AU2009320213B2 - Fast results hybrid capture assay and system - Google Patents

Fast results hybrid capture assay and system Download PDF

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Publication number
AU2009320213B2
AU2009320213B2 AU2009320213A AU2009320213A AU2009320213B2 AU 2009320213 B2 AU2009320213 B2 AU 2009320213B2 AU 2009320213 A AU2009320213 A AU 2009320213A AU 2009320213 A AU2009320213 A AU 2009320213A AU 2009320213 B2 AU2009320213 B2 AU 2009320213B2
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Australia
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nucleic acid
antibody
sample
detergent
target nucleic
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AU2009320213A
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AU2009320213A1 (en
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Laura Bell
Paul Eder
Irina Nazarenko
Eric Payne
Sugi Ramanchandran
Arvind Virmani
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Qiagen Gaithersburg LLC
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Qiagen Gaithersburg LLC
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/708Specific hybridization probes for papilloma

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
AU2009320213A 2008-10-27 2009-10-26 Fast results hybrid capture assay and system Ceased AU2009320213B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10868708P 2008-10-27 2008-10-27
US61/108,687 2008-10-27
US17484809P 2009-05-01 2009-05-01
US61/174,848 2009-05-01
PCT/US2009/062061 WO2010062556A1 (en) 2008-10-27 2009-10-26 Fast results hybrid capture assay and system

Publications (2)

Publication Number Publication Date
AU2009320213A1 AU2009320213A1 (en) 2010-06-03
AU2009320213B2 true AU2009320213B2 (en) 2016-06-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009320213A Ceased AU2009320213B2 (en) 2008-10-27 2009-10-26 Fast results hybrid capture assay and system

Country Status (9)

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US (3) US8288520B2 (enExample)
EP (1) EP2347011B1 (enExample)
JP (2) JP2012506705A (enExample)
CN (1) CN102203293A (enExample)
AU (1) AU2009320213B2 (enExample)
CA (1) CA2741650C (enExample)
ES (1) ES2622062T3 (enExample)
TW (3) TWI417389B (enExample)
WO (2) WO2010062546A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703492B2 (en) 2007-04-06 2014-04-22 Qiagen Gaithersburg, Inc. Open platform hybrid manual-automated sample processing system
US8357538B2 (en) * 2007-04-06 2013-01-22 Qiagen Gaithersburg, Inc. Automated assay and system
CN102203293A (zh) 2008-10-27 2011-09-28 奇亚根盖瑟斯堡股份有限公司 快速结果杂交捕获测定和系统
CA2711418C (en) 2009-01-05 2015-12-15 Afl Telecommunications Llc Universal mounting bracket
JP5826752B2 (ja) 2009-09-14 2015-12-02 キアジェン ゲイサーズバーグ インコーポレイテッド 細胞学用培地に固定された組織サンプルから核酸またはタンパク質を回収するための組成物および方法
WO2011063139A1 (en) 2009-11-18 2011-05-26 Qiagen Laboratory central control unit method and system
US9107652B2 (en) * 2009-11-19 2015-08-18 Qiagen Gaithersburg, Inc. Sampling devices and methods
WO2011094528A2 (en) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an hpv in a sample
US9689047B2 (en) * 2010-01-29 2017-06-27 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
EP2572001A2 (en) 2010-05-19 2013-03-27 QIAGEN Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
WO2011149897A1 (en) * 2010-05-25 2011-12-01 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
US9885092B2 (en) 2011-02-24 2018-02-06 Qiagen Gaithersburg Inc. Materials and methods for detection of HPV nucleic acids
HUE068153T2 (hu) 2011-04-15 2024-12-28 Univ Johns Hopkins Biztonságos szekvenálási rendszer
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US11931740B2 (en) 2012-02-13 2024-03-19 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9050594B2 (en) 2012-02-13 2015-06-09 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US20130231261A1 (en) * 2012-02-17 2013-09-05 Institute For Systems Biology Rnase h-based rna profiling
US9435718B2 (en) 2012-10-22 2016-09-06 Qiagen Gaithersburg, Inc. Automated pelletized sample decanting apparatus and methods
US9260763B2 (en) * 2012-10-22 2016-02-16 Qiagen Gaithersburg, Inc. Sample processing method using tube strips and tube strip holder
US9310281B2 (en) 2012-10-22 2016-04-12 Qiagen Gaithersburg, Inc. Automated pelletized sample blotting apparatus and methods
DK2912174T3 (da) 2012-10-25 2019-08-26 Neumodx Molecular Inc Fremgangsmåde og materialer til isolering af nukleinsyrematerialer
ES2886507T5 (es) 2012-10-29 2024-11-15 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
US11007183B2 (en) 2013-12-20 2021-05-18 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of PI3K/Akt pathway and ERK inhibitors
EP3082800B1 (en) 2013-12-20 2022-02-02 Biomed Valley Discoveries, Inc. Cancer treatment using combinations of erk and raf inhibitors
WO2015095842A2 (en) 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers
EP3984537B1 (en) 2013-12-20 2024-03-20 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of type 2 mek and erk inhibitors
WO2015095840A1 (en) 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of cdk and erk inhibitors
CN104020291B (zh) * 2014-06-26 2016-03-30 南京大学 一种基于酶联免疫分析的hpv核酸检测试剂盒及其应用
EP3252040B1 (en) * 2015-01-27 2023-04-19 BGI Shenzhen Stabilizer for preserving biological samples
CN108027379B (zh) 2015-06-26 2021-07-23 雅培实验室 用于诊断分析设备的反应容器交换装置
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
WO2018160907A1 (en) * 2017-03-03 2018-09-07 Counsyl, Inc. Extraction of nucleic acids for reduced probe count variability
SG11202001010UA (en) 2017-08-07 2020-03-30 Univ Johns Hopkins Methods and materials for assessing and treating cancer
EP3976816A4 (en) * 2019-05-28 2023-10-25 Case Western Reserve University COMPOSITIONS AND METHODS FOR PRESERVING DNA METHYLATION
AU2021219794A1 (en) 2020-02-14 2022-09-08 The Johns Hopkins University Methods and materials for assessing nucleic acids
EP4158016A4 (en) 2020-05-27 2024-06-05 Case Western Reserve University COMPOSITIONS AND METHODS FOR PRESERVING DNA METHYLATION
US11421217B1 (en) * 2021-04-07 2022-08-23 Convergent Genomics, Inc. Methods and compositions for collection and preservation of biologicals

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010263A1 (en) * 1991-11-14 1993-05-27 Digene Diagnostics, Inc. Non-radioactive hybridization assay and kit
US20080200344A1 (en) * 2005-11-15 2008-08-21 Shu-Ling Cheng Protein chips for HPV detection

Family Cites Families (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732847A (en) * 1981-06-09 1988-03-22 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4486536A (en) * 1982-05-28 1984-12-04 Smithkline Diagnostics, Inc. Specimen slide for occult blood testing
US4865980A (en) * 1982-12-29 1989-09-12 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
US5288611A (en) * 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
EP0756010B1 (en) * 1983-01-10 2001-07-04 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
EP0144914A3 (en) 1983-12-12 1986-08-13 Miles Inc. Hybridization assay employing labeled pairs of hybrid binding reagents
US4743535A (en) * 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
AU3844485A (en) 1984-02-09 1985-08-15 Enzo Biochem Inc. Heterologous detection of cabeled dna
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
US4512442A (en) * 1984-03-30 1985-04-23 Westinghouse Electric Corp. Method and apparatus for improving the servicing of an elevator system
US6221581B1 (en) * 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
CA1253777A (en) 1984-06-01 1989-05-09 Robert J. Carrico Nucleic acid hybridization assay employing immobilized rna probes
ZA853756B (en) 1984-06-01 1986-01-29 Miles Lab Nucleic acid hybridization assay employing immobilized rna probes
IL75648A0 (en) 1984-07-05 1985-10-31 Gen Probe Inc Accelerated nucleic acid reassociation method
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4775619A (en) 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4689294A (en) * 1984-11-19 1987-08-25 Miles Laboratories, Inc. Enhancement of hybridization of nucleic acids by anionic polymers
US4751177A (en) * 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US5641630A (en) * 1985-06-13 1997-06-24 Amgen Inc. Method and kit for performing nucleic acid hybridization assays
ES8707343A1 (es) 1985-06-13 1987-07-16 Amgen Un metodo para aislar una secuencia de acido nucleico objetivo seleccionada
US4710472A (en) * 1985-09-25 1987-12-01 The United States Of America As Represented By The Secretary Of The Navy Magnetic separation device
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US5750338A (en) * 1986-10-23 1998-05-12 Amoco Corporation Target and background capture methods with amplification for affinity assays
US5220013A (en) * 1986-11-17 1993-06-15 Scios Nova Inc. DNA sequence useful for the detection of Alzheimer's disease
PT86204B (pt) 1986-11-24 1990-11-07 Hogan James John Metodo para a preparacao de sondas de acido nucleico para a deteccao e/ou quantificacao de organismos nao-virais
AU601021B2 (en) 1987-03-11 1990-08-30 Molecular Diagnostics, Inc. Assay for necleic acid sequences in a sample
IL85551A0 (en) 1987-04-01 1988-08-31 Miles Inc Rapid hybridization assay and reagent system used therein
US5656731A (en) * 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
JP2795503B2 (ja) * 1987-12-01 1998-09-10 アモコ・コーポレーション サルモネラ菌の検出
US5082830A (en) * 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
DE68916671T2 (de) 1988-03-18 1995-03-02 Baylor College Medicine Mutationsnachweis durch kompetitiven Oligonukleotid-Priming.
US6326136B1 (en) * 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
US5374524A (en) * 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
NO165894C (no) 1988-05-24 1991-04-24 Gunnar Paulsen Analysemetode for gener.
ATE133714T1 (de) 1988-09-29 1996-02-15 Chiron Corp Polynukleotid-bestimmung mit selektierbaren spaltstellen
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
DE69017204T2 (de) * 1989-03-10 1995-08-03 Amoco Corp Immobilisierte oligonukleotidsonden und ihre verwendungen.
US5106727A (en) * 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
EP0405913B1 (en) * 1989-06-30 1998-12-23 Chiron Corporation Hydrophobic nucleic acid probe
US5116734A (en) * 1989-09-01 1992-05-26 Digene Diagnostics, Inc. Highly sensitive method for detecting peroxidase
EP0502994B1 (en) 1989-12-01 1995-09-06 Amoco Corporation Detection of hpv transcripts
US5629153A (en) 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
US5792606A (en) * 1990-02-26 1998-08-11 Boehringer Mannheim Gmbh Nucleic acid hybridization based assay for determining a substance of interest
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5695926A (en) * 1990-06-11 1997-12-09 Bio Merieux Sandwich hybridization assays using very short capture probes noncovalently bound to a hydrophobic support
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5484699A (en) * 1990-09-28 1996-01-16 Abbott Laboratories Nucleotide sequences useful as type specific probes, PCR primers and LCR probes for the amplification and detection of human papilloma virus, and related kits and methods
US5210704A (en) * 1990-10-02 1993-05-11 Technology International Incorporated System for prognosis and diagnostics of failure and wearout monitoring and for prediction of life expectancy of helicopter gearboxes and other rotating equipment
US5474895A (en) * 1990-11-14 1995-12-12 Siska Diagnostics Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
EP0575491B1 (en) 1991-03-07 2003-08-13 Virogenetics Corporation Genetically engineered vaccine strain
US5283175A (en) * 1991-04-15 1994-02-01 The Research Foundation Of State University Of New York Genus-specific oligomers of Borrelia and methods of using same
US5556748A (en) * 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
US5981179A (en) * 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5747244A (en) * 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
DE69231693T2 (de) * 1991-12-23 2001-05-31 Bayer Corp., East Walpole Hbv amplifizierungssonden zur verwendung in hybridisierungssandwichassay in der lösungsphase
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
EP0877050B1 (en) * 1992-09-15 2008-05-21 Dow Global Technologies Inc. Impact modification of thermoplastics
WO1994010335A2 (en) * 1992-10-09 1994-05-11 Amoco Corporation Assay methods
US5400267A (en) * 1992-12-08 1995-03-21 Hemostatix Corporation Local in-device memory feature for electrically powered medical equipment
DE69430665T2 (de) 1993-01-15 2002-11-21 The Public Health Research Institute Of The City Of New York, Inc. Empfindlicher nukleinsäure-sandwichhybridisierungs-assay und kits
WO1994028156A1 (en) * 1993-05-20 1994-12-08 Dana-Farber Cancer Institute Compositions and methods for treatment of herpesvirus infections
JP3026843B2 (ja) * 1993-07-23 2000-03-27 ジェン−プローブ・インコーポレーテッド 核酸増幅の促進法
DE4331012A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
DK145493D0 (da) 1993-12-23 1993-12-23 Dako As Antistof
AUPM358894A0 (en) * 1994-01-31 1994-02-24 Csl Limited Modified papilloma virus l2 protein and vlps formed therefrom
DE69535500D1 (de) * 1994-02-14 2007-07-05 Macfarlane Burnet Ct For Medic Nicht pathogene stämme des hiv-1
BR9507343A (pt) * 1994-04-04 1997-09-16 Ciba Corning Diagnostics Corp Testes de hibridização - ligação para a detecção de sequências de ácido nucléico específicas
CA2126952C (en) 1994-06-28 2010-12-14 Sithian Pandian Probe, kit, and method of amplification for increasing the sensitivity of nucleic acid hybridization assays
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
JP3093116B2 (ja) * 1994-09-30 2000-10-03 株式会社豊田中央研究所 核酸検出方法
US6057099A (en) * 1994-12-02 2000-05-02 Intelligene Ltd. Detection of nucleic acid sequences
US5747248A (en) 1994-12-05 1998-05-05 Chiron Corporation Discontinuous probe design using hybritope mapping
US20030104361A1 (en) 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
CA2139070C (en) 1994-12-23 2010-03-30 Burton W. Blais Method for enhancing detection ability of nucleic acid assays employing polymerase chain reaction
US5731153A (en) * 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
US5888724A (en) 1995-02-17 1999-03-30 The Trustees Of Columbia University In The City Of New York Detection of high oncogenic-risk papilloma virus in high grade cervical lesions and cancers by a PCR/ELISA assay
US6083925A (en) * 1995-06-07 2000-07-04 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
WO1996040992A2 (en) * 1995-06-07 1996-12-19 Abbott Laboratories Probe masking method of reducing background in an amplification reaction
FR2737502B1 (fr) * 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
CA2237891C (en) 1995-11-15 2013-07-30 Gen-Probe Incorporated Nucleic acid probes complementary to human papillomavirus nucleic acid and related methods and kits
EP2574617B1 (en) 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
JP3881029B2 (ja) * 1996-02-15 2007-02-14 バイオセンス・インコーポレイテッド フィールドトランスデューサを備えた医療用プローブ
US20010039007A1 (en) * 1996-10-15 2001-11-08 Robert Hallowitz Methods and compositions for determining latent viral load
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
GB9624165D0 (en) * 1996-11-19 1997-01-08 Amdex A S Use of nucleic acids bound to carrier macromolecules
US6110676A (en) * 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US6132368A (en) * 1996-12-12 2000-10-17 Intuitive Surgical, Inc. Multi-component telepresence system and method
US6331181B1 (en) * 1998-12-08 2001-12-18 Intuitive Surgical, Inc. Surgical robotic tools, data architecture, and use
US20020034737A1 (en) 1997-03-04 2002-03-21 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
JPH10210982A (ja) * 1997-01-31 1998-08-11 Fuji Yakuhin Kogyo Kk 新規なタンパク質
US6151039A (en) * 1997-06-04 2000-11-21 Hewlett-Packard Company Ink level estimation using drop count and ink level sense
AU7986398A (en) * 1997-06-25 1999-01-04 Tularik Inc. High-throughput screening assays for modulators of primase activity
US6043038A (en) * 1998-03-31 2000-03-28 Tularik, Inc. High-throughput screening assays for modulators of primase activity
US5843995A (en) 1997-07-07 1998-12-01 University Of Medicine And Dentistry Of New Jersey Inhibition of HIV-1 replication using oligocarbamate derivatives
IL121348A0 (en) * 1997-07-21 1998-04-05 Bio Rad Lab Israel Inc System and method for device monitoring
JP2001521765A (ja) 1997-11-04 2001-11-13 ロシュ ダイアグノスティックス ゲーエムベーハー 特異的かつ高感度な核酸検出方法
JP2002508190A (ja) 1997-12-12 2002-03-19 ダイジーン・コーポレーション 万能収集媒質
US6225053B1 (en) * 1997-12-12 2001-05-01 Digene Corporation Detection of hepatitis B virus
US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
EP1600512B1 (en) 1997-12-22 2008-05-28 Hitachi Chemical Co., Ltd. mRNA purification on microplates
JP2002517981A (ja) 1998-01-13 2002-06-25 ビオヒプ テヒノロギース ゲゼルシャフト ミット ベシュレンクテル ハフツング 核酸配列を検出するための方法
US6280954B1 (en) * 1998-02-02 2001-08-28 Amersham Pharmacia Biotech Ab Arrayed primer extension technique for nucleic acid analysis
US6686151B1 (en) 1998-02-06 2004-02-03 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US5994079A (en) 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
US7399589B2 (en) 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
EP0973454B1 (en) * 1998-02-10 2007-01-17 Biosense Webster, Inc. Probe assembly for improved catheter calibration
DE69820853T2 (de) 1998-03-23 2004-11-18 Spal S.R.L., Correggio Axiallüfter
US6183956B1 (en) 1998-03-31 2001-02-06 Tularik, Incorporated High throughput in vitro screening assays for transcription modulators
US6246200B1 (en) * 1998-08-04 2001-06-12 Intuitive Surgical, Inc. Manipulator positioning linkage for robotic surgery
US20020004198A1 (en) * 1998-12-16 2002-01-10 Hardwicke Mary Ann Novel anti-infectives
US20010055766A1 (en) * 1999-04-02 2001-12-27 Alexander Aristarkhov Immunosorbant assay using branched bis-biotin/avidin/multiple label complex as a detection reagent
AU4051300A (en) 1999-04-02 2000-10-23 Tropix, Inc. High throughput and high sensitivity detection assays
US7019822B1 (en) 1999-04-29 2006-03-28 Mss, Inc. Multi-grade object sorting system and method
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6200746B1 (en) 1999-08-25 2001-03-13 Pharmacia & Upjohn Company Methods of identifying anti-viral agents
US6611793B1 (en) * 1999-09-07 2003-08-26 Scimed Life Systems, Inc. Systems and methods to identify and disable re-use single use devices based on detecting environmental changes
US20060275784A1 (en) 1999-10-26 2006-12-07 Ventana Medical Systems, Inc. Detection of Human Papilloma Virus in Papanicolaou (Pap) Smears
US6893819B1 (en) 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US6436662B1 (en) * 2000-04-04 2002-08-20 Digene Corporation Device and method for cytology slide preparation
US6521190B1 (en) * 2000-05-19 2003-02-18 Digene Corporation Cell collection apparatus
AU2001274869A1 (en) 2000-05-20 2001-12-03 The Regents Of The University Of Michigan Method of producing a dna library using positional amplification
AU2001267191A1 (en) 2000-06-06 2001-12-17 Tm Bioscience Corporation Capture moieties for nucleic acids and uses thereof
US7601497B2 (en) * 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
DE60142048D1 (de) 2000-06-21 2010-06-17 Qiagen Gaithersburg Inc Universelles sammelmedium
WO2002010681A1 (de) * 2000-08-01 2002-02-07 Mirko Essling Messanordnung und messverfahren zur entfernungs- und/oder positionsbestimmung
CA2431644A1 (en) 2000-12-12 2002-06-20 Invitrogen Corporation Compositions and methods for the release of nucleic acid molecules from solid matrices
ES2322841T3 (es) 2001-02-16 2009-06-30 Promega Corporation Aislamiento y purificacion magnetica de acidos nucleicos.
US6542856B2 (en) * 2001-06-15 2003-04-01 General Electric Company System and method for monitoring gas turbine plants
WO2003001329A2 (en) * 2001-06-20 2003-01-03 Power Medical Interventions, Inc. A method and system for integrated medical tracking
SI1421200T1 (sl) 2001-08-23 2007-04-30 Merck & Co Inc Poskusi PCR fluorescentnih multipleks HPV-jev z uporabo vec fluoroforov
AU2002336762A1 (en) * 2001-09-24 2003-04-07 Duke University Fas ligand
LU90840B1 (en) * 2001-09-25 2003-03-26 Delphi Tech Inc Method for controlling the operation of a system sub-system or component
US20050032105A1 (en) 2001-10-12 2005-02-10 Bair Robert Jackson Compositions and methods for using a solid support to purify DNA
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
ES2282599T3 (es) 2002-01-07 2007-10-16 Norchip A/S Metodo para detectar arnm del virus del papiloma humano.
JP4521152B2 (ja) * 2002-03-05 2010-08-11 株式会社東芝 半導体製造装置
US20030175828A1 (en) 2002-03-15 2003-09-18 Lazar James G. Signal amplification by Hybrid Capture
US20030208196A1 (en) * 2002-05-03 2003-11-06 Arthrocare Corporation Control system for limited-use device
EP1507148B1 (en) 2003-08-25 2005-02-23 MTM Laboratories AG Method for detecting carcinomas in a solubilized cervical body sample
US7648678B2 (en) * 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
CA2513535C (en) * 2003-01-29 2012-06-12 454 Corporation Bead emulsion nucleic acid amplification
ATE550099T1 (de) 2003-04-04 2012-04-15 Hoffmann La Roche Verbessertes system für mehrfarbige echtzeit-pcr
US7129260B2 (en) * 2003-06-02 2006-10-31 Abbott Laboratories Isoindolinone kinase inhibitors
US8048627B2 (en) 2003-07-05 2011-11-01 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
WO2005033333A2 (en) 2003-10-07 2005-04-14 Dako Denmark A/S Methods and compositions for the diagnosis of cancer
US8012944B2 (en) * 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
US20070083286A1 (en) * 2004-03-09 2007-04-12 Olympus Corporation Medical instrument and equipment for managing of the same
CN1690223B (zh) 2004-04-27 2010-05-05 亚能生物技术(深圳)有限公司 人乳头瘤病毒分型基因芯片检测系统
US7398181B2 (en) * 2004-06-02 2008-07-08 Hewlett-Packard Development Company, L.P. Method for retrieving reliability data in a system
US20060095096A1 (en) * 2004-09-09 2006-05-04 Debenedictis Leonard C Interchangeable tips for medical laser treatments and methods for using same
ES2668911T3 (es) * 2004-09-30 2018-05-23 Epigenomics Ag Método para proveer fragmentos de ADN derivados de una muestra archivada
AU2005302453A1 (en) * 2004-10-29 2006-05-11 Medimmune, Llc Methods of preventing and treating RSV infections and related conditions
US20060129269A1 (en) * 2004-12-15 2006-06-15 Xerox Corporation Processes for using a memory storage device in conjunction with tooling
WO2006075245A2 (en) * 2005-01-14 2006-07-20 The Regents Of The University Of Michigan Systems, methods, and compositions for detection of human papilloma virus in biological samples
US20060240449A1 (en) 2005-01-19 2006-10-26 Mcglennen Ronald C Methods and compositions for preparation of biological samples
EP1928560A2 (en) 2005-04-06 2008-06-11 Verenium Corporation Enzymes and formulations for broad-specificity decontamination of chemical and biological warfare agents
WO2007130519A2 (en) 2006-05-02 2007-11-15 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Viral nucleic acid microarray and method of use
US8962262B2 (en) 2006-05-11 2015-02-24 Arbor Vita Corporation Method of protein extraction from cells
US20080206777A1 (en) 2007-02-27 2008-08-28 Nuclea Biomarkers, Llc Gene and protein expression profiles associated with the therapeutic efficacy of EGFR-TK inhibitors
US8357538B2 (en) 2007-04-06 2013-01-22 Qiagen Gaithersburg, Inc. Automated assay and system
