CH623820A5 - Process for the preparation of 1-(benzazolylalkyl)piperidine derivatives - Google Patents

Process for the preparation of 1-(benzazolylalkyl)piperidine derivatives Download PDF

Info

Publication number
CH623820A5
CH623820A5 CH929176A CH929176A CH623820A5 CH 623820 A5 CH623820 A5 CH 623820A5 CH 929176 A CH929176 A CH 929176A CH 929176 A CH929176 A CH 929176A CH 623820 A5 CH623820 A5 CH 623820A5
Authority
CH
Switzerland
Prior art keywords
formula
dihydro
parts
benzimidazol
compounds
Prior art date
Application number
CH929176A
Other languages
German (de)
English (en)
Inventor
Jan Vandenberk
Ludo E J Kennis
Marcel J M C Van Der Aa
Albert H M Th Van Heertum
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/687,139 external-priority patent/US4066772A/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CH623820A5 publication Critical patent/CH623820A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH929176A 1975-07-21 1976-07-20 Process for the preparation of 1-(benzazolylalkyl)piperidine derivatives CH623820A5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59779375A 1975-07-21 1975-07-21
US05/687,139 US4066772A (en) 1975-07-21 1976-05-17 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
KR7601697A KR810000334B1 (ko) 1975-07-21 1976-07-12 1-(벤즈 아조릴알킬) 피페리딘 유도체의 제조방법

Publications (1)

Publication Number Publication Date
CH623820A5 true CH623820A5 (en) 1981-06-30

Family

ID=27348142

Family Applications (1)

Application Number Title Priority Date Filing Date
CH929176A CH623820A5 (en) 1975-07-21 1976-07-20 Process for the preparation of 1-(benzazolylalkyl)piperidine derivatives

Country Status (25)

Country Link
JP (1) JPS5217475A (xx)
AT (1) AT364358B (xx)
AU (1) AU511027B2 (xx)
BG (1) BG26526A3 (xx)
CA (1) CA1085852A (xx)
CH (1) CH623820A5 (xx)
CS (1) CS202550B2 (xx)
DE (1) DE2632870A1 (xx)
DK (1) DK154950C (xx)
ES (3) ES449740A1 (xx)
FI (1) FI62667C (xx)
GB (1) GB1542514A (xx)
HK (1) HK14180A (xx)
IE (1) IE43496B1 (xx)
IT (1) IT1062614B (xx)
KE (1) KE3215A (xx)
LU (1) LU75354A1 (xx)
MY (1) MY8100017A (xx)
NL (1) NL187442C (xx)
NZ (1) NZ181256A (xx)
PH (1) PH13710A (xx)
PT (1) PT65387B (xx)
RO (1) RO70566A (xx)
SE (2) SE426490B (xx)
YU (1) YU39969B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501749A (en) * 1983-10-31 1985-02-26 Merck & Co., Inc. Peripherally selective dopamine antagonists in the treatment of ocular hypertension
JPS6248684A (ja) * 1985-08-26 1987-03-03 Sumitomo Chem Co Ltd 新規なヨ−ドブチロフエノン誘導体およびその製造法
JPS62251313A (ja) * 1986-04-25 1987-11-02 信越ポリマー株式会社 結束装置
US6355659B1 (en) 1994-07-29 2002-03-12 Laboratorios Del Dr. Esteve, S.A. 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
JO2785B1 (en) 2003-05-27 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinazoline derivatives
US7799772B2 (en) 2003-12-18 2010-09-21 Janssen Pharmaceutica N.V. Pyrido-and pyrimidopyrimidine derivatives as anti-profilerative agents
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
JP2009542778A (ja) 2006-07-13 2009-12-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｍｔｋｉキナゾリン誘導体
EP1997805A1 (en) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
JP5536647B2 (ja) 2007-07-27 2014-07-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピロロピリミジン
EP2433935A1 (en) 2007-08-31 2012-03-28 Purdue Pharma LP Substituted-quinoxaline-type-piperidine compounds and the uses thereof
WO2014102594A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
JP7296185B2 (ja) * 2016-02-04 2023-06-22 シンリックス ファーマ、エルエルシー 重水素化ドンペリドン組成物及び疾患の治療方法
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (xx) * 1962-06-13
BE633914A (xx) * 1962-06-22
US3629267A (en) * 1968-10-28 1971-12-21 Smith Kline French Lab Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione
AU4698672A (en) * 1972-09-22 1972-11-09 Ciba-Geigy Ag Azacycloaliphatic compounds, process for their manufacture and compositions containing them
FR2218100A1 (en) * 1973-02-20 1974-09-13 Janssen Pharmaceutica Nv Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones
US3989707A (en) * 1974-06-21 1976-11-02 Janssen Pharmaceutica N.V. Benzimidazolinone derivatives

Also Published As

Publication number Publication date
BG26526A3 (xx) 1979-04-12
LU75354A1 (xx) 1977-02-28
NL187442B (nl) 1991-05-01
DE2632870C2 (xx) 1989-02-16
NL7608023A (nl) 1977-01-25
CA1085852A (en) 1980-09-16
ES461630A1 (es) 1978-06-16
IE43496L (en) 1977-01-21
IE43496B1 (en) 1981-03-11
PT65387B (en) 1978-06-09
DK154950C (da) 1989-05-29
IT1062614B (it) 1984-10-20
SE426490B (sv) 1983-01-24
NZ181256A (en) 1978-04-28
ES449740A1 (es) 1978-02-16
AU1596476A (en) 1978-01-19
PH13710A (en) 1980-09-09
HK14180A (en) 1980-03-28
AT364358B (de) 1981-10-12
MY8100017A (en) 1981-12-31
RO70566A (ro) 1982-10-11
FI762086A (xx) 1977-01-22
JPS5217475A (en) 1977-02-09
DK327576A (da) 1977-01-22
YU179476A (en) 1983-01-21
JPS6131109B2 (xx) 1986-07-17
ATA534776A (de) 1981-03-15
SE435621B (sv) 1984-10-08
NL187442C (nl) 1991-10-01
SE8008713L (sv) 1980-12-11
ES461631A1 (es) 1978-12-01
YU39969B (en) 1985-06-30
FI62667C (fi) 1983-02-10
KE3215A (en) 1982-07-09
PT65387A (en) 1976-08-01
CS202550B2 (en) 1981-01-30
GB1542514A (en) 1979-03-21
DK154950B (da) 1989-01-09
SE7608265L (sv) 1977-01-22
DE2632870A1 (de) 1977-02-10
FI62667B (fi) 1982-10-29
AU511027B2 (en) 1980-07-24

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PL Patent ceased