AU2005294575B2 - Lactam compounds useful as protein kinase inhibitors - Google Patents

Lactam compounds useful as protein kinase inhibitors Download PDF

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Publication number
AU2005294575B2
AU2005294575B2 AU2005294575A AU2005294575A AU2005294575B2 AU 2005294575 B2 AU2005294575 B2 AU 2005294575B2 AU 2005294575 A AU2005294575 A AU 2005294575A AU 2005294575 A AU2005294575 A AU 2005294575A AU 2005294575 B2 AU2005294575 B2 AU 2005294575B2
Authority
AU
Australia
Prior art keywords
dihydro
pyrimido
benzazepin
oxo
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005294575A
Other languages
English (en)
Other versions
AU2005294575A1 (en
Inventor
Christopher Blackburn
Christopher F. Claiborne
Courtney A. Cullis
Natalie A. Dales
Michael A. Patane
Matthew Stirling
Omar G. Stradella
Gabriel S. Weatherhead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of AU2005294575A1 publication Critical patent/AU2005294575A1/en
Application granted granted Critical
Publication of AU2005294575B2 publication Critical patent/AU2005294575B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005294575A 2004-10-04 2005-10-03 Lactam compounds useful as protein kinase inhibitors Ceased AU2005294575B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61576104P 2004-10-04 2004-10-04
US60/615,761 2004-10-04
PCT/US2005/035458 WO2006041773A2 (en) 2004-10-04 2005-10-03 Lactam compounds useful as protein kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012201059A Division AU2012201059A1 (en) 2004-10-04 2012-02-23 Lactam compounds useful as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
AU2005294575A1 AU2005294575A1 (en) 2006-04-20
AU2005294575B2 true AU2005294575B2 (en) 2011-11-24

Family

ID=35789256

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005294575A Ceased AU2005294575B2 (en) 2004-10-04 2005-10-03 Lactam compounds useful as protein kinase inhibitors

Country Status (7)

Country Link
US (4) US7459448B2 (enExample)
EP (2) EP1799684B1 (enExample)
JP (2) JP5002460B2 (enExample)
CN (2) CN102766142A (enExample)
AU (1) AU2005294575B2 (enExample)
CA (1) CA2582235A1 (enExample)
WO (1) WO2006041773A2 (enExample)

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JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
AU2008287339A1 (en) 2007-08-15 2009-02-19 Vertex Pharmaceuticals Incorporated 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases
CN101878216B (zh) * 2007-09-28 2013-07-10 西克拉塞尔有限公司 作为蛋白激酶抑制剂的嘧啶衍生物
JP5562865B2 (ja) 2007-12-17 2014-07-30 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｔｒｐｖ１のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター
WO2009081222A1 (en) 2007-12-21 2009-07-02 Glenmark Pharmaceuticals, S.A. Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands
GB0800383D0 (en) * 2008-01-10 2008-02-20 Univ Strathclyde Weight reducing compounds
EP2100894A1 (en) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
US7998952B2 (en) * 2008-12-05 2011-08-16 Millennium Pharmaceuticals, Inc. Thiolactams and uses thereof
GEP20207129B (en) 2009-06-17 2020-07-10 Vertex Pharma Inhibitors of influenza viruses replication
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
EP2668177B1 (en) 2011-01-28 2014-10-22 Boehringer Ingelheim International GmbH Substituted pyridinyl-pyrimidines and their use as medicaments
CN102174016A (zh) * 2011-03-02 2011-09-07 宁波人健药业集团有限公司 一种制备7-氯-2,3,4,5-四氢-1h-1-苯并氮杂卓-2,5-二酮的方法
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2013033093A1 (en) * 2011-08-29 2013-03-07 Biocryst Pharmaceuticals, Inc. Heterocyclic compounds as janus kinase inhibitors
MX364895B (es) 2013-03-13 2019-05-10 Forma Therapeutics Inc Nuevos compuestos y composiciones para la inhibicion de fasn.
HUE038820T2 (hu) 2013-11-13 2018-11-28 Vertex Pharma Eljárás influenzavírusok replikációjának inhibitorai elõállítására
PT3068776T (pt) 2013-11-13 2019-08-26 Vertex Pharma Inibidores da replicação de vírus da gripe
CN103601678B (zh) * 2013-11-21 2015-02-11 爱斯特（成都）医药技术有限公司 7-氯-1,2,3,4-四氢苯并[b]氮杂卓-5-酮的合成方法
KR102061390B1 (ko) 2014-04-17 2019-12-31 이뮤노메트테라퓨틱스 인코포레이티드 구아니딘 화합물 및 그의 용도
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
WO2017070235A1 (en) * 2015-10-19 2017-04-27 Attenua, Inc. Antitussive compositions and methods
RS63116B1 (sr) 2016-05-06 2022-05-31 Shanghai De Novo Pharmatech Co Ltd Derivat benzazepina, postupak za dobijanje, farmaceutska kompozicija i njegova upotreba
CN113382633A (zh) 2018-10-29 2021-09-10 福马治疗股份有限公司 (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式

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PL378116A1 (pl) * 2003-02-27 2006-03-06 Abbott Laboratories Heterocykliczne inhibitory kinazy
ES2331245T3 (es) 2003-07-21 2009-12-28 Pfizer Products Inc. Compuestos azapoliciclicos condensados con heteroarilo que reducen la adiccion a la nicotina.
CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
KR101792651B1 (ko) * 2004-05-14 2017-11-20 밀레니엄 파머슈티컬스 인코퍼레이티드 아우로라 키나아제의 억제에 의해 유사분열 진행을 억제하기 위한 화합물 및 그 화합물을 포함하는 약학적 조성물
EP1799684B1 (en) 2004-10-04 2014-12-03 Millennium Pharmaceuticals, Inc. Lactam compounds useful as protein kinase inhibitors
PE20070171A1 (es) 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
US7998952B2 (en) * 2008-12-05 2011-08-16 Millennium Pharmaceuticals, Inc. Thiolactams and uses thereof

Also Published As

Publication number Publication date
CN101068815A (zh) 2007-11-07
CN101068815B (zh) 2012-09-05
JP5002460B2 (ja) 2012-08-15
EP1799684B1 (en) 2014-12-03
US20090105213A1 (en) 2009-04-23
CN102766142A (zh) 2012-11-07
US20060100194A1 (en) 2006-05-11
JP2008515798A (ja) 2008-05-15
US20120178739A1 (en) 2012-07-12
WO2006041773A3 (en) 2006-05-18
CA2582235A1 (en) 2006-04-20
JP2012092143A (ja) 2012-05-17
AU2005294575A1 (en) 2006-04-20
US7935694B2 (en) 2011-05-03
US7459448B2 (en) 2008-12-02
EP2439207A1 (en) 2012-04-11
EP1799684A2 (en) 2007-06-27
US20110039820A1 (en) 2011-02-17
WO2006041773A2 (en) 2006-04-20

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired