AT382780B - Verfahren zur herstellung einer insulinloesung - Google Patents
Verfahren zur herstellung einer insulinloesungInfo
- Publication number
- AT382780B AT382780B AT0038983A AT38983A AT382780B AT 382780 B AT382780 B AT 382780B AT 0038983 A AT0038983 A AT 0038983A AT 38983 A AT38983 A AT 38983A AT 382780 B AT382780 B AT 382780B
- Authority
- AT
- Austria
- Prior art keywords
- producing
- insulin solution
- insulin
- solution
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
- H05K13/06—Wiring by machine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK49182 | 1982-02-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA38983A ATA38983A (de) | 1986-09-15 |
AT382780B true AT382780B (de) | 1987-04-10 |
Family
ID=8094159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0038983A AT382780B (de) | 1982-02-05 | 1983-02-04 | Verfahren zur herstellung einer insulinloesung |
Country Status (22)
Country | Link |
---|---|
US (1) | US4476118A (de) |
JP (1) | JPS58192818A (de) |
AT (1) | AT382780B (de) |
AU (1) | AU549981B2 (de) |
BE (1) | BE895832A (de) |
CA (1) | CA1203476A (de) |
CH (1) | CH657530A5 (de) |
DE (1) | DE3303860A1 (de) |
ES (1) | ES8500060A1 (de) |
FI (1) | FI78616C (de) |
FR (1) | FR2521009B1 (de) |
GB (1) | GB2114573B (de) |
GR (1) | GR77388B (de) |
IE (1) | IE54548B1 (de) |
IT (1) | IT1178455B (de) |
LU (1) | LU84632A1 (de) |
NL (1) | NL187269C (de) |
NO (1) | NO161204C (de) |
NZ (1) | NZ203189A (de) |
PT (1) | PT76195B (de) |
SE (1) | SE460948B (de) |
ZA (1) | ZA83742B (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0166971B1 (de) * | 1984-06-09 | 1990-02-28 | Hoechst Aktiengesellschaft | Insulinzubereitungen, Verfahren zu deren Herstellung und deren Verwendung |
JP2520262B2 (ja) * | 1987-08-21 | 1996-07-31 | 春幸 川原 | パツチテスト材料 |
US4789660A (en) * | 1987-09-10 | 1988-12-06 | American Home Products Corporation | Insulin administration using methyl and propyl paraben |
US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
US5534488A (en) * | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
AR002976A1 (es) * | 1995-03-31 | 1998-05-27 | Lilly Co Eli | Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas |
US5807315A (en) * | 1995-11-13 | 1998-09-15 | Minimed, Inc. | Methods and devices for the delivery of monomeric proteins |
AU2260097A (en) * | 1996-03-12 | 1997-10-01 | Life Technologies, Inc. | Hematopoietic cell culture nutrient supplement |
DE59711533D1 (de) * | 1996-07-26 | 2004-05-27 | Aventis Pharma Gmbh | Insulinderivate mit erhöhter Zinkbindung |
PE79099A1 (es) | 1997-06-13 | 1999-08-24 | Lilly Co Eli | Formulaciones de insulina estables |
EP1283051B1 (de) * | 1997-06-13 | 2006-06-14 | Eli Lilly And Company | Stabile Insulinformulierungen |
AU1302499A (en) * | 1997-11-12 | 1999-05-31 | Alza Corporation | Buffered drug formulations for transdermal electrotransport delivery |
DE19825447A1 (de) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
ES2228728T3 (es) * | 1998-10-16 | 2005-04-16 | Novo Nordisk A/S | Preparaciones concentradas estables de insulina para administracion pulmonar. |
DE19930676B4 (de) * | 1999-07-02 | 2006-01-19 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln |
WO2001072323A2 (en) * | 2000-03-24 | 2001-10-04 | Genentech, Inc. | Use of insulin for the treatment of cartilagenous disorders |
JP4147234B2 (ja) * | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | 吐出用液体、吐出方法、カートリッジ及び吐出装置 |
AU2003236201A1 (en) | 2002-05-07 | 2003-11-11 | Novo Nordisk A/S | Soluble formulations comprising monomeric insulin and acylated insulin |
US20050065066A1 (en) * | 2002-12-20 | 2005-03-24 | Kaarsholm Niels Christian | Stabilised insulin compositions |
ATE378063T1 (de) * | 2002-12-20 | 2007-11-15 | Novo Nordisk As | Pharmazeutische zusammensetzungen mit insulin und insulin-hexamer-liganden |
WO2004096266A1 (en) * | 2003-05-02 | 2004-11-11 | Novo Nordisk A/S | Improved physical stability of insulin formulations |
EP2264065B1 (de) * | 2003-08-05 | 2017-03-08 | Novo Nordisk A/S | Neue insulinderivate |
CN105801686B (zh) * | 2004-07-19 | 2020-04-07 | 比奥孔有限公司 | 胰岛素-低聚物共轭物、制剂及其用途 |
CN101389650B (zh) * | 2005-12-28 | 2012-10-10 | 诺沃-诺迪斯克有限公司 | 包含酰化胰岛素和锌的组合物以及制备所述组合物的方法 |
US20090136538A1 (en) * | 2006-05-22 | 2009-05-28 | Jan Jezek | Stable vaccine formulation |
GB0700523D0 (en) * | 2007-01-11 | 2007-02-21 | Insense Ltd | The Stabilisation Of Proteins |
CA2681158C (en) | 2007-03-13 | 2018-09-18 | Nutrition 21, Inc. | Methods and compositions for the sustained release of chromium |
WO2008152106A1 (en) * | 2007-06-13 | 2008-12-18 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
CA2705821A1 (en) | 2007-11-16 | 2009-05-22 | Novo Nordisk A/S | Pharmaceutical compositions containing insulin and an insulinotropic peptide |
EP2341940A1 (de) * | 2008-07-16 | 2011-07-13 | Arecor Limited | Stabilisierung von proteinen |
EP2328607A1 (de) * | 2008-07-16 | 2011-06-08 | Arecor Limited | Stabile formulierung eines therapeutischen proteins |
ES2607003T3 (es) * | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
BR112013010345A2 (pt) | 2010-10-27 | 2017-07-25 | Novo Nordisk As | tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção |
WO2012119007A1 (en) | 2011-03-01 | 2012-09-07 | N21 Acquisition Holding, Llc | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders |
AU2013346624B2 (en) | 2012-11-13 | 2018-08-09 | Adocia | Quick-acting insulin formulation including a substituted anionic compound |
JP6111475B2 (ja) * | 2012-12-19 | 2017-04-12 | ウォックハート リミテッド | ヒトインスリン又はその類似体もしくは誘導体を含む安定な水性組成物 |
CN104870469A (zh) | 2012-12-26 | 2015-08-26 | 沃克哈特有限公司 | 药物组合物 |
TWI641381B (zh) * | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
EP2991672A1 (de) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Neuartiges verabreichungsschema |
WO2015084694A2 (en) * | 2013-12-04 | 2015-06-11 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin |
AR102869A1 (es) | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
CN109069532A (zh) | 2016-02-11 | 2018-12-21 | 营养21有限责任公司 | 含铬组合物用于改善健康和健身 |
CA3034972C (en) * | 2016-09-29 | 2024-04-09 | Arecor Limited | A pharmaceutical insulin formulation |
JP6920471B2 (ja) | 2017-06-01 | 2021-08-18 | イーライ リリー アンド カンパニー | 迅速に作用するインスリン組成物 |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2882202A (en) * | 1950-04-05 | 1959-04-14 | Novo Terapeutisk Labor As | Insulin crystal preparations and methods of producing them |
US2787575A (en) * | 1950-11-22 | 1957-04-02 | Organon | Zinc-glycine-insulin composition and production thereof |
