CH637388A5 - Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner ester sowie verfahren zur herstellung dieser komplexe. - Google Patents

Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner ester sowie verfahren zur herstellung dieser komplexe. Download PDF

Info

Publication number
CH637388A5
CH637388A5 CH995078A CH995078A CH637388A5 CH 637388 A5 CH637388 A5 CH 637388A5 CH 995078 A CH995078 A CH 995078A CH 995078 A CH995078 A CH 995078A CH 637388 A5 CH637388 A5 CH 637388A5
Authority
CH
Switzerland
Prior art keywords
prostacyclin
cyclodextrin
esters
solution
formula
Prior art date
Application number
CH995078A
Other languages
German (de)
English (en)
Inventor
Jozsef Dr Szejtli
Magdolna Dr Szejtli-Rengei
Gyoergy Dr Cseh
Istvan Dr Stadler
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of CH637388A5 publication Critical patent/CH637388A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CH995078A 1977-09-23 1978-09-22 Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner ester sowie verfahren zur herstellung dieser komplexe. CH637388A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1770A HU179141B (pl) 1977-09-23 1977-09-23

Publications (1)

Publication Number Publication Date
CH637388A5 true CH637388A5 (de) 1983-07-29

Family

ID=10994670

Family Applications (1)

Application Number Title Priority Date Filing Date
CH995078A CH637388A5 (de) 1977-09-23 1978-09-22 Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner ester sowie verfahren zur herstellung dieser komplexe.

Country Status (20)

Country Link
JP (1) JPS5456685A (pl)
AT (1) AT369362B (pl)
BE (1) BE870646A (pl)
CH (1) CH637388A5 (pl)
CS (1) CS200242B2 (pl)
DD (1) DD138600A5 (pl)
DE (1) DE2840142A1 (pl)
DK (1) DK420778A (pl)
FI (1) FI65912C (pl)
FR (1) FR2404006A1 (pl)
GB (1) GB2006193B (pl)
GR (1) GR65001B (pl)
HU (1) HU179141B (pl)
IL (1) IL55569A (pl)
IT (1) IT1160661B (pl)
NL (1) NL7809643A (pl)
PL (1) PL121664B1 (pl)
SE (1) SE447574B (pl)
SU (1) SU847914A3 (pl)
YU (1) YU220678A (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds
US4352793A (en) * 1979-04-26 1982-10-05 Sumitomo Chemical Company, Limited Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin
JPS5920230A (ja) * 1982-07-19 1984-02-01 チバ−ガイギ−・アクチエンゲゼルシヤフト ピルプロフエン含有薬剤
JPS61289034A (ja) * 1985-06-17 1986-12-19 Teijin Ltd イソカルバサイクリン類脂肪乳剤
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
DE3740838A1 (de) * 1987-11-27 1989-06-08 Schering Ag Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
JPWO2005073223A1 (ja) * 2004-01-29 2007-09-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 マクロライド系化合物の安定化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS503362B1 (pl) * 1970-06-10 1975-02-04
US3953435A (en) * 1974-01-10 1976-04-27 Ono Pharmaceutical Company Aldehyde derivatives of prostaglandins
JPS5395958A (en) * 1977-01-31 1978-08-22 Ono Pharmaceut Co Ltd Prostaglandin analogues and process for their preparation
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds

Also Published As

Publication number Publication date
SE7809946L (sv) 1979-03-24
PL209773A1 (pl) 1979-06-04
PL121664B1 (en) 1982-05-31
SE447574B (sv) 1986-11-24
DE2840142A1 (de) 1979-04-05
IT7869160A0 (it) 1978-09-19
FI782878A (fi) 1979-03-24
FR2404006B1 (pl) 1981-07-31
AT369362B (de) 1982-12-27
JPS5456685A (en) 1979-05-07
HU179141B (pl) 1982-08-28
GB2006193A (en) 1979-05-02
SU847914A3 (ru) 1981-07-15
CS200242B2 (en) 1980-08-29
DD138600A5 (de) 1979-11-14
DK420778A (da) 1979-03-24
GR65001B (en) 1980-06-12
FI65912B (fi) 1984-04-30
BE870646A (fr) 1979-01-15
IT1160661B (it) 1987-03-11
NL7809643A (nl) 1979-03-27
YU220678A (en) 1983-10-31
IL55569A0 (en) 1978-12-17
FI65912C (fi) 1984-08-10
ATA677478A (de) 1982-05-15
GB2006193B (en) 1982-05-26
FR2404006A1 (fr) 1979-04-20
IL55569A (en) 1981-12-31

Similar Documents

Publication Publication Date Title
DE68910138T2 (de) Fumagillin als angiostatisches Mittel.
DE2128674C2 (de) Clathratverbindungen von Prostaglandinen oder ihren Analogen mit Cyclodextrin, Verfahren zu deren Herstellung und diese Clathratverbindungen enthaltende pharmazeutische Zubereitungen
DE69722615T2 (de) Zusammensetzungen die ein anti-pilz agens und ein acetat-puffer enthalten
WO1987005294A1 (en) Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs
DE68906762T2 (de) Prostaglandin-Polysaccharid-Konjugat.
EP0716648B1 (de) Neue 9-chlor-prostaglandin-derivate
DE2819447A1 (de) Prostaglandin-analoge enthaltende praeparate
DE2948869A1 (de) Die mit cyclodextrin gebildeten einschlusskomplexe des allycins sowie verfahren zur herstellung dieser komplexe und diese enthaltende arzneimittelpraeparate
CH637388A5 (de) Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner ester sowie verfahren zur herstellung dieser komplexe.
US4623641A (en) Method of treating ulcers and erosions in the gastrointestinal system using PGI2 -methyl ester-beta cyclodextrin inclusion complexes
DE2515001C2 (de) Prostaglandin enthaltende gefriergetrocknete Pulver
DE2720999C2 (de) Postacyclin (bzw. (5Z)-5,6-Didehydro-9-desoxy-6,9α-epoxyprostaglandin F↓1↓↓α↓), Verfahren zu dessen Herstellung und diese Verbindung enthaltende pharmazeutische Formulierungen
DE68906193T2 (de) Hypersphyxia verursachende zusammensetzung.
DD208549A5 (de) Verfahren zur herstellung mit gamma-cyclodextrin gebildete einschlusskomplexe von steroidverbindungen
DE2353797A1 (de) Stabilisierung von prostaglandinen
DE2604481A1 (de) Waessrige loesung eines polysaccharids
DE2719690A1 (de) Stabilisierte prostaglandinzubereitung und verfahren zur herstellung derselben
AT396687B (de) Cyclodextrinclathrate von 5-cyanoprostacyclinderivaten und ihre verwendung als arzneimittel
EP0243369A1 (de) 9-halogenprostaglandin-clathrate und ihre verwendung als arzneimittel.
EP0116358B1 (de) Komplexe von Prostaglandinen
US4937265A (en) Antidiabetic method comprising 7-thiaprostaglandin E1 or its derivatives
JPH07157431A (ja) 安定なプロスタグランジンe製剤
DE2535343C2 (de) 2-(6'-Carboxy-n-hexyl)-3-n-hexyl-cyclopentanole und -derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
EP0719286B1 (de) Dextranester, verfahren zu ihrer herstellung und ihre verwendung zur umhüllung oder einbettung von arzneimitteln
US2850426A (en) Anthelmintic piperazine-phosphoric acid compositions and method of combatting helminth infestations therewith

Legal Events

Date Code Title Description
PL Patent ceased