CA3102404A1 - Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease - Google Patents

Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease Download PDF

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Publication number
CA3102404A1
CA3102404A1 CA3102404A CA3102404A CA3102404A1 CA 3102404 A1 CA3102404 A1 CA 3102404A1 CA 3102404 A CA3102404 A CA 3102404A CA 3102404 A CA3102404 A CA 3102404A CA 3102404 A1 CA3102404 A1 CA 3102404A1
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CA
Canada
Prior art keywords
acylated
ketone body
active agent
group containing
fatty acid
Prior art date
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Pending
Application number
CA3102404A
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English (en)
French (fr)
Inventor
Steven John Taylor
John Robert Proudfoot
Mi-Jeong Kim
Kathleen NUDEL
Timothy F. Briggs
Afrand KAMALI SARVESTANI
Leonard Buckbinder
Bernard LANTER
Ferdinand Edward MASSARI
Koji Yasuda
Spencer Cory PECK
Cheri SNEDEKER
Diana LE
Jessica ALEXANDER
Anna LIANG
Dinara GUNASEKERA
David Arthur Berry
John Patrick CASEY, Jr.
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Flagship Pioneering Innovations V Inc
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Flagship Pioneering Innovations V Inc
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Publication date
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Publication of CA3102404A1 publication Critical patent/CA3102404A1/en
Pending legal-status Critical Current

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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019236772A1 (en) 2018-06-05 2019-12-12 Flagship Pioneering Innovations V, Inc. Acylated active agents and methods of their use for the treatment of autoimmune disorders
AU2019282691A1 (en) 2018-06-05 2020-12-24 Flagship Pioneering Innovations V, Inc. Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease
EP3836971A4 (en) 2018-08-13 2022-06-22 Flagship Pioneering Innovations V, Inc. CONJUGATES AND METHODS OF USE THEREOF
CA3163342A1 (en) * 2019-12-05 2021-06-10 Flagship Pioneering Innovations V, Inc. Acylated active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease
JP7737231B2 (ja) * 2020-03-31 2025-09-10 大阪瓦斯株式会社 ジオール化合物およびその重合体ならびにそれらの製造方法
WO2021222702A1 (en) * 2020-05-01 2021-11-04 Flagship Pioneering Innovations V, Inc. Crystalline forms, compositions containing them, and methods of their use
RU2742414C1 (ru) * 2020-06-16 2021-02-05 Владимир Сергеевич Понамарёв Препарат комплексный с гепатопротекторной активностью для крупного рогатого скота
EP4171573A4 (en) * 2020-06-26 2025-04-09 Durect Corporation USE OF OXYGENATED CHOLESTEROL SULFATES FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS, NEURODEGENERATIVE DISEASES AND ADDICTION
JP2024502909A (ja) * 2020-12-24 2024-01-23 アルマルソン、オーン キサントフィル誘導体
WO2022140580A1 (en) * 2020-12-24 2022-06-30 Orn Almarsson Xanthophyll derivatives
CN113244208B (zh) * 2021-05-20 2022-07-12 云南中医药大学 Hpa在制备治疗非酒精性脂肪性肝病药物中的应用
WO2023280750A1 (en) * 2021-07-09 2023-01-12 Dsm Ip Assets B.V. Synthesis of butyrate compounds
WO2024100756A1 (ja) * 2022-11-08 2024-05-16 ミヤリサン製薬株式会社 子宮、卵管および卵巣における炎症の予防および／または治療剤
KR20250107214A (ko) * 2022-11-10 2025-07-11 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 간질환 또는 간장애의 치료 또는 예방 방법
CA3215648C (en) * 2023-04-26 2026-03-31 Cavaleri Health, Inc. Short chain fatty acids & gallates compositions
CN118580213B (zh) * 2024-08-05 2024-10-11 中国农业大学 一种黄酮衍生物及其在制备治疗糖尿病药物中的用途
CN118834192A (zh) * 2024-08-20 2024-10-25 江南大学 一种4'-羟基-3, 5, 7, 3', 5'-五甲氧基黄酮、其酶法生物合成、分离制备方法及降脂活性提升研究

