|
US1016075A
(en)
|
1911-10-18 |
1912-01-30 |
George Kowalsky |
Feed-bag.
|
|
US5317103A
(en)
|
1991-01-15 |
1994-05-31 |
Merck Sharp & Dohme Limited |
Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
|
|
US5998438A
(en)
|
1996-11-26 |
1999-12-07 |
Allelix Biopharmaceuticals, Inc. |
5-cyclo indole compounds
|
|
TR200001079T2
(tr)
|
1997-10-20 |
2000-07-21 |
F.Hoffmann-La Roche Ag |
Bisiklik kinaz inhibitörleri.
|
|
US6358992B1
(en)
|
1998-11-25 |
2002-03-19 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with indole derivatives
|
|
US6281356B1
(en)
|
1999-12-22 |
2001-08-28 |
Hoffmann-La Roche Inc. |
Substituted pyrroles
|
|
NZ519121A
(en)
|
1999-12-24 |
2004-05-28 |
Aventis Pharma Ltd |
Azaindoles useful as Syk kinase inhibitors
|
|
GB0031315D0
(en)
|
2000-12-21 |
2001-02-07 |
Glaxo Group Ltd |
Indole derivatives
|
|
US20040110785A1
(en)
|
2001-02-02 |
2004-06-10 |
Tao Wang |
Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
|
|
EP1314733A1
(en)
|
2001-11-22 |
2003-05-28 |
Aventis Pharma Deutschland GmbH |
Indole-2-carboxamides as factor Xa inhibitors
|
|
US20040171062A1
(en)
|
2002-02-28 |
2004-09-02 |
Plexxikon, Inc. |
Methods for the design of molecular scaffolds and ligands
|
|
JP2005534619A
(ja)
|
2002-03-28 |
2005-11-17 |
エーザイ株式会社 |
C−junn−末端キナーゼ阻害剤としてのアザインドール
|
|
AU2003261415C1
(en)
|
2002-08-09 |
2010-01-14 |
Merck Sharp & Dohme Corp. |
Tyrosine kinase inhibitors
|
|
US20040142864A1
(en)
|
2002-09-16 |
2004-07-22 |
Plexxikon, Inc. |
Crystal structure of PIM-1 kinase
|
|
US20050048573A1
(en)
|
2003-02-03 |
2005-03-03 |
Plexxikon, Inc. |
PDE5A crystal structure and uses
|
|
US20040167188A1
(en)
|
2003-02-14 |
2004-08-26 |
Zhili Xin |
Protein-tyrosine phosphatase inhibitors and uses thereof
|
|
US20050170431A1
(en)
|
2003-02-28 |
2005-08-04 |
Plexxikon, Inc. |
PYK2 crystal structure and uses
|
|
EP2295433A3
(en)
|
2003-03-06 |
2011-07-06 |
Eisai R&D Management Co., Ltd. |
JNK inhibitors
|
|
SE0301569D0
(sv)
|
2003-05-27 |
2003-05-27 |
Astrazeneca Ab |
Novel compounds
|
|
