CN100579532C - 具有改善水溶性的氟苯尼考前药 - Google Patents

具有改善水溶性的氟苯尼考前药 Download PDF

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Publication number
CN100579532C
CN100579532C CN200480038867A CN200480038867A CN100579532C CN 100579532 C CN100579532 C CN 100579532C CN 200480038867 A CN200480038867 A CN 200480038867A CN 200480038867 A CN200480038867 A CN 200480038867A CN 100579532 C CN100579532 C CN 100579532C
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China
Prior art keywords
florfenicol
phosphate ester
salt
florfenicol phosphate
pharmaceutical composition
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Expired - Lifetime
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CN200480038867A
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English (en)
Chinese (zh)
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CN1897954A (zh
Inventor
S·J·哈克
S·V·潘赛尔
T·W·格林卡
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Intervet International BV
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先灵-普劳有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200480038867A 2003-12-23 2004-12-20 具有改善水溶性的氟苯尼考前药 Expired - Lifetime CN100579532C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53222703P 2003-12-23 2003-12-23
US60/532,227 2003-12-23

Publications (2)

Publication Number Publication Date
CN1897954A CN1897954A (zh) 2007-01-17
CN100579532C true CN100579532C (zh) 2010-01-13

Family

ID=34738768

Family Applications (1)

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CN200480038867A Expired - Lifetime CN100579532C (zh) 2003-12-23 2004-12-20 具有改善水溶性的氟苯尼考前药

Country Status (18)

Country Link
US (2) US7153842B2 (enExample)
EP (1) EP1696934B1 (enExample)
JP (2) JP4719160B2 (enExample)
KR (1) KR20060111605A (enExample)
CN (1) CN100579532C (enExample)
AR (1) AR046970A1 (enExample)
BR (1) BRPI0418133A2 (enExample)
CA (1) CA2550660C (enExample)
EC (1) ECSP066670A (enExample)
IL (2) IL176342A (enExample)
MX (1) MXPA06007215A (enExample)
NO (1) NO20063244L (enExample)
NZ (1) NZ547592A (enExample)
PE (1) PE20050822A1 (enExample)
RU (1) RU2006126519A (enExample)
TW (1) TWI262181B (enExample)
WO (1) WO2005063257A1 (enExample)
ZA (1) ZA200605165B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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PE20050386A1 (es) * 2003-05-29 2005-06-23 Schering Plough Ltd Composiciones farmaceuticas de florfenicol
US7439268B2 (en) 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
CA2550660C (en) * 2003-12-23 2011-03-15 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
WO2005066119A2 (en) * 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof
NZ553777A (en) 2004-09-23 2010-11-26 Schering Plough Ltd Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
MX2007006072A (es) 2004-11-19 2007-07-11 Schering Plough Ltd Control de parasitos en animales mediante el uso de derivados del parasiticida 2-fenil-3-(1h-pirrol-2-il)acrilonitrilo.
EP1890547A2 (en) * 2005-06-09 2008-02-27 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
EP2091909A1 (en) * 2006-12-13 2009-08-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
CN101600422A (zh) * 2006-12-13 2009-12-09 先灵-普劳有限公司 在亲脂性溶媒系统中的水溶性苯丙醇前药
MX2009006467A (es) * 2006-12-13 2009-08-21 Schering Plough Ltd Profarmacos solubles en agua de cloranfenicol, tiamfenicol y analogos de los mismos.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX368680B (es) 2007-06-27 2019-10-11 Du Pont Administración subcutánea de un derivado de isoxazol-benzamida para usarse en un método para proteger un mamífero de una pulga.
US20090170954A1 (en) * 2007-12-14 2009-07-02 Schering-Plough Ltd. Process for Recovering Florfenicol and Florfenicol Analogs
CA2732017A1 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
EP2461684A2 (en) 2009-08-05 2012-06-13 E. I. du Pont de Nemours and Company Mesoionic pesticides
BR112012002524A2 (pt) 2009-08-05 2019-09-24 Du Pont "composto de fórmula, composição, composição para proteger um animal de uma praga parasítica de invertebrados, métodos para controlar uma praga invertebrada e semente tratada"
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
MX2013012820A (es) 2011-05-02 2014-02-10 Zoetis Llc Cefalosporinas novedosas utiles como agentes antibacteriales.
JP2014520151A (ja) 2011-06-20 2014-08-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 蠕虫感染を処置するためのヘテロ環式化合物
RU2014126367A (ru) 2011-11-28 2016-01-27 Е.И.Дюпон Де Немур Энд Компани Производные n-(4-хинолинметил)сульфонамидов и их применение в качестве антигельминтных средств
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
CN103242363B (zh) * 2013-04-18 2015-10-28 湖北龙翔药业有限公司 氟苯尼考磷酸二酯及盐及其制备方法
CN103923118A (zh) * 2014-04-08 2014-07-16 张家港威胜生物医药有限公司 一种水溶性氟苯尼考衍生物的合成方法
CN105111234B (zh) * 2015-09-23 2017-05-17 河北远征禾木药业有限公司 一种氟苯尼考磷酸酯的合成方法
CN110078729A (zh) * 2019-06-11 2019-08-02 石家庄学院 一种水溶性氟苯尼考前药及其制备方法
CN115286544A (zh) * 2022-10-08 2022-11-04 世华合创生物技术开发(山东)有限公司 一种氟苯尼考衍生物、制备方法及其在抗细菌感染的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014437A2 (en) * 1979-02-05 1980-08-20 Schering Corporation Novel 1-aryl-2-acylamido-3-fluoro-1-propanols, their preparation and pharmaceutical compositions containing them
WO2003077828A2 (en) * 2002-03-08 2003-09-25 Schering-Plough, Ltd. Novel florfenicol-type antibiotics

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776992A (en) 1956-03-14 1957-01-08 Du Pont Trifluoromethylsulfonylphenyldichloracetamidopropandiol
FR2562543B1 (fr) * 1984-04-10 1987-09-25 Elf Aquitaine Nouveaux phosphonites cycliques, leur preparation et applications
US5352832A (en) 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US6864240B1 (en) 1999-06-15 2005-03-08 Elan Pharmaceuticals, Inc. Dipeptide inhibitors of β-secretase
US6670344B2 (en) 2000-09-14 2003-12-30 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts
WO2002102766A2 (en) 2001-06-15 2002-12-27 Arizona Board Of Regents Combretastatin a-3 prodrug
US7439268B2 (en) 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
CA2550660C (en) 2003-12-23 2011-03-15 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
WO2005066119A2 (en) 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014437A2 (en) * 1979-02-05 1980-08-20 Schering Corporation Novel 1-aryl-2-acylamido-3-fluoro-1-propanols, their preparation and pharmaceutical compositions containing them
WO2003077828A2 (en) * 2002-03-08 2003-09-25 Schering-Plough, Ltd. Novel florfenicol-type antibiotics

Also Published As

Publication number Publication date
AU2004308913A1 (en) 2005-07-14
CA2550660C (en) 2011-03-15
US7153842B2 (en) 2006-12-26
MXPA06007215A (es) 2006-08-18
IL176342A (en) 2011-08-31
EP1696934A1 (en) 2006-09-06
IL176342A0 (en) 2006-10-05
US20050182031A1 (en) 2005-08-18
KR20060111605A (ko) 2006-10-27
CA2550660A1 (en) 2005-07-14
PE20050822A1 (es) 2005-10-01
BRPI0418133A2 (pt) 2009-03-24
ECSP066670A (es) 2006-10-25
TW200533640A (en) 2005-10-16
NZ547592A (en) 2009-07-31
RU2006126519A (ru) 2008-01-27
EP1696934B1 (en) 2013-05-29
IL200041A0 (en) 2010-04-15
US7572777B2 (en) 2009-08-11
JP4719160B2 (ja) 2011-07-06
JP2011148804A (ja) 2011-08-04
NO20063244L (no) 2006-09-20
JP2007516286A (ja) 2007-06-21
US20070021387A1 (en) 2007-01-25
AR046970A1 (es) 2006-01-04
ZA200605165B (en) 2007-12-27
CN1897954A (zh) 2007-01-17
WO2005063257A1 (en) 2005-07-14
TWI262181B (en) 2006-09-21

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SE01 Entry into force of request for substantive examination
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Owner name: INTERVET INT BV

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Effective date: 20150910

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Patentee after: INTERVET INTERNATIONAL B.V.

Address before: Luzern, Switzerland

Patentee before: Schering-Plough Ltd.

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Granted publication date: 20100113