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO87311B (ro) * 1983-10-04 1985-12-01 Nicolaie Oita Medicament cu actiune metabolica complexa si procedeu de obtinere a acestuia
JPS6081127A (ja) 1983-10-13 1985-05-09 Chugai Pharmaceut Co Ltd 食欲抑制剤
US5385938B1 (en) 1986-12-23 1997-07-15 Tristrata Inc Method of using glycolic acid for treating wrinkles
JP3165279B2 (ja) * 1993-03-29 2001-05-14 三井農林株式会社 ３−アシル化カテキンを含有する油溶性抗酸化剤
CN1315473C (zh) 1997-03-17 2007-05-16 英国技术集团国际有限公司 治疗组合物
JPH11199598A (ja) 1998-01-08 1999-07-27 Yokohama Kokusai Bio Kenkyusho:Kk ウルソデオキシコール酸誘導体とその製造法
DE19860698A1 (de) * 1998-12-30 2000-07-06 Hexal Ag Neue pharmazeutische Zusammensetzung
AU7365900A (en) 1999-09-08 2001-04-10 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
JP2002145875A (ja) 2000-11-06 2002-05-22 Fancl Corp キサンチンオキシダーゼ阻害剤
US20040033480A1 (en) 2002-08-15 2004-02-19 Wong Norman C.W. Use of resveratrol to regulate expression of apolipoprotein A1
WO2004105779A2 (en) 2003-05-27 2004-12-09 Cesare Montecucco Green tea and oplyphenol inhibitors of bacterial proteases
DE10335725A1 (de) 2003-08-05 2005-03-03 Bayer Cropscience Gmbh Safener auf Basis aromatisch-aliphatischer Carbonsäuredarivate
CA2538106A1 (en) 2003-09-12 2005-04-21 Mitsui Norin Co., Ltd Antimicrobial compositions comprising modified catechins and methods of use therein
KR100592796B1 (ko) 2004-03-19 2006-06-26 삼아약품 주식회사 녹차카테킨을 유효성분으로 포함하는 고지혈증 예방 및치료제
DE602005002136T2 (de) 2004-04-26 2008-05-21 Dsm Ip Assets B.V. Verfahren zur herstellung von tocopherylacylaten
JP5009619B2 (ja) 2004-07-05 2012-08-22 サントリーホールディングス株式会社 リパーゼ阻害剤
GB0415181D0 (en) 2004-07-06 2004-08-11 School Of Pharmacy The Univers Compounds for use in the treatment of infection
US7544816B2 (en) 2004-08-19 2009-06-09 The Hong Kong Polytechnic University (−)-Epigallocatechin gallate derivatives for inhibiting proteasome
GB0425658D0 (en) 2004-11-22 2004-12-22 Stanford Rook Ltd Immunotherapeutic agent
CA2491763A1 (en) * 2005-01-06 2006-07-06 Tassos P. Anastassiades Blood glucose control with n-acylated glucosamines
JP2006249056A (ja) 2005-03-07 2006-09-21 Mitsui Norin Co Ltd 子宮癌抑制剤
WO2006116535A1 (en) 2005-04-26 2006-11-02 University Of South Florida Green tea polyphenol alpha secretase enhancers and methods of use
ATE455783T1 (de) 2005-07-07 2010-02-15 Aditech Pharma Ag Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung
WO2007021789A1 (en) 2005-08-11 2007-02-22 Medical College Of Georgia Research Institute Modified green tea polyphenol formulations
WO2008132552A2 (en) * 2006-11-01 2008-11-06 Pronova Biopharma Norge As Omega-3 lipid compounds
CN105152983A (zh) * 2007-01-29 2015-12-16 韩诺生物制药株式会社 N,n-二甲基亚氨基二碳亚氨酸二酰胺乙酸盐、其制备方法和包含其的药物组合物
US8026285B2 (en) 2007-09-04 2011-09-27 Bezwada Biomedical, Llc Control release of biologically active compounds from multi-armed oligomers
FR2923717B1 (fr) 2007-11-15 2015-01-16 Caudalie Compositions de derives polyphenoliques stilbeniques et leurs applications pour lutter contre les pathologies et le veillissement des organismes vivants
EP2240017B1 (en) 2008-01-04 2019-03-13 Oxford University Innovation Limited Ketone bodies and ketone body esters as blood lipid lowering agents
ITRM20080214A1 (it) 2008-04-21 2009-10-22 Uni Degli Studi Di Napoli Federico Ii Derivati dell'acido butirrico somministrabili per via orale, formulazioni che li contengono e loro uso clinico.
KR100918776B1 (ko) * 2009-04-20 2009-09-24 계명대학교 산학협력단 폴리에틸렌 글리콜과 갈레이트 카테킨을 이용한 혈당상승 억제 조성물
ES2343773B1 (es) 2008-11-07 2011-06-24 Consejo Superior De Investigaciones Cientificas (Csic) Procedimiento enzimatico para la acilacion en posicion 3- del resveratrol.
CA2772618C (en) 2009-09-01 2018-08-21 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
EP2619194A4 (en) * 2010-04-08 2014-09-10 Genesis Group Inc CATECHIN FATTY ACID DERIVATIVES AND METHODS OF USE
KR101212612B1 (ko) * 2010-10-12 2012-12-14 전남대학교산학협력단 항산화활성 및 과산화물생성억제활성 중 하나 이상의 활성을 갖는 신규 화합물 및 퉁퉁마디로부터의 상기 신규 화합물 분리방법
