AT382780B - Verfahren zur herstellung einer insulinloesung - Google Patents

Verfahren zur herstellung einer insulinloesung

Info

Publication number
AT382780B
AT382780B AT0038983A AT38983A AT382780B AT 382780 B AT382780 B AT 382780B AT 0038983 A AT0038983 A AT 0038983A AT 38983 A AT38983 A AT 38983A AT 382780 B AT382780 B AT 382780B
Authority
AT
Austria
Prior art keywords
producing
insulin solution
insulin
solution
Prior art date
Application number
AT0038983A
Other languages
English (en)
Other versions
ATA38983A (de
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of ATA38983A publication Critical patent/ATA38983A/de
Application granted granted Critical
Publication of AT382780B publication Critical patent/AT382780B/de

Links

Classifications

    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05KPRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06Wiring by machine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT0038983A 1982-02-05 1983-02-04 Verfahren zur herstellung einer insulinloesung AT382780B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (2)

Publication Number Publication Date
ATA38983A ATA38983A (de) 1986-09-15
AT382780B true AT382780B (de) 1987-04-10

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0038983A AT382780B (de) 1982-02-05 1983-02-04 Verfahren zur herstellung einer insulinloesung

Country Status (22)

Country Link
US (1) US4476118A (de)
JP (1) JPS58192818A (de)
AT (1) AT382780B (de)
AU (1) AU549981B2 (de)
BE (1) BE895832A (de)
CA (1) CA1203476A (de)
CH (1) CH657530A5 (de)
DE (1) DE3303860A1 (de)
ES (1) ES8500060A1 (de)
FI (1) FI78616C (de)
FR (1) FR2521009B1 (de)
GB (1) GB2114573B (de)
GR (1) GR77388B (de)
IE (1) IE54548B1 (de)
IT (1) IT1178455B (de)
LU (1) LU84632A1 (de)
NL (1) NL187269C (de)
NO (1) NO161204C (de)
NZ (1) NZ203189A (de)
PT (1) PT76195B (de)
SE (1) SE460948B (de)
ZA (1) ZA83742B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166971B1 (de) * 1984-06-09 1990-02-28 Hoechst Aktiengesellschaft Insulinzubereitungen, Verfahren zu deren Herstellung und deren Verwendung
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
AR002976A1 (es) * 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
US5807315A (en) * 1995-11-13 1998-09-15 Minimed, Inc. Methods and devices for the delivery of monomeric proteins
AU2260097A (en) * 1996-03-12 1997-10-01 Life Technologies, Inc. Hematopoietic cell culture nutrient supplement
DE59711533D1 (de) * 1996-07-26 2004-05-27 Aventis Pharma Gmbh Insulinderivate mit erhöhter Zinkbindung
PE79099A1 (es) 1997-06-13 1999-08-24 Lilly Co Eli Formulaciones de insulina estables
EP1283051B1 (de) * 1997-06-13 2006-06-14 Eli Lilly And Company Stabile Insulinformulierungen
AU1302499A (en) * 1997-11-12 1999-05-31 Alza Corporation Buffered drug formulations for transdermal electrotransport delivery
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
ES2228728T3 (es) * 1998-10-16 2005-04-16 Novo Nordisk A/S Preparaciones concentradas estables de insulina para administracion pulmonar.
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
WO2001072323A2 (en) * 2000-03-24 2001-10-04 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
AU2003236201A1 (en) 2002-05-07 2003-11-11 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
ATE378063T1 (de) * 2002-12-20 2007-11-15 Novo Nordisk As Pharmazeutische zusammensetzungen mit insulin und insulin-hexamer-liganden
WO2004096266A1 (en) * 2003-05-02 2004-11-11 Novo Nordisk A/S Improved physical stability of insulin formulations
EP2264065B1 (de) * 2003-08-05 2017-03-08 Novo Nordisk A/S Neue insulinderivate
CN105801686B (zh) * 2004-07-19 2020-04-07 比奥孔有限公司 胰岛素-低聚物共轭物、制剂及其用途
CN101389650B (zh) * 2005-12-28 2012-10-10 诺沃-诺迪斯克有限公司 包含酰化胰岛素和锌的组合物以及制备所述组合物的方法
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
CA2681158C (en) 2007-03-13 2018-09-18 Nutrition 21, Inc. Methods and compositions for the sustained release of chromium
WO2008152106A1 (en) * 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
CA2705821A1 (en) 2007-11-16 2009-05-22 Novo Nordisk A/S Pharmaceutical compositions containing insulin and an insulinotropic peptide
EP2341940A1 (de) * 2008-07-16 2011-07-13 Arecor Limited Stabilisierung von proteinen
EP2328607A1 (de) * 2008-07-16 2011-06-08 Arecor Limited Stabile formulierung eines therapeutischen proteins
ES2607003T3 (es) * 2008-10-30 2017-03-28 Novo Nordisk A/S Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
WO2012119007A1 (en) 2011-03-01 2012-09-07 N21 Acquisition Holding, Llc Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders
AU2013346624B2 (en) 2012-11-13 2018-08-09 Adocia Quick-acting insulin formulation including a substituted anionic compound
JP6111475B2 (ja) * 2012-12-19 2017-04-12 ウォックハート リミテッド ヒトインスリン又はその類似体もしくは誘導体を含む安定な水性組成物
CN104870469A (zh) 2012-12-26 2015-08-26 沃克哈特有限公司 药物组合物
TWI641381B (zh) * 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
EP2991672A1 (de) 2013-04-30 2016-03-09 Novo Nordisk A/S Neuartiges verabreichungsschema
WO2015084694A2 (en) * 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
AR102869A1 (es) 2014-12-16 2017-03-29 Lilly Co Eli Composiciones de insulina de rápida acción
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
CN109069532A (zh) 2016-02-11 2018-12-21 营养21有限责任公司 含铬组合物用于改善健康和健身
CA3034972C (en) * 2016-09-29 2024-04-09 Arecor Limited A pharmaceutical insulin formulation
JP6920471B2 (ja) 2017-06-01 2021-08-18 イーライ リリー アンド カンパニー 迅速に作用するインスリン組成物
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
EP0018609B1 (de) * 1979-04-30 1983-09-21 Hoechst Aktiengesellschaft Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
WO1983003054A1 (en) * 1982-03-03 1983-09-15 Johansen, Kristian, Betton A proces for producing an insulin preparation

Also Published As

Publication number Publication date
US4476118A (en) 1984-10-09
ES519533A0 (es) 1984-10-16
ES8500060A1 (es) 1984-10-16
FI78616C (fi) 1989-09-11
GR77388B (de) 1984-09-11
IE54548B1 (en) 1989-11-08
NL187269B (nl) 1991-03-01
ZA83742B (en) 1983-11-30
FR2521009A1 (fr) 1983-08-12
GB8303133D0 (en) 1983-03-09
SE460948B (sv) 1989-12-11
AU549981B2 (en) 1986-02-20
BE895832A (fr) 1983-08-04
AU1113683A (en) 1983-08-11
SE8300598L (sv) 1983-08-06
IT1178455B (it) 1987-09-09
NO161204B (no) 1989-04-10
DE3303860C2 (de) 1989-12-28
FI830375L (fi) 1983-08-06
CH657530A5 (de) 1986-09-15
JPH0367056B2 (de) 1991-10-21
PT76195A (en) 1983-03-01
PT76195B (en) 1986-01-27
NL187269C (nl) 1991-08-01
DE3303860A1 (de) 1983-08-18
SE8300598D0 (sv) 1983-02-04
IT8319420A0 (it) 1983-02-04
ATA38983A (de) 1986-09-15
FI78616B (fi) 1989-05-31
IE830220L (en) 1983-08-05
FI830375A0 (fi) 1983-02-03
LU84632A1 (fr) 1983-09-08
NZ203189A (en) 1985-07-31
NO830385L (no) 1983-08-08
CA1203476A (en) 1986-04-22
NO161204C (no) 1989-07-19
FR2521009B1 (fr) 1987-07-17
NL8300440A (nl) 1983-09-01
GB2114573B (en) 1985-05-01
JPS58192818A (ja) 1983-11-10
GB2114573A (en) 1983-08-24

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee