JP4719160B2 - 改善された水溶性を有するフロルフェニコールプロドラッグ - Google Patents

改善された水溶性を有するフロルフェニコールプロドラッグ Download PDF

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JP4719160B2
JP4719160B2 JP2006547183A JP2006547183A JP4719160B2 JP 4719160 B2 JP4719160 B2 JP 4719160B2 JP 2006547183 A JP2006547183 A JP 2006547183A JP 2006547183 A JP2006547183 A JP 2006547183A JP 4719160 B2 JP4719160 B2 JP 4719160B2
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florfenicol
pharmaceutical composition
prodrug
phosphate
pharmaceutically acceptable
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JP2007516286A5 (enExample
JP2007516286A (ja
Inventor
スコット ジェイ． ヘッカー，
サニル ブイ． パンサーレ，
トマス ダブリュー． グリンカ，
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シェーリング−プラウ・リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2006547183A 2003-12-23 2004-12-20 改善された水溶性を有するフロルフェニコールプロドラッグ Expired - Fee Related JP4719160B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53222703P 2003-12-23 2003-12-23
US60/532,227 2003-12-23
PCT/US2004/042591 WO2005063257A1 (en) 2003-12-23 2004-12-20 Florfenicol prodrug having improved water solubility

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011037689A Division JP2011148804A (ja) 2003-12-23 2011-02-23 改善された水溶性を有するフロルフェニコールプロドラッグ

Publications (3)

Publication Number Publication Date
JP2007516286A JP2007516286A (ja) 2007-06-21
JP2007516286A5 JP2007516286A5 (enExample) 2008-02-07
JP4719160B2 true JP4719160B2 (ja) 2011-07-06

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ID=34738768

Family Applications (2)

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JP2006547183A Expired - Fee Related JP4719160B2 (ja) 2003-12-23 2004-12-20 改善された水溶性を有するフロルフェニコールプロドラッグ
JP2011037689A Withdrawn JP2011148804A (ja) 2003-12-23 2011-02-23 改善された水溶性を有するフロルフェニコールプロドラッグ

Family Applications After (1)

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JP2011037689A Withdrawn JP2011148804A (ja) 2003-12-23 2011-02-23 改善された水溶性を有するフロルフェニコールプロドラッグ

Country Status (18)