CN104024213A (zh) * 2011-06-16 2014-09-03 香港理工大学 合成的表没食子儿茶素没食子酸酯(egcg)类似物
WO2013022846A2 (en) * 2011-08-05 2013-02-14 Cardero Therapeutics, Inc. Flavonoid compounds
WO2013115742A1 (en) * 2012-01-31 2013-08-08 Mahmut Bilgic Pharmaceutical composition comprising alpha-glucosidase inhibitor
SK50062012A3 (sk) 2012-02-29 2013-09-03 Ustav Experimentalnej Farmakologie A Toxikologie Sav Quercetin derivatives, pharmaceutical compositions comprising them and their use
DK4233858T3 (da) 2012-06-27 2025-05-12 Amazentis Sa Forbedring af autofagi eller forøgelse af levetiden ved indgivelse af urolithiner eller forstadier til disse
WO2014029327A1 (en) * 2012-08-20 2014-02-27 The Hong Kong Polytechnic University Prodrug of green tea epigallocatechin-3-gallate (pro-egcg) for use in the treatment of endometriosis
KR101480600B1 (ko) 2013-01-22 2015-01-08 경북대학교 산학협력단 레스베라트롤 유도체의 피부미백 용도
WO2014162320A2 (en) 2013-04-04 2014-10-09 Sphaera Pharma Pvt. Ltd. Novel analogues of epicatechin and related polyphenols
WO2015006355A2 (en) 2013-07-09 2015-01-15 Puretech Ventures, Llc Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease
WO2015019193A2 (en) 2013-08-08 2015-02-12 Dalhousie University Acylated derivatives of phloridzin and isoquercetrin as anticancer therapeutics and methods of use thereof
US20150056194A1 (en) * 2013-08-21 2015-02-26 Georgia Regents Research Institute, Inc. Modified green tea polyphenols and methods thereof for treating liver disease
RU2693455C2 (ru) * 2014-05-20 2019-07-03 Аста Фармасьютикалз Ко., Лтд. Каротеноидное производное, его фармацевтически приемлемая соль и фармацевтическая композиция, содержащая его
WO2016013654A1 (ja) 2014-07-24 2016-01-28 株式会社プロテクティア アレルゲン活性の抑制剤およびその用途
JP2017524790A (ja) 2014-08-13 2017-08-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 生分解性トレハロースグリコポリマー
WO2016026139A1 (zh) * 2014-08-22 2016-02-25 财团法人国防教育研究基金会 用于治疗非酒精性脂肪肝疾病的药物及应用
WO2016086453A1 (zh) * 2014-12-04 2016-06-09 中国药科大学 五环三萜类胆固醇酯转运蛋白抑制剂、其药物组合物及医药用途
KR101702076B1 (ko) 2015-02-25 2017-02-02 주식회사 휴메딕스 지방산 컨쥬게이션된 7-데하이드로콜레스테롤 유도체
CN104940181B (zh) * 2015-06-29 2018-02-16 齐锦生 β‑羟丁酸或其药学上可接受的盐的用途
US9545419B1 (en) * 2015-11-24 2017-01-17 Elorac Inc Method and compositions for treating chronic inflammatory disorders
KR102676056B1 (ko) * 2015-12-31 2024-06-19 베이징 구쉔 라이프 헬스 테크놀로지 컴퍼니 리미티드 비알코올성 지방간 질환의 치료 또는 예방용 의약의 제조에서의 트리아세틸-3-하이드록시페닐아데노신의 용도
JP6830580B2 (ja) 2016-01-13 2021-02-17 国立大学法人富山大学 セラミド含量増加剤
WO2017132775A1 (en) 2016-02-05 2017-08-10 Viteava Pharmaceuticals Inc. Novel compositions and methods for the treatment of leiomyoma
CN106995474B (zh) * 2017-04-25 2019-11-05 中国海洋大学 双半乳糖基二酰基甘油酯及其制备方法与用途
EP3634430B1 (en) 2017-06-05 2024-08-07 Flagship Pioneering Innovations V, Inc. Multibiotic agents and methods of using the same
JP2021527048A (ja) 2018-06-05 2021-10-11 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド 癌治療のためのアシル化カテキンポリフェノールおよびその使用方法
WO2019236772A1 (en) * 2018-06-05 2019-12-12 Flagship Pioneering Innovations V, Inc. Acylated active agents and methods of their use for the treatment of autoimmune disorders
AU2019282691A1 (en) 2018-06-05 2020-12-24 Flagship Pioneering Innovations V, Inc. Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease
EP3836971A4 (en) 2018-08-13 2022-06-22 Flagship Pioneering Innovations V, Inc. CONJUGATES AND METHODS OF USE THEREOF
WO2021222702A1 (en) * 2020-05-01 2021-11-04 Flagship Pioneering Innovations V, Inc. Crystalline forms, compositions containing them, and methods of their use

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US20240180941A1 (en) 2024-06-06
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IL279161A (en) 2021-01-31
US20210177877A1 (en) 2021-06-17
AU2019282691A1 (en) 2020-12-24
CN112367987A (zh) 2021-02-12
PH12020552060A1 (en) 2021-07-05
KR20210016407A (ko) 2021-02-15
US10953027B2 (en) 2021-03-23
EP3801496A4 (en) 2022-07-06
US20200197428A1 (en) 2020-06-25
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