CN100374420C - 具有糖原磷酸化酶抑制活性的吲哚酰胺衍生物 - Google Patents
具有糖原磷酸化酶抑制活性的吲哚酰胺衍生物 Download PDFInfo
- Publication number
- CN100374420C CN100374420C CNB038053098A CN03805309A CN100374420C CN 100374420 C CN100374420 C CN 100374420C CN B038053098 A CNB038053098 A CN B038053098A CN 03805309 A CN03805309 A CN 03805309A CN 100374420 C CN100374420 C CN 100374420C
- Authority
- CN
- China
- Prior art keywords
- alkyl
- amino
- chloro
- indenes
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0205176.1 | 2002-03-06 | ||
GBGB0205176.1A GB0205176D0 (en) | 2002-03-06 | 2002-03-06 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1639120A CN1639120A (zh) | 2005-07-13 |
CN100374420C true CN100374420C (zh) | 2008-03-12 |
Family
ID=9932340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB038053098A Expired - Fee Related CN100374420C (zh) | 2002-03-06 | 2003-03-04 | 具有糖原磷酸化酶抑制活性的吲哚酰胺衍生物 |
Country Status (20)
Country | Link |
---|---|
US (1) | US7138415B2 (de) |
EP (1) | EP1483240A1 (de) |
JP (1) | JP2005524667A (de) |
KR (1) | KR20040097145A (de) |
CN (1) | CN100374420C (de) |
AR (1) | AR038889A1 (de) |
AU (1) | AU2003216988A1 (de) |
BR (1) | BR0308144A (de) |
CA (1) | CA2477717A1 (de) |
GB (1) | GB0205176D0 (de) |
IL (1) | IL163823A0 (de) |
IS (1) | IS7435A (de) |
MX (1) | MXPA04008612A (de) |
NO (1) | NO20044032L (de) |
NZ (1) | NZ534683A (de) |
PL (1) | PL373872A1 (de) |
RU (1) | RU2004125182A (de) |
TW (1) | TW200304817A (de) |
WO (1) | WO2003074484A1 (de) |
ZA (1) | ZA200406681B (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205162D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0222912D0 (en) | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
GB0222909D0 (en) | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
CA2503727A1 (en) * | 2002-11-07 | 2004-05-21 | Pfizer Products Inc. | Anti-diabetic agents |
GB0318464D0 (en) * | 2003-08-07 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
GB0319690D0 (en) * | 2003-08-22 | 2003-09-24 | Astrazeneca Ab | Chemical compounds |
WO2005020985A1 (en) * | 2003-08-29 | 2005-03-10 | Astrazeneca Ab | Indolamide derivatives which possess glycogen phosphorylase inhibitory activity |
WO2006055435A1 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
WO2006053274A2 (en) * | 2004-11-15 | 2006-05-18 | Bristol-Myers Squibb Company | 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
US7226942B2 (en) | 2004-11-15 | 2007-06-05 | Bristol-Myers Squibb Company | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
US7365061B2 (en) | 2004-11-15 | 2008-04-29 | Bristol-Myers Squibb Company | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
WO2006082400A1 (en) * | 2005-02-05 | 2006-08-10 | Astrazeneca Ab | Indan-amide derivatives with glycogen phosphorylase inhibitory activity |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
JP2017538659A (ja) * | 2014-09-10 | 2017-12-28 | エピザイム インコーポレイテッド | Smyd阻害剤 |
CN112442022B (zh) * | 2019-09-02 | 2022-05-20 | 承德医学院 | 苯并嗪-4-酮类化合物、其制备方法及医药用途 |
CN114403150B (zh) * | 2022-02-09 | 2022-11-04 | 中国农业大学 | 一种吲哚酰胺类化合物作为海藻糖-6-磷酸合成酶抑制剂的应用 |
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CN1182417A (zh) * | 1995-03-04 | 1998-05-20 | 意大利葛兰素惠尔康股份公司 | 吲哚衍生物 |
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2002
- 2002-03-06 GB GBGB0205176.1A patent/GB0205176D0/en not_active Ceased
-
2003
- 2003-03-04 PL PL03373872A patent/PL373872A1/xx not_active Application Discontinuation
- 2003-03-04 CN CNB038053098A patent/CN100374420C/zh not_active Expired - Fee Related
- 2003-03-04 AU AU2003216988A patent/AU2003216988A1/en not_active Abandoned
- 2003-03-04 MX MXPA04008612A patent/MXPA04008612A/es active IP Right Grant
- 2003-03-04 NZ NZ534683A patent/NZ534683A/en unknown
- 2003-03-04 JP JP2003572954A patent/JP2005524667A/ja not_active Withdrawn
- 2003-03-04 BR BR0308144-3A patent/BR0308144A/pt not_active IP Right Cessation
- 2003-03-04 RU RU2004125182/04A patent/RU2004125182A/ru not_active Application Discontinuation
- 2003-03-04 CA CA002477717A patent/CA2477717A1/en not_active Abandoned
- 2003-03-04 IL IL16382303A patent/IL163823A0/xx unknown
- 2003-03-04 EP EP03712310A patent/EP1483240A1/de not_active Withdrawn
- 2003-03-04 US US10/506,554 patent/US7138415B2/en not_active Expired - Fee Related
- 2003-03-04 WO PCT/GB2003/000883 patent/WO2003074484A1/en active Application Filing
- 2003-03-04 KR KR10-2004-7013859A patent/KR20040097145A/ko not_active Application Discontinuation
- 2003-03-05 TW TW092104668A patent/TW200304817A/zh unknown
- 2003-03-06 AR ARP030100769A patent/AR038889A1/es unknown
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2004
- 2004-08-23 ZA ZA200406681A patent/ZA200406681B/en unknown
- 2004-09-02 IS IS7435A patent/IS7435A/is unknown
- 2004-09-24 NO NO20044032A patent/NO20044032L/no not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1182417A (zh) * | 1995-03-04 | 1998-05-20 | 意大利葛兰素惠尔康股份公司 | 吲哚衍生物 |
CN1140709A (zh) * | 1995-06-06 | 1997-01-22 | 辉瑞大药厂 | 被取代的N-(吲哚-2-羰基)-β-丙氨酰胺与作为抗糖尿病药的衍生物 |
CN1142492A (zh) * | 1995-06-06 | 1997-02-12 | 辉瑞大药厂 | 用作抗糖尿病剂的取代n-(吲哚-2-羰基)甘氨酰胺及其衍生物 |
CN1202105A (zh) * | 1995-09-08 | 1998-12-16 | 诺沃挪第克公司 | 2-烷基吡咯烷化合物 |
WO2000029405A1 (fr) * | 1998-11-16 | 2000-05-25 | Sanofi-Synthelabo | Procede de preparation du (2s)-1-[(2r,3s)-5- chloro-3-(2- chlorophenyl) -1-(3,4-dimethoxy benzenesulfonyl) -3-hydroxy-2, 3-dihydro-1h- indole-2-carbonyl] pyrrolidine-2- carboxamide |
EP1149580A1 (de) * | 2000-03-07 | 2001-10-31 | Pfizer Products Inc. | Verwendung von heteroaryl SUBSTITUIERTE N-(INDOL-2-CARBONYL)-AMIDE zur Herstellung eines Arzneimittels zur Behandlung von Infektion |
Also Published As
Publication number | Publication date |
---|---|
AU2003216988A1 (en) | 2003-09-16 |
WO2003074484A1 (en) | 2003-09-12 |
TW200304817A (en) | 2003-10-16 |
MXPA04008612A (es) | 2004-12-06 |
US7138415B2 (en) | 2006-11-21 |
CA2477717A1 (en) | 2003-09-12 |
AR038889A1 (es) | 2005-02-02 |
JP2005524667A (ja) | 2005-08-18 |
NZ534683A (en) | 2006-02-24 |
CN1639120A (zh) | 2005-07-13 |
IL163823A0 (en) | 2005-12-18 |
BR0308144A (pt) | 2004-12-07 |
KR20040097145A (ko) | 2004-11-17 |
PL373872A1 (en) | 2005-09-19 |
ZA200406681B (en) | 2005-09-22 |
IS7435A (is) | 2004-09-02 |
NO20044032L (no) | 2004-10-05 |
EP1483240A1 (de) | 2004-12-08 |
RU2004125182A (ru) | 2005-06-10 |
US20050107362A1 (en) | 2005-05-19 |
GB0205176D0 (en) | 2002-04-17 |
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