CA2607934C - Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids - Google Patents

Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids Download PDF

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Publication number
CA2607934C
CA2607934C CA2607934A CA2607934A CA2607934C CA 2607934 C CA2607934 C CA 2607934C CA 2607934 A CA2607934 A CA 2607934A CA 2607934 A CA2607934 A CA 2607934A CA 2607934 C CA2607934 C CA 2607934C
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CA
Canada
Prior art keywords
formula
compound
acid
optionally substituted
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2607934A
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English (en)
French (fr)
Other versions
CA2607934A1 (en
Inventor
Rafael Shapiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corteva Agriscience LLC
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of CA2607934A1 publication Critical patent/CA2607934A1/en
Application granted granted Critical
Publication of CA2607934C publication Critical patent/CA2607934C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2607934A 2005-05-06 2006-04-28 Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids Expired - Lifetime CA2607934C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67826405P 2005-05-06 2005-05-06
US60/678,264 2005-05-06
PCT/US2006/016340 WO2006121648A2 (en) 2005-05-06 2006-04-28 Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids

Publications (2)

Publication Number Publication Date
CA2607934A1 CA2607934A1 (en) 2006-11-16
CA2607934C true CA2607934C (en) 2013-10-01

Family

ID=36952291

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2607934A Expired - Lifetime CA2607934C (en) 2005-05-06 2006-04-28 Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids

Country Status (25)

Country Link
US (2) US8198442B2 (enExample)
EP (1) EP1877384B1 (enExample)
JP (1) JP5161764B2 (enExample)
KR (1) KR101379967B1 (enExample)
CN (2) CN101171237B (enExample)
AT (1) ATE506352T1 (enExample)
AU (1) AU2006246374B2 (enExample)
BR (1) BRPI0612475B8 (enExample)
CA (1) CA2607934C (enExample)
DE (1) DE602006021411D1 (enExample)
DK (1) DK1877384T3 (enExample)
EG (1) EG25480A (enExample)
ES (1) ES2362005T3 (enExample)
GE (1) GEP20105099B (enExample)
IL (2) IL185885A (enExample)
MA (1) MA29464B1 (enExample)
ME (1) ME00498B (enExample)
MX (1) MX2007013424A (enExample)
NZ (1) NZ561399A (enExample)
PL (1) PL1877384T3 (enExample)
RS (2) RS51804B (enExample)
TN (1) TNSN07403A1 (enExample)
UA (1) UA92171C2 (enExample)
WO (1) WO2006121648A2 (enExample)
ZA (1) ZA200707975B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006013970D1 (de) * 2005-05-16 2010-06-10 Du Pont Verfahren zur herstellung substituierter pyrimidine
US20080249329A1 (en) * 2005-09-29 2008-10-09 Dsm Ip Assets B.V. Process For Esterification Of An Organic Acid
WO2009023438A1 (en) * 2007-08-13 2009-02-19 Dow Agrosciences Llc 2-(2-fluoro-substituted phenyl)-6-amino-5-chloro-4-pyrimidinecarboxylates and their use as herbicides
HUE030847T2 (hu) 2007-10-02 2017-06-28 Dow Agrosciences Llc 2-szubsztituált-6-amino-5-alkil-, alkenil- vagy alkinil-4-pirimidin-karbonsavak és 6-szubsztituált-4-amino-3-alkil-, alkenil- vagy alkinil-pikolinsavak és alkalmazásuk herbicidként
BRPI0911207B8 (pt) * 2008-04-18 2022-10-11 Dow Agrosciences Llc 2-(fenil substituído)-6-hidróxi ou alcóxi-5-substituído-4-pirimidinacarboxilatos, composição herbicida, e método para controle de vegetação indesejável".
TWI596088B (zh) * 2011-01-25 2017-08-21 陶氏農業科學公司 ４－胺基－６－（經取代的苯基）吡啶甲酸酯及６－胺基－２－（經取代的苯基）－４－嘧啶羧酸酯之芳烷酯以及其等作為除草劑之用途
MX370455B (es) * 2011-07-27 2019-12-13 Bayer Ip Gmbh Ácidos picolínicos y piridimin-4-carboxílicos sustituidos, procedimiento para su preparación y su uso como herbicidas y reguladores del crecimiento de plantas.
US9113629B2 (en) * 2013-03-15 2015-08-25 Dow Agrosciences Llc 4-amino-6-(4-substituted-phenyl)-picolinates and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylates and their use as herbicides
US9637505B2 (en) 2013-03-15 2017-05-02 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
PT2970185T (pt) * 2013-03-15 2023-10-06 Corteva Agriscience Llc 4-amino-6-(heterocíclico)picolinatos e 6-amino-2-(heterocíclico)pirimidino-4-carboxilatos e seu uso como herbicidas
EP3193607A4 (en) 2014-09-15 2018-05-02 Dow AgroSciences LLC Synergistic weed control from applications of pyridine carboxylic acid herbicides and photosystem ii inhibitors
AR101858A1 (es) 2014-09-15 2017-01-18 Dow Agrosciences Llc Composiciones herbicidas protegidas que comprenden un herbicida de ácido piridincarboxílico
TWI689252B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與乙醯乳酸合成酶（ａｌｓ）抑制劑的協同性雜草控制
TWI685302B (zh) 2014-09-15 2020-02-21 美商陶氏農業科學公司 包含吡啶羧酸除草劑之安全的除草組成物
TWI689251B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與合成生長素除草劑及/或生長素轉運抑制劑的協同性雜草控制
WO2026028053A2 (en) 2024-07-27 2026-02-05 Assia Chemical Industries Ltd. Process for the preparation of tovorafenib

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA207185A (en) 1921-01-04 C. Wagner Virgil Warming plate
JPS60100559A (ja) * 1983-11-05 1985-06-04 Morishita Seiyaku Kk ２−アニリノ−１，６−ジヒドロ−６−オキソ−５−ピリミジンカルボン酸誘導体，その製法及び該化合物を含有する抗アレルギ−剤
JPH0331267A (ja) 1989-06-28 1991-02-12 Morishita Pharmaceut Co Ltd ２―アニリノ―１，６―ジヒドロ―６―オキソ―４―ピリミジンカルボン酸誘導体
JPH0341071A (ja) 1989-07-06 1991-02-21 Morishita Pharmaceut Co Ltd １，６―ジヒドロ―６―オキソ―２―フェノキシアルキルチオ―５―ピリミジンカルボン酸類
DE3935277A1 (de) * 1989-10-24 1991-05-02 Hoechst Ag Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
US5637618A (en) * 1990-06-01 1997-06-10 Bioresearch, Inc. Specific eatable taste modifiers
DE4029654A1 (de) 1990-09-19 1992-04-02 Hoechst Ag 2-phenyl-pyrimidine, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide
DE4131924A1 (de) * 1991-09-25 1993-07-08 Hoechst Ag Substituierte 4-alkoxypyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
DE4408404A1 (de) * 1994-03-12 1995-09-14 Huels Chemische Werke Ag Verfahren zur Herstellung von Chlorpyrimidinen
EA200000840A1 (ru) * 1998-02-17 2001-02-26 Туларик, Инк. Антивирусные производные пиримидина
ATE293608T1 (de) 1999-04-15 2005-05-15 Basf Ag Verfahren zur herstellung von substituierten pyrimidinen
US6281358B1 (en) 1999-04-15 2001-08-28 American Cyanamid Company Process for the preparation of substituted pyrimidines
AU2002258400A1 (en) 2001-02-16 2002-08-28 Tularik Inc. Methods of using pyrimidine-based antiviral agents
EP1646615B1 (en) 2003-06-06 2009-08-26 Vertex Pharmaceuticals Incorporated Pyrimidine derivatives as modulators of atp-binding cassette transporters
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
EP1849765A4 (en) 2005-02-02 2010-05-05 Ajinomoto Kk PROCESS FOR PREPARING A PYRIMIDINE COMPOUND
DE102005027150A1 (de) 2005-03-12 2006-09-28 Bayer Healthcare Ag Pyrimidincarbonsäure-Derivate und ihre Verwendung
DE602006013970D1 (de) * 2005-05-16 2010-06-10 Du Pont Verfahren zur herstellung substituierter pyrimidine

Also Published As

Publication number Publication date
ZA200707975B (en) 2008-11-26
CN101171237B (zh) 2011-04-20
CN102153516B (zh) 2013-02-06
TNSN07403A1 (en) 2009-03-17
IL185885A (en) 2012-10-31
AU2006246374A1 (en) 2006-11-16
ES2362005T3 (es) 2011-06-27
CA2607934A1 (en) 2006-11-16
MX2007013424A (es) 2008-01-16
US8198442B2 (en) 2012-06-12
US20120232271A1 (en) 2012-09-13
RS51804B (sr) 2011-12-31
MA29464B1 (fr) 2008-05-02
ME00498B (me) 2011-10-10
GEP20105099B (en) 2010-10-25
KR20080006576A (ko) 2008-01-16
CN101171237A (zh) 2008-04-30
RS20070434A (sr) 2009-01-22
EG25480A (en) 2012-01-15
BRPI0612475B8 (pt) 2022-12-06
IL185885A0 (en) 2008-01-06
WO2006121648A3 (en) 2006-12-28
ATE506352T1 (de) 2011-05-15
CN102153516A (zh) 2011-08-17
JP5161764B2 (ja) 2013-03-13
DE602006021411D1 (de) 2011-06-01
IL222041A (en) 2016-10-31
KR101379967B1 (ko) 2014-04-01
UA92171C2 (ru) 2010-10-11
DK1877384T3 (da) 2011-08-15
JP2008540414A (ja) 2008-11-20
US20090043098A1 (en) 2009-02-12
BRPI0612475A2 (pt) 2010-11-23
NZ561399A (en) 2009-11-27
BRPI0612475B1 (pt) 2020-03-10
WO2006121648A2 (en) 2006-11-16
PL1877384T3 (pl) 2011-09-30
EP1877384A2 (en) 2008-01-16
EP1877384B1 (en) 2011-04-20
AU2006246374B2 (en) 2012-03-29

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