CN102203293A - 快速结果杂交捕获测定和系统 - Google Patents

快速结果杂交捕获测定和系统 Download PDF

Info

Publication number
CN102203293A
CN102203293A CN2009801436829A CN200980143682A CN102203293A CN 102203293 A CN102203293 A CN 102203293A CN 2009801436829 A CN2009801436829 A CN 2009801436829A CN 200980143682 A CN200980143682 A CN 200980143682A CN 102203293 A CN102203293 A CN 102203293A
Authority
CN
China
Prior art keywords
types
sample
nucleic acid
antibody
hand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801436829A
Other languages
English (en)
Chinese (zh)
Inventor
保罗.埃德
埃里克.佩恩
艾里娜.纳扎伦科
萨吉.雷曼钱德兰
阿尔文德.弗马尼
劳拉.贝尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qiagen Gaithersburg LLC
Original Assignee
Qiagen Gaithersburg LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qiagen Gaithersburg LLC filed Critical Qiagen Gaithersburg LLC
Publication of CN102203293A publication Critical patent/CN102203293A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
CN2009801436829A 2008-10-27 2009-10-26 快速结果杂交捕获测定和系统 Pending CN102203293A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10868708P 2008-10-27 2008-10-27
US61/108,687 2008-10-27
US17484809P 2009-05-01 2009-05-01
US61/174,848 2009-05-01
PCT/US2009/062061 WO2010062556A1 (en) 2008-10-27 2009-10-26 Fast results hybrid capture assay and system

Publications (1)

Publication Number Publication Date
CN102203293A true CN102203293A (zh) 2011-09-28

Family

ID=41401545

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801436829A Pending CN102203293A (zh) 2008-10-27 2009-10-26 快速结果杂交捕获测定和系统

Country Status (9)

