CN101171237B - 用于制备任选2-取代的1，6-二氢-6-氧代-4-嘧啶羧酸的方法 - Google Patents

用于制备任选2-取代的1，6-二氢-6-氧代-4-嘧啶羧酸的方法 Download PDF

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Publication number
CN101171237B
CN101171237B CN200680015454XA CN200680015454A CN101171237B CN 101171237 B CN101171237 B CN 101171237B CN 200680015454X A CN200680015454X A CN 200680015454XA CN 200680015454 A CN200680015454 A CN 200680015454A CN 101171237 B CN101171237 B CN 101171237B
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formula
compound
replaces
acid
cyclopropyl
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CN101171237A (zh
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R·夏皮罗
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Kedihua Agricultural Technology Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200680015454XA 2005-05-06 2006-04-28 用于制备任选2-取代的1，6-二氢-6-氧代-4-嘧啶羧酸的方法 Expired - Lifetime CN101171237B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67826405P 2005-05-06 2005-05-06
US60/678,264 2005-05-06
PCT/US2006/016340 WO2006121648A2 (en) 2005-05-06 2006-04-28 Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids

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CN2011100456237A Division CN102153516B (zh) 2005-05-06 2006-04-28 用于制备嘧啶羧酸化合物的中间体

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CN101171237A CN101171237A (zh) 2008-04-30
CN101171237B true CN101171237B (zh) 2011-04-20

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CN200680015454XA Expired - Lifetime CN101171237B (zh) 2005-05-06 2006-04-28 用于制备任选2-取代的1，6-二氢-6-氧代-4-嘧啶羧酸的方法
CN2011100456237A Expired - Lifetime CN102153516B (zh) 2005-05-06 2006-04-28 用于制备嘧啶羧酸化合物的中间体

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US (2) US8198442B2 (enExample)
EP (1) EP1877384B1 (enExample)
JP (1) JP5161764B2 (enExample)
KR (1) KR101379967B1 (enExample)
CN (2) CN101171237B (enExample)
AT (1) ATE506352T1 (enExample)
AU (1) AU2006246374B2 (enExample)
BR (1) BRPI0612475B8 (enExample)
CA (1) CA2607934C (enExample)
DE (1) DE602006021411D1 (enExample)
DK (1) DK1877384T3 (enExample)
EG (1) EG25480A (enExample)
ES (1) ES2362005T3 (enExample)
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IL (2) IL185885A (enExample)
MA (1) MA29464B1 (enExample)
ME (1) ME00498B (enExample)
MX (1) MX2007013424A (enExample)
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PL (1) PL1877384T3 (enExample)
RS (2) RS51804B (enExample)
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UA (1) UA92171C2 (enExample)
WO (1) WO2006121648A2 (enExample)
ZA (1) ZA200707975B (enExample)

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DE602006013970D1 (de) * 2005-05-16 2010-06-10 Du Pont Verfahren zur herstellung substituierter pyrimidine
US20080249329A1 (en) * 2005-09-29 2008-10-09 Dsm Ip Assets B.V. Process For Esterification Of An Organic Acid
WO2009023438A1 (en) * 2007-08-13 2009-02-19 Dow Agrosciences Llc 2-(2-fluoro-substituted phenyl)-6-amino-5-chloro-4-pyrimidinecarboxylates and their use as herbicides
HUE030847T2 (hu) 2007-10-02 2017-06-28 Dow Agrosciences Llc 2-szubsztituált-6-amino-5-alkil-, alkenil- vagy alkinil-4-pirimidin-karbonsavak és 6-szubsztituált-4-amino-3-alkil-, alkenil- vagy alkinil-pikolinsavak és alkalmazásuk herbicidként
BRPI0911207B8 (pt) * 2008-04-18 2022-10-11 Dow Agrosciences Llc 2-(fenil substituído)-6-hidróxi ou alcóxi-5-substituído-4-pirimidinacarboxilatos, composição herbicida, e método para controle de vegetação indesejável".
TWI596088B (zh) * 2011-01-25 2017-08-21 陶氏農業科學公司 ４－胺基－６－（經取代的苯基）吡啶甲酸酯及６－胺基－２－（經取代的苯基）－４－嘧啶羧酸酯之芳烷酯以及其等作為除草劑之用途
MX370455B (es) * 2011-07-27 2019-12-13 Bayer Ip Gmbh Ácidos picolínicos y piridimin-4-carboxílicos sustituidos, procedimiento para su preparación y su uso como herbicidas y reguladores del crecimiento de plantas.
US9113629B2 (en) * 2013-03-15 2015-08-25 Dow Agrosciences Llc 4-amino-6-(4-substituted-phenyl)-picolinates and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylates and their use as herbicides
US9637505B2 (en) 2013-03-15 2017-05-02 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
PT2970185T (pt) * 2013-03-15 2023-10-06 Corteva Agriscience Llc 4-amino-6-(heterocíclico)picolinatos e 6-amino-2-(heterocíclico)pirimidino-4-carboxilatos e seu uso como herbicidas
EP3193607A4 (en) 2014-09-15 2018-05-02 Dow AgroSciences LLC Synergistic weed control from applications of pyridine carboxylic acid herbicides and photosystem ii inhibitors
AR101858A1 (es) 2014-09-15 2017-01-18 Dow Agrosciences Llc Composiciones herbicidas protegidas que comprenden un herbicida de ácido piridincarboxílico
TWI689252B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與乙醯乳酸合成酶（ａｌｓ）抑制劑的協同性雜草控制
TWI685302B (zh) 2014-09-15 2020-02-21 美商陶氏農業科學公司 包含吡啶羧酸除草劑之安全的除草組成物
TWI689251B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與合成生長素除草劑及/或生長素轉運抑制劑的協同性雜草控制
WO2026028053A2 (en) 2024-07-27 2026-02-05 Assia Chemical Industries Ltd. Process for the preparation of tovorafenib

Citations (1)

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US4666915A (en) * 1983-11-05 1987-05-19 Morishita Pharmaceutical Co. Ltd. 2-anilino-1,6-dihydro-6-oxo-5-pyrimidine-carboxylic acid derivatives, process for the preparation thereof, and antiallergic agent containing the same

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CA207185A (en) 1921-01-04 C. Wagner Virgil Warming plate
JPH0331267A (ja) 1989-06-28 1991-02-12 Morishita Pharmaceut Co Ltd ２―アニリノ―１，６―ジヒドロ―６―オキソ―４―ピリミジンカルボン酸誘導体
JPH0341071A (ja) 1989-07-06 1991-02-21 Morishita Pharmaceut Co Ltd １，６―ジヒドロ―６―オキソ―２―フェノキシアルキルチオ―５―ピリミジンカルボン酸類
DE3935277A1 (de) * 1989-10-24 1991-05-02 Hoechst Ag Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
US5637618A (en) * 1990-06-01 1997-06-10 Bioresearch, Inc. Specific eatable taste modifiers
DE4029654A1 (de) 1990-09-19 1992-04-02 Hoechst Ag 2-phenyl-pyrimidine, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide
DE4131924A1 (de) * 1991-09-25 1993-07-08 Hoechst Ag Substituierte 4-alkoxypyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
DE4408404A1 (de) * 1994-03-12 1995-09-14 Huels Chemische Werke Ag Verfahren zur Herstellung von Chlorpyrimidinen
EA200000840A1 (ru) * 1998-02-17 2001-02-26 Туларик, Инк. Антивирусные производные пиримидина
ATE293608T1 (de) 1999-04-15 2005-05-15 Basf Ag Verfahren zur herstellung von substituierten pyrimidinen
US6281358B1 (en) 1999-04-15 2001-08-28 American Cyanamid Company Process for the preparation of substituted pyrimidines
AU2002258400A1 (en) 2001-02-16 2002-08-28 Tularik Inc. Methods of using pyrimidine-based antiviral agents
EP1646615B1 (en) 2003-06-06 2009-08-26 Vertex Pharmaceuticals Incorporated Pyrimidine derivatives as modulators of atp-binding cassette transporters
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
EP1849765A4 (en) 2005-02-02 2010-05-05 Ajinomoto Kk PROCESS FOR PREPARING A PYRIMIDINE COMPOUND
DE102005027150A1 (de) 2005-03-12 2006-09-28 Bayer Healthcare Ag Pyrimidincarbonsäure-Derivate und ihre Verwendung
DE602006013970D1 (de) * 2005-05-16 2010-06-10 Du Pont Verfahren zur herstellung substituierter pyrimidine

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US4666915A (en) * 1983-11-05 1987-05-19 Morishita Pharmaceutical Co. Ltd. 2-anilino-1,6-dihydro-6-oxo-5-pyrimidine-carboxylic acid derivatives, process for the preparation thereof, and antiallergic agent containing the same

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Title
Daves G. D. et al.Pyrimidines. Ⅱ. Orotic Acid Analogs.《J. Org. Chem.》.1961,第26卷(第8期),2755-2763.
Daves G. D. et al.Pyrimidines. Ⅱ. Orotic Acid Analogs.《J. Org. Chem.》.1961,第26卷(第8期),2755-2763. *
Gershon H..Pyrimidines. Ⅱ. Chlorinated Pyrimidines Derived from OroticAcid.《J. Org. Chem.》.1962,第27卷(第10期),3507-3510. *
徐进宜等.1-取代2-烷基-4-氯-1 6-二氢-6-甲基-5-嘧啶甲酸乙酯类化合物的合成及其降压活性.《中国药科大学学报》.1999
徐进宜等.1-取代2-烷基-4-氯-1, 6-二氢-6-甲基-5-嘧啶甲酸乙酯类化合物的合成及其降压活性.《中国药科大学学报》.1999,第30卷(第6期),406-410. *

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Publication number Publication date
ZA200707975B (en) 2008-11-26
CN102153516B (zh) 2013-02-06
TNSN07403A1 (en) 2009-03-17
IL185885A (en) 2012-10-31
AU2006246374A1 (en) 2006-11-16
ES2362005T3 (es) 2011-06-27
CA2607934A1 (en) 2006-11-16
MX2007013424A (es) 2008-01-16
US8198442B2 (en) 2012-06-12
US20120232271A1 (en) 2012-09-13
RS51804B (sr) 2011-12-31
MA29464B1 (fr) 2008-05-02
ME00498B (me) 2011-10-10
GEP20105099B (en) 2010-10-25
KR20080006576A (ko) 2008-01-16
CN101171237A (zh) 2008-04-30
RS20070434A (sr) 2009-01-22
EG25480A (en) 2012-01-15
BRPI0612475B8 (pt) 2022-12-06
IL185885A0 (en) 2008-01-06
WO2006121648A3 (en) 2006-12-28
ATE506352T1 (de) 2011-05-15
CN102153516A (zh) 2011-08-17
JP5161764B2 (ja) 2013-03-13
DE602006021411D1 (de) 2011-06-01
IL222041A (en) 2016-10-31
KR101379967B1 (ko) 2014-04-01
UA92171C2 (ru) 2010-10-11
DK1877384T3 (da) 2011-08-15
JP2008540414A (ja) 2008-11-20
US20090043098A1 (en) 2009-02-12
BRPI0612475A2 (pt) 2010-11-23
NZ561399A (en) 2009-11-27
BRPI0612475B1 (pt) 2020-03-10
WO2006121648A2 (en) 2006-11-16
PL1877384T3 (pl) 2011-09-30
EP1877384A2 (en) 2008-01-16
EP1877384B1 (en) 2011-04-20
CA2607934C (en) 2013-10-01
AU2006246374B2 (en) 2012-03-29

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Effective date of registration: 20220908

Address after: Indiana, USA

Patentee after: Kedihua Agricultural Technology Co.,Ltd.

Address before: Delaware USA

Patentee before: DuPont