IT8319420A0 - Soluzioni di insulina stabilizzate e metodi per la loro produzione. - Google Patents

Soluzioni di insulina stabilizzate e metodi per la loro produzione.

Info

Publication number
IT8319420A0
IT8319420A0 IT8319420A IT1942083A IT8319420A0 IT 8319420 A0 IT8319420 A0 IT 8319420A0 IT 8319420 A IT8319420 A IT 8319420A IT 1942083 A IT1942083 A IT 1942083A IT 8319420 A0 IT8319420 A0 IT 8319420A0
Authority
IT
Italy
Prior art keywords
production
methods
insulin solutions
stabilized insulin
stabilized
Prior art date
Application number
IT8319420A
Other languages
English (en)
Other versions
IT1178455B (it
Inventor
Jens Jorgen Vejlgaard Brange
Svend Havelund
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of IT8319420A0 publication Critical patent/IT8319420A0/it
Application granted granted Critical
Publication of IT1178455B publication Critical patent/IT1178455B/it

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06—Wiring by machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
IT19420/83A 1982-02-05 1983-02-04 Soluzioni di insulina stabilizzate e metodi per la loro produzione IT1178455B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (2)

Publication Number Publication Date
IT8319420A0 true IT8319420A0 (it) 1983-02-04
IT1178455B IT1178455B (it) 1987-09-09

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19420/83A IT1178455B (it) 1982-02-05 1983-02-04 Soluzioni di insulina stabilizzate e metodi per la loro produzione

Country Status (22)

Country Link
US (1) US4476118A (it)
JP (1) JPS58192818A (it)
AT (1) AT382780B (it)
AU (1) AU549981B2 (it)
BE (1) BE895832A (it)
CA (1) CA1203476A (it)
CH (1) CH657530A5 (it)
DE (1) DE3303860A1 (it)
ES (1) ES519533A0 (it)
FI (1) FI78616C (it)
FR (1) FR2521009B1 (it)
GB (1) GB2114573B (it)
GR (1) GR77388B (it)
IE (1) IE54548B1 (it)
IT (1) IT1178455B (it)
LU (1) LU84632A1 (it)
NL (1) NL187269C (it)
NO (1) NO161204C (it)
NZ (1) NZ203189A (it)
PT (1) PT76195B (it)
SE (1) SE460948B (it)
ZA (1) ZA83742B (it)

Families Citing this family (49)

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DE3576120D1 (de) * 1984-06-09 1990-04-05 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
EP0861089B1 (en) * 1995-11-13 2002-07-17 Medtronic MiniMed, Inc. Methods and compositions for the delivery of monomeric proteins
JP2000507812A (ja) * 1996-03-12 2000-06-27 ライフ テクノロジーズ，インコーポレイテッド 造血細胞培養栄養補充成分
DK0821006T3 (da) * 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulinderivater med öget zinkbinding
AR012894A1 (es) * 1997-06-13 2000-11-22 Lilly Co Eli Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma.
DK1283051T3 (da) * 1997-06-13 2006-10-16 Lilly Co Eli Stabile insulinformuleringer
CA2309818C (en) * 1997-11-12 2009-05-05 Alza Corporation Buffered drug formulations for transdermal electrotransport delivery
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
HUP0104111A3 (en) * 1998-10-16 2002-05-28 Novo Nordisk As Stable concentrated insulin preparations for pulmonary delivery
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
EP1265630B1 (en) * 2000-03-24 2006-06-07 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
DE60335797D1 (de) 2002-05-07 2011-03-03 Novo Nordisk As Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
WO2004056347A2 (en) * 2002-12-20 2004-07-08 Novo Nordisk A/S Pharmaceutical compositions comprising insulin and legends of insulin hexamer
WO2004096266A1 (en) * 2003-05-02 2004-11-11 Novo Nordisk A/S Improved physical stability of insulin formulations
EP1660531A2 (en) * 2003-08-05 2006-05-31 Novo Nordisk A/S Novel insulin derivatives
UA91512C2 (ru) 2004-07-19 2010-08-10 Биокон Лимитед Коньюгати олигомеров инсулина, их композиция (варианты) и применение
PL1969004T3 (pl) * 2005-12-28 2012-01-31 Novo Nordisk As Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
ES2579229T3 (es) 2007-03-13 2016-08-08 Jds Therapeutics, Llc Procedimientos y composiciones para la liberación sostenida de cromo
ES2744384T3 (es) * 2007-06-13 2020-02-24 Novo Nordisk As Formulación farmacéutica que comprende un derivado de insulina
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
BRPI0820535B8 (pt) * 2007-11-16 2021-05-25 Novo Nordisk As composições farmacêuticas contendo insulina e um peptídeo insulinotrópico
EP2341940A1 (en) * 2008-07-16 2011-07-13 Arecor Limited The stabilisation of proteins
EP2328607A1 (en) * 2008-07-16 2011-06-08 Arecor Limited Stable formulation of a therapeutic protein
KR20110085985A (ko) * 2008-10-30 2011-07-27 노보 노르디스크 에이/에스 하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
CA2828572C (en) 2011-03-01 2021-02-23 Jds Therapeutics, Llc Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders
ES2670969T3 (es) 2012-11-13 2018-06-04 Adocia Formulación de acción rápida de insulina que comprende un compuesto aniónico sustituido
CA2889165A1 (en) 2012-12-19 2014-06-26 Wockhardt Limited A stable aqueous composition comprising human insulin or an analogue or derivative thereof
RU2015130613A (ru) 2012-12-26 2017-01-31 Вокхардт Лимитед Фармацевтическая композиция
TWI780236B (zh) * 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
US9822158B2 (en) * 2013-12-04 2017-11-21 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
WO2017139337A1 (en) 2016-02-11 2017-08-17 Nutrition 21, Llc Chromium containing compositions for improving health and fitness
DK3518892T3 (da) * 2016-09-29 2023-07-31 Arecor Ltd Farmaceutisk formulering, der indeholder en insulinforbindelse
CN110662551B (zh) 2017-06-01 2023-07-18 伊莱利利公司 速效胰岛素组合物
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
EP0018609B1 (de) * 1979-04-30 1983-09-21 Hoechst Aktiengesellschaft Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
ES8403723A1 (es) * 1982-03-03 1984-04-16 Nordisk Insulinlab Procedimiento de producir preparaciones de insulina.

Also Published As

Publication number Publication date
IT1178455B (it) 1987-09-09
NZ203189A (en) 1985-07-31
PT76195B (en) 1986-01-27
BE895832A (fr) 1983-08-04
JPS58192818A (ja) 1983-11-10
SE8300598L (sv) 1983-08-06
NO161204B (no) 1989-04-10
NL187269B (nl) 1991-03-01
SE460948B (sv) 1989-12-11
FI78616B (fi) 1989-05-31
PT76195A (en) 1983-03-01
ATA38983A (de) 1986-09-15
ES8500060A1 (es) 1984-10-16
DE3303860A1 (de) 1983-08-18
LU84632A1 (fr) 1983-09-08
CH657530A5 (de) 1986-09-15
FR2521009A1 (fr) 1983-08-12
GR77388B (it) 1984-09-11
AU1113683A (en) 1983-08-11
NO830385L (no) 1983-08-08
FI78616C (fi) 1989-09-11
FI830375A0 (fi) 1983-02-03
CA1203476A (en) 1986-04-22
NO161204C (no) 1989-07-19
JPH0367056B2 (it) 1991-10-21
NL8300440A (nl) 1983-09-01
US4476118A (en) 1984-10-09
DE3303860C2 (it) 1989-12-28
FI830375L (fi) 1983-08-06
NL187269C (nl) 1991-08-01
FR2521009B1 (fr) 1987-07-17
GB8303133D0 (en) 1983-03-09
ES519533A0 (es) 1984-10-16
IE830220L (en) 1983-08-05
GB2114573A (en) 1983-08-24
AU549981B2 (en) 1986-02-20
SE8300598D0 (sv) 1983-02-04
ZA83742B (en) 1983-11-30
GB2114573B (en) 1985-05-01
AT382780B (de) 1987-04-10
IE54548B1 (en) 1989-11-08

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970226