CH657530A5 - Stabilisierte insulinloesungen und verfahren zu ihrer herstellung. - Google Patents

Stabilisierte insulinloesungen und verfahren zu ihrer herstellung. Download PDF

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Publication number
CH657530A5
CH657530A5 CH657/83A CH65783A CH657530A5 CH 657530 A5 CH657530 A5 CH 657530A5 CH 657/83 A CH657/83 A CH 657/83A CH 65783 A CH65783 A CH 65783A CH 657530 A5 CH657530 A5 CH 657530A5
Authority
CH
Switzerland
Prior art keywords
insulin
zinc
solution according
solution
hexamer
Prior art date
Application number
CH657/83A
Other languages
German (de)
English (en)
Inventor
Jens Jorgen Vejlgaard Brange
Svend Havelund
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of CH657530A5 publication Critical patent/CH657530A5/de

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06—Wiring by machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CH657/83A 1982-02-05 1983-02-04 Stabilisierte insulinloesungen und verfahren zu ihrer herstellung. CH657530A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (1)

Publication Number Publication Date
CH657530A5 true CH657530A5 (de) 1986-09-15

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
CH657/83A CH657530A5 (de) 1982-02-05 1983-02-04 Stabilisierte insulinloesungen und verfahren zu ihrer herstellung.

Country Status (22)

Country Link
US (1) US4476118A (enExample)
JP (1) JPS58192818A (enExample)
AT (1) AT382780B (enExample)
AU (1) AU549981B2 (enExample)
BE (1) BE895832A (enExample)
CA (1) CA1203476A (enExample)
CH (1) CH657530A5 (enExample)
DE (1) DE3303860A1 (enExample)
ES (1) ES519533A0 (enExample)
FI (1) FI78616C (enExample)
FR (1) FR2521009B1 (enExample)
GB (1) GB2114573B (enExample)
GR (1) GR77388B (enExample)
IE (1) IE54548B1 (enExample)
IT (1) IT1178455B (enExample)
LU (1) LU84632A1 (enExample)
NL (1) NL187269C (enExample)
NO (1) NO161204C (enExample)
NZ (1) NZ203189A (enExample)
PT (1) PT76195B (enExample)
SE (1) SE460948B (enExample)
ZA (1) ZA83742B (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3576120D1 (de) * 1984-06-09 1990-04-05 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
AR002976A1 (es) * 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
JP4307550B2 (ja) * 1995-11-13 2009-08-05 メドトロニック ミニメッド、 インコーポレイティド 単量体状タンパク質の送達のための方法及び組成物
EP0891419A4 (en) * 1996-03-12 2000-03-01 Life Technologies Inc NUTRIENT ADDITIVE FOR HEMATOPOETIC CELL CULTURES
EP0821006B1 (de) * 1996-07-26 2004-04-21 Aventis Pharma Deutschland GmbH Insulinderivate mit erhöhter Zinkbindung
SI0884053T1 (en) * 1997-06-13 2003-02-28 Eli Lilly And Company Stable insulin formulations
AR012894A1 (es) * 1997-06-13 2000-11-22 Lilly Co Eli Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma.
WO1999024071A1 (en) * 1997-11-12 1999-05-20 Alza Corporation Method for decreasing self-association of polypeptides
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
RU2218935C2 (ru) * 1998-10-16 2003-12-20 Ново Нордиск А/С Стабильные концентрированные препаративные формы инсулина для доставки через легкие
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
US6689747B2 (en) * 2000-03-24 2004-02-10 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
JP5599543B2 (ja) 2002-05-07 2014-10-01 ノヴォ ノルディスク アー／エス 単量体インスリン及びアシル化インスリンを含む可溶性製剤
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
WO2004056347A2 (en) * 2002-12-20 2004-07-08 Novo Nordisk A/S Pharmaceutical compositions comprising insulin and legends of insulin hexamer
WO2004096266A1 (en) * 2003-05-02 2004-11-11 Novo Nordisk A/S Improved physical stability of insulin formulations
EP2264065B1 (en) * 2003-08-05 2017-03-08 Novo Nordisk A/S Novel insulin derivatives
EP2626368B1 (en) * 2004-07-19 2016-12-21 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
EP1969004B1 (en) 2005-12-28 2011-08-10 Novo Nordisk A/S Compositions comprising an acylated insulin and zinc and method of making the said compositions
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
EP2134351B1 (en) 2007-03-13 2016-04-27 Nutrition 21, Inc. Methods and compositions for the sustained release of chromium
JP5552046B2 (ja) * 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
PT2597103T (pt) * 2007-11-16 2017-02-08 Novo Nordisk As Composições farmacêuticas contendo insulina e um péptido insulinotrófico
EP2328607A1 (en) * 2008-07-16 2011-06-08 Arecor Limited Stable formulation of a therapeutic protein
EP2341940A1 (en) * 2008-07-16 2011-07-13 Arecor Limited The stabilisation of proteins
WO2010049488A1 (en) * 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
DK2632478T3 (da) 2010-10-27 2019-10-07 Novo Nordisk As Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
US8933022B2 (en) 2011-03-01 2015-01-13 Jds Therapeutics, Llc Methods and compositions for the treatment and prevention Hypoglycemia and related disorders
WO2014076423A1 (fr) 2012-11-13 2014-05-22 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
NZ707160A (en) 2012-12-19 2016-08-26 Wockhardt Ltd A stable aqueous composition comprising human insulin or an analogue or derivative thereof
NZ707168A (en) 2012-12-26 2016-09-30 Wockhardt Ltd Pharmaceutical composition of insulins
TWI780236B (zh) * 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
EP3077414B1 (en) * 2013-12-04 2020-06-17 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
EP3413900A1 (en) 2016-02-11 2018-12-19 Nutrition 21, LLC Chromium containing compositions for improving health and fitness
CN109803639B (zh) * 2016-09-29 2024-01-02 艾瑞克有限公司 新制剂
EP3630166B1 (en) 2017-06-01 2022-04-06 Eli Lilly and Company Rapid-acting insulin compositions
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
US12343383B2 (en) 2019-07-12 2025-07-01 Novo Nordisk A/S High concentration insulin formulation
CN120142500B (zh) * 2025-02-28 2025-10-10 中国计量科学研究院 一种具有互换性的活性人胰岛素溶液标准物质及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
DE2459515C3 (de) * 1974-12-17 1982-02-11 Hoechst Ag, 6000 Frankfurt Arzneimittelzubereitungen mit antidiabetischer Wirkung
EP0018609B1 (de) * 1979-04-30 1983-09-21 Hoechst Aktiengesellschaft Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
WO1983003054A1 (en) * 1982-03-03 1983-09-15 Johansen, Kristian, Betton A proces for producing an insulin preparation

Also Published As

Publication number Publication date
SE8300598L (sv) 1983-08-06
GR77388B (enExample) 1984-09-11
ZA83742B (en) 1983-11-30
FR2521009A1 (fr) 1983-08-12
DE3303860A1 (de) 1983-08-18
PT76195A (en) 1983-03-01
AT382780B (de) 1987-04-10
IT8319420A0 (it) 1983-02-04
IE830220L (en) 1983-08-05
LU84632A1 (fr) 1983-09-08
BE895832A (fr) 1983-08-04
JPH0367056B2 (enExample) 1991-10-21
NL8300440A (nl) 1983-09-01
GB2114573A (en) 1983-08-24
NO161204C (no) 1989-07-19
DE3303860C2 (enExample) 1989-12-28
FI830375L (fi) 1983-08-06
AU549981B2 (en) 1986-02-20
NZ203189A (en) 1985-07-31
ATA38983A (de) 1986-09-15
NO161204B (no) 1989-04-10
PT76195B (en) 1986-01-27
JPS58192818A (ja) 1983-11-10
GB8303133D0 (en) 1983-03-09
GB2114573B (en) 1985-05-01
FI78616C (fi) 1989-09-11
SE460948B (sv) 1989-12-11
NO830385L (no) 1983-08-08
NL187269B (nl) 1991-03-01
ES8500060A1 (es) 1984-10-16
CA1203476A (en) 1986-04-22
FR2521009B1 (fr) 1987-07-17
AU1113683A (en) 1983-08-11
NL187269C (nl) 1991-08-01
FI830375A0 (fi) 1983-02-03
IT1178455B (it) 1987-09-09
SE8300598D0 (sv) 1983-02-04
IE54548B1 (en) 1989-11-08
US4476118A (en) 1984-10-09
FI78616B (fi) 1989-05-31
ES519533A0 (es) 1984-10-16

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