Country Link
US (3) US8877436B2 (enExample)
EP (1) EP2347011B1 (enExample)
JP (2) JP2012506705A (enExample)
CN (1) CN102203293A (enExample)
AU (1) AU2009320213B2 (enExample)
CA (1) CA2741650C (enExample)
ES (1) ES2622062T3 (enExample)
TW (3) TWI394839B (enExample)
WO (2) WO2010062546A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703492B2 (en) 2007-04-06 2014-04-22 Qiagen Gaithersburg, Inc. Open platform hybrid manual-automated sample processing system
US8357538B2 (en) * 2007-04-06 2013-01-22 Qiagen Gaithersburg, Inc. Automated assay and system
JP2012506705A (ja) * 2008-10-27 2012-03-22 キアジェン ゲイサーズバーグ インコーポレイテッド 迅速に結果を得るハイブリッドキャプチャー法による分析およびシステム
WO2010078574A1 (en) 2009-01-05 2010-07-08 Afl Telecommunications Llc Universal mounting bracket
WO2011032124A1 (en) 2009-09-14 2011-03-17 Qiagen Gaithersburg, Inc. Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
US9953141B2 (en) 2009-11-18 2018-04-24 Becton, Dickinson And Company Laboratory central control unit method and system
US9107652B2 (en) * 2009-11-19 2015-08-18 Qiagen Gaithersburg, Inc. Sampling devices and methods
JP2013517803A (ja) 2010-01-29 2013-05-20 キアジェン ゲイサーズバーグ インコーポレイテッド サンプル中のｈｐｖの存在を決定および確認する方法
JP6103941B2 (ja) * 2010-01-29 2017-03-29 キアジェン ゲイサーズバーグ インコーポレイテッド 核酸の配列特異的精製および多重分析のための方法および組成物
CA2799200A1 (en) 2010-05-19 2011-11-24 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
WO2012116220A2 (en) 2011-02-24 2012-08-30 Qiagen Gaithersburg, Inc. Materials and methods for detection of hpv nucleic acid
PL3246416T3 (pl) 2011-04-15 2024-09-30 The Johns Hopkins University Bezpieczny system sekwencjonowania
US9339812B2 (en) 2012-02-13 2016-05-17 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US11648561B2 (en) 2012-02-13 2023-05-16 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
WO2013123440A1 (en) * 2012-02-17 2013-08-22 Institute For Systems Biology Rnase h-based rna profiling
US9310281B2 (en) 2012-10-22 2016-04-12 Qiagen Gaithersburg, Inc. Automated pelletized sample blotting apparatus and methods
US9435718B2 (en) 2012-10-22 2016-09-06 Qiagen Gaithersburg, Inc. Automated pelletized sample decanting apparatus and methods
US9260763B2 (en) * 2012-10-22 2016-02-16 Qiagen Gaithersburg, Inc. Sample processing method using tube strips and tube strip holder
ES2741749T3 (es) 2012-10-25 2020-02-12 Neumodx Molecular Inc Método y materiales para el aislamiento de materiales de ácido nucleico
CN109457030B (zh) 2012-10-29 2022-02-18 约翰·霍普金斯大学 卵巢和子宫内膜癌的帕帕尼科拉乌测试
EP4512480A3 (en) 2013-12-20 2025-05-07 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of cdk and erk inhibitors
WO2015095819A2 (en) 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Cancer treatment using combinations of erk and raf inhibitors
AU2014368916B2 (en) 2013-12-20 2020-04-30 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of PI3K/Akt pathway and ERK inhibitors
ES2986019T3 (es) 2013-12-20 2024-11-08 Biomed Valley Discoveries Inc Tratamientos contra el cáncer que usan combinaciones de inhibidores de ERK y MEK de tipo 2
WO2015095842A2 (en) 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers
CN104020291B (zh) * 2014-06-26 2016-03-30 南京大学 一种基于酶联免疫分析的hpv核酸检测试剂盒及其应用
CN105636937B (zh) * 2015-01-27 2018-07-17 深圳华大生命科学研究院 用于保存生物样品的稳定剂
CN108027379B (zh) 2015-06-26 2021-07-23 雅培实验室 用于诊断分析设备的反应容器交换装置
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
WO2018160907A1 (en) * 2017-03-03 2018-09-07 Counsyl, Inc. Extraction of nucleic acids for reduced probe count variability
EP3665308A1 (en) 2017-08-07 2020-06-17 The Johns Hopkins University Methods and materials for assessing and treating cancer
EP3976816A4 (en) * 2019-05-28 2023-10-25 Case Western Reserve University COMPOSITIONS AND METHODS FOR PRESERVING DNA METHYLATION
BR112022015909A2 (pt) 2020-02-14 2022-10-04 Univ Johns Hopkins Métodos e materiais para avaliação de ácidos nucleicos
AU2021281223A1 (en) 2020-05-27 2023-01-05 Case Western Reserve University Compositions and methods for preserving DNA methylation
US11421217B1 (en) * 2021-04-07 2022-08-23 Convergent Genomics, Inc. Methods and compositions for collection and preservation of biologicals

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010263A1 (en) * 1991-11-14 1993-05-27 Digene Diagnostics, Inc. Non-radioactive hybridization assay and kit
JPH10210982A (ja) * 1997-01-31 1998-08-11 Fuji Yakuhin Kogyo Kk 新規なタンパク質
US6010895A (en) * 1994-02-14 2000-01-04 Macfarlane Burnet Centre For Medical Research Limited Non-pathogenic strains of HIV-1 containing mutations in the NEF gene or the U3 region of the long terminal repeat
US20030078228A1 (en) * 2001-09-24 2003-04-24 Taylor Doris A. Fas Ligand
US20050026976A1 (en) * 2003-06-02 2005-02-03 Curtin Michael L. Isoindolinone kinase inhibitors
US7138505B1 (en) * 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
CN1901939A (zh) * 2003-10-30 2007-01-24 艾吉拉医疗股份有限公司 利用反义iap寡聚物和化疗剂治疗增生性疾病

Family Cites Families (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732847A (en) 1981-06-09 1988-03-22 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4486536A (en) 1982-05-28 1984-12-04 Smithkline Diagnostics, Inc. Specimen slide for occult blood testing
US4865980A (en) * 1982-12-29 1989-09-12 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
DE131052T1 (de) 1983-01-10 1987-03-19 Gen-Probe Partners, San Diego, Calif. Verfahren zum aufspueren, identifizieren und quantifizieren von organismen und viren.
US5288611A (en) 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
EP0144914A3 (en) 1983-12-12 1986-08-13 Miles Inc. Hybridization assay employing labeled pairs of hybrid binding reagents
US4743535A (en) * 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
AU3844485A (en) 1984-02-09 1985-08-15 Enzo Biochem Inc. Heterologous detection of cabeled dna
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
US4512442A (en) * 1984-03-30 1985-04-23 Westinghouse Electric Corp. Method and apparatus for improving the servicing of an elevator system
US6221581B1 (en) 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
ZA853756B (en) 1984-06-01 1986-01-29 Miles Lab Nucleic acid hybridization assay employing immobilized rna probes
CA1253777A (en) 1984-06-01 1989-05-09 Robert J. Carrico Nucleic acid hybridization assay employing immobilized rna probes
IL75648A0 (en) 1984-07-05 1985-10-31 Gen Probe Inc Accelerated nucleic acid reassociation method
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4775619A (en) 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4689294A (en) 1984-11-19 1987-08-25 Miles Laboratories, Inc. Enhancement of hybridization of nucleic acids by anionic polymers
US5641630A (en) 1985-06-13 1997-06-24 Amgen Inc. Method and kit for performing nucleic acid hybridization assays
US4751177A (en) * 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
IL79112A (en) 1985-06-13 1992-01-15 Abbott Lab Method for the isolation of a nucleic acid sequence and kit for performing a hybridization assay
US4710472A (en) * 1985-09-25 1987-12-01 The United States Of America As Represented By The Secretary Of The Navy Magnetic separation device
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US5750338A (en) * 1986-10-23 1998-05-12 Amoco Corporation Target and background capture methods with amplification for affinity assays
US5220013A (en) * 1986-11-17 1993-06-15 Scios Nova Inc. DNA sequence useful for the detection of Alzheimer's disease
WO1988003957A1 (en) 1986-11-24 1988-06-02 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
AU601021B2 (en) 1987-03-11 1990-08-30 Molecular Diagnostics, Inc. Assay for necleic acid sequences in a sample
IL85551A0 (en) 1987-04-01 1988-08-31 Miles Inc Rapid hybridization assay and reagent system used therein
US5656731A (en) * 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
AU2932889A (en) 1987-12-01 1989-07-05 Amoco Corporation Detection of salmonella
US5082830A (en) * 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
DE68916671T2 (de) 1988-03-18 1995-03-02 Baylor College Medicine Mutationsnachweis durch kompetitiven Oligonukleotid-Priming.
US6326136B1 (en) * 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
US5374524A (en) * 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
NO165894C (no) 1988-05-24 1991-04-24 Gunnar Paulsen Analysemetode for gener.
ATE133714T1 (de) 1988-09-29 1996-02-15 Chiron Corp Polynukleotid-bestimmung mit selektierbaren spaltstellen
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
AU5269590A (en) * 1989-03-10 1990-10-09 Gene-Trak Systems Immobilized oligonucleotide probes and uses therefor
US5106727A (en) 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
DE69032847T2 (de) 1989-06-30 1999-05-12 Chiron Corp., Emeryville, Calif. Hydrophobe Nukleinsäure-Sonde
US5116734A (en) 1989-09-01 1992-05-26 Digene Diagnostics, Inc. Highly sensitive method for detecting peroxidase
DE69033850T2 (de) 1989-12-01 2002-06-06 Vysis, Inc. Nukleinsäuresonden zum Nachweis von HPV-Transkripts
US5629153A (en) 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
US5792606A (en) 1990-02-26 1998-08-11 Boehringer Mannheim Gmbh Nucleic acid hybridization based assay for determining a substance of interest
CA2039517C (en) 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5695926A (en) * 1990-06-11 1997-12-09 Bio Merieux Sandwich hybridization assays using very short capture probes noncovalently bound to a hydrophobic support
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5484699A (en) 1990-09-28 1996-01-16 Abbott Laboratories Nucleotide sequences useful as type specific probes, PCR primers and LCR probes for the amplification and detection of human papilloma virus, and related kits and methods
US5210704A (en) * 1990-10-02 1993-05-11 Technology International Incorporated System for prognosis and diagnostics of failure and wearout monitoring and for prediction of life expectancy of helicopter gearboxes and other rotating equipment
EP0557456A4 (en) 1990-11-14 1995-11-15 Siska Diagnostics Inc Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
JP3602530B2 (ja) 1991-03-07 2004-12-15 ヴァイロジェネティクス コーポレイション 遺伝子操作したワクチン菌株
US5283175A (en) 1991-04-15 1994-02-01 The Research Foundation Of State University Of New York Genus-specific oligomers of Borrelia and methods of using same
US5556748A (en) 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5747244A (en) 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
DE69231693T2 (de) 1991-12-23 2001-05-31 Bayer Corp., East Walpole Hbv amplifizierungssonden zur verwendung in hybridisierungssandwichassay in der lösungsphase
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
DE69322871T2 (de) 1992-09-15 1999-05-12 The Dow Chemical Co., Midland, Mich. Schlagzähmodifizierung von thermoplastiken
EP0625213B1 (en) 1992-10-09 1999-12-29 VYSIS, Inc. Assay methods
US5400267A (en) * 1992-12-08 1995-03-21 Hemostatix Corporation Local in-device memory feature for electrically powered medical equipment
DE69430665T2 (de) 1993-01-15 2002-11-21 The Public Health Research Institute Of The City Of New York, Inc. Empfindlicher nukleinsäure-sandwichhybridisierungs-assay und kits
WO1994028156A1 (en) 1993-05-20 1994-12-08 Dana-Farber Cancer Institute Compositions and methods for treatment of herpesvirus infections
KR100189229B1 (ko) * 1993-07-23 1999-06-01 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 핵산 증폭을 강화하는 방법
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
DK145493D0 (da) 1993-12-23 1993-12-23 Dako As Antistof
AUPM358894A0 (en) 1994-01-31 1994-02-24 Csl Limited Modified papilloma virus l2 protein and vlps formed therefrom
WO1995027078A1 (en) 1994-04-04 1995-10-12 Ciba Corning Diagnostics Corp. Hibridization-ligation assays for the detection of specific nucleic acid sequences
CA2126952C (en) 1994-06-28 2010-12-14 Sithian Pandian Probe, kit, and method of amplification for increasing the sensitivity of nucleic acid hybridization assays
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
JP3093116B2 (ja) 1994-09-30 2000-10-03 株式会社豊田中央研究所 核酸検出方法
US6057099A (en) 1994-12-02 2000-05-02 Intelligene Ltd. Detection of nucleic acid sequences
US5747248A (en) 1994-12-05 1998-05-05 Chiron Corporation Discontinuous probe design using hybritope mapping
US20030104361A1 (en) 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
CA2139070C (en) 1994-12-23 2010-03-30 Burton W. Blais Method for enhancing detection ability of nucleic acid assays employing polymerase chain reaction
US5731153A (en) 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
US5888724A (en) 1995-02-17 1999-03-30 The Trustees Of Columbia University In The City Of New York Detection of high oncogenic-risk papilloma virus in high grade cervical lesions and cancers by a PCR/ELISA assay
US6083925A (en) 1995-06-07 2000-07-04 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
CA2223050A1 (en) 1995-06-07 1996-12-19 Abbott Laboratories Probe masking method of reducing background in an amplification reaction
FR2737502B1 (fr) 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