Country Link
US (2) US7153842B2 (enExample)
EP (1) EP1696934B1 (enExample)
JP (2) JP4719160B2 (enExample)
KR (1) KR20060111605A (enExample)
CN (1) CN100579532C (enExample)
AR (1) AR046970A1 (enExample)
BR (1) BRPI0418133A2 (enExample)
CA (1) CA2550660C (enExample)
EC (1) ECSP066670A (enExample)
IL (2) IL176342A (enExample)
MX (1) MXPA06007215A (enExample)
NO (1) NO20063244L (enExample)
NZ (1) NZ547592A (enExample)
PE (1) PE20050822A1 (enExample)
RU (1) RU2006126519A (enExample)
TW (1) TWI262181B (enExample)
WO (1) WO2005063257A1 (enExample)
ZA (1) ZA200605165B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2004001293A1 (es) 2003-05-29 2005-05-06 Schering Plough Ltd Composicion farmaceutica que comprende compuestos antibacterianos como florfenicol, tiamfenicol, cloramfenicol en combinacion con al menos un portador seleccionado de triacetina, dimetilacetamida o una mezcla de ellas; y su uso en el tratamiento de u
US7439268B2 (en) 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
EP1696934B1 (en) * 2003-12-23 2013-05-29 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
US7361689B2 (en) * 2003-12-31 2008-04-22 Schering-Plough Animal Health Corporation Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof
ES2314724T3 (es) 2004-09-23 2009-03-16 Schering-Plough Ltd. Control de parasitos en animales mediante el uso de nuevos derivados de eter de trifluorometanosulfonanilida oxima.
US7705038B2 (en) 2004-11-19 2010-04-27 Intervet, Inc. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives
MX2007015729A (es) * 2005-06-09 2008-02-21 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida.
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
MX2009006282A (es) * 2006-12-13 2009-06-23 Schering Plough Ltd Profarmacos solubles en agua de florfenicol y sus analogos.
EP2102154A1 (en) * 2006-12-13 2009-09-23 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
MX2009006468A (es) * 2006-12-13 2009-08-20 Schering Plough Ltd Profarmacos de fenicol solubles en agua en un sistema de vehiculo lipofilico.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
HUE037127T2 (hu) 2007-06-27 2018-08-28 Du Pont Állati károkozó irtására szolgáló eljárás
PE20091171A1 (es) * 2007-12-14 2009-08-03 Schering Plough Ltd Proceso para recuperar florfenicol y analogos de florfenicol
JP2011529895A (ja) * 2008-07-30 2011-12-15 インターベツト・インターナシヨナル・ベー・ベー フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
JP2013501063A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
JP2013501059A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
JP2014513116A (ja) 2011-05-02 2014-05-29 ゾエティス・エルエルシー 抗菌剤として有用な新規セファロスポリン
JP2014520151A (ja) 2011-06-20 2014-08-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 蠕虫感染を処置するためのヘテロ環式化合物
WO2013081783A1 (en) 2011-11-28 2013-06-06 E. I. Du Pont De Nemours And Company N- (4 -quinolinylmethyl) sulfonamide derivatives and their use as anthelmintics
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
CN103242363B (zh) * 2013-04-18 2015-10-28 湖北龙翔药业有限公司 氟苯尼考磷酸二酯及盐及其制备方法
CN103923118A (zh) * 2014-04-08 2014-07-16 张家港威胜生物医药有限公司 一种水溶性氟苯尼考衍生物的合成方法
CN105111234B (zh) * 2015-09-23 2017-05-17 河北远征禾木药业有限公司 一种氟苯尼考磷酸酯的合成方法
CN110078729A (zh) * 2019-06-11 2019-08-02 石家庄学院 一种水溶性氟苯尼考前药及其制备方法
CN115286544A (zh) * 2022-10-08 2022-11-04 世华合创生物技术开发(山东)有限公司 一种氟苯尼考衍生物、制备方法及其在抗细菌感染的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776992A (en) 1956-03-14 1957-01-08 Du Pont Trifluoromethylsulfonylphenyldichloracetamidopropandiol
US4235892A (en) 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
FR2562543B1 (fr) * 1984-04-10 1987-09-25 Elf Aquitaine Nouveaux phosphonites cycliques, leur preparation et applications
US5352832A (en) 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US6864240B1 (en) 1999-06-15 2005-03-08 Elan Pharmaceuticals, Inc. Dipeptide inhibitors of β-secretase
US6670344B2 (en) 2000-09-14 2003-12-30 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts
EP1395265A4 (en) 2001-06-15 2005-08-10 Univ Arizona COMBRETASTATIN A-3 PRO MEDICINE
KR20040091698A (ko) 2002-03-08 2004-10-28 쉐링-플라우 리미티드. 신규한 플로르페니콜형 항생제
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
EP1696934B1 (en) 2003-12-23 2013-05-29 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
US7361689B2 (en) 2003-12-31 2008-04-22 Schering-Plough Animal Health Corporation Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof

Also Published As

Publication number Publication date
ECSP066670A (es) 2006-10-25
IL176342A (en) 2011-08-31
IL176342A0 (en) 2006-10-05
AU2004308913A1 (en) 2005-07-14
US7153842B2 (en) 2006-12-26
NO20063244L (no) 2006-09-20
CN100579532C (zh) 2010-01-13
CA2550660A1 (en) 2005-07-14
MXPA06007215A (es) 2006-08-18
NZ547592A (en) 2009-07-31
RU2006126519A (ru) 2008-01-27
KR20060111605A (ko) 2006-10-27
US20050182031A1 (en) 2005-08-18
EP1696934B1 (en) 2013-05-29
TW200533640A (en) 2005-10-16
CN1897954A (zh) 2007-01-17
US7572777B2 (en) 2009-08-11
TWI262181B (en) 2006-09-21
JP2007516286A (ja) 2007-06-21
JP2011148804A (ja) 2011-08-04
ZA200605165B (en) 2007-12-27
EP1696934A1 (en) 2006-09-06
AR046970A1 (es) 2006-01-04
PE20050822A1 (es) 2005-10-01
IL200041A0 (en) 2010-04-15
US20070021387A1 (en) 2007-01-25
CA2550660C (en) 2011-03-15
BRPI0418133A2 (pt) 2009-03-24
WO2005063257A1 (en) 2005-07-14

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