CL2008001933A1 - Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. - Google Patents
Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros.Info
- Publication number
- CL2008001933A1 CL2008001933A1 CL2008001933A CL2008001933A CL2008001933A1 CL 2008001933 A1 CL2008001933 A1 CL 2008001933A1 CL 2008001933 A CL2008001933 A CL 2008001933A CL 2008001933 A CL2008001933 A CL 2008001933A CL 2008001933 A1 CL2008001933 A1 CL 2008001933A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- disorder
- cardiac
- bone
- neurodegenerative
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 8
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 201000010099 disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000002062 proliferating effect Effects 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 title 1
- 230000000747 cardiac effect Effects 0.000 title 1
- 230000001900 immune effect Effects 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 230000000626 neurodegenerative effect Effects 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 208000035475 disorder Diseases 0.000 abstract 6
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 208000020446 Cardiac disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
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| JP2009522295A (ja) * | 2005-12-30 | 2009-06-11 | アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド | 置換ビス−アミドメタロプロテアーゼ阻害剤 |
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