|
SE0104140D0
(sv)
*
|
2001-12-07 |
2001-12-07 |
Astrazeneca Ab |
Novel Compounds
|
|
PT1812440E
(pt)
*
|
2004-11-04 |
2011-01-25 |
Vertex Pharma |
Pirazolo[1,5-a]pirimidinas úteis enquanto inibidores de proteínas cinases
|
|
SI1853588T1
(sl)
*
|
2005-02-16 |
2008-10-31 |
Astrazeneca Ab |
Kemične spojine
|
|
US20090156617A1
(en)
*
|
2005-05-12 |
2009-06-18 |
Northrup Alan B |
Tyrosine kinase inhibitors
|
|
US20080287437A1
(en)
*
|
2005-05-16 |
2008-11-20 |
Astrazeneca Ab |
Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
|
|
WO2007046867A2
(en)
*
|
2005-05-19 |
2007-04-26 |
Xenon Pharmaceuticals Inc. |
Piperidine derivatives and their uses as therapeutic agents
|
|
EP2354140A1
(en)
*
|
2005-05-20 |
2011-08-10 |
Vertex Pharmaceuticals Incorporated |
Pyrrolopyridines useful as inhibitors of protein kinase
|
|
JP2009513615A
(ja)
*
|
2005-10-28 |
2009-04-02 |
アストラゼネカ アクチボラグ |
癌の治療においてチロシンキナーゼ阻害剤として使用するための4−(3−アミノピラゾール)ピリミジン誘導体
|
|
SG10202003901UA
(en)
|
2005-12-13 |
2020-05-28 |
Incyte Holdings Corp |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
|
|
GB0601638D0
(en)
*
|
2006-01-27 |
2006-03-08 |
Merck Sharp & Dohme |
Therapeutic treatment
|
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
CA2668286C
(en)
|
2006-11-03 |
2014-09-16 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
MX2009010127A
(es)
*
|
2007-03-22 |
2009-11-05 |
Vertex Pharma |
Compuestos utiles como inhibidores de janus cinasas.
|
|
JP2010524911A
(ja)
*
|
2007-04-18 |
2010-07-22 |
アストラゼネカ アクチボラグ |
5−アミノピラゾール−3−イル−3H−イミダゾ[4,5−b]ピリジン誘導体と癌の治療のためのその使用
|
|
UA99459C2
(en)
*
|
2007-05-04 |
2012-08-27 |
Астразенека Аб |
9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
|
|
WO2008135786A1
(en)
*
|
2007-05-04 |
2008-11-13 |
Astrazeneca Ab |
Amino-thiazolyl- pyrimidine derivatives and their use for the treatment of cancer
|
|
KR20150036210A
(ko)
|
2007-06-13 |
2015-04-07 |
인사이트 코포레이션 |
야누스 키나제 억제제(R)―3―(4―(7H―피롤로[2,3-d]피리미딘―4―일)―1H―피라졸―1―일)―3―사이클로펜틸프로판니트릴의 염
|
|
KR20100087298A
(ko)
*
|
2007-09-28 |
2010-08-04 |
교와 핫꼬 기린 가부시키가이샤 |
피부 질환의 예방 및/또는 치료제
|
|
UA104849C2
(uk)
*
|
2007-11-16 |
2014-03-25 |
Інсайт Корпорейшн |
4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janus
|
|
AU2008343813B2
(en)
*
|
2007-12-19 |
2012-04-12 |
Amgen Inc. |
Inhibitors of PI3 kinase
|
|
CN101932583A
(zh)
*
|
2007-12-19 |
2010-12-29 |
沃泰克斯药物股份有限公司 |
用作JAK2抑制剂的吡唑并[1,5-a]嘧啶类
|
|
JP5638961B2
(ja)
*
|
2008-03-13 |
2014-12-10 |
ザ ジェネラル ホスピタル コーポレイション |
Bmpシグナル伝達経路のインヒビター
|
|
KR20110017445A
(ko)
*
|
2008-06-11 |
2011-02-21 |
아스트라제네카 아베 |
암 및 골수증식성 장애의 치료에 유용한 트리시클릭 2,4-디아미노-l,3,5-트리아진 유도체
|
|
JP5746032B2
(ja)
*
|
2008-09-19 |
2015-07-08 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
3,4−ジヒドロ−2H−ピロロ[1,2−a]ピラジン−1−オン誘導体
|
|
WO2010033941A1
(en)
|
2008-09-22 |
2010-03-25 |
Array Biopharma Inc. |
Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
|
|
BRPI0919488A2
(pt)
*
|
2008-09-30 |
2015-12-01 |
Astrazeneca Ab |
composto, uso de um composto, método para tratar câncer em um animal de sangue quente, composição farmacêutica, e, processo para preparar um composto
|
|
EP2348860B1
(en)
*
|
2008-10-31 |
2015-05-27 |
Genentech, Inc. |
Pyrazolopyrimidine jak inhibitor compounds and methods
|
|
GB0821913D0
(en)
|
2008-12-02 |
2009-01-07 |
Price & Co |
Antibacterial compounds
|
|
AR076794A1
(es)
|
2009-05-22 |
2011-07-06 |
Incyte Corp |
Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
|
|
SI2432472T1
(sl)
*
|
2009-05-22 |
2019-11-29 |
Incyte Holdings Corp |
3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
|
|
CA2762479A1
(en)
*
|
2009-05-28 |
2010-12-02 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-met protein kinase
|
|
LT3141252T
(lt)
|
2009-06-17 |
2018-11-12 |
Vertex Pharmaceuticals Inc. |
Gripo virusų replikacijos inhibitoriai
|
|
UA110324C2
(en)
|
2009-07-02 |
2015-12-25 |
Genentech Inc |
Jak inhibitory compounds based on pyrazolo pyrimidine
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
NZ598985A
(en)
|
2009-09-04 |
2013-07-26 |
Biogen Idec Inc |
Bruton's tyrosine kinase inhibitors
|
|
EP3354652B1
(en)
|
2010-03-10 |
2020-05-06 |
Incyte Holdings Corporation |
Piperidin-4-yl azetidine derivatives as jak1 inhibitors
|
|
US20130096160A1
(en)
*
|
2010-04-14 |
2013-04-18 |
Secretary, Department Of Health And Human Services |
Arylthiazolyl piperidines and related compounds as modulators of survival motor neuron (smn) protein production
|
|
NZ604306A
(en)
|
2010-05-17 |
2015-02-27 |
Incozen Therapeutics Pvt Ltd |
Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases
|
|
ME03376B
(me)
|
2010-05-20 |
2020-01-20 |
Array Biopharma Inc |
Makrociklička jedinjenja kао inhibiтori trk kinaze
|
|
PE20130216A1
(es)
|
2010-05-21 |
2013-02-27 |
Incyte Corp |
Formulacion topica para un inhibidor de jak
|
|
GB2480814A
(en)
*
|
2010-06-01 |
2011-12-07 |
Summit Corp Plc |
Compounds for the treatment of clostridium difficile-associated disease
|
|
ES2803556T3
(es)
|
2010-06-01 |
2021-01-27 |
Summit Oxford Ltd |
Compuestos para el tratamiento de enfermedades asociadas a clostridium difficile
|
|
PE20140146A1
(es)
|
2010-11-19 |
2014-02-06 |
Incyte Corp |
Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
|
|
US9034884B2
(en)
|
2010-11-19 |
2015-05-19 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
|
|
RU2013132681A
(ru)
*
|
2010-12-16 |
2015-01-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
Ингибиторы репликации вирусов гриппа
|
|
MX354412B
(es)
*
|
2011-06-10 |
2018-03-05 |
Merck Patent Gmbh |
Composiciones y metodos para la produccion de compuestos de pirimidina con actividad inhibidora de tirosina cinasa de bruton.
|
|
CN103797010B
(zh)
|
2011-06-20 |
2016-02-24 |
因塞特控股公司 |
作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
|
|
US9309250B2
(en)
|
2011-06-22 |
2016-04-12 |
Vertex Pharmaceuticals Incorporated |
Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
|
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
WO2013028263A1
(en)
*
|
2011-08-24 |
2013-02-28 |
Glaxosmithkline Llc |
Pyrazolopyrimidine derivatives as pi3 kinase inhibitors
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
CN107082779A
(zh)
|
2012-03-30 |
2017-08-22 |
理森制药股份公司 |
作为c‑met 蛋白激酶调节剂的新化合物
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
AR091273A1
(es)
*
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
WO2014028829A1
(en)
*
|
2012-08-16 |
2014-02-20 |
The Scripps Research Institute |
Novel kappa opioid ligands
|
|
PH12020551186B1
(en)
|
2012-11-15 |
2024-03-20 |
Incyte Holdings Corp |
Sustained-release dosage forms of ruxolitinib
|
|
WO2014081996A1
(en)
*
|
2012-11-23 |
2014-05-30 |
Glaxosmithkline Llc |
Novel compounds as diacylglycerol acyltransferase inhibitors
|
|
SI2941432T1
(en)
|
2012-12-07 |
2018-07-31 |
Vertex Pharmaceuticals Incorporated |
2-AMINO-6-FLUORO-N- (5-FLUORO-4- (4- (4- (OXETHAN-3-YL) PIPERAZIN-1-CARBONYL) PIPERIDIN-1-YLIPRIDIN-3-YL) 1,5 ALFA) PYRIMIDINE-3-CARBOXAMIDE AS ATR KINAZE INHIBITOR
|
|
TW201501713A
(zh)
*
|
2013-03-01 |
2015-01-16 |
Kyowa Hakko Kirin Co Ltd |
眼炎症性疾病之預防及/或治療劑
|
|
RS62867B1
(sr)
|
2013-03-06 |
2022-02-28 |
Incyte Holdings Corp |
Postupci i intermedijeri za dobijanje inhibitora jak
|
|
WO2014160203A2
(en)
|
2013-03-14 |
2014-10-02 |
The Brigham And Women's Hospital, Inc. |
Bmp inhibitors and methods of use thereof
|
|
EP2970288A1
(en)
*
|
2013-03-15 |
2016-01-20 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2014143240A1
(en)
|
2013-03-15 |
2014-09-18 |
Vertex Pharmaceuticals Incorporated |
Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
|
|
US8957078B2
(en)
|
2013-03-15 |
2015-02-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
WO2014175370A1
(ja)
*
|
2013-04-25 |
2014-10-30 |
塩野義製薬株式会社 |
ピロリジン誘導体およびそれらを含有する医薬組成物
|
|
SMT202000315T1
(it)
|
2013-08-07 |
2020-07-08 |
Incyte Corp |
Forme di dosaggio a rilascio prolungato per un inibitore di jak1
|
|
JP6618901B2
(ja)
|
2013-11-13 |
2019-12-11 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
インフルエンザウイルスの複製の阻害剤を調製する方法
|
|
LT3068776T
(lt)
|
2013-11-13 |
2019-08-12 |
Vertex Pharmaceuticals Incorporated |
Gripo virusų replikacijos inhibitoriai
|
|
WO2015073267A1
(en)
*
|
2013-11-15 |
2015-05-21 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
CN104650092B
(zh)
*
|
2013-11-16 |
2017-11-10 |
广东东阳光药业有限公司 |
取代的杂芳基化合物及其组合物和用途
|
|
PT3077397T
(pt)
|
2013-12-06 |
2020-01-22 |
Vertex Pharma |
Composto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inibidor da atr quinase, a sua preparação, diferentes formas sólidas e derivados radiomarcados do mesmo
|
|
JP2017516850A
(ja)
|
2014-05-23 |
2017-06-22 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
Jak阻害剤である5−クロロ−2−ジフルオロメトキシフェニルピラゾロピリミジン化合物
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
MX373102B
(es)
|
2014-06-05 |
2020-04-17 |
Vertex Pharma |
Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útil como inhibidor de ataxia telangiectasia mutada y rad3 relacionado (atr) cinasa, preparación de tal compuesto y diferentes formas sólidas del mismo.
|
|
SG11201610500WA
(en)
|
2014-06-17 |
2017-01-27 |
Vertex Pharma |
Method for treating cancer using a combination of chk1 and atr inhibitors
|
|
US10513521B2
(en)
|
2014-07-15 |
2019-12-24 |
The Brigham And Women's Hospital, Inc. |
Compositions and methods for inhibiting BMP
|
|
CN113354649B
(zh)
|
2014-11-16 |
2024-12-10 |
阵列生物制药公司 |
一种新的晶型
|
|
EP3294735B8
(en)
|
2015-05-13 |
2022-01-05 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
EP3294717B1
(en)
|
2015-05-13 |
2020-07-29 |
Vertex Pharmaceuticals Inc. |
Methods of preparing inhibitors of influenza viruses replication
|
|
AU2016331955B2
(en)
|
2015-09-30 |
2022-07-21 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
|
|
EP3368039A1
(en)
|
2015-10-26 |
2018-09-05 |
The Regents of The University of Colorado, A Body Corporate |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
FI3439662T3
(fi)
|
2016-04-04 |
2024-09-04 |
Loxo Oncology Inc |
(s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
EP3458456B1
(en)
|
2016-05-18 |
2020-11-25 |
Loxo Oncology Inc. |
Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
|
|
PL3484888T3
(pl)
*
|
2016-07-18 |
2023-06-26 |
University Health Network |
Stałe postacie inhibitora TTK
|
|
JP7214632B2
(ja)
|
2016-07-21 |
2023-01-30 |
バイオジェン エムエー インク. |
ブルトン型チロシンキナーゼ阻害剤のコハク酸塩形態および組成物
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
EP3615538B1
(en)
|
2017-04-27 |
2024-02-07 |
The Brigham and Women's Hospital, Inc. |
Novel alk2 inhibitors and methods for inhibiting bmp signaling
|
|
PL233595B1
(pl)
*
|
2017-05-12 |
2019-11-29 |
Celon Pharma Spolka Akcyjna |
Pochodne pirazolo[1,5-a]pirymidyny jako inhibitory kinazy JAK
|
|
MX387969B
(es)
|
2017-05-22 |
2025-03-19 |
Hoffmann La Roche |
Composiciones y compuestos terapéuticos, y métodos para su uso.
|
|
WO2019113487A1
(en)
|
2017-12-08 |
2019-06-13 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
|
BR112020015396A2
(pt)
|
2018-01-29 |
2020-12-08 |
Merck Patent Gmbh |
Inididores de gcn2 e usos dos mesmos
|
|
JP7229257B2
(ja)
*
|
2018-01-29 |
2023-02-28 |
メルク パテント ゲーエムベーハー |
Gcn2阻害剤およびその使用
|
|
SG11202007164UA
(en)
|
2018-01-30 |
2020-08-28 |
Incyte Corp |
Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
|
|
SMT202400306T1
(it)
|
2018-03-30 |
2024-09-16 |
Incyte Corp |
Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak.
|
|
EP3870181B1
(en)
*
|
2018-10-26 |
2024-08-14 |
Keros Therapeutics, Inc. |
Crystal forms of an alk2 inhibitor
|
|
CA3124088A1
(en)
*
|
2018-12-20 |
2020-06-25 |
Incyte Corporation |
Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2
|
|
US12508262B2
(en)
|
2020-04-30 |
2025-12-30 |
Keros Therapeutics, Inc. |
Methods of using ALK2 inhibitors
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
WO2022098812A1
(en)
|
2020-11-04 |
2022-05-12 |
Keros Therapeutics, Inc. |
Methods of treating iron overload
|
|
EP4392418A4
(en)
*
|
2021-08-24 |
2025-06-18 |
The Johns Hopkins University |
Compositions and methods for treating proteotoxicity-associated diseases
|
|
CN116987083A
(zh)
*
|
2022-04-25 |
2023-11-03 |
杭州健崃生物科技有限公司 |
吡唑并[1,5-a]嘧啶衍生物及其制备方法和用途
|
|
KR102912267B1
(ko)
|
2023-04-20 |
2026-01-15 |
한국화학연구원 |
신규한 헤테로고리 화합물 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물
|