393383A patent/CN102766142A/zh active Pending
- 2005-10-03 AU AU2005294575A patent/AU2005294575B2/en not_active Ceased
- 2005-10-03 US US11/242,413 patent/US7459448B2/en not_active Expired - Lifetime
- 2005-10-03 JP JP2007534851A patent/JP5002460B2/ja not_active Expired - Fee Related
- 2005-10-03 EP EP11182921A patent/EP2439207A1/en not_active Withdrawn
- 2005-10-03 CA CA002582235A patent/CA2582235A1/en not_active Abandoned
- 2005-10-03 WO PCT/US2005/035458 patent/WO2006041773A2/en not_active Ceased
- 2005-10-03 CN CN2005800414294A patent/CN101068815B/zh not_active Expired - Fee Related
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2008
- 2008-09-04 US US12/231,661 patent/US7935694B2/en not_active Expired - Lifetime
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2010
- 2010-10-13 US US12/903,370 patent/US20110039820A1/en not_active Abandoned
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2012
- 2012-02-01 JP JP2012019746A patent/JP2012092143A/ja not_active Withdrawn
- 2012-03-14 US US13/419,663 patent/US20120178739A1/en not_active Abandoned
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| CN101068815A (zh) | 2007-11-07 |
| CN101068815B (zh) | 2012-09-05 |
| JP5002460B2 (ja) | 2012-08-15 |
| EP1799684B1 (en) | 2014-12-03 |
| US20090105213A1 (en) | 2009-04-23 |
| US20060100194A1 (en) | 2006-05-11 |
| JP2008515798A (ja) | 2008-05-15 |
| US20120178739A1 (en) | 2012-07-12 |
| WO2006041773A3 (en) | 2006-05-18 |
| CA2582235A1 (en) | 2006-04-20 |
| JP2012092143A (ja) | 2012-05-17 |
| AU2005294575A1 (en) | 2006-04-20 |
| AU2005294575B2 (en) | 2011-11-24 |
| US7935694B2 (en) | 2011-05-03 |
| US7459448B2 (en) | 2008-12-02 |
| EP2439207A1 (en) | 2012-04-11 |
| EP1799684A2 (en) | 2007-06-27 |
| US20110039820A1 (en) | 2011-02-17 |
| WO2006041773A2 (en) | 2006-04-20 |
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