CA2607934C - Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids - Google Patents

Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids Download PDF

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Publication number
CA2607934C
CA2607934C CA2607934A CA2607934A CA2607934C CA 2607934 C CA2607934 C CA 2607934C CA 2607934 A CA2607934 A CA 2607934A CA 2607934 A CA2607934 A CA 2607934A CA 2607934 C CA2607934 C CA 2607934C
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CA
Canada
Prior art keywords
formula
compound
acid
optionally substituted
water
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA2607934A
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English (en)
French (fr)
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CA2607934A1 (en
Inventor
Rafael Shapiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corteva Agriscience LLC
Original Assignee
EI Du Pont de Nemours and Co
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Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of CA2607934A1 publication Critical patent/CA2607934A1/en
Application granted granted Critical
Publication of CA2607934C publication Critical patent/CA2607934C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2607934A 2005-05-06 2006-04-28 Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids Expired - Lifetime CA2607934C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67826405P 2005-05-06 2005-05-06
US60/678,264 2005-05-06
PCT/US2006/016340 WO2006121648A2 (en) 2005-05-06 2006-04-28 Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids

Publications (2)

Publication Number Publication Date
CA2607934A1 CA2607934A1 (en) 2006-11-16
CA2607934C true CA2607934C (en) 2013-10-01

Family

ID=36952291

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2607934A Expired - Lifetime CA2607934C (en) 2005-05-06 2006-04-28 Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids

Country Status (25)

Country Link
US (2) US8198442B2 (enExample)
EP (1) EP1877384B1 (enExample)
JP (1) JP5161764B2 (enExample)
KR (1) KR101379967B1 (enExample)
CN (2) CN101171237B (enExample)
AT (1) ATE506352T1 (enExample)
AU (1) AU2006246374B2 (enExample)
BR (1) BRPI0612475B8 (enExample)
CA (1) CA2607934C (enExample)
DE (1) DE602006021411D1 (enExample)
DK (1) DK1877384T3 (enExample)
EG (1) EG25480A (enExample)
ES (1) ES2362005T3 (enExample)
GE (1) GEP20105099B (enExample)
IL (2) IL185885A (enExample)
MA (1) MA29464B1 (enExample)
ME (1) ME00498B (enExample)
MX (1) MX2007013424A (enExample)
NZ (1) NZ561399A (enExample)
PL (1) PL1877384T3 (enExample)
RS (2) RS51804B (enExample)
TN (1) TNSN07403A1 (enExample)
UA (1) UA92171C2 (enExample)
WO (1) WO2006121648A2 (enExample)
ZA (1) ZA200707975B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006247581B2 (en) * 2005-05-16 2011-10-20 E. I. Du Pont De Nemours And Company Method for preparing substituted pyrimidines
WO2007039522A2 (en) * 2005-09-29 2007-04-12 Dsm Ip Assets B.V. Process for esterification of an organic acid
CN101778829B (zh) * 2007-08-13 2013-07-31 陶氏益农公司 2-(2-氟-取代的苯基)-6-氨基-5-氯-4-嘧啶羧酸衍生物及其作为除草剂的用途
EP2327694B1 (en) 2007-10-02 2013-07-24 Dow AgroSciences LLC Substituted 4-amino-picolinic acids and their use as herbicides
CA2720848C (en) * 2008-04-18 2014-02-11 Dow Agrosciences Llc 2-(substituted phenyl)-6-hydroxy or alkoxy-5-substituted-4-pyrimidinecarboxylates and their use as herbicides
TWI596088B (zh) * 2011-01-25 2017-08-21 陶氏農業科學公司 ４－胺基－６－（經取代的苯基）吡啶甲酸酯及６－胺基－２－（經取代的苯基）－４－嘧啶羧酸酯之芳烷酯以及其等作為除草劑之用途
EP2736897B1 (de) * 2011-07-27 2015-11-25 Bayer Intellectual Property GmbH Substituierte picolinsäuren und pyrimidin-4-carbonsäuren, verfahren zu deren herstellung sowie deren verwendung als herbizide und pflanzenwachstumsregulatoren
US9113629B2 (en) * 2013-03-15 2015-08-25 Dow Agrosciences Llc 4-amino-6-(4-substituted-phenyl)-picolinates and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylates and their use as herbicides
US9637505B2 (en) 2013-03-15 2017-05-02 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
KR20210125575A (ko) * 2013-03-15 2021-10-18 코르테바 애그리사이언스 엘엘씨 4-아미노-6-(헤테로시클릭)피콜리네이트 및 6-아미노-2-(헤테로시클릭)피리미딘-4-카르복실레이트 및 제초제로서의 그의 용도
TWI689252B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與乙醯乳酸合成酶（ａｌｓ）抑制劑的協同性雜草控制
TWI689251B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與合成生長素除草劑及/或生長素轉運抑制劑的協同性雜草控制
TWI685302B (zh) 2014-09-15 2020-02-21 美商陶氏農業科學公司 包含吡啶羧酸除草劑之安全的除草組成物
AR101863A1 (es) 2014-09-15 2017-01-18 Dow Agrosciences Llc Control sinérgico de malezas a partir de aplicaciones de herbicidas de ácido piridín carboxílico e inhibidores de fotosistema ii
TWI694770B (zh) 2014-09-15 2020-06-01 美商陶氏農業科學公司 包含吡啶羧酸除草劑之安全的除草組成物（二）
WO2026028053A2 (en) 2024-07-27 2026-02-05 Assia Chemical Industries Ltd. Process for the preparation of tovorafenib

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA207185A (en) 1921-01-04 C. Wagner Virgil Warming plate
JPS60100559A (ja) * 1983-11-05 1985-06-04 Morishita Seiyaku Kk ２−アニリノ−１，６−ジヒドロ−６−オキソ−５−ピリミジンカルボン酸誘導体，その製法及び該化合物を含有する抗アレルギ−剤
JPH0331267A (ja) 1989-06-28 1991-02-12 Morishita Pharmaceut Co Ltd ２―アニリノ―１，６―ジヒドロ―６―オキソ―４―ピリミジンカルボン酸誘導体
JPH0341071A (ja) 1989-07-06 1991-02-21 Morishita Pharmaceut Co Ltd １，６―ジヒドロ―６―オキソ―２―フェノキシアルキルチオ―５―ピリミジンカルボン酸類
DE3935277A1 (de) * 1989-10-24 1991-05-02 Hoechst Ag Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
US5637618A (en) * 1990-06-01 1997-06-10 Bioresearch, Inc. Specific eatable taste modifiers
DE4029654A1 (de) 1990-09-19 1992-04-02 Hoechst Ag 2-phenyl-pyrimidine, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide
DE4131924A1 (de) * 1991-09-25 1993-07-08 Hoechst Ag Substituierte 4-alkoxypyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
DE4408404A1 (de) * 1994-03-12 1995-09-14 Huels Chemische Werke Ag Verfahren zur Herstellung von Chlorpyrimidinen
ATE245641T1 (de) * 1998-02-17 2003-08-15 Tularik Inc Antivirale pyrimidinderivate
US6281358B1 (en) 1999-04-15 2001-08-28 American Cyanamid Company Process for the preparation of substituted pyrimidines
DE60019606T2 (de) 1999-04-15 2005-08-18 Basf Ag Verfahren zur herstellung von substituierten pyrimidinen
AU2002258400A1 (en) 2001-02-16 2002-08-28 Tularik Inc. Methods of using pyrimidine-based antiviral agents
ATE440825T1 (de) * 2003-06-06 2009-09-15 Vertex Pharma Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern
TWI355894B (en) 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
EP1849765A4 (en) 2005-02-02 2010-05-05 Ajinomoto Kk PROCESS FOR PREPARING A PYRIMIDINE COMPOUND
DE102005027150A1 (de) 2005-03-12 2006-09-28 Bayer Healthcare Ag Pyrimidincarbonsäure-Derivate und ihre Verwendung
AU2006247581B2 (en) * 2005-05-16 2011-10-20 E. I. Du Pont De Nemours And Company Method for preparing substituted pyrimidines

Also Published As

Publication number Publication date
IL185885A (en) 2012-10-31
AU2006246374B2 (en) 2012-03-29
PL1877384T3 (pl) 2011-09-30
US20120232271A1 (en) 2012-09-13
ATE506352T1 (de) 2011-05-15
CA2607934A1 (en) 2006-11-16
WO2006121648A2 (en) 2006-11-16
US20090043098A1 (en) 2009-02-12
AU2006246374A1 (en) 2006-11-16
KR20080006576A (ko) 2008-01-16
ZA200707975B (en) 2008-11-26
ME00498B (me) 2011-10-10
CN101171237A (zh) 2008-04-30
CN102153516A (zh) 2011-08-17
RS51804B (sr) 2011-12-31
GEP20105099B (en) 2010-10-25
EG25480A (en) 2012-01-15
BRPI0612475B8 (pt) 2022-12-06
DE602006021411D1 (de) 2011-06-01
NZ561399A (en) 2009-11-27
IL222041A (en) 2016-10-31
EP1877384A2 (en) 2008-01-16
UA92171C2 (ru) 2010-10-11
CN101171237B (zh) 2011-04-20
DK1877384T3 (da) 2011-08-15
TNSN07403A1 (en) 2009-03-17
KR101379967B1 (ko) 2014-04-01
JP5161764B2 (ja) 2013-03-13
US8198442B2 (en) 2012-06-12
ES2362005T3 (es) 2011-06-27
MX2007013424A (es) 2008-01-16
BRPI0612475B1 (pt) 2020-03-10
CN102153516B (zh) 2013-02-06
MA29464B1 (fr) 2008-05-02
JP2008540414A (ja) 2008-11-20
EP1877384B1 (en) 2011-04-20
RS20070434A (sr) 2009-01-22
WO2006121648A3 (en) 2006-12-28
IL185885A0 (en) 2008-01-06
BRPI0612475A2 (pt) 2010-11-23

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