US7985375B2 (en) 2007-04-06 2011-07-26 Qiagen Gaithersburg, Inc. Sample preparation system and method for processing clinical specimens
US8703492B2 (en) 2007-04-06 2014-04-22 Qiagen Gaithersburg, Inc. Open platform hybrid manual-automated sample processing system
WO2008139938A1 (ja) 2007-05-02 2008-11-20 National University Corporation Tokyo Medical And Dental University ヒトパピローマウイルス16型遺伝子を標的とする二本鎖核酸分子及びそれを含む医薬
US8623599B2 (en) 2007-06-08 2014-01-07 Epigenomics Ag Method for methylation analysis
CN101177701B (zh) 2007-09-29 2010-08-18 潮州凯普生物化学有限公司 人乳头状瘤病毒基因分型检测试剂盒及其基因芯片制备方法
CA2702241A1 (en) 2007-10-11 2009-04-16 The Ohio State University Research Foundation Methods and compositions for the diagnosis and treatment of esophageal adenocarcinomas
JP2009106220A (ja) 2007-10-31 2009-05-21 Genodive Pharma Kk 基板上での等温増幅反応による標的塩基配列の捕捉及び検出方法
US9435001B2 (en) 2007-11-01 2016-09-06 Self-Screen B.V. Detection method for cervical HPVS
WO2009123996A2 (en) 2008-03-31 2009-10-08 The Ohio State University Research Foundation Hybridization quantitation method for modified micro-rna and -dna based oligonucleotides
WO2009129505A2 (en) * 2008-04-17 2009-10-22 Qiagen Gaithersburg, Inc. Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid
WO2010004251A1 (en) 2008-06-16 2010-01-14 Oncomethylome Sciences Sa Dna methylomes
US20100121046A1 (en) 2008-09-05 2010-05-13 Mayo Foundation For Medical Education And Research Collecting and processing complex macromolecular mixtures
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
CN102203293A (zh) 2008-10-27 2011-09-28 奇亚根盖瑟斯堡股份有限公司 快速结果杂交捕获测定和系统
EP2184368A1 (en) 2008-11-07 2010-05-12 DKFZ Deutsches Krebsforschungszentrum Diagnostic transcript and splice patterns of HPV16 in different cervical lesions
WO2010088273A1 (en) * 2009-01-27 2010-08-05 Qiagen Gaithersburg Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
CA2750338C (en) * 2009-01-28 2019-06-25 Qiagen Gaithersburg, Inc. Sequence-specific large volume sample preparation method and assay
EP2425019B1 (en) 2009-05-01 2014-03-19 QIAGEN Gaithersburg, Inc. A non-target amplification method for detection of rna splice-forms in a sample
WO2011028974A1 (en) * 2009-09-03 2011-03-10 Qiagen Gaithersburg, Inc. Methods and kits for determining viral load in clinical samples
JP5826752B2 (ja) * 2009-09-14 2015-12-02 キアジェン ゲイサーズバーグ インコーポレイテッド 細胞学用培地に固定された組織サンプルから核酸またはタンパク質を回収するための組成物および方法
AU2011203450B2 (en) * 2010-01-04 2016-01-07 Qiagen Gaithersburg, Inc. Methods, compositions, and kits for recovery of nucleic acids or proteins from fixed tissue samples
EP2521795B8 (en) * 2010-01-08 2014-01-08 QIAGEN Gaithersburg, Inc. Materials and methods for isothermal nucleic acid amplification
WO2011094528A2 (en) * 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an hpv in a sample
US9689047B2 (en) * 2010-01-29 2017-06-27 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
EP2572001A2 (en) * 2010-05-19 2013-03-27 QIAGEN Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
WO2011149897A1 (en) * 2010-05-25 2011-12-01 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010263A1 (en) * 1991-11-14 1993-05-27 Digene Diagnostics, Inc. Non-radioactive hybridization assay and kit
US20080200344A1 (en) * 2005-11-15 2008-08-21 Shu-Ling Cheng Protein chips for HPV detection

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BHAN, P. et al., Nucleic Acids Research, 1997, Vol. 25, No. 16, pages 3310-3317 *
Genentech Diagnostics: Digene® HBV Test Hybrid Capture® II, 6 June 2008, Retrieved from the internet: URL:http://www.genetechin.com/hbvdnatestkit.htm [retrieved on 11-12-2009] *
HANTZ, S. et al., Pathologie-Biologie, February 2008, Vol. 56, No. 1, pages 29-35 *
SANDRI, M. et al., Journal of Clinical Microbiology, June 2006, Vol. 44, No. 6, pages 2141-2146 *

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