ATE90355T1 - Weiche steroide mit anti-entzuendungswirkung. - Google Patents
Weiche steroide mit anti-entzuendungswirkung.Info
- Publication number
- ATE90355T1 ATE90355T1 AT87907186T AT87907186T ATE90355T1 AT E90355 T1 ATE90355 T1 AT E90355T1 AT 87907186 T AT87907186 T AT 87907186T AT 87907186 T AT87907186 T AT 87907186T AT E90355 T1 ATE90355 T1 AT E90355T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- agents
- inflammatory effects
- hydroxyandrost
- alkoxy
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000007970 thio esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP87907186A EP0334853B1 (de) | 1987-10-13 | 1987-10-13 | Weiche steroide mit anti-entzündungswirkung |
| PCT/US1987/002590 WO1989003390A1 (en) | 1987-10-13 | 1987-10-13 | Soft steroids having anti-inflammatory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE90355T1 true ATE90355T1 (de) | 1993-06-15 |
Family
ID=22202600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87907186T ATE90355T1 (de) | 1987-10-13 | 1987-10-13 | Weiche steroide mit anti-entzuendungswirkung. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0334853B1 (de) |
| AT (1) | ATE90355T1 (de) |
| DE (1) | DE3786174T2 (de) |
| WO (1) | WO1989003390A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4018168A1 (de) * | 1990-06-01 | 1991-12-05 | Schering Ag | Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen |
| PT2348032E (pt) | 2000-08-05 | 2015-10-14 | Glaxo Group Ltd | Éster s-fluorometílico do ácido 6.alfa.,9.alfa.-difluoro- 17.alfa.-'(2-furanilcarboxil)oxi]-11.beta.-hidroxi-16.alfa.- metil-3-oxo-androsta-1,4-dieno-17-carbotióico como um agente anti-inflamatório |
| US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
| CA2445839A1 (en) | 2001-04-30 | 2002-11-07 | Glaxo Group Limited | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha |
| GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| JP2006506445A (ja) * | 2002-08-28 | 2006-02-23 | ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド | 治療処置の方法 |
| GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| AU2004285592B2 (en) * | 2003-11-03 | 2010-02-18 | Norton Healthcare, Ltd. | Soft steroid compositions for use in dry powder inhalers |
| US7579335B2 (en) | 2005-01-10 | 2009-08-25 | Glaxo Group Limited | Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions |
| PT105723B (pt) * | 2011-05-26 | 2014-03-24 | Hovione Farmaci Ncia S A | Método para a preparação de compostos orgânicos biologicamente activos |
| US8900626B2 (en) | 2011-06-20 | 2014-12-02 | Senju Usa, Inc. | Transdermal drug delivery system and method of using the same |
| US20150376225A1 (en) * | 2013-01-23 | 2015-12-31 | Sphaera Pharma Pvtd. Ltd. | Novel compounds of 11beta-hydroxy-steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion |
| JP6781148B2 (ja) | 2014-07-23 | 2020-11-04 | スファエラ ファーマ プライベート リミテッド | ヒドロキシステロイド化合物、それらの中間体、それらの調製方法、組成物および使用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558675A (en) * | 1969-06-30 | 1971-01-26 | Merck & Co Inc | Steroid carbonates and process |
| GB1438940A (en) * | 1972-07-19 | 1976-06-09 | Glaxo Lab Ltd | 17beta-haloalkoxycarbonyl-17alpha-oxysteroids |
| US4093721A (en) * | 1974-08-30 | 1978-06-06 | Glaxo Laboratories Limited | Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof |
| US4263289A (en) * | 1978-04-05 | 1981-04-21 | Syntex (U.S.A.) Inc. | Thio etianic acid derivatives |
| SE449106B (sv) * | 1980-07-10 | 1987-04-06 | Otsuka Pharma Co Ltd | Steroid med anti-inflammatorisk verkan samt komposition innehallande denna |
-
1987
- 1987-10-13 EP EP87907186A patent/EP0334853B1/de not_active Expired - Lifetime
- 1987-10-13 AT AT87907186T patent/ATE90355T1/de not_active IP Right Cessation
- 1987-10-13 WO PCT/US1987/002590 patent/WO1989003390A1/en not_active Ceased
- 1987-10-13 DE DE87907186T patent/DE3786174T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0334853B1 (de) | 1993-06-09 |
| WO1989003390A1 (en) | 1989-04-20 |
| DE3786174D1 (de) | 1993-07-15 |
| DE3786174T2 (de) | 1993-10-21 |
| EP0334853A4 (de) | 1990-02-26 |
| EP0334853A1 (de) | 1989-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |