CN101094853B - 可用作蛋白激酶抑制剂的吡唑并[1,5-a]嘧啶 - Google Patents

可用作蛋白激酶抑制剂的吡唑并[1,5-a]嘧啶 Download PDF

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Publication number
CN101094853B
CN101094853B CN2005800450252A CN200580045025A CN101094853B CN 101094853 B CN101094853 B CN 101094853B CN 2005800450252 A CN2005800450252 A CN 2005800450252A CN 200580045025 A CN200580045025 A CN 200580045025A CN 101094853 B CN101094853 B CN 101094853B
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compound
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CN101094853A (zh
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J-M·吉米内斯
R·克奈格泰尔
J-D·凯瑞尔
D·斯塔默斯
李磐
J·R·科姆
A·阿罗诺夫
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
CN2005800450252A 2004-11-04 2005-11-04 可用作蛋白激酶抑制剂的吡唑并[1,5-a]嘧啶 Expired - Fee Related CN101094853B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62544604P 2004-11-04 2004-11-04
US60/625,446 2004-11-04
PCT/US2005/040344 WO2006052913A1 (en) 2004-11-04 2005-11-04 PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES

Publications (2)

Publication Number Publication Date
CN101094853A CN101094853A (zh) 2007-12-26
CN101094853B true CN101094853B (zh) 2011-07-13

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CN2005800450252A Expired - Fee Related CN101094853B (zh) 2004-11-04 2005-11-04 可用作蛋白激酶抑制剂的吡唑并[1,5-a]嘧啶

Country Status (20)

Country Link
US (1) US7528138B2 (https=)
EP (1) EP1812440B1 (https=)
JP (2) JP5030229B2 (https=)
KR (1) KR20070090172A (https=)
CN (1) CN101094853B (https=)
AT (1) ATE482213T1 (https=)
AU (1) AU2005304784B2 (https=)
CA (1) CA2586375A1 (https=)
DE (1) DE602005023763D1 (https=)
DK (1) DK1812440T3 (https=)
ES (1) ES2354824T3 (https=)
IL (1) IL182893A0 (https=)
MX (1) MX337817B (https=)
NO (1) NO20072795L (https=)
NZ (1) NZ555236A (https=)
PT (1) PT1812440E (https=)
RU (1) RU2417996C2 (https=)
SI (1) SI1812440T1 (https=)
WO (1) WO2006052913A1 (https=)
ZA (1) ZA200704476B (https=)

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