CN102143961B - 具有nos抑制活性的苯并噁嗪、苯并噻嗪及相关化合物 - Google Patents
具有nos抑制活性的苯并噁嗪、苯并噻嗪及相关化合物 Download PDFInfo
- Publication number
- CN102143961B CN102143961B CN200980134295.9A CN200980134295A CN102143961B CN 102143961 B CN102143961 B CN 102143961B CN 200980134295 A CN200980134295 A CN 200980134295A CN 102143961 B CN102143961 B CN 102143961B
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- Prior art keywords
- compound
- benzo
- pain
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- alkyl
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC1C2C(CCC(CCC*c3c4)c3ccc4NC(C3*C=CC3)NC)CCCC12 Chemical compound CC1C2C(CCC(CCC*c3c4)c3ccc4NC(C3*C=CC3)NC)CCCC12 0.000 description 11
- DCEBBQJBJGMMDF-RSSMCMFDSA-N C/C=C(\CCC1c(ccc(NC(C2=CCCS2)=N)c2)c2OCCC1)/I Chemical compound C/C=C(\CCC1c(ccc(NC(C2=CCCS2)=N)c2)c2OCCC1)/I DCEBBQJBJGMMDF-RSSMCMFDSA-N 0.000 description 1
- LPBQFZWRQGCRIS-RBBJEVKSSA-N CC(C)CCN[C@H](C)[C@H](CCC/C(/C)=C/C)SC Chemical compound CC(C)CCN[C@H](C)[C@H](CCC/C(/C)=C/C)SC LPBQFZWRQGCRIS-RBBJEVKSSA-N 0.000 description 1
- OTZDHFGSUSYPGS-UHFFFAOYSA-N CC(C1=CC(C2)C2S1)=N Chemical compound CC(C1=CC(C2)C2S1)=N OTZDHFGSUSYPGS-UHFFFAOYSA-N 0.000 description 1
- BYRWLQZQIJXNHF-UHFFFAOYSA-N CC1C(CCN2c(ccc(C3NC3CC(c3ccc[s]3)=N)c3)c3OCC2=O)CCCCC1 Chemical compound CC1C(CCN2c(ccc(C3NC3CC(c3ccc[s]3)=N)c3)c3OCC2=O)CCCCC1 BYRWLQZQIJXNHF-UHFFFAOYSA-N 0.000 description 1
- XVOJGYRWCKZMFW-UHFFFAOYSA-N CC1C=CSC1C(Nc(cc1)cc2c1N(CCC1C(C)CCCCC1)CCO2)=N Chemical compound CC1C=CSC1C(Nc(cc1)cc2c1N(CCC1C(C)CCCCC1)CCO2)=N XVOJGYRWCKZMFW-UHFFFAOYSA-N 0.000 description 1
- UAEPNZWRGJTJPN-UHFFFAOYSA-N CC1CCCCC1 Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 1
- OMTSIOYPPZDRHP-UHFFFAOYSA-N CCCC(C)CCCCCCCCc1cc(NC(C2SC=CC2)=N)ccc1C Chemical compound CCCC(C)CCCCCCCCc1cc(NC(C2SC=CC2)=N)ccc1C OMTSIOYPPZDRHP-UHFFFAOYSA-N 0.000 description 1
- IIUSOYNTHSXVFY-UHFFFAOYSA-N CCCN1c(ccc(NC(C2SC=CC2C)=N)c2)c2SCC1 Chemical compound CCCN1c(ccc(NC(C2SC=CC2C)=N)c2)c2SCC1 IIUSOYNTHSXVFY-UHFFFAOYSA-N 0.000 description 1
- QKFKYQYCNGLBBG-UHFFFAOYSA-N CN(C)CCN1c(cc(cc2)N(C)C(c3ccc[s]3)=N)c2OCC1 Chemical compound CN(C)CCN1c(cc(cc2)N(C)C(c3ccc[s]3)=N)c2OCC1 QKFKYQYCNGLBBG-UHFFFAOYSA-N 0.000 description 1
- QSLSIESWJGEDTD-UHFFFAOYSA-N CN1C(CCC(CCC(COc2c3)OC)c2ccc3NC(c2ccc[s]2)=N)CCC1 Chemical compound CN1C(CCC(CCC(COc2c3)OC)c2ccc3NC(c2ccc[s]2)=N)CCC1 QSLSIESWJGEDTD-UHFFFAOYSA-N 0.000 description 1
- NJZGBYNRVNNPQI-UHFFFAOYSA-N CNCCN1c(cc(cc2)NC(c3ccc[s]3)=N)c2OCC1 Chemical compound CNCCN1c(cc(cc2)NC(c3ccc[s]3)=N)c2OCC1 NJZGBYNRVNNPQI-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13388708P | 2008-07-03 | 2008-07-03 | |
| US61/133,887 | 2008-07-03 | ||
| PCT/CA2009/000923 WO2010000073A1 (en) | 2008-07-03 | 2009-07-03 | Benzoxazines, benzothiazines, and related compounds having nos inhibitory activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102143961A CN102143961A (zh) | 2011-08-03 |
| CN102143961B true CN102143961B (zh) | 2014-11-05 |
Family
ID=41465440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980134295.9A Expired - Fee Related CN102143961B (zh) | 2008-07-03 | 2009-07-03 | 具有nos抑制活性的苯并噁嗪、苯并噻嗪及相关化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8106043B2 (https=) |
| EP (1) | EP2310386A4 (https=) |
| JP (1) | JP5572157B2 (https=) |
| KR (1) | KR20110036607A (https=) |
| CN (1) | CN102143961B (https=) |
| AR (1) | AR072471A1 (https=) |
| AU (1) | AU2009266386B2 (https=) |
| BR (1) | BRPI0913915A2 (https=) |
| CA (1) | CA2729246C (https=) |
| CL (1) | CL2010001633A1 (https=) |
| EA (1) | EA021798B1 (https=) |
| IL (1) | IL210195A (https=) |
| MX (1) | MX2011000124A (https=) |
| MY (1) | MY158796A (https=) |
| NZ (1) | NZ590727A (https=) |
| SG (1) | SG192470A1 (https=) |
| TW (1) | TWI458726B (https=) |
| UA (1) | UA105182C2 (https=) |
| WO (1) | WO2010000073A1 (https=) |
| ZA (1) | ZA201100436B (https=) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| CN101830894B (zh) * | 2010-06-01 | 2013-05-29 | 上海交通大学 | 一类苯并[d]噁唑化合物及其制备方法 |
| WO2013076590A1 (en) * | 2011-11-23 | 2013-05-30 | Oxygen Healthcare Research Pvt. Ltd | Benzothiazine compounds as h3 receptor ligands |
| CN102491919B (zh) * | 2011-12-15 | 2014-03-19 | 南京友杰医药科技有限公司 | 去甲维拉帕米的合成方法 |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US11229640B2 (en) | 2013-11-05 | 2022-01-25 | Antecip Bioventures Ii Llc | Combination of dextromethorphan and bupropion for treating depression |
| US11197839B2 (en) | 2013-11-05 | 2021-12-14 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US10105327B2 (en) | 2013-11-05 | 2018-10-23 | Antecip Bioventures Ii Llc | Compositions and methods for increasing the metabolic lifetime of dextromethorphane and related pharmacodynamic effects |
| US11419867B2 (en) | 2013-11-05 | 2022-08-23 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
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| US9457025B2 (en) | 2013-11-05 | 2016-10-04 | Antecip Bioventures Ii Llc | Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan |
| US10813924B2 (en) | 2018-03-20 | 2020-10-27 | Antecip Bioventures Ii Llc | Bupropion and dextromethorphan for treating nicotine addiction |
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| US11123344B2 (en) | 2013-11-05 | 2021-09-21 | Axsome Therapeutics, Inc. | Bupropion as a modulator of drug activity |
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| US10966942B2 (en) | 2019-01-07 | 2021-04-06 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US10799497B2 (en) | 2013-11-05 | 2020-10-13 | Antecip Bioventures Ii Llc | Combination of dextromethorphan and bupropion for treating depression |
| US9457023B1 (en) | 2013-11-05 | 2016-10-04 | Antecip Bioventures Ii Llc | Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects |
| US11497721B2 (en) | 2013-11-05 | 2022-11-15 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
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| US20160361305A1 (en) | 2013-11-05 | 2016-12-15 | Antecip Bioventures Ii Llc | Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan |
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| US11273133B2 (en) | 2013-11-05 | 2022-03-15 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US10105361B2 (en) | 2013-11-05 | 2018-10-23 | Antecip Bioventures Ii Llc | Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects |
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| US11058648B2 (en) | 2013-11-05 | 2021-07-13 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2011526251A (ja) | 2011-10-06 |
| TWI458726B (zh) | 2014-11-01 |
| US20100009975A1 (en) | 2010-01-14 |
| KR20110036607A (ko) | 2011-04-07 |
| EP2310386A4 (en) | 2012-04-11 |
| EA021798B1 (ru) | 2015-09-30 |
| EP2310386A1 (en) | 2011-04-20 |
| AR072471A1 (es) | 2010-09-01 |
| NZ590727A (en) | 2012-12-21 |
| US20140163016A1 (en) | 2014-06-12 |
| MY158796A (en) | 2016-11-15 |
| IL210195A (en) | 2015-08-31 |
| BRPI0913915A2 (pt) | 2015-10-13 |
| US8618286B2 (en) | 2013-12-31 |
| CA2729246C (en) | 2018-08-21 |
| US8106043B2 (en) | 2012-01-31 |
| MX2011000124A (es) | 2011-02-24 |
| CA2729246A1 (en) | 2010-01-07 |
| AU2009266386B2 (en) | 2015-02-19 |
| EA201170130A1 (ru) | 2011-08-30 |
| US20120122855A1 (en) | 2012-05-17 |
| IL210195A0 (en) | 2011-03-31 |
| ZA201100436B (en) | 2012-10-31 |
| UA105182C2 (ru) | 2014-04-25 |
| WO2010000073A1 (en) | 2010-01-07 |
| JP5572157B2 (ja) | 2014-08-13 |
| TW201002701A (en) | 2010-01-16 |
| SG192470A1 (en) | 2013-08-30 |
| AU2009266386A1 (en) | 2010-01-07 |
| CL2010001633A1 (es) | 2011-05-20 |
| CN102143961A (zh) | 2011-08-03 |
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