CH648856A5 - Soft-steroide mit anti-inflammatorischer aktivitaet. - Google Patents

Soft-steroide mit anti-inflammatorischer aktivitaet. Download PDF

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Publication number
CH648856A5
CH648856A5 CH4497/81A CH449781A CH648856A5 CH 648856 A5 CH648856 A5 CH 648856A5 CH 4497/81 A CH4497/81 A CH 4497/81A CH 449781 A CH449781 A CH 449781A CH 648856 A5 CH648856 A5 CH 648856A5
Authority
CH
Switzerland
Prior art keywords
alkyl
hydroxy
carboxylate
chloromethyl
formula
Prior art date
Application number
CH4497/81A
Other languages
German (de)
English (en)
Inventor
Nicholas Stephen Bodor
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of CH648856A5 publication Critical patent/CH648856A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH4497/81A 1980-07-10 1981-07-08 Soft-steroide mit anti-inflammatorischer aktivitaet. CH648856A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16845380A 1980-07-10 1980-07-10
US26578581A 1981-05-21 1981-05-21

Publications (1)

Publication Number Publication Date
CH648856A5 true CH648856A5 (de) 1985-04-15

Family

ID=26864131

Family Applications (1)

Application Number Title Priority Date Filing Date
CH4497/81A CH648856A5 (de) 1980-07-10 1981-07-08 Soft-steroide mit anti-inflammatorischer aktivitaet.

Country Status (17)

Country Link
KR (2) KR860000266B1 (nl)
AT (1) AT379816B (nl)
AU (1) AU540898B2 (nl)
CA (1) CA1174667A (nl)
CH (1) CH648856A5 (nl)
DE (1) DE3126732C2 (nl)
DK (1) DK165837C (nl)
ES (2) ES8300785A1 (nl)
FI (1) FI71748C (nl)
FR (1) FR2486529A1 (nl)
GB (1) GB2079755B (nl)
IT (1) IT1205446B (nl)
NL (1) NL192343C (nl)
NO (1) NO163285C (nl)
PH (1) PH25874A (nl)
PT (1) PT73348B (nl)
SE (1) SE449106B (nl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
JPS6041607A (ja) * 1983-08-12 1985-03-05 Otsuka Pharmaceut Co Ltd 軟膏基剤
SE8501693D0 (sv) * 1985-04-04 1985-04-04 Draco Ab Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
ATE90355T1 (de) * 1987-10-13 1993-06-15 Nicholas S Bodor Weiche steroide mit anti-entzuendungswirkung.
DE4025342A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel
WO1999001467A2 (en) * 1997-06-30 1999-01-14 Glaxo Group Limited Therapeutically active compounds with low systemic activity due to reduce half life
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
CA2417825C (en) 2000-08-05 2008-07-22 Glaxo Group Limited 6.alpha., 9.alpha.-difluoro-17.alpha.-`(2-furanylcarboxyl)oxy!-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid s-fluoromethyl ester as an anti-inflammatory agent
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
UA82323C2 (uk) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань
GB0316290D0 (en) 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
EP1841780B1 (en) 2005-01-10 2011-07-27 Glaxo Group Limited Androstane 17-alpha-carbonate derivatives for use in the treatment of allergic and inflammatory conditions
TWI374147B (en) * 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones
US7691811B2 (en) * 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity
CN101942001B (zh) * 2010-08-24 2013-02-06 山东省医药工业研究所 一种氯替泼诺的提纯方法
CN103183714A (zh) * 2011-12-29 2013-07-03 山东方明药业集团股份有限公司 一种氯替泼诺的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
IT1114534B (it) * 1978-02-08 1986-01-27 Glaxo Group Ltd Steroide anti-infiammatorio della serie dell'androstano composizioni che lo contengono e procedimento per produrlo
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung

Also Published As

Publication number Publication date
ATA307081A (de) 1985-07-15
KR860000266B1 (ko) 1986-03-22
DE3126732A1 (de) 1982-03-25
AU540898B2 (en) 1984-12-06
NO163285B (no) 1990-01-22
DE3126732C2 (de) 1987-04-30
DK302181A (da) 1982-01-11
NL192343B (nl) 1997-02-03
ES8306767A1 (es) 1983-06-16
ES514633A0 (es) 1983-06-16
KR850002759A (ko) 1985-05-15
PT73348A (en) 1981-08-01
SE8104132L (sv) 1982-01-11
DK165837B (da) 1993-01-25
IT8105186A0 (it) 1981-07-09
KR830006327A (ko) 1983-09-24
KR860000452B1 (ko) 1986-04-26
PH25874A (en) 1991-12-02
AU7259181A (en) 1982-01-14
NL8103315A (nl) 1982-02-01
GB2079755B (en) 1985-01-30
IT1205446B (it) 1989-03-23
AT379816B (de) 1986-03-10
CA1174667A (en) 1984-09-18
NL192343C (nl) 1997-06-04
NO812344L (no) 1982-01-11
FI812175L (fi) 1982-01-11
FI71748C (fi) 1987-02-09
NO163285C (no) 1990-05-02
PT73348B (en) 1982-09-23
GB2079755A (en) 1982-01-27
ES504340A0 (es) 1982-12-01
ES8300785A1 (es) 1982-12-01
FR2486529A1 (fr) 1982-01-15
SE449106B (sv) 1987-04-06
DK165837C (da) 1993-06-21
FR2486529B1 (nl) 1985-01-04
FI71748B (fi) 1986-10-31

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Legal Events

Date Code Title Description
PUE Assignment

Owner name: DR. NICHOLAS STEPHEN BODOR

PL Patent ceased