CN101525339A - 新颖的氧杂双哌啶(oxabispidine)化合物以及它们在心律失常治疗中的应用 - Google Patents

新颖的氧杂双哌啶(oxabispidine)化合物以及它们在心律失常治疗中的应用 Download PDF

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Publication number
CN101525339A
CN101525339A CN200910134138A CN200910134138A CN101525339A CN 101525339 A CN101525339 A CN 101525339A CN 200910134138 A CN200910134138 A CN 200910134138A CN 200910134138 A CN200910134138 A CN 200910134138A CN 101525339 A CN101525339 A CN 101525339A
Authority
CN
China
Prior art keywords
ethyl
group
oxa
diazabicylo
ninth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200910134138A
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English (en)
Chinese (zh)
Inventor
A·布乔里
P·邦
U·格兰
J·卡贾努斯
C·奥尔森
F·庞坦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32710059&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101525339(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN101525339A publication Critical patent/CN101525339A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN200910134138A 2004-06-15 2005-06-13 新颖的氧杂双哌啶(oxabispidine)化合物以及它们在心律失常治疗中的应用 Pending CN101525339A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0401539A SE0401539D0 (sv) 2004-06-15 2004-06-15 New compounds
SE04015392 2004-06-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA200580019259XA Division CN1968956A (zh) 2004-06-15 2005-06-13 新颖的氧杂双哌啶（oxabispidine）化合物以及它们在心律失常治疗中的应用

Publications (1)

Publication Number Publication Date
CN101525339A true CN101525339A (zh) 2009-09-09

Family

ID=32710059

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200910134138A Pending CN101525339A (zh) 2004-06-15 2005-06-13 新颖的氧杂双哌啶(oxabispidine)化合物以及它们在心律失常治疗中的应用
CNA200580019259XA Pending CN1968956A (zh) 2004-06-15 2005-06-13 新颖的氧杂双哌啶（oxabispidine）化合物以及它们在心律失常治疗中的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA200580019259XA Pending CN1968956A (zh) 2004-06-15 2005-06-13 新颖的氧杂双哌啶（oxabispidine）化合物以及它们在心律失常治疗中的应用

Country Status (22)

Country Link
US (2) US7648985B2 (https=)
EP (1) EP1765832B8 (https=)
JP (1) JP2008502678A (https=)
KR (1) KR20070039045A (https=)
CN (2) CN101525339A (https=)
AR (1) AR049823A1 (https=)
AU (2) AU2005254924B2 (https=)
BR (1) BRPI0512012A (https=)
CA (1) CA2568895A1 (https=)
DK (1) DK1765832T3 (https=)
ES (1) ES2434043T3 (https=)
IL (1) IL179560A0 (https=)
MX (1) MXPA06014692A (https=)
NO (1) NO20070148L (https=)
RU (1) RU2379311C9 (https=)
SE (1) SE0401539D0 (https=)
SG (1) SG153822A1 (https=)
TW (1) TW200612907A (https=)
UA (1) UA85877C2 (https=)
UY (1) UY28959A1 (https=)
WO (1) WO2005123748A1 (https=)
ZA (2) ZA200610418B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
JP2008543750A (ja) 2005-06-13 2008-12-04 アストラゼネカ アクチボラグ 心不整脈の処置用の新規オキサビスピジン化合物
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
JP2011524398A (ja) 2008-06-16 2011-09-01 エフ．ホフマン−ラ ロシュ アーゲー オレキシニン受容体アンタゴニストとしてのヘテロ芳香族モノアミド
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
WO2010059119A1 (en) * 2008-11-21 2010-05-27 Astrazeneca Ab A combination of tert -butyl (2-{7- [2- (4-cyano-2- f luorophenoxy) ethyl] -9-oxa-3, 7-diazabicyclo [3.3.1] non-3- yl } ethyl) carbamate and certain antiarrhythmic benzofurans
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN117384037B (zh) * 2023-12-13 2024-03-08 山东国邦药业有限公司 一种二氟乙酸乙酯的制备方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196154A (en) * 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) * 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
DE2428792A1 (de) 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
JPS5772977A (en) 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
PT88381B (pt) 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
FI100151B (fi) 1992-09-04 1997-09-30 Nokia Mobile Phones Ltd Tehonsäästö matkaviestimessä
US5294621A (en) * 1992-10-07 1994-03-15 Ortho Pharmaceutical Corporation Thieno tetrahydropyridines useful as class III antiarrhythmic agents
JPH06284071A (ja) 1993-01-27 1994-10-07 Casio Comput Co Ltd 無線受信機
US5468858A (en) 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
FR2713081B1 (fr) 1993-11-29 1996-01-12 Celsa Lg Filtre sanguin perfectionné à deux séries de pattes en pétales.
US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
CZ20013608A3 (cs) 1999-04-09 2002-05-15 Astrazeneca Ab Adamantanové deriváty
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101323D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0201662D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds

Also Published As

Publication number Publication date
CA2568895A1 (en) 2005-12-29
US7648985B2 (en) 2010-01-19
SE0401539D0 (sv) 2004-06-15
US20090005558A1 (en) 2009-01-01
AU2005254924B2 (en) 2009-08-27
EP1765832A1 (en) 2007-03-28
MXPA06014692A (es) 2007-02-12
US20090270383A1 (en) 2009-10-29
EP1765832B8 (en) 2013-09-25
SG153822A1 (en) 2009-07-29
TW200612907A (en) 2006-05-01
UY28959A1 (es) 2006-01-31
ES2434043T3 (es) 2013-12-13
NO20070148L (no) 2007-01-09
RU2006145202A (ru) 2008-07-20
BRPI0512012A (pt) 2008-02-06
WO2005123748A1 (en) 2005-12-29
AU2005254924A1 (en) 2005-12-29
DK1765832T3 (da) 2013-10-21
CN1968956A (zh) 2007-05-23
AU2009222548A1 (en) 2009-10-22
IL179560A0 (en) 2007-05-15
EP1765832B1 (en) 2013-08-14
JP2008502678A (ja) 2008-01-31
ZA200610418B (en) 2008-07-30
RU2379311C9 (ru) 2010-05-27
AR049823A1 (es) 2006-09-06
KR20070039045A (ko) 2007-04-11
RU2379311C2 (ru) 2010-01-20
ZA200710111B (en) 2009-08-26
UA85877C2 (uk) 2009-03-10

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SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
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Open date: 20090909