BRPI0418133A2 - pró-fármaco de florfenicol tendo solubilidade em água melhorada - Google Patents

pró-fármaco de florfenicol tendo solubilidade em água melhorada

Info

Publication number
BRPI0418133A2
BRPI0418133A2 BRPI0418133-6A BRPI0418133A BRPI0418133A2 BR PI0418133 A2 BRPI0418133 A2 BR PI0418133A2 BR PI0418133 A BRPI0418133 A BR PI0418133A BR PI0418133 A2 BRPI0418133 A2 BR PI0418133A2
Authority
BR
Brazil
Prior art keywords
florfenicol
water solubility
improved water
florfenicol prodrug
solubility
Prior art date
Application number
BRPI0418133-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Scott J Hecker
Sunil V Pansare
Tomasz W Glinka
Original Assignee
Schering Plough Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34738768&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0418133(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Plough Ltd filed Critical Schering Plough Ltd
Publication of BRPI0418133A2 publication Critical patent/BRPI0418133A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0418133-6A 2003-12-23 2004-12-20 pró-fármaco de florfenicol tendo solubilidade em água melhorada BRPI0418133A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53222703P 2003-12-23 2003-12-23
PCT/US2004/042591 WO2005063257A1 (en) 2003-12-23 2004-12-20 Florfenicol prodrug having improved water solubility

Publications (1)

Publication Number Publication Date
BRPI0418133A2 true BRPI0418133A2 (pt) 2009-03-24

Family

ID=34738768

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418133-6A BRPI0418133A2 (pt) 2003-12-23 2004-12-20 pró-fármaco de florfenicol tendo solubilidade em água melhorada

Country Status (18)

