CL2010001633A1 - Compuestos derivados de benzoxazina y benzotiazina, inhibidores de nos; composicion farmaceutica que los comprende; y su uso en el tratamiento de cefalea, dolor neuropatico, inflamatorio, visceral, neuroinfalamacion, hiperalgesia, alodinia, entre otras. - Google Patents
Compuestos derivados de benzoxazina y benzotiazina, inhibidores de nos; composicion farmaceutica que los comprende; y su uso en el tratamiento de cefalea, dolor neuropatico, inflamatorio, visceral, neuroinfalamacion, hiperalgesia, alodinia, entre otras.Info
- Publication number
- CL2010001633A1 CL2010001633A1 CL2010001633A CL2010001633A CL2010001633A1 CL 2010001633 A1 CL2010001633 A1 CL 2010001633A1 CL 2010001633 A CL2010001633 A CL 2010001633A CL 2010001633 A CL2010001633 A CL 2010001633A CL 2010001633 A1 CL2010001633 A1 CL 2010001633A1
- Authority
- CL
- Chile
- Prior art keywords
- treatment
- pharmaceutical composition
- headache
- benzothiazine
- neuroinflammation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000004454 Hyperalgesia Diseases 0.000 title 2
- UJVBZCCNLAAMOV-UHFFFAOYSA-N 2h-1,2-benzothiazine Chemical compound C1=CC=C2C=CNSC2=C1 UJVBZCCNLAAMOV-UHFFFAOYSA-N 0.000 title 1
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical compound C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title 1
- 206010019233 Headaches Diseases 0.000 title 1
- 208000035154 Hyperesthesia Diseases 0.000 title 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 title 1
- 206010053552 allodynia Diseases 0.000 title 1
- 231100000869 headache Toxicity 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000003959 neuroinflammation Effects 0.000 title 1
- 230000002981 neuropathic effect Effects 0.000 title 1
- 208000009935 visceral pain Diseases 0.000 title 1
- IUNUDTQWFOQODF-UHFFFAOYSA-N 1,2,3-benzoxathiazine Chemical class C1=CC=C2OSN=CC2=C1 IUNUDTQWFOQODF-UHFFFAOYSA-N 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13388708P | 2008-07-03 | 2008-07-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2010001633A1 true CL2010001633A1 (es) | 2011-05-20 |
Family
ID=41465440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2010001633A CL2010001633A1 (es) | 2008-07-03 | 2010-12-30 | Compuestos derivados de benzoxazina y benzotiazina, inhibidores de nos; composicion farmaceutica que los comprende; y su uso en el tratamiento de cefalea, dolor neuropatico, inflamatorio, visceral, neuroinfalamacion, hiperalgesia, alodinia, entre otras. |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8106043B2 (https=) |
| EP (1) | EP2310386A4 (https=) |
| JP (1) | JP5572157B2 (https=) |
| KR (1) | KR20110036607A (https=) |
| CN (1) | CN102143961B (https=) |
| AR (1) | AR072471A1 (https=) |
| AU (1) | AU2009266386B2 (https=) |
| BR (1) | BRPI0913915A2 (https=) |
| CA (1) | CA2729246C (https=) |
| CL (1) | CL2010001633A1 (https=) |
| EA (1) | EA021798B1 (https=) |
| IL (1) | IL210195A (https=) |
| MX (1) | MX2011000124A (https=) |
| MY (1) | MY158796A (https=) |
| NZ (1) | NZ590727A (https=) |
| SG (1) | SG192470A1 (https=) |
| TW (1) | TWI458726B (https=) |
| UA (1) | UA105182C2 (https=) |
| WO (1) | WO2010000073A1 (https=) |
| ZA (1) | ZA201100436B (https=) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| CN101830894B (zh) * | 2010-06-01 | 2013-05-29 | 上海交通大学 | 一类苯并[d]噁唑化合物及其制备方法 |
| WO2013076590A1 (en) * | 2011-11-23 | 2013-05-30 | Oxygen Healthcare Research Pvt. Ltd | Benzothiazine compounds as h3 receptor ligands |
| CN102491919B (zh) * | 2011-12-15 | 2014-03-19 | 南京友杰医药科技有限公司 | 去甲维拉帕米的合成方法 |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US11090300B2 (en) | 2013-11-05 | 2021-08-17 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
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| UA61962C2 (uk) | 1997-06-30 | 2003-12-15 | Мерц Фарма Гмбх Унд Ко. Кгаа | Сполука 1-аміноалкілциклогексану, фармацевтична композиція на її основі та спосіб лікування |
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| US6552043B1 (en) | 1998-09-30 | 2003-04-22 | Merck Sharpe & Dohme Ltd. | Benzimidazolinyl piperidines as CGRP ligands |
| AU4249700A (en) * | 1999-04-19 | 2000-11-02 | Sumitomo Pharmaceuticals Company, Limited | Hydroxamic acid derivative |
| DE19952146A1 (de) | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
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| US20030082225A1 (en) | 2001-10-19 | 2003-05-01 | Mason Paul Arthur | Sterile, breathable patch for treating wound pain |
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| ES2357129T3 (es) * | 2005-04-13 | 2011-04-19 | Neuraxon Inc. | Compuestos indólicos sustituidos que tienen actividad inhibidora de nos. |
| WO2007017764A2 (en) * | 2005-05-18 | 2007-02-15 | Neuraxon, Inc. | Substituted benzimidazole compounds with dual nos inhibitory activity and muopioid agonist activity |
| US7700592B2 (en) * | 2005-08-25 | 2010-04-20 | Schering Corporation | α2C adrenoreceptor agonists |
| RU2008110902A (ru) * | 2005-08-25 | 2009-09-27 | Шеринг Корпорейшн (US) | Агонисты адренорецепторов альфа а2с |
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| MX2010005343A (es) | 2007-11-16 | 2010-08-09 | Neuraxon Inc | Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina. |
-
2009
- 2009-03-07 UA UAA201101136A patent/UA105182C2/ru unknown
- 2009-07-03 TW TW098122515A patent/TWI458726B/zh not_active IP Right Cessation
- 2009-07-03 CN CN200980134295.9A patent/CN102143961B/zh not_active Expired - Fee Related
- 2009-07-03 WO PCT/CA2009/000923 patent/WO2010000073A1/en not_active Ceased
- 2009-07-03 BR BRPI0913915A patent/BRPI0913915A2/pt not_active IP Right Cessation
- 2009-07-03 MY MYPI2010006341A patent/MY158796A/en unknown
- 2009-07-03 KR KR1020117002783A patent/KR20110036607A/ko not_active Ceased
- 2009-07-03 NZ NZ590727A patent/NZ590727A/xx not_active IP Right Cessation
- 2009-07-03 EA EA201170130A patent/EA021798B1/ru not_active IP Right Cessation
- 2009-07-03 AU AU2009266386A patent/AU2009266386B2/en not_active Ceased
- 2009-07-03 MX MX2011000124A patent/MX2011000124A/es active IP Right Grant
- 2009-07-03 SG SG2013051644A patent/SG192470A1/en unknown
- 2009-07-03 AR ARP090102506A patent/AR072471A1/es unknown
- 2009-07-03 JP JP2011515041A patent/JP5572157B2/ja not_active Expired - Fee Related
- 2009-07-03 CA CA2729246A patent/CA2729246C/en not_active Expired - Fee Related
- 2009-07-03 EP EP09771883A patent/EP2310386A4/en not_active Withdrawn
- 2009-07-06 US US12/498,185 patent/US8106043B2/en not_active Expired - Fee Related
-
2010
- 2010-12-23 IL IL210195A patent/IL210195A/en not_active IP Right Cessation
- 2010-12-30 CL CL2010001633A patent/CL2010001633A1/es unknown
-
2011
- 2011-01-17 ZA ZA2011/00436A patent/ZA201100436B/en unknown
-
2012
- 2012-01-27 US US13/360,029 patent/US8618286B2/en not_active Expired - Fee Related
-
2013
- 2013-12-11 US US14/103,446 patent/US20140163016A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW201002701A (en) | 2010-01-16 |
| CN102143961A (zh) | 2011-08-03 |
| EA021798B1 (ru) | 2015-09-30 |
| TWI458726B (zh) | 2014-11-01 |
| MX2011000124A (es) | 2011-02-24 |
| JP5572157B2 (ja) | 2014-08-13 |
| EP2310386A1 (en) | 2011-04-20 |
| EP2310386A4 (en) | 2012-04-11 |
| US8618286B2 (en) | 2013-12-31 |
| US20120122855A1 (en) | 2012-05-17 |
| BRPI0913915A2 (pt) | 2015-10-13 |
| CA2729246C (en) | 2018-08-21 |
| KR20110036607A (ko) | 2011-04-07 |
| AU2009266386A1 (en) | 2010-01-07 |
| CN102143961B (zh) | 2014-11-05 |
| ZA201100436B (en) | 2012-10-31 |
| US8106043B2 (en) | 2012-01-31 |
| CA2729246A1 (en) | 2010-01-07 |
| UA105182C2 (ru) | 2014-04-25 |
| IL210195A0 (en) | 2011-03-31 |
| MY158796A (en) | 2016-11-15 |
| JP2011526251A (ja) | 2011-10-06 |
| IL210195A (en) | 2015-08-31 |
| NZ590727A (en) | 2012-12-21 |
| EA201170130A1 (ru) | 2011-08-30 |
| AU2009266386B2 (en) | 2015-02-19 |
| SG192470A1 (en) | 2013-08-30 |
| US20140163016A1 (en) | 2014-06-12 |
| WO2010000073A1 (en) | 2010-01-07 |
| US20100009975A1 (en) | 2010-01-14 |
| AR072471A1 (es) | 2010-09-01 |
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