ES2058561T3 - Esteroides sustituidos con acido fosfonico como inhibidores de la esteroide-5alfa-reductasa. - Google Patents
Esteroides sustituidos con acido fosfonico como inhibidores de la esteroide-5alfa-reductasa.Info
- Publication number
- ES2058561T3 ES2058561T3 ES89313264T ES89313264T ES2058561T3 ES 2058561 T3 ES2058561 T3 ES 2058561T3 ES 89313264 T ES89313264 T ES 89313264T ES 89313264 T ES89313264 T ES 89313264T ES 2058561 T3 ES2058561 T3 ES 2058561T3
- Authority
- ES
- Spain
- Prior art keywords
- reductase
- inhibitors
- 5alpha
- steroid
- phosphonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
COMPONENTES DE ESTRUCTURA (I) EN EL QUE LAS LINEAS DOTADAS INDICAN LA PRESENCIA OPCIONAL DE ENLACES DOBLES E INTER ALIA Z ES (CH2)N DONDE N ES 0-2, R ES H, HIDROXI O ACETOXI, R1 ES H O AUSENTE Y R2 ESTA AUSENTE, H O CH3; PROCESOS PARA SU PREPARACION, COMPOSICIONES QUE LOS CONTIENEN Y SU USO EN MEDICINA COMO INHIBIDORES DE REDUCTASA-A-5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/290,211 US4946834A (en) | 1988-12-23 | 1988-12-23 | Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058561T3 true ES2058561T3 (es) | 1994-11-01 |
Family
ID=23114990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89313264T Expired - Lifetime ES2058561T3 (es) | 1988-12-23 | 1989-12-19 | Esteroides sustituidos con acido fosfonico como inhibidores de la esteroide-5alfa-reductasa. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4946834A (es) |
EP (1) | EP0375351B1 (es) |
JP (1) | JPH02215795A (es) |
AT (1) | ATE110736T1 (es) |
AU (1) | AU631387B2 (es) |
CA (1) | CA2005165A1 (es) |
DE (1) | DE68917885T2 (es) |
DK (1) | DK645289A (es) |
ES (1) | ES2058561T3 (es) |
IE (1) | IE65517B1 (es) |
PT (1) | PT92722A (es) |
ZA (1) | ZA899670B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5026882A (en) * | 1988-12-23 | 1991-06-25 | Smithkline Beecham Corporation | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase |
US4970204A (en) * | 1989-08-23 | 1990-11-13 | Smithkline Beecham Corporation | 3-substituted nitro-steroid derivatives as 5-α-reductase inhibitors |
US5300294A (en) * | 1990-06-27 | 1994-04-05 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
IL104601A0 (en) * | 1992-02-07 | 1993-07-08 | Smithkline Beecham Corp | Process for the preparation of steroidal dienes |
ES2105108T3 (es) * | 1992-04-20 | 1997-10-16 | Sankyo Co | Esteroides para el tratamiento de la hipertrofia prostatica, su preparacion y su utilizacion. |
EP0641211A1 (en) * | 1992-05-21 | 1995-03-08 | Endorecherche Inc. | INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY |
TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
US5637310A (en) * | 1993-12-20 | 1997-06-10 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
EP0754701B1 (en) * | 1994-04-04 | 1998-08-12 | Meiji Milk Products Company Limited | Novel progesterone compound and use thereof |
US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
JP2000309599A (ja) | 1999-04-13 | 2000-11-07 | Kyowa Hakko Kogyo Co Ltd | エストラ−1,3,5(10),16−テトラエン誘導体 |
EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用 |
HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4191759A (en) * | 1978-04-13 | 1980-03-04 | Merck & Co., Inc. | N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors |
US4377584A (en) * | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
US4317817A (en) * | 1979-08-27 | 1982-03-02 | Richardson-Merrell Inc. | Novel steroid 5α-reductase inhibitors |
DK465481A (da) * | 1980-11-21 | 1982-05-22 | Hoffmann La Roche | Fremgangsmaade til fremstilling af d-homostemoider |
CA1252778A (en) * | 1983-08-25 | 1989-04-18 | Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee | Steroids |
US4910226A (en) * | 1987-04-29 | 1990-03-20 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
-
1988
- 1988-12-23 US US07/290,211 patent/US4946834A/en not_active Expired - Fee Related
-
1989
- 1989-12-12 CA CA002005165A patent/CA2005165A1/en not_active Abandoned
- 1989-12-18 ZA ZA899670A patent/ZA899670B/xx unknown
- 1989-12-19 ES ES89313264T patent/ES2058561T3/es not_active Expired - Lifetime
- 1989-12-19 DK DK645289A patent/DK645289A/da not_active Application Discontinuation
- 1989-12-19 DE DE68917885T patent/DE68917885T2/de not_active Expired - Fee Related
- 1989-12-19 AT AT89313264T patent/ATE110736T1/de not_active IP Right Cessation
- 1989-12-19 EP EP89313264A patent/EP0375351B1/en not_active Expired - Lifetime
- 1989-12-20 IE IE411089A patent/IE65517B1/en not_active IP Right Cessation
- 1989-12-20 AU AU47003/89A patent/AU631387B2/en not_active Ceased
- 1989-12-22 PT PT92722A patent/PT92722A/pt not_active Application Discontinuation
- 1989-12-22 JP JP1334671A patent/JPH02215795A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2005165A1 (en) | 1990-06-23 |
AU4700389A (en) | 1990-06-28 |
DK645289A (da) | 1990-06-24 |
IE894110L (en) | 1990-06-23 |
US4946834A (en) | 1990-08-07 |
ATE110736T1 (de) | 1994-09-15 |
ZA899670B (en) | 1990-11-28 |
DK645289D0 (da) | 1989-12-19 |
IE65517B1 (en) | 1995-11-01 |
AU631387B2 (en) | 1992-11-26 |
JPH02215795A (ja) | 1990-08-28 |
PT92722A (pt) | 1990-06-29 |
DE68917885T2 (de) | 1994-12-22 |
EP0375351B1 (en) | 1994-08-31 |
EP0375351A1 (en) | 1990-06-27 |
DE68917885D1 (de) | 1994-10-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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