FR2521009B1 - Solutions stabilisees d'insuline et procede pour la preparation de celles-ci - Google Patents

Solutions stabilisees d'insuline et procede pour la preparation de celles-ci

Info

Publication number
FR2521009B1
FR2521009B1 FR8301790A FR8301790A FR2521009B1 FR 2521009 B1 FR2521009 B1 FR 2521009B1 FR 8301790 A FR8301790 A FR 8301790A FR 8301790 A FR8301790 A FR 8301790A FR 2521009 B1 FR2521009 B1 FR 2521009B1
Authority
FR
France
Prior art keywords
preparation
insulin solutions
stabilized insulin
stabilized
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8301790A
Other languages
English (en)
Other versions
FR2521009A1 (fr
Inventor
Jens Jorgen Vejlgaard Brange
Svend Havelund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Industri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri AS filed Critical Novo Industri AS
Publication of FR2521009A1 publication Critical patent/FR2521009A1/fr
Application granted granted Critical
Publication of FR2521009B1 publication Critical patent/FR2521009B1/fr
Expired legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06—Wiring by machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
FR8301790A 1982-02-05 1983-02-04 Solutions stabilisees d'insuline et procede pour la preparation de celles-ci Expired FR2521009B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (2)

Publication Number Publication Date
FR2521009A1 FR2521009A1 (fr) 1983-08-12
FR2521009B1 true FR2521009B1 (fr) 1987-07-17

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8301790A Expired FR2521009B1 (fr) 1982-02-05 1983-02-04 Solutions stabilisees d'insuline et procede pour la preparation de celles-ci

Country Status (22)

Country Link
US (1) US4476118A (fr)
JP (1) JPS58192818A (fr)
AT (1) AT382780B (fr)
AU (1) AU549981B2 (fr)
BE (1) BE895832A (fr)
CA (1) CA1203476A (fr)
CH (1) CH657530A5 (fr)
DE (1) DE3303860A1 (fr)
ES (1) ES8500060A1 (fr)
FI (1) FI78616C (fr)
FR (1) FR2521009B1 (fr)
GB (1) GB2114573B (fr)
GR (1) GR77388B (fr)
IE (1) IE54548B1 (fr)
IT (1) IT1178455B (fr)
LU (1) LU84632A1 (fr)
NL (1) NL187269C (fr)
NO (1) NO161204C (fr)
NZ (1) NZ203189A (fr)
PT (1) PT76195B (fr)
SE (1) SE460948B (fr)
ZA (1) ZA83742B (fr)

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DE3576120D1 (de) * 1984-06-09 1990-04-05 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
AU7678196A (en) * 1995-11-13 1997-06-05 Minimed, Inc. Methods and compositions for the delivery of monomeric proteins
US6733746B2 (en) * 1996-03-12 2004-05-11 Invitrogen Corporation Hematopoietic cell culture nutrient supplement
ATE264871T1 (de) * 1996-07-26 2004-05-15 Aventis Pharma Gmbh Insulinderivate mit erhöhter zinkbindung
DK1283051T3 (da) * 1997-06-13 2006-10-16 Lilly Co Eli Stabile insulinformuleringer
ZA984697B (en) * 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
AU1375199A (en) * 1997-11-12 1999-05-31 Alza Corporation Method for decreasing self-association of polypeptides
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
IL142011A0 (en) * 1998-10-16 2002-03-10 Novo Nordisk As Stable concentrated insulin preparations for pulmonary delivery
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
AU4935701A (en) * 2000-03-24 2001-10-08 Genentech Inc Use of insulin for the treatment of cartilagenous disorders
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
AU2003236201A1 (en) 2002-05-07 2003-11-11 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
WO2004056347A2 (fr) * 2002-12-20 2004-07-08 Novo Nordisk A/S Compositions d'insuline stabilisees
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
WO2004096266A1 (fr) * 2003-05-02 2004-11-11 Novo Nordisk A/S Stabilite physique amelioree de preparations d'insuline
EP2107069B1 (fr) * 2003-08-05 2013-01-16 Novo Nordisk A/S Nouveaux dérivés d'insuline
NZ553263A (en) 2004-07-19 2010-06-25 Biocon Ltd Insulin-oligomer conjugates, formulations and uses thereof
ES2371361T3 (es) * 2005-12-28 2011-12-30 Novo Nordisk A/S Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
EP3050568B1 (fr) 2007-03-13 2020-12-02 JDS Therapeutics, LLC Procédés et compositions pour la libération prolongée de chrome
JP5552046B2 (ja) * 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
WO2009002867A2 (fr) 2007-06-26 2008-12-31 Nutrition 21, Inc. Forme posologique à unités multiples contenant un agent thérapeutique en combinaison avec un complément alimentaire
US8937042B2 (en) 2007-11-16 2015-01-20 Novo Nordisk A/S Pharmaceutical compositions comprising GLP-1 peptides or extendin-4 and a basal insulin peptide
EP2341940A1 (fr) * 2008-07-16 2011-07-13 Arecor Limited Stabilisation des proteines
EP2328607A1 (fr) * 2008-07-16 2011-06-08 Arecor Limited Formulation stable d'une protéine thérapeutique
US9603904B2 (en) * 2008-10-30 2017-03-28 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
CN103702672B (zh) 2011-03-01 2016-04-27 Jds治疗有限公司 用于预防和治疗糖尿病、低血糖症及相关病症的胰岛素和铬组合物
KR20150082640A (ko) 2012-11-13 2015-07-15 아도시아 치환된 음이온성 화합물을 포함하는 속효성 인슐린 제형
JP6111475B2 (ja) * 2012-12-19 2017-04-12 ウォックハート リミテッド ヒトインスリン又はその類似体もしくは誘導体を含む安定な水性組成物
AU2013368990B2 (en) 2012-12-26 2017-05-18 Wockhardt Limited Pharmaceutical composition
TWI780236B (zh) * 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
EP2991672A1 (fr) 2013-04-30 2016-03-09 Novo Nordisk A/S Schéma d'administration d'un nouveau type
US9822158B2 (en) * 2013-12-04 2017-11-21 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
AR102869A1 (es) 2014-12-16 2017-03-29 Lilly Co Eli Composiciones de insulina de rápida acción
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
GB2564295A (en) 2016-02-11 2019-01-09 Nutrition 21 Llc Chromium containing compositions for improving health and fitness
CN109803639B (zh) * 2016-09-29 2024-01-02 艾瑞克有限公司 新制剂
IL270975B2 (en) 2017-06-01 2024-02-01 Lilly Co Eli Fast-acting insulin preparations
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
WO1983003054A1 (fr) * 1982-03-03 1983-09-15 Johansen, Kristian, Betton Procede de production d'une preparation d'insuline

Also Published As

Publication number Publication date
LU84632A1 (fr) 1983-09-08
SE8300598L (sv) 1983-08-06
CA1203476A (fr) 1986-04-22
ZA83742B (en) 1983-11-30
ES519533A0 (es) 1984-10-16
NO161204B (no) 1989-04-10
AU549981B2 (en) 1986-02-20
FI830375A0 (fi) 1983-02-03
PT76195B (en) 1986-01-27
NZ203189A (en) 1985-07-31
IE830220L (en) 1983-08-05
SE8300598D0 (sv) 1983-02-04
NL187269C (nl) 1991-08-01
GB2114573A (en) 1983-08-24
DE3303860A1 (de) 1983-08-18
US4476118A (en) 1984-10-09
GB2114573B (en) 1985-05-01
GB8303133D0 (en) 1983-03-09
NL187269B (nl) 1991-03-01
ATA38983A (de) 1986-09-15
IT1178455B (it) 1987-09-09
IE54548B1 (en) 1989-11-08
SE460948B (sv) 1989-12-11
JPS58192818A (ja) 1983-11-10
NO830385L (no) 1983-08-08
AT382780B (de) 1987-04-10
GR77388B (fr) 1984-09-11
DE3303860C2 (fr) 1989-12-28
FI830375L (fi) 1983-08-06
ES8500060A1 (es) 1984-10-16
FI78616B (fi) 1989-05-31
NL8300440A (nl) 1983-09-01
NO161204C (no) 1989-07-19
CH657530A5 (de) 1986-09-15
JPH0367056B2 (fr) 1991-10-21
PT76195A (en) 1983-03-01
AU1113683A (en) 1983-08-11
IT8319420A0 (it) 1983-02-04
FR2521009A1 (fr) 1983-08-12
BE895832A (fr) 1983-08-04
FI78616C (fi) 1989-09-11

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