CN101365801B - 抑制亨廷顿基因表达的组合物和方法 - Google Patents
抑制亨廷顿基因表达的组合物和方法 Download PDFInfo
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- CN101365801B CN101365801B CN200680046400XA CN200680046400A CN101365801B CN 101365801 B CN101365801 B CN 101365801B CN 200680046400X A CN200680046400X A CN 200680046400XA CN 200680046400 A CN200680046400 A CN 200680046400A CN 101365801 B CN101365801 B CN 101365801B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73155505P | 2005-10-28 | 2005-10-28 | |
| US60/731,555 | 2005-10-28 | ||
| US81903806P | 2006-07-07 | 2006-07-07 | |
| US83604006P | 2006-08-07 | 2006-08-07 | |
| US60/836,040 | 2006-08-07 | ||
| PCT/US2006/042420 WO2007051045A2 (en) | 2005-10-28 | 2006-10-27 | Compositions and methods for inhibiting expression of huntingtin gene |
| US60/819,038 | 2013-05-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101365801A CN101365801A (zh) | 2009-02-11 |
| CN101365801B true CN101365801B (zh) | 2013-03-27 |
Family
ID=37968618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200680046400XA Expired - Fee Related CN101365801B (zh) | 2005-10-28 | 2006-10-27 | 抑制亨廷顿基因表达的组合物和方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7320965B2 (enExample) |
| EP (2) | EP2325315B1 (enExample) |
| JP (1) | JP5111385B2 (enExample) |
| CN (1) | CN101365801B (enExample) |
| AU (2) | AU2006305886C1 (enExample) |
| CA (1) | CA2627025A1 (enExample) |
| WO (1) | WO2007051045A2 (enExample) |
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| ES2969371T3 (es) * | 2003-09-12 | 2024-05-17 | Univ Massachusetts | Interferencia por ARN para el tratamiento de trastornos de ganancia de función |
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| ES2549122T3 (es) | 2007-05-31 | 2015-10-23 | University Of Iowa Research Foundation | Reducción de toxicidad por interferencia de ARN desviada de su diana |
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| EP2317847B1 (en) * | 2008-07-29 | 2019-04-17 | The Board of Regents of The University of Texas System | Selective inhibition of polyglutamine protein expression |
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Also Published As
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| EP2325315B1 (en) | 2014-05-07 |
| US20070099860A1 (en) | 2007-05-03 |
| US7749978B2 (en) | 2010-07-06 |
| AU2006305886B2 (en) | 2010-11-18 |
| JP2009513144A (ja) | 2009-04-02 |
| AU2010241477B2 (en) | 2014-01-23 |
| AU2006305886A1 (en) | 2007-05-03 |
| US8314075B2 (en) | 2012-11-20 |
| US8080532B2 (en) | 2011-12-20 |
| AU2006305886C1 (en) | 2011-03-17 |
| US20100298405A1 (en) | 2010-11-25 |
| US7320965B2 (en) | 2008-01-22 |
| WO2007051045A2 (en) | 2007-05-03 |
| JP5111385B2 (ja) | 2013-01-09 |
| WO2007051045A3 (en) | 2007-07-26 |
| EP2325315A1 (en) | 2011-05-25 |
| CA2627025A1 (en) | 2007-05-03 |
| US20080221055A1 (en) | 2008-09-11 |
| US20120095076A1 (en) | 2012-04-19 |
| AU2010241477A1 (en) | 2010-12-09 |
| CN101365801A (zh) | 2009-02-11 |
| EP1941059A2 (en) | 2008-07-09 |
| EP1941059A4 (en) | 2010-11-03 |
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