CN101006053A - 用于治疗炎症的吲哚 - Google Patents

用于治疗炎症的吲哚 Download PDF

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Publication number
CN101006053A
CN101006053A CNA2005800277808A CN200580027780A CN101006053A CN 101006053 A CN101006053 A CN 101006053A CN A2005800277808 A CNA2005800277808 A CN A2005800277808A CN 200580027780 A CN200580027780 A CN 200580027780A CN 101006053 A CN101006053 A CN 101006053A
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China
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compound
represent
randomly
phenyl
alkyl
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Chinese (zh)
Inventor
克里斯托弗·奥洛夫森
埃德加斯·休纳
本杰明·佩尔科曼
维塔·奥佐拉
马丁斯·凯特凯维克斯
伊瓦尔斯·卡尔文斯
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Biolipox AB
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Biolipox AB
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Publication of CN101006053A publication Critical patent/CN101006053A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
CNA2005800277808A 2004-06-18 2005-06-17 用于治疗炎症的吲哚 Pending CN101006053A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58040104P 2004-06-18 2004-06-18
US60/580,401 2004-06-18

Publications (1)

Publication Number Publication Date
CN101006053A true CN101006053A (zh) 2007-07-25

Family

ID=34956079

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800277808A Pending CN101006053A (zh) 2004-06-18 2005-06-17 用于治疗炎症的吲哚

Country Status (16)

Country Link
US (1) US7705023B2 (enExample)
EP (1) EP1778632B1 (enExample)
JP (1) JP2008502669A (enExample)
KR (1) KR20070028553A (enExample)
CN (1) CN101006053A (enExample)
AT (1) ATE405549T1 (enExample)
AU (1) AU2005254782A1 (enExample)
BR (1) BRPI0512252A (enExample)
CA (1) CA2570363A1 (enExample)
DE (1) DE602005009209D1 (enExample)
ES (1) ES2315877T3 (enExample)
IL (1) IL179728A0 (enExample)
MX (1) MXPA06014535A (enExample)
RU (1) RU2007101705A (enExample)
WO (1) WO2005123673A1 (enExample)
ZA (1) ZA200610357B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108929203A (zh) * 2018-08-14 2018-12-04 重庆市化工研究院 一种芳香族乙烯基醚及其合成方法和应用
CN113233980A (zh) * 2021-04-02 2021-08-10 台州学院 一种β-氯代酸酯及α，β-不饱和酸酯类化合物的合成方法
CN118121595A (zh) * 2024-05-06 2024-06-04 广州市朝利良生物科技有限公司 化合物eh-p005j在制备促伤口愈合药物中的用途

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UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
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WO2008009924A2 (en) * 2006-07-18 2008-01-24 Biolipox Ab Indoles useful in the treatment of inflammation
MX2009011210A (es) * 2007-04-16 2009-10-30 Abbott Lab Inhibidores de mcl1 de indol 7-no sustituido.
CN102186845B (zh) 2008-10-17 2016-09-07 阿卡制药有限公司 S1p受体调节剂以及它们的用途
EP2344446A4 (en) 2008-10-17 2012-04-04 Akaal Pharma Pty Ltd S1P RECEPTOR MODULATORS
US20120029016A1 (en) 2008-12-30 2012-02-02 Biolipox Ab Indoles Useful in the Treatment of Inflammation
WO2010127152A2 (en) * 2009-04-29 2010-11-04 Irm Llc Compounds and compositions as microsomal prostaglandin e synthase-1 inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
WO2021040393A1 (ko) * 2019-08-26 2021-03-04 국제약품 주식회사 인돌 카복사미드 유도체 및 그를 포함하는 약제학적 조성물

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AU2005254782A1 (en) 2005-12-29
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