CN100351393C - 核苷酸多态性的检测方法 - Google Patents

核苷酸多态性的检测方法 Download PDF

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Publication number
CN100351393C
CN100351393C CNB028079310A CN02807931A CN100351393C CN 100351393 C CN100351393 C CN 100351393C CN B028079310 A CNB028079310 A CN B028079310A CN 02807931 A CN02807931 A CN 02807931A CN 100351393 C CN100351393 C CN 100351393C
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nucleotide
nucleic acid
base
target nucleic
nucleotides
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CN1524127A (zh
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佐川裕章
小林英二
加藤郁之进
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Takara Bio Inc
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Takara Bio Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB028079310A 2001-02-15 2002-02-14 核苷酸多态性的检测方法 Expired - Fee Related CN100351393C (zh)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
JP2001039268 2001-02-15
JP39268/2001 2001-02-15
JP40721/2001 2001-02-16
JP2001040721 2001-02-16
JP2001101055 2001-03-30
JP101055/2001 2001-03-30
JP177381/2001 2001-06-12
JP2001177381 2001-06-12
JP290384/2001 2001-09-25
JP2001290384 2001-09-25
JP2001338440 2001-11-02
JP338440/2001 2001-11-02
JP2001368929 2001-12-03
JP368929/2001 2001-12-03

Publications (2)

Publication Number Publication Date
CN1524127A CN1524127A (zh) 2004-08-25
CN100351393C true CN100351393C (zh) 2007-11-28

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CNB028079310A Expired - Fee Related CN100351393C (zh) 2001-02-15 2002-02-14 核苷酸多态性的检测方法

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US (1) US7135291B2 (https=)
EP (1) EP1367136A4 (https=)
JP (3) JP3681729B2 (https=)
KR (1) KR100809949B1 (https=)
CN (1) CN100351393C (https=)
AU (1) AU2002232177B2 (https=)
CA (1) CA2438574C (https=)
EA (1) EA005141B1 (https=)
WO (1) WO2002064833A1 (https=)

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US10227641B2 (en) 2008-04-30 2019-03-12 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2333109B1 (en) * 2008-09-03 2013-08-07 Takara Bio, Inc. Composition for detection of rna
CN105200097A (zh) * 2008-10-20 2015-12-30 霍夫曼-拉罗奇有限公司 改进的等位基因特异性扩增
US20110117559A1 (en) * 2009-11-13 2011-05-19 Integrated Dna Technologies, Inc. Small rna detection assays
US9238832B2 (en) 2009-12-11 2016-01-19 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids
US8614071B2 (en) 2009-12-11 2013-12-24 Roche Molecular Systems, Inc. Preferential amplification of mRNA over DNA using chemically modified primers
WO2012135053A2 (en) 2011-03-25 2012-10-04 Integrated Dna Technologies, Inc. Rnase h-based assays utilizing modified rna monomers
WO2013123238A1 (en) 2012-02-14 2013-08-22 Great Basin Scientific Methods of isothermal amplification using blocked primers
JP6009649B2 (ja) 2013-03-14 2016-10-19 タカラバイオ株式会社 耐熱性のミスマッチエンドヌクレアーゼの利用方法
CA2906365A1 (en) * 2013-03-15 2014-09-18 Integrated Dna Technologies, Inc. Rnase h-based assays utilizing modified rna monomers
JP2016536995A (ja) 2013-11-14 2016-12-01 インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド 増大した鋳型識別活性を有するｄｎａポリメラーゼ突然変異体
CA2951514C (en) 2014-06-18 2025-09-09 Clear Gene, Inc. METHODS, COMPOSITIONS AND DEVICES FOR THE RAPID ANALYSIS OF BIOLOGICAL MARKERS
KR20170053636A (ko) 2014-09-11 2017-05-16 다카라 바이오 가부시키가이샤 내열성의 미스매치 엔도뉴클레아제의 이용방법
US9909169B2 (en) 2014-12-17 2018-03-06 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
EP3272865A4 (en) * 2015-03-20 2018-10-17 Takara Bio Inc. High-sensitivity method for detecting target nucleic acid
CA3008273A1 (en) 2015-12-18 2017-06-22 Clear Gene, Inc. Methods, compositions, kits and devices for rapid analysis of biological markers
US12275994B2 (en) 2017-06-22 2025-04-15 Clear Gene, Inc. Methods and compositions for the analysis of cancer biomarkers
CN108148895A (zh) * 2017-12-29 2018-06-12 星阵（广州）基因科技有限公司 用于检测突变的人akt1基因的引物、试剂盒及方法
AU2022216246A1 (en) * 2021-02-02 2023-09-14 Rhodx, Inc. Synthetic polynucleotides and methods for selectively amplifying alleles
CN113215163B (zh) * 2021-05-12 2023-05-12 苏州海苗生物科技有限公司 一种特异性扩增目的基因的分子锁及应用

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WO1992002638A1 (en) * 1990-08-06 1992-02-20 F. Hoffmann-La Roche Ag Homogeneous assay system
US5660988A (en) * 1993-11-17 1997-08-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
EP0705905A2 (de) * 1994-07-16 1996-04-10 Roche Diagnostics GmbH Verfahren zum sensitiven Nachweis von Nukleinsäuren
JP2001136965A (ja) * 1999-11-12 2001-05-22 Takara Shuzo Co Ltd 核酸配列の増幅方法

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Publication number Publication date
JP2005245465A (ja) 2005-09-15
US20040137451A1 (en) 2004-07-15
KR20030074797A (ko) 2003-09-19
CA2438574A1 (en) 2002-08-22
JP3681729B2 (ja) 2005-08-10
WO2002064833A1 (en) 2002-08-22
US7135291B2 (en) 2006-11-14
JP2004298200A (ja) 2004-10-28
EP1367136A1 (en) 2003-12-03
EP1367136A4 (en) 2005-01-12
EA005141B1 (ru) 2004-12-30
KR100809949B1 (ko) 2008-03-06
JPWO2002064833A1 (ja) 2004-06-17
CA2438574C (en) 2009-08-11
CN1524127A (zh) 2004-08-25
EA200300880A1 (ru) 2004-02-26
AU2002232177B2 (en) 2006-11-09

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