ZA899670B - Phosphonic acid substituted steroids as steroid 5-alpha-reductase inhibitors - Google Patents

Phosphonic acid substituted steroids as steroid 5-alpha-reductase inhibitors

Info

Publication number
ZA899670B
ZA899670B ZA899670A ZA899670A ZA899670B ZA 899670 B ZA899670 B ZA 899670B ZA 899670 A ZA899670 A ZA 899670A ZA 899670 A ZA899670 A ZA 899670A ZA 899670 B ZA899670 B ZA 899670B
Authority
ZA
South Africa
Prior art keywords
alpha
steroid
phosphonic acid
reductase inhibitors
acid substituted
Prior art date
Application number
ZA899670A
Other languages
English (en)
Inventor
Dennis Alan Holt
Alan Holt Dennis
Mark Alan Levy
Alan Levy Mark
Brian Walter Metcalf
Walter Metcalf Brian
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of ZA899670B publication Critical patent/ZA899670B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA899670A 1988-12-23 1989-12-18 Phosphonic acid substituted steroids as steroid 5-alpha-reductase inhibitors ZA899670B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/290,211 US4946834A (en) 1988-12-23 1988-12-23 Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors

Publications (1)

Publication Number Publication Date
ZA899670B true ZA899670B (en) 1990-11-28

Family

ID=23114990

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA899670A ZA899670B (en) 1988-12-23 1989-12-18 Phosphonic acid substituted steroids as steroid 5-alpha-reductase inhibitors

Country Status (12)

Country Link
US (1) US4946834A (es)
EP (1) EP0375351B1 (es)
JP (1) JPH02215795A (es)
AT (1) ATE110736T1 (es)
AU (1) AU631387B2 (es)
CA (1) CA2005165A1 (es)
DE (1) DE68917885T2 (es)
DK (1) DK645289A (es)
ES (1) ES2058561T3 (es)
IE (1) IE65517B1 (es)
PT (1) PT92722A (es)
ZA (1) ZA899670B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026882A (en) * 1988-12-23 1991-06-25 Smithkline Beecham Corporation Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase
US4970204A (en) * 1989-08-23 1990-11-13 Smithkline Beecham Corporation 3-substituted nitro-steroid derivatives as 5-α-reductase inhibitors
US5300294A (en) * 1990-06-27 1994-04-05 Smithkline Beecham Corporation Method of treating prostatic adenocarcinoma
IL104601A0 (en) * 1992-02-07 1993-07-08 Smithkline Beecham Corp Process for the preparation of steroidal dienes
DE69311837T2 (de) * 1992-04-20 1998-02-12 Sankyo Co Steroide zur Behandlung von Prostatisch-Hypertrophe, ihre Herstellung und Verwendung
CZ286894A3 (en) * 1992-05-21 1995-09-13 Endorecherche Inc Pharmaceutical preparation
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5637310A (en) * 1993-12-20 1997-06-10 Smithkline Beecham Corporation Method of treating prostatic adenocarcinoma
US5693629A (en) * 1994-04-04 1997-12-02 Meiji Milk Products Co., Ltd. Progesterone compound and use thereof
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
ES2347027T3 (es) 1998-05-22 2010-10-22 The Board Of Trustees Of The Leland Stanford Junior University Moleculas bifuncionales y terapias basadas en las mismas.
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
JP5564517B2 (ja) 2009-02-20 2014-07-30 ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ グルタチオンをベースとする薬物送達システム
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191759A (en) * 1978-04-13 1980-03-04 Merck & Co., Inc. N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4317817A (en) * 1979-08-27 1982-03-02 Richardson-Merrell Inc. Novel steroid 5α-reductase inhibitors
DK465481A (da) * 1980-11-21 1982-05-22 Hoffmann La Roche Fremgangsmaade til fremstilling af d-homostemoider
CA1252778A (en) * 1983-08-25 1989-04-18 Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee Steroids
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors

Also Published As

Publication number Publication date
IE894110L (en) 1990-06-23
DK645289D0 (da) 1989-12-19
US4946834A (en) 1990-08-07
DK645289A (da) 1990-06-24
DE68917885D1 (de) 1994-10-06
JPH02215795A (ja) 1990-08-28
ATE110736T1 (de) 1994-09-15
CA2005165A1 (en) 1990-06-23
AU4700389A (en) 1990-06-28
IE65517B1 (en) 1995-11-01
EP0375351A1 (en) 1990-06-27
DE68917885T2 (de) 1994-12-22
EP0375351B1 (en) 1994-08-31
ES2058561T3 (es) 1994-11-01
PT92722A (pt) 1990-06-29
AU631387B2 (en) 1992-11-26

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