JP2000500342A (ja) 1995-11-15 2000-01-18 ジェン−プローブ・インコーポレーテッド ヒトパピローマウイルス核酸に相補的な核酸プローブおよび関連する方法およびキット
CA2244891C (en) 1996-02-09 2008-12-30 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP0910299B1 (en) * 1996-02-15 2003-02-12 Biosense, Inc. Method for configuring and operating a probe
US20010039007A1 (en) * 1996-10-15 2001-11-08 Robert Hallowitz Methods and compositions for determining latent viral load
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
GB9624165D0 (en) * 1996-11-19 1997-01-08 Amdex A S Use of nucleic acids bound to carrier macromolecules
US6110676A (en) * 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US6331181B1 (en) * 1998-12-08 2001-12-18 Intuitive Surgical, Inc. Surgical robotic tools, data architecture, and use
US6132368A (en) * 1996-12-12 2000-10-17 Intuitive Surgical, Inc. Multi-component telepresence system and method
US20020034737A1 (en) 1997-03-04 2002-03-21 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
US6151039A (en) * 1997-06-04 2000-11-21 Hewlett-Packard Company Ink level estimation using drop count and ink level sense
WO1998059044A1 (en) * 1997-06-25 1998-12-30 Tularik Inc. High-throughput screening assays for modulators of primase activity
US6043038A (en) 1998-03-31 2000-03-28 Tularik, Inc. High-throughput screening assays for modulators of primase activity
US5843995A (en) 1997-07-07 1998-12-01 University Of Medicine And Dentistry Of New Jersey Inhibition of HIV-1 replication using oligocarbamate derivatives
IL121348A0 (en) * 1997-07-21 1998-04-05 Bio Rad Lab Israel Inc System and method for device monitoring
AU1232099A (en) 1997-11-04 1999-05-24 Roche Diagnostics Gmbh Specific and sensitive method for detecting nucleic acids
US6225053B1 (en) 1997-12-12 2001-05-01 Digene Corporation Detection of hepatitis B virus
PT1038022E (pt) 1997-12-12 2005-11-30 Digene Corp Avaliacao de doencas relacionadas com o virus papiloma humano
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
JP4325114B2 (ja) 1997-12-22 2009-09-02 日立化成工業株式会社 オリゴヌクレオチド固定化ｐｃｒマイクロプレート上での直接ｒｔ−ｐｃｒ
WO1999036571A2 (en) 1998-01-13 1999-07-22 Biochip Technologies Gmbh Method for the detection or nucleic acid of nucleic acid sequences
WO1999039001A2 (en) 1998-02-02 1999-08-05 Amersham Pharmacia Biotech Ab Nucleic acid analysis method
US6686151B1 (en) 1998-02-06 2004-02-03 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US7399589B2 (en) 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US5994079A (en) * 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
DE69836907T2 (de) * 1998-02-10 2007-11-08 Biosense Webster, Inc., Diamond Bar Sondenanordnung zur verbesserten katheterkalibrierung
DE69820853T2 (de) 1998-03-23 2004-11-18 Spal S.R.L., Correggio Axiallüfter
US6183956B1 (en) 1998-03-31 2001-02-06 Tularik, Incorporated High throughput in vitro screening assays for transcription modulators
DE69940850D1 (de) * 1998-08-04 2009-06-18 Intuitive Surgical Inc Gelenkvorrichtung zur Positionierung eines Manipulators für Robotik-Chirurgie
US20020004198A1 (en) * 1998-12-16 2002-01-10 Hardwicke Mary Ann Novel anti-infectives
US20010055766A1 (en) * 1999-04-02 2001-12-27 Alexander Aristarkhov Immunosorbant assay using branched bis-biotin/avidin/multiple label complex as a detection reagent
AU4051300A (en) 1999-04-02 2000-10-23 Tropix, Inc. High throughput and high sensitivity detection assays
US7019822B1 (en) 1999-04-29 2006-03-28 Mss, Inc. Multi-grade object sorting system and method
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6200746B1 (en) 1999-08-25 2001-03-13 Pharmacia & Upjohn Company Methods of identifying anti-viral agents
US6611793B1 (en) * 1999-09-07 2003-08-26 Scimed Life Systems, Inc. Systems and methods to identify and disable re-use single use devices based on detecting environmental changes
US20060275784A1 (en) 1999-10-26 2006-12-07 Ventana Medical Systems, Inc. Detection of Human Papilloma Virus in Papanicolaou (Pap) Smears
US6893819B1 (en) 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US6436662B1 (en) * 2000-04-04 2002-08-20 Digene Corporation Device and method for cytology slide preparation
US6521190B1 (en) 2000-05-19 2003-02-18 Digene Corporation Cell collection apparatus
EP1290225A4 (en) 2000-05-20 2004-09-15 Univ Michigan METHOD FOR PRODUCING A DNA BANK BY POSITIONAL REPRODUCTION
WO2001094625A2 (en) 2000-06-06 2001-12-13 Tm Bioscience Corporation Capture moieties for nucleic acids and uses thereof
US7439016B1 (en) * 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US7601497B2 (en) * 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
BR0112385A (pt) 2000-06-21 2003-06-17 Digene Corp Meio de coleta universal
US7110092B2 (en) * 2000-08-01 2006-09-19 Michael Kasper Measuring device and measuring method for determining distance and/or position
JP2004518421A (ja) 2000-12-12 2004-06-24 インビトロジェン コーポレイション 固体マトリックスから核酸分子を解放させるための組成物および方法
EP1368629B1 (en) 2001-02-16 2009-02-11 Cortex Biochem Inc. Magnetic isolation and purification of nucleic acids
US6542856B2 (en) * 2001-06-15 2003-04-01 General Electric Company System and method for monitoring gas turbine plants
AU2002315397A1 (en) * 2001-06-20 2003-01-08 Power Medical Interventions, Inc. A method and system for integrated medical tracking
SI1421200T1 (sl) 2001-08-23 2007-04-30 Merck & Co Inc Poskusi PCR fluorescentnih multipleks HPV-jev z uporabo vec fluoroforov
LU90840B1 (en) * 2001-09-25 2003-03-26 Delphi Tech Inc Method for controlling the operation of a system sub-system or component
US20050032105A1 (en) 2001-10-12 2005-02-10 Bair Robert Jackson Compositions and methods for using a solid support to purify DNA
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
EP2272988A3 (en) 2002-01-07 2011-06-15 Norchip A/S Method for detecting human papillomavirus mRNA
JP4521152B2 (ja) * 2002-03-05 2010-08-11 株式会社東芝 半導体製造装置
US20030175828A1 (en) 2002-03-15 2003-09-18 Lazar James G. Signal amplification by Hybrid Capture
US20030208196A1 (en) * 2002-05-03 2003-11-06 Arthrocare Corporation Control system for limited-use device
EP1507148B1 (en) * 2003-08-25 2005-02-23 MTM Laboratories AG Method for detecting carcinomas in a solubilized cervical body sample
US7648678B2 (en) * 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
AU2004209001B2 (en) * 2003-01-29 2007-10-11 454 Life Sciences Corporation Bead emulsion nucleic acid amplification
WO2004087950A2 (en) 2003-04-04 2004-10-14 Roche Diagnostics Gmbh Improved system for multi color real time pcr
JP5183063B2 (ja) 2003-07-05 2013-04-17 ザ ジョンズ ホプキンス ユニバーシティ 遺伝的変異の検出および列挙のための方法ならびに組成物
WO2005033333A2 (en) 2003-10-07 2005-04-14 Dako Denmark A/S Methods and compositions for the diagnosis of cancer
US20070083286A1 (en) * 2004-03-09 2007-04-12 Olympus Corporation Medical instrument and equipment for managing of the same
CN1690223B (zh) 2004-04-27 2010-05-05 亚能生物技术（深圳）有限公司 人乳头瘤病毒分型基因芯片检测系统
US7398181B2 (en) * 2004-06-02 2008-07-08 Hewlett-Packard Development Company, L.P. Method for retrieving reliability data in a system
US20060095096A1 (en) * 2004-09-09 2006-05-04 Debenedictis Leonard C Interchangeable tips for medical laser treatments and methods for using same
ES2564659T3 (es) 2004-09-30 2016-03-28 Epigenomics Ag Método para proveer fragmentos de ADN derivados de una muestra archivada
AU2005302453A1 (en) 2004-10-29 2006-05-11 Medimmune, Llc Methods of preventing and treating RSV infections and related conditions
US20060129269A1 (en) * 2004-12-15 2006-06-15 Xerox Corporation Processes for using a memory storage device in conjunction with tooling
WO2006075245A2 (en) 2005-01-14 2006-07-20 The Regents Of The University Of Michigan Systems, methods, and compositions for detection of human papilloma virus in biological samples
US20060240449A1 (en) 2005-01-19 2006-10-26 Mcglennen Ronald C Methods and compositions for preparation of biological samples
EP1928560A2 (en) 2005-04-06 2008-06-11 Verenium Corporation Enzymes and formulations for broad-specificity decontamination of chemical and biological warfare agents
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
US20080003565A1 (en) 2006-05-02 2008-01-03 Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services Viral nucleic acid microarray and method of use
CN101460636A (zh) 2006-05-11 2009-06-17 伯克顿迪金森公司 从细胞中提取蛋白质的方法
US20080206777A1 (en) 2007-02-27 2008-08-28 Nuclea Biomarkers, Llc Gene and protein expression profiles associated with the therapeutic efficacy of EGFR-TK inhibitors
US7985375B2 (en) 2007-04-06 2011-07-26 Qiagen Gaithersburg, Inc. Sample preparation system and method for processing clinical specimens
US8357538B2 (en) 2007-04-06 2013-01-22 Qiagen Gaithersburg, Inc. Automated assay and system
US8703492B2 (en) 2007-04-06 2014-04-22 Qiagen Gaithersburg, Inc. Open platform hybrid manual-automated sample processing system
JPWO2008139938A1 (ja) 2007-05-02 2010-08-05 国立大学法人 東京医科歯科大学 ヒトパピローマウイルス１６型遺伝子を標的とする二本鎖核酸分子及びそれを含む医薬
EP2152902A2 (en) 2007-06-08 2010-02-17 Epigenomics AG Method for methylation analysis
CN101177701B (zh) 2007-09-29 2010-08-18 潮州凯普生物化学有限公司 人乳头状瘤病毒基因分型检测试剂盒及其基因芯片制备方法
CA2702241A1 (en) 2007-10-11 2009-04-16 The Ohio State University Research Foundation Methods and compositions for the diagnosis and treatment of esophageal adenocarcinomas
JP2009106220A (ja) 2007-10-31 2009-05-21 Genodive Pharma Kk 基板上での等温増幅反応による標的塩基配列の捕捉及び検出方法
CA2704151C (en) 2007-11-01 2017-04-25 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg New detection method for cervical hpvs
WO2009123996A2 (en) 2008-03-31 2009-10-08 The Ohio State University Research Foundation Hybridization quantitation method for modified micro-rna and -dna based oligonucleotides
EP2262911B1 (en) * 2008-04-17 2016-10-12 QIAGEN Gaithersburg, Inc. Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid
WO2010004251A1 (en) 2008-06-16 2010-01-14 Oncomethylome Sciences Sa Dna methylomes
US20100121046A1 (en) 2008-09-05 2010-05-13 Mayo Foundation For Medical Education And Research Collecting and processing complex macromolecular mixtures
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
JP2012506705A (ja) 2008-10-27 2012-03-22 キアジェン ゲイサーズバーグ インコーポレイテッド 迅速に結果を得るハイブリッドキャプチャー法による分析およびシステム
EP2184368A1 (en) 2008-11-07 2010-05-12 DKFZ Deutsches Krebsforschungszentrum Diagnostic transcript and splice patterns of HPV16 in different cervical lesions
CA2750820A1 (en) * 2009-01-27 2010-08-05 Qiagen Gaithersburg Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
CA2750338C (en) * 2009-01-28 2019-06-25 Qiagen Gaithersburg, Inc. Sequence-specific large volume sample preparation method and assay
CN102414327B (zh) * 2009-05-01 2015-04-08 奇亚根盖瑟斯堡股份有限公司 用于在样品中检测rna剪接形式的非靶向扩增方法
US20110053143A1 (en) * 2009-09-03 2011-03-03 Qiagen Gaithersburg Inc. Methods and kits for determining viral load in clinical samples
WO2011032124A1 (en) * 2009-09-14 2011-03-17 Qiagen Gaithersburg, Inc. Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
WO2011082415A2 (en) * 2010-01-04 2011-07-07 Qiagen Gaithersburg, Inc. Methods, compositions, and kits for recovery of nucleic acids or proteins from fixed tissue samples
JP2013516192A (ja) * 2010-01-08 2013-05-13 キアジェン ゲイサーズバーグ インコーポレイテッド 等温核酸増幅のための材料および方法
JP2013517803A (ja) * 2010-01-29 2013-05-20 キアジェン ゲイサーズバーグ インコーポレイテッド サンプル中のｈｐｖの存在を決定および確認する方法
JP6103941B2 (ja) * 2010-01-29 2017-03-29 キアジェン ゲイサーズバーグ インコーポレイテッド 核酸の配列特異的精製および多重分析のための方法および組成物
CA2799200A1 (en) * 2010-05-19 2011-11-24 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9376727B2 (en) * 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138505B1 (en) * 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
WO1993010263A1 (en) * 1991-11-14 1993-05-27 Digene Diagnostics, Inc. Non-radioactive hybridization assay and kit
US6010895A (en) * 1994-02-14 2000-01-04 Macfarlane Burnet Centre For Medical Research Limited Non-pathogenic strains of HIV-1 containing mutations in the NEF gene or the U3 region of the long terminal repeat
JPH10210982A (ja) * 1997-01-31 1998-08-11 Fuji Yakuhin Kogyo Kk 新規なタンパク質
US20030078228A1 (en) * 2001-09-24 2003-04-24 Taylor Doris A. Fas Ligand
US20050026976A1 (en) * 2003-06-02 2005-02-03 Curtin Michael L. Isoindolinone kinase inhibitors
CN1901939A (zh) * 2003-10-30 2007-01-24 艾吉拉医疗股份有限公司 利用反义iap寡聚物和化疗剂治疗增生性疾病

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PURSHOTAM BHAN ET AL: "24,54-Linked oligo-34-deoxyribonucleoside phosphorothioate chimeras: thermal stability and antisense inhibition of gene expression", 《NUCLEIC ACIDS RESEARCH》 *

Also Published As

Publication number Publication date
TW201022447A (en) 2010-06-16
AU2009320213B2 (en) 2016-06-16
WO2010062556A1 (en) 2010-06-03
TW201022448A (en) 2010-06-16
ES2622062T3 (es) 2017-07-05
US8735564B2 (en) 2014-05-27
AU2009320213A1 (en) 2010-06-03
JP2012506705A (ja) 2012-03-22
EP2347011B1 (en) 2017-01-18
CA2741650C (en) 2017-09-05
TWI417389B (zh) 2013-12-01
JP2015119719A (ja) 2015-07-02
CA2741650A1 (en) 2010-06-03
TW201323616A (zh) 2013-06-16
US20100105060A1 (en) 2010-04-29
US20100159463A1 (en) 2010-06-24
US20130011830A1 (en) 2013-01-10
WO2010062546A1 (en) 2010-06-03
EP2347011A1 (en) 2011-07-27
US8877436B2 (en) 2014-11-04
US8288520B2 (en) 2012-10-16
TWI419974B (zh) 2013-12-21
TWI394839B (zh) 2013-05-01

Similar Documents

Publication Publication Date Title
CN102203293A (zh) 快速结果杂交捕获测定和系统
JP2012506705A5 (enExample)
EP2262911B1 (en) Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid
JP6108661B2 (ja) 配列特異的な大量試料調製方法およびアッセイ法
AU2011258501B2 (en) Fast results hybrid capture assay and associated strategically-truncated probes
RU2796820C1 (ru) Способ детекции чумного микроба и набор реагентов для его осуществления
KR102900608B1 (ko) 바토넬라균 검출용 프라이머 세트
EP1778870A2 (en) Determination of nucleic acid analytes by treatment with microwaves

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20110928