CA3221995C - Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer - Google Patents

Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer Download PDF

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Publication number
CA3221995C
CA3221995C CA3221995A CA3221995A CA3221995C CA 3221995 C CA3221995 C CA 3221995C CA 3221995 A CA3221995 A CA 3221995A CA 3221995 A CA3221995 A CA 3221995A CA 3221995 C CA3221995 C CA 3221995C
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cells
cancer
tumor
antigen
human
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French (fr)
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CA3221995A1 (en
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Gregory P. CHANG
Ann F. CHEUNG
William Haney
Asya Grinberg
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Dragonfly Therapeutics Inc
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Dragonfly Therapeutics Inc
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
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  • Urology & Nephrology (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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CA3221995A 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer Active CA3221995C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762456535P 2017-02-08 2017-02-08
US62/456,535 2017-02-08
CA3053010A CA3053010A1 (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

Related Parent Applications (1)

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CA3053010A Division CA3053010A1 (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

Publications (2)

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CA3221995A1 CA3221995A1 (en) 2018-08-16
CA3221995C true CA3221995C (en) 2024-05-28

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CA3221995A Active CA3221995C (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
CA3053010A Pending CA3053010A1 (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

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US (2) US11834506B2 (cg-RX-API-DMAC7.html)
EP (2) EP4491234A3 (cg-RX-API-DMAC7.html)
JP (3) JP2020506971A (cg-RX-API-DMAC7.html)
KR (3) KR20240023449A (cg-RX-API-DMAC7.html)
CN (1) CN110944651A (cg-RX-API-DMAC7.html)
AU (1) AU2018219887B2 (cg-RX-API-DMAC7.html)
CA (2) CA3221995C (cg-RX-API-DMAC7.html)
DK (1) DK3579848T3 (cg-RX-API-DMAC7.html)
ES (1) ES3005783T3 (cg-RX-API-DMAC7.html)
FI (1) FI3579848T3 (cg-RX-API-DMAC7.html)
IL (1) IL268554B2 (cg-RX-API-DMAC7.html)
MX (1) MX2019009468A (cg-RX-API-DMAC7.html)
PT (1) PT3579848T (cg-RX-API-DMAC7.html)
RS (1) RS66445B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201907299XA (cg-RX-API-DMAC7.html)
WO (1) WO2018148445A1 (cg-RX-API-DMAC7.html)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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CA3221995C (en) * 2017-02-08 2024-05-28 Dragonfly Therapeutics, Inc. Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
US20190375838A1 (en) * 2017-02-10 2019-12-12 Dragonfly Therapeutics, Inc. Proteins binding bcma, nkg2d and cd16
SG11201907646YA (en) * 2017-02-20 2019-09-27 Dragonfly Therapeutics Inc Proteins binding her2, nkg2d and cd16
SG11201907638QA (en) * 2017-02-20 2019-09-27 Dragonfly Therapeutics Inc Proteins binding cd33, nkg2d and cd16
SG11201907648XA (en) * 2017-02-20 2019-09-27 Dragonfly Therapeutics Inc Proteins binding gd2, nkg2d and cd16
AU2018224319B2 (en) * 2017-02-27 2024-04-04 Dragonfly Therapeutics, Inc. Multispecific binding proteins targeting CEA
MX2019014000A (es) * 2017-05-23 2020-07-29 Dragonfly Therapeutics Inc Una proteína que se une a nkg2d, cd16 y un antígeno asociado a un tumor.
BR112019024620A2 (pt) * 2017-05-23 2020-06-23 Dragonfly Therapeutics, Inc. Ligante de proteína nkg2d, cd16 e antígeno associado a tumor
US20200277383A1 (en) * 2017-09-07 2020-09-03 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and a tumor-associated antigen
PT3749346T (pt) 2018-02-08 2024-09-05 Dragonfly Therapeutics Inc Combinações de domínios variáveis de anticorpos dirigidas ao receptor nkg2d
KR20200118824A (ko) 2018-02-08 2020-10-16 드래곤플라이 쎄라퓨틱스, 인크. 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법
CA3091424A1 (en) * 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
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