CH657530A5 - Stabilisierte insulinloesungen und verfahren zu ihrer herstellung. - Google Patents

Stabilisierte insulinloesungen und verfahren zu ihrer herstellung. Download PDF

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Publication number
CH657530A5
CH657530A5 CH657/83A CH65783A CH657530A5 CH 657530 A5 CH657530 A5 CH 657530A5 CH 657/83 A CH657/83 A CH 657/83A CH 65783 A CH65783 A CH 65783A CH 657530 A5 CH657530 A5 CH 657530A5
Authority
CH
Switzerland
Prior art keywords
insulin
zinc
solution according
solution
hexamer
Prior art date
Application number
CH657/83A
Other languages
German (de)
English (en)
Inventor
Jens Jorgen Vejlgaard Brange
Svend Havelund
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of CH657530A5 publication Critical patent/CH657530A5/de

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06—Wiring by machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CH657/83A 1982-02-05 1983-02-04 Stabilisierte insulinloesungen und verfahren zu ihrer herstellung. CH657530A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (1)

Publication Number Publication Date
CH657530A5 true CH657530A5 (de) 1986-09-15

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
CH657/83A CH657530A5 (de) 1982-02-05 1983-02-04 Stabilisierte insulinloesungen und verfahren zu ihrer herstellung.

Country Status (22)

Country Link
US (1) US4476118A (enExample)
JP (1) JPS58192818A (enExample)
AT (1) AT382780B (enExample)
AU (1) AU549981B2 (enExample)
BE (1) BE895832A (enExample)
CA (1) CA1203476A (enExample)
CH (1) CH657530A5 (enExample)
DE (1) DE3303860A1 (enExample)
ES (1) ES519533A0 (enExample)
FI (1) FI78616C (enExample)
FR (1) FR2521009B1 (enExample)
GB (1) GB2114573B (enExample)
GR (1) GR77388B (enExample)
IE (1) IE54548B1 (enExample)
IT (1) IT1178455B (enExample)
LU (1) LU84632A1 (enExample)
NL (1) NL187269C (enExample)
NO (1) NO161204C (enExample)
NZ (1) NZ203189A (enExample)
PT (1) PT76195B (enExample)
SE (1) SE460948B (enExample)
ZA (1) ZA83742B (enExample)

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US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
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YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
AU7678196A (en) * 1995-11-13 1997-06-05 Minimed, Inc. Methods and compositions for the delivery of monomeric proteins
EP0891419A4 (en) * 1996-03-12 2000-03-01 Life Technologies Inc NUTRIENT ADDITIVE FOR HEMATOPOETIC CELL CULTURES
DK0821006T3 (da) * 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulinderivater med öget zinkbinding
ZA984697B (en) * 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
SI0884053T1 (en) * 1997-06-13 2003-02-28 Eli Lilly And Company Stable insulin formulations
DE69826705T2 (de) * 1997-11-12 2006-02-23 Alza Corp., Palo Alto Verfahren zur dermalen verabreichung von polypeptiden
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
PT1121144E (pt) * 1998-10-16 2002-11-29 Novo Nordisk As Preparados de insulina concentrada estavel para administracao pulmonar
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
JP2003528149A (ja) * 2000-03-24 2003-09-24 ジェネンテック・インコーポレーテッド 軟骨性疾患の治療のためのインスリンの使用
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
ATE496064T1 (de) 2002-05-07 2011-02-15 Novo Nordisk As Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
AU2003291972A1 (en) * 2002-12-20 2004-07-14 Novo Nordisk A/S Pharmaceutical compositions comprising insulin and legends of insulin hexamer
WO2004096266A1 (en) * 2003-05-02 2004-11-11 Novo Nordisk A/S Improved physical stability of insulin formulations
KR101159559B1 (ko) * 2003-08-05 2012-06-26 노보 노르디스크 에이/에스 신규의 인슐린 유도체
MX2007000883A (es) * 2004-07-19 2007-04-02 Biocon Ltd Conjugados de insulina-oligomero, formulaciones y usos de los mismos.
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
ES2579229T3 (es) 2007-03-13 2016-08-08 Jds Therapeutics, Llc Procedimientos y composiciones para la liberación sostenida de cromo
WO2008152106A1 (en) * 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
ES2612736T3 (es) * 2007-11-16 2017-05-18 Novo Nordisk A/S Composiciones farmacéuticas estables que comprenden liraglutida y degludec
EP2341940A1 (en) * 2008-07-16 2011-07-13 Arecor Limited The stabilisation of proteins
EP2328607A1 (en) * 2008-07-16 2011-06-08 Arecor Limited Stable formulation of a therapeutic protein
CA2738615A1 (en) * 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
AU2012223282B2 (en) 2011-03-01 2017-02-02 Nutrition 21, Llc Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders
KR20150082640A (ko) 2012-11-13 2015-07-15 아도시아 치환된 음이온성 화합물을 포함하는 속효성 인슐린 제형
MX360420B (es) * 2012-12-19 2018-10-31 Wockhardt Ltd Una composicion acuosa estable que comprende insulina humana o un analogo o derivado de la misma.
MX2015006997A (es) 2012-12-26 2015-09-23 Wockhardt Ltd Composicion farmaceutica.
TWI641381B (zh) * 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
WO2014177623A1 (en) 2013-04-30 2014-11-06 Novo Nordisk A/S Novel administration regime
WO2015084694A2 (en) * 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
AU2017217466A1 (en) 2016-02-11 2018-08-23 Nutrition 21, Llc Chromium containing compositions for improving health and fitness
AU2017334290B2 (en) * 2016-09-29 2023-04-20 Arecor Limited Novel formulations
WO2018222787A1 (en) 2017-06-01 2018-12-06 Eli Lilly And Company Rapid-acting insulin compositions
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CN114096269B (zh) 2019-07-12 2024-06-11 诺和诺德股份有限公司 高浓度胰岛素制剂
CN114887039B (zh) * 2022-05-13 2026-01-30 西北工业大学 一种锌离子介导的自组装胰岛素纳米药物、制备方法和应用
CN120142500B (zh) * 2025-02-28 2025-10-10 中国计量科学研究院 一种具有互换性的活性人胰岛素溶液标准物质及其制备方法和应用

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
DE2459515C3 (de) * 1974-12-17 1982-02-11 Hoechst Ag, 6000 Frankfurt Arzneimittelzubereitungen mit antidiabetischer Wirkung
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
ES520249A0 (es) * 1982-03-03 1984-04-16 Nordisk Insulinlab Procedimiento de producir preparaciones de insulina.

Also Published As

Publication number Publication date
CA1203476A (en) 1986-04-22
GB2114573B (en) 1985-05-01
US4476118A (en) 1984-10-09
IE54548B1 (en) 1989-11-08
FR2521009A1 (fr) 1983-08-12
IT1178455B (it) 1987-09-09
JPS58192818A (ja) 1983-11-10
GB8303133D0 (en) 1983-03-09
IT8319420A0 (it) 1983-02-04
PT76195B (en) 1986-01-27
ZA83742B (en) 1983-11-30
AU1113683A (en) 1983-08-11
FI830375A0 (fi) 1983-02-03
PT76195A (en) 1983-03-01
LU84632A1 (fr) 1983-09-08
DE3303860C2 (enExample) 1989-12-28
FI830375L (fi) 1983-08-06
FI78616C (fi) 1989-09-11
BE895832A (fr) 1983-08-04
NO161204C (no) 1989-07-19
JPH0367056B2 (enExample) 1991-10-21
FR2521009B1 (fr) 1987-07-17
FI78616B (fi) 1989-05-31
NO830385L (no) 1983-08-08
NL8300440A (nl) 1983-09-01
SE8300598D0 (sv) 1983-02-04
NZ203189A (en) 1985-07-31
NO161204B (no) 1989-04-10
NL187269C (nl) 1991-08-01
ES8500060A1 (es) 1984-10-16
NL187269B (nl) 1991-03-01
IE830220L (en) 1983-08-05
GB2114573A (en) 1983-08-24
SE460948B (sv) 1989-12-11
ATA38983A (de) 1986-09-15
SE8300598L (sv) 1983-08-06
AU549981B2 (en) 1986-02-20
ES519533A0 (es) 1984-10-16
AT382780B (de) 1987-04-10
GR77388B (enExample) 1984-09-11
DE3303860A1 (de) 1983-08-18

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