CN101906026A - 利用防氧化效果高的溶剂生产还原型辅酶q10的方法 - Google Patents

利用防氧化效果高的溶剂生产还原型辅酶q10的方法 Download PDF

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Publication number
CN101906026A
CN101906026A CN2010101807452A CN201010180745A CN101906026A CN 101906026 A CN101906026 A CN 101906026A CN 2010101807452 A CN2010101807452 A CN 2010101807452A CN 201010180745 A CN201010180745 A CN 201010180745A CN 101906026 A CN101906026 A CN 101906026A
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CN
China
Prior art keywords
reduced coenzyme
coenzyme
solvent
crystallization
preferred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010101807452A
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English (en)
Chinese (zh)
Inventor
植田尚宏
北村志郎
上田恭义
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
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Kanegafuchi Chemical Industry Co Ltd
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26618740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101906026(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Publication of CN101906026A publication Critical patent/CN101906026A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/816—Enzyme separation or purification by solubility

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN2010101807452A 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法 Pending CN101906026A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP214471/01 2001-07-13
JP2001214471 2001-07-13
JP2002114854 2002-04-17
JP114854/02 2002-04-17

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA028141369A Division CN1527807A (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法

Publications (1)

Publication Number Publication Date
CN101906026A true CN101906026A (zh) 2010-12-08

Family

ID=26618740

Family Applications (3)

Application Number Title Priority Date Filing Date
CN2010101807452A Pending CN101906026A (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法
CN200910266328.7A Expired - Lifetime CN101774996B (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法
CNA028141369A Pending CN1527807A (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN200910266328.7A Expired - Lifetime CN101774996B (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法
CNA028141369A Pending CN1527807A (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法

Country Status (9)

Country Link
US (1) US7145044B2 (enExample)
EP (4) EP3321248A3 (enExample)
JP (1) JP4057523B2 (enExample)
KR (1) KR100876509B1 (enExample)
CN (3) CN101906026A (enExample)
AU (1) AU2002318843B2 (enExample)
CA (1) CA2453158C (enExample)
TW (1) TWI310029B (enExample)
WO (1) WO2003006408A1 (enExample)

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JP3822479B2 (ja) * 2001-10-10 2006-09-20 株式会社カネカ 還元型補酵素ｑ水溶液の安定化組成
TWI349039B (en) 2001-12-27 2011-09-21 Kaneka Corp Processes for producing coenzyme q10
US7358402B2 (en) * 2003-09-10 2008-04-15 Kaneka Corporation Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
ES2727923T3 (es) * 2003-09-10 2019-10-21 Kaneka Corp Cristal de coenzima Q10 reducida excelente en estabilidad y composición que contiene cristal de coenzima Q10 reducida
US20060147542A1 (en) * 2004-12-24 2006-07-06 Tadao Ono Solid preparation containing reduced coenzyme Q10 and method for producing the same
US8067217B2 (en) * 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
JPWO2006104153A1 (ja) * 2005-03-29 2008-09-11 株式会社カネカ 血液中の抗酸化活性を高める組成物
JP4469772B2 (ja) * 2005-09-15 2010-05-26 株式会社資生堂 コエンザイムｑ１０高負荷細胞の作製方法、コエンザイムｑ１０高負荷細胞増殖添加剤及びコエンザイムｑ１０高負荷培地
US8506956B2 (en) 2005-10-31 2013-08-13 Kaneka Corporation Method for stabilizing reduced coenzyme Q10
TW200808344A (en) 2006-04-28 2008-02-16 Kaneka Corp Stabilization method of reduced coenzyme Q10
JPWO2007126086A1 (ja) 2006-04-28 2009-09-10 株式会社カネカ 還元型補酵素ｑ１０の精製方法
JP5286086B2 (ja) 2006-09-08 2013-09-11 株式会社カネカ 還元型補酵素ｑ１０及びリゾレシチンを含有する組成物
WO2009044852A1 (ja) * 2007-10-05 2009-04-09 Kaneka Corporation 還元型補酵素ｑ１０の製造方法
CN101842340B (zh) * 2007-10-30 2014-08-13 株式会社钟化 使用含水有机溶剂制备还原型辅酶q10的方法
DK2268160T3 (da) 2008-03-20 2013-01-07 Virun Inc Emulsioner omfattende et PEG-derivat af tokoferol
WO2010008475A2 (en) * 2008-06-23 2010-01-21 Virun, Inc. Compositions containing nono-polar compounds
CN101514148B (zh) * 2009-03-27 2015-05-13 玉溪健坤生物药业有限公司 一种还原型辅酶q10的制备方法
CN102369005B (zh) * 2009-03-31 2014-03-26 三菱瓦斯化学株式会社 泛醌类制剂用粉末的制造方法及其制造物
JP2010275253A (ja) * 2009-05-29 2010-12-09 Mitsubishi Gas Chemical Co Inc コエンザイムｑ１０含有経口投与組成物
JP4855551B2 (ja) 2009-10-16 2012-01-18 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
JP4786000B2 (ja) 2009-10-16 2011-10-05 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
EP2563164B1 (en) 2010-03-23 2016-06-29 Virun, Inc. Nanoemulsion including sucrose fatty acid ester
JP5546935B2 (ja) * 2010-04-20 2014-07-09 株式会社カネカ 還元型補酵素ｑ１０含有組成物及びその製法方法
US8741373B2 (en) 2010-06-21 2014-06-03 Virun, Inc. Compositions containing non-polar compounds
CN103635452B (zh) * 2011-06-24 2017-03-15 株式会社钟化 稳定性优良的还原型辅酶q10晶体
WO2013120025A1 (en) 2012-02-10 2013-08-15 Virun, Inc. Beverage compositions containing non-polar compounds
JP2013224272A (ja) * 2012-04-20 2013-10-31 Idemitsu Kosan Co Ltd １−アダマンタノールの製造方法
JP2015131766A (ja) 2012-04-27 2015-07-23 株式会社カネカ 還元型補酵素ｑ１０の製造方法
CN104119209B (zh) * 2013-04-25 2018-03-02 浙江医药股份有限公司新昌制药厂 一种还原型辅酶q10干粉及其组合物以及制备方法
CN104109880B (zh) * 2014-04-22 2016-05-18 北京泰克美高新技术有限公司 一种还原型辅酶q10的制备方法及其装置
WO2016151447A1 (en) * 2015-03-20 2016-09-29 Gnosis S.P.A. Solid forms of menaquinols
WO2020045571A1 (ja) * 2018-08-30 2020-03-05 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof
CN115087631B (zh) * 2020-02-12 2024-05-14 株式会社钟化 FormII型的还原型辅酶Q10结晶的制造方法

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JPS5915894B2 (ja) 1975-12-15 1984-04-12 ニツシンセイフン カブシキガイシヤ ホコウソｑノセイゾウホウホウ
JPS609796B2 (ja) 1977-04-21 1985-03-13 日清製粉株式会社 補酵素ｑの製造法
JPS54140793A (en) * 1978-04-21 1979-11-01 Fujisawa Pharmaceut Co Ltd Preparation of dihydro-coenzyme q10
JPS5692238A (en) * 1979-12-26 1981-07-25 Ajinomoto Co Inc Separation and recovery of hydroquinone derivative
JPS5770834A (en) 1980-10-17 1982-05-01 Takara Shuzo Co Ltd Preparation of coenzyme q
JPS6075294A (ja) 1984-03-16 1985-04-27 Nisshin Flour Milling Co Ltd 補酵素ｑの製造法
JPS6419933A (en) 1987-07-13 1989-01-24 Shibaura Eng Works Ltd Motor
EP0796108A2 (en) * 1994-12-06 1997-09-24 Ryan Pharmaceuticals, Inc. Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
IT1284873B1 (it) * 1996-07-26 1998-05-22 Idi Farmaceutici Spa Derivati stabili di ubichinolo procedimenti per la loro produzione e loro impiego farmaceutico
JP3889481B2 (ja) * 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
JP3926888B2 (ja) * 1997-05-27 2007-06-06 株式会社カネカ コレステロール低下剤
US8753675B1 (en) * 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications

Also Published As

Publication number Publication date
CA2453158C (en) 2011-05-24
EP1415969A4 (en) 2005-04-27
WO2003006408A1 (fr) 2003-01-23
EP2402303A2 (en) 2012-01-04
CN101774996A (zh) 2010-07-14
KR100876509B1 (ko) 2008-12-31
KR20040017293A (ko) 2004-02-26
EP3321248A3 (en) 2018-06-06
JPWO2003006408A1 (ja) 2004-10-28
CN1527807A (zh) 2004-09-08
EP1415969A1 (en) 2004-05-06
CN101774996B (zh) 2015-02-11
AU2002318843A2 (en) 2003-01-29
AU2002318843B2 (en) 2008-10-30
US7145044B2 (en) 2006-12-05
US20040215040A1 (en) 2004-10-28
CA2453158A1 (en) 2003-01-23
TWI310029B (enExample) 2009-05-21
EP3321248A2 (en) 2018-05-16
EP2228360A1 (en) 2010-09-15
JP4057523B2 (ja) 2008-03-05
EP2402303A3 (en) 2012-04-25

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Open date: 20101208