ES2067557T3 - Esteroides aromaticos sustituidos con acido fosfinico como inhibidores de la esteroide 5-d-reductasa. - Google Patents
Esteroides aromaticos sustituidos con acido fosfinico como inhibidores de la esteroide 5-d-reductasa.Info
- Publication number
- ES2067557T3 ES2067557T3 ES89313257T ES89313257T ES2067557T3 ES 2067557 T3 ES2067557 T3 ES 2067557T3 ES 89313257 T ES89313257 T ES 89313257T ES 89313257 T ES89313257 T ES 89313257T ES 2067557 T3 ES2067557 T3 ES 2067557T3
- Authority
- ES
- Spain
- Prior art keywords
- reductase
- inhibitors
- steroid
- phosphinic acid
- steroids substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
COMPONENTES DE ESTRUCTURA (I) EN LA QUE LAS LINEAS DOTADAS INDICAN LA PRESENCIA OPCIONAL DE UN DOBLE ENLACE, X1, X2 Y X3 SON H, HALOGENO, CF3, ALQUIL C1-6, ALCOXI C1-6, CN, NO2, N(R1)2, CHO, O CO2R1; R1 ES H O ALQUIL C1-8 Y R ES HIDROGENO, HIDROXI O ACETOXI; PROCESOS PARA SU PREPARACION, COMPOSICIONES QUE LOS CONTIENEN Y SU USO EN MEDICINA COMO INHIBIDORES DE REDUCTASA-A-5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/290,057 US4937237A (en) | 1988-12-23 | 1988-12-23 | Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2067557T3 true ES2067557T3 (es) | 1995-04-01 |
Family
ID=23114364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89313257T Expired - Lifetime ES2067557T3 (es) | 1988-12-23 | 1989-12-19 | Esteroides aromaticos sustituidos con acido fosfinico como inhibidores de la esteroide 5-d-reductasa. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4937237A (es) |
EP (1) | EP0375344B1 (es) |
JP (1) | JPH02225496A (es) |
AT (1) | ATE118505T1 (es) |
AU (1) | AU631388B2 (es) |
CA (1) | CA2004945A1 (es) |
DE (1) | DE68921174T2 (es) |
DK (1) | DK644989A (es) |
ES (1) | ES2067557T3 (es) |
IE (1) | IE894109L (es) |
PT (1) | PT92721A (es) |
ZA (1) | ZA899674B (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571817A (en) * | 1984-02-27 | 1996-11-05 | Merck & Co., Inc. | Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones] |
US5138063A (en) * | 1984-02-27 | 1992-08-11 | Merck & Co., Inc. | 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones |
US4882319A (en) * | 1988-12-23 | 1989-11-21 | Smithkline Beckman Corporation | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase |
US5026882A (en) * | 1988-12-23 | 1991-06-25 | Smithkline Beecham Corporation | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase |
US5098908A (en) * | 1990-06-20 | 1992-03-24 | Merck & Co., Inc. | 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors |
US5162332A (en) * | 1990-06-20 | 1992-11-10 | Merck & Co., Inc. | Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors |
US5151430A (en) * | 1990-06-20 | 1992-09-29 | Merck & Co., Inc. | Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents |
US5061802A (en) * | 1990-06-20 | 1991-10-29 | Merck & Co. Inc. | 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents |
US5300294A (en) * | 1990-06-27 | 1994-04-05 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
US5091380A (en) * | 1990-06-28 | 1992-02-25 | Merck & Co., Inc. | N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors |
NZ241979A (en) * | 1991-03-20 | 1996-01-26 | Merck & Co Inc | Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker |
GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
US6476011B1 (en) | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
GB9118465D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
US6903084B2 (en) | 1991-08-29 | 2005-06-07 | Sterix Limited | Steroid sulphatase inhibitors |
CA2126203A1 (en) * | 1991-12-20 | 1993-07-08 | Stephen V. Frye | Inhibitors of 5-alpha-testosterone reductase |
IL104303A0 (en) * | 1992-01-06 | 1993-05-13 | Smithkline Beecham Corp | Process |
CA2135055A1 (en) * | 1992-05-20 | 1993-11-25 | Bruce E. Witzel | 4-azasteroid 5-alpha-reductase inhibitors |
RU94046044A (ru) * | 1992-05-20 | 1996-10-10 | Мерк Энд Ко. | Новые 7 бета -замещенные 4-аза- 5 альфа -холестан-оны в качестве ингибиторов 5 альфа -редуктазы, фармацевтическая композиция на их основе, способ ее получения |
US5536727A (en) * | 1992-05-20 | 1996-07-16 | Merck & Co., Inc. | 17-Ethers and thioethers of 4-aza-steroids |
US5237064A (en) * | 1992-05-20 | 1993-08-17 | Merck & Co., Inc. | Process for producing 7β-substituted-aza-5αandrostan-3-ones |
WO1993023041A1 (en) * | 1992-05-20 | 1993-11-25 | Merck & Co., Inc. | Ester derivatives of 4-aza-steroids |
US5639741A (en) * | 1992-05-20 | 1997-06-17 | Merck & Co., Inc. | 17-amino substituted 4-azasteroid 5α-reductase inhibitors |
EP0641211A1 (en) * | 1992-05-21 | 1995-03-08 | Endorecherche Inc. | INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY |
JPH0641038A (ja) | 1992-07-17 | 1994-02-15 | Mitsubishi Kasei Corp | カルボン酸誘導体 |
US5302589A (en) * | 1992-08-07 | 1994-04-12 | Glaxo, Inc. | Heterocyclic inhibitors of 5-α-testosterone reductase |
US5324734A (en) * | 1992-09-15 | 1994-06-28 | Merck & Co., Inc. | Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione |
US5278159A (en) * | 1992-10-06 | 1994-01-11 | Merck & Co., Inc. | Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors |
US5359071A (en) * | 1993-03-12 | 1994-10-25 | Merck & Co., Inc. | 15-substituted 4-azasteroids |
WO1994021614A1 (en) * | 1993-03-24 | 1994-09-29 | Merck & Co., Inc. | SUBSTITUTED 3-PHENANTHRIDINONE DERIVATIVES AS 5α-REDUCTASE INHIBITORS |
ATE158301T1 (de) * | 1993-06-28 | 1997-10-15 | Merck & Co Inc | 4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren |
TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
US5637310A (en) * | 1993-12-20 | 1997-06-10 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
US20040127473A1 (en) * | 1996-12-05 | 2004-07-01 | Reed Michael John | Compound |
US6642220B1 (en) | 1996-12-05 | 2003-11-04 | Sterix Limited | Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same |
CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
US7335650B2 (en) * | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
WO2001066562A1 (fr) * | 2000-03-08 | 2001-09-13 | Kuraray Co., Ltd. | Derives steroides et leur procede de fabrication |
US7435757B2 (en) * | 2004-07-02 | 2008-10-14 | Schering Ag | 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 |
EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用 |
HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2919970A (en) * | 1955-05-09 | 1960-01-05 | Owens Corning Fiberglass Corp | Method for attenuating and treating glass fibers |
BE755899A (fr) * | 1969-09-15 | 1971-03-09 | Ici Ltd | Ameliorations a la production de fibres de verre |
CA1049498A (en) * | 1973-11-29 | 1979-02-27 | Gunther Kruger | Steroid compounds and processes therefor |
US4377584A (en) * | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
US4191759A (en) * | 1978-04-13 | 1980-03-04 | Merck & Co., Inc. | N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors |
US4179453A (en) * | 1978-04-13 | 1979-12-18 | Merck & Co., Inc. | Process for preparing 17β-carboxy-5-androsten-3-ones |
AU534679B2 (en) * | 1979-03-15 | 1984-02-09 | Commonwealth Scientific And Industrial Research Organisation | Steroid immunogens |
US4246299A (en) * | 1979-06-07 | 1981-01-20 | Corning Glass Works | Method of coating optical waveguide filaments |
US4317817A (en) * | 1979-08-27 | 1982-03-02 | Richardson-Merrell Inc. | Novel steroid 5α-reductase inhibitors |
DK465481A (da) * | 1980-11-21 | 1982-05-22 | Hoffmann La Roche | Fremgangsmaade til fremstilling af d-homostemoider |
JPS5953417A (ja) * | 1982-09-21 | 1984-03-28 | Shiseido Co Ltd | 皮膚外用剤 |
JPS60116657A (ja) * | 1983-11-30 | 1985-06-24 | Ono Pharmaceut Co Ltd | アニリン誘導体 |
JPS60142941A (ja) * | 1983-12-28 | 1985-07-29 | Ono Pharmaceut Co Ltd | ケトン化合物 |
JPS60146885A (ja) * | 1984-01-06 | 1985-08-02 | Mitsubishi Petrochem Co Ltd | フルフリルアミン及び/又はテトラヒドロフルフリルアミンの製造法 |
CA1261835A (en) * | 1984-08-20 | 1989-09-26 | Masaaki Toda | (fused) benz(thio)amides |
US4910226A (en) * | 1987-04-29 | 1990-03-20 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
-
1988
- 1988-12-23 US US07/290,057 patent/US4937237A/en not_active Expired - Fee Related
-
1989
- 1989-12-08 CA CA002004945A patent/CA2004945A1/en not_active Abandoned
- 1989-12-18 ZA ZA899674A patent/ZA899674B/xx unknown
- 1989-12-19 AT AT89313257T patent/ATE118505T1/de not_active IP Right Cessation
- 1989-12-19 DK DK644989A patent/DK644989A/da not_active Application Discontinuation
- 1989-12-19 EP EP89313257A patent/EP0375344B1/en not_active Expired - Lifetime
- 1989-12-19 DE DE68921174T patent/DE68921174T2/de not_active Expired - Fee Related
- 1989-12-19 ES ES89313257T patent/ES2067557T3/es not_active Expired - Lifetime
- 1989-12-20 AU AU47004/89A patent/AU631388B2/en not_active Ceased
- 1989-12-20 IE IE894109A patent/IE894109L/xx unknown
- 1989-12-20 JP JP1330928A patent/JPH02225496A/ja active Pending
- 1989-12-22 PT PT92721A patent/PT92721A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0375344B1 (en) | 1995-02-15 |
JPH02225496A (ja) | 1990-09-07 |
IE894109L (en) | 1990-06-23 |
DE68921174T2 (de) | 1995-06-29 |
ZA899674B (en) | 1990-11-28 |
AU4700489A (en) | 1990-06-28 |
DE68921174D1 (de) | 1995-03-23 |
AU631388B2 (en) | 1992-11-26 |
ATE118505T1 (de) | 1995-03-15 |
PT92721A (pt) | 1990-06-29 |
CA2004945A1 (en) | 1990-06-23 |
DK644989D0 (da) | 1989-12-19 |
US4937237A (en) | 1990-06-26 |
DK644989A (da) | 1990-06-24 |
EP0375344A1 (en) | 1990-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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