Country Link
US (2) US7153842B2 (enExample)
EP (1) EP1696934B1 (enExample)
JP (2) JP4719160B2 (enExample)
KR (1) KR20060111605A (enExample)
CN (1) CN100579532C (enExample)
AR (1) AR046970A1 (enExample)
BR (1) BRPI0418133A2 (enExample)
CA (1) CA2550660C (enExample)
EC (1) ECSP066670A (enExample)
IL (2) IL176342A (enExample)
MX (1) MXPA06007215A (enExample)
NO (1) NO20063244L (enExample)
NZ (1) NZ547592A (enExample)
PE (1) PE20050822A1 (enExample)
RU (1) RU2006126519A (enExample)
TW (1) TWI262181B (enExample)
WO (1) WO2005063257A1 (enExample)
ZA (1) ZA200605165B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050386A1 (es) * 2003-05-29 2005-06-23 Schering Plough Ltd Composiciones farmaceuticas de florfenicol
US7439268B2 (en) 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
CA2550660C (en) * 2003-12-23 2011-03-15 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
WO2005066119A2 (en) * 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof
NZ553777A (en) 2004-09-23 2010-11-26 Schering Plough Ltd Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
MX2007006072A (es) 2004-11-19 2007-07-11 Schering Plough Ltd Control de parasitos en animales mediante el uso de derivados del parasiticida 2-fenil-3-(1h-pirrol-2-il)acrilonitrilo.
EP1890547A2 (en) * 2005-06-09 2008-02-27 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
EP2091909A1 (en) * 2006-12-13 2009-08-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
CN101600422A (zh) * 2006-12-13 2009-12-09 先灵-普劳有限公司 在亲脂性溶媒系统中的水溶性苯丙醇前药
MX2009006467A (es) * 2006-12-13 2009-08-21 Schering Plough Ltd Profarmacos solubles en agua de cloranfenicol, tiamfenicol y analogos de los mismos.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX368680B (es) 2007-06-27 2019-10-11 Du Pont Administración subcutánea de un derivado de isoxazol-benzamida para usarse en un método para proteger un mamífero de una pulga.
US20090170954A1 (en) * 2007-12-14 2009-07-02 Schering-Plough Ltd. Process for Recovering Florfenicol and Florfenicol Analogs
CA2732017A1 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
EP2461684A2 (en) 2009-08-05 2012-06-13 E. I. du Pont de Nemours and Company Mesoionic pesticides
BR112012002524A2 (pt) 2009-08-05 2019-09-24 Du Pont "composto de fórmula, composição, composição para proteger um animal de uma praga parasítica de invertebrados, métodos para controlar uma praga invertebrada e semente tratada"
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
MX2013012820A (es) 2011-05-02 2014-02-10 Zoetis Llc Cefalosporinas novedosas utiles como agentes antibacteriales.
JP2014520151A (ja) 2011-06-20 2014-08-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 蠕虫感染を処置するためのヘテロ環式化合物
RU2014126367A (ru) 2011-11-28 2016-01-27 Е.И.Дюпон Де Немур Энд Компани Производные n-(4-хинолинметил)сульфонамидов и их применение в качестве антигельминтных средств
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
CN103242363B (zh) * 2013-04-18 2015-10-28 湖北龙翔药业有限公司 氟苯尼考磷酸二酯及盐及其制备方法
CN103923118A (zh) * 2014-04-08 2014-07-16 张家港威胜生物医药有限公司 一种水溶性氟苯尼考衍生物的合成方法
CN105111234B (zh) * 2015-09-23 2017-05-17 河北远征禾木药业有限公司 一种氟苯尼考磷酸酯的合成方法
CN110078729A (zh) * 2019-06-11 2019-08-02 石家庄学院 一种水溶性氟苯尼考前药及其制备方法
CN115286544A (zh) * 2022-10-08 2022-11-04 世华合创生物技术开发(山东)有限公司 一种氟苯尼考衍生物、制备方法及其在抗细菌感染的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776992A (en) 1956-03-14 1957-01-08 Du Pont Trifluoromethylsulfonylphenyldichloracetamidopropandiol
US4235892A (en) 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
FR2562543B1 (fr) * 1984-04-10 1987-09-25 Elf Aquitaine Nouveaux phosphonites cycliques, leur preparation et applications
US5352832A (en) 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US6864240B1 (en) 1999-06-15 2005-03-08 Elan Pharmaceuticals, Inc. Dipeptide inhibitors of β-secretase
US6670344B2 (en) 2000-09-14 2003-12-30 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts
WO2002102766A2 (en) 2001-06-15 2002-12-27 Arizona Board Of Regents Combretastatin a-3 prodrug
JP2005538937A (ja) 2002-03-08 2005-12-22 シェーリング−プラウ， リミテッド 新規なフロルフェニコール型抗生物質
US7439268B2 (en) 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
CA2550660C (en) 2003-12-23 2011-03-15 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
WO2005066119A2 (en) 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof

Also Published As

Publication number Publication date
AU2004308913A1 (en) 2005-07-14
CA2550660C (en) 2011-03-15
US7153842B2 (en) 2006-12-26
MXPA06007215A (es) 2006-08-18
IL176342A (en) 2011-08-31
EP1696934A1 (en) 2006-09-06
IL176342A0 (en) 2006-10-05
US20050182031A1 (en) 2005-08-18
KR20060111605A (ko) 2006-10-27
CA2550660A1 (en) 2005-07-14
PE20050822A1 (es) 2005-10-01
ECSP066670A (es) 2006-10-25
TW200533640A (en) 2005-10-16
NZ547592A (en) 2009-07-31
RU2006126519A (ru) 2008-01-27
EP1696934B1 (en) 2013-05-29
IL200041A0 (en) 2010-04-15
US7572777B2 (en) 2009-08-11
JP4719160B2 (ja) 2011-07-06
JP2011148804A (ja) 2011-08-04
NO20063244L (no) 2006-09-20
JP2007516286A (ja) 2007-06-21
US20070021387A1 (en) 2007-01-25
AR046970A1 (es) 2006-01-04
ZA200605165B (en) 2007-12-27
CN100579532C (zh) 2010-01-13
CN1897954A (zh) 2007-01-17
WO2005063257A1 (en) 2005-07-14
TWI262181B (en) 2006-09-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.

B15K Others concerning applications: alteration of classification

Ipc: C07F 9/09 (2006.01), A61P 31/00 (2006.01), C07F 9/