US2882203A (en) * | 1951-06-26 | 1959-04-14 | Novo Terapeutisk Labor As | Injectable insulin preparation with protracted effect |
DE1044360B (de) * | 1953-08-19 | 1958-11-20 | Roskilde Medical Company Ltd R | Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt |
DE956098C (de) * | 1954-02-18 | 1957-01-10 | Dr Dr Guenther Weitzel | Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen |
US3058885A (en) * | 1957-06-08 | 1962-10-16 | Novo Terapeutisk Labor As | Process for treatment of insulin crystals and for production of insulin preparationstherefrom |
US3014842A (en) * | 1957-08-10 | 1961-12-26 | Novo Terapeutish Lab A S | Injectable bovine insulin crystal suspensions and process of producing same |
US3091573A (en) * | 1958-05-12 | 1963-05-28 | Novo Terapeutisk Labor As | Quick acting insulin preparation |
FR1263220A (fr) * | 1958-08-01 | 1961-06-09 | Novo Terapeutisk Labor As | Procédé de production d'une préparation d'insuline à action rapide |
DK116527B (da) * | 1967-03-01 | 1970-01-19 | Nordisk Insulinlab | Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse. |
GB1285023A (en) * | 1968-08-09 | 1972-08-09 | Novo Terapeutisk Labor As | Improvements in or relating to injectable insulin preparations |
US3657425A (en) * | 1969-03-12 | 1972-04-18 | Burroughs Wellcome Co | Beef insulin preparations |
EP0018609B1 (de) * | 1979-04-30 | 1983-09-21 | Hoechst Aktiengesellschaft | Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung |
DK80781A (da) * | 1980-02-29 | 1981-08-30 | Hospital For Sick Children | Oploesninger af polypeptider |
WO1983003054A1 (en) * | 1982-03-03 | 1983-09-15 | Johansen, Kristian, Betton | A proces for producing an insulin preparation |
-
1983
- 1983-02-03 FI FI830375A patent/FI78616C/fi not_active IP Right Cessation
- 1983-02-04 PT PT76195A patent/PT76195B/pt unknown
- 1983-02-04 ES ES519533A patent/ES8500060A1/es not_active Expired
- 1983-02-04 CA CA000420907A patent/CA1203476A/en not_active Expired
- 1983-02-04 DE DE19833303860 patent/DE3303860A1/de active Granted
- 1983-02-04 JP JP58016303A patent/JPS58192818A/ja active Granted
- 1983-02-04 IE IE220/83A patent/IE54548B1/en not_active IP Right Cessation
- 1983-02-04 ZA ZA83742A patent/ZA83742B/xx unknown
- 1983-02-04 NL NLAANVRAGE8300440,A patent/NL187269C/xx not_active IP Right Cessation
- 1983-02-04 BE BE6/47775A patent/BE895832A/fr not_active IP Right Cessation
- 1983-02-04 IT IT19420/83A patent/IT1178455B/it active
- 1983-02-04 NZ NZ203189A patent/NZ203189A/en unknown
- 1983-02-04 AT AT0038983A patent/AT382780B/de not_active IP Right Cessation
- 1983-02-04 GB GB08303133A patent/GB2114573B/en not_active Expired
- 1983-02-04 LU LU84632A patent/LU84632A1/de unknown
- 1983-02-04 FR FR8301790A patent/FR2521009B1/fr not_active Expired
- 1983-02-04 NO NO830385A patent/NO161204C/no not_active IP Right Cessation
- 1983-02-04 CH CH657/83A patent/CH657530A5/de not_active IP Right Cessation
- 1983-02-04 SE SE8300598A patent/SE460948B/sv not_active IP Right Cessation
- 1983-02-04 US US06/463,730 patent/US4476118A/en not_active Expired - Lifetime
- 1983-02-04 AU AU11136/83A patent/AU549981B2/en not_active Expired
- 1983-02-04 GR GR70416A patent/GR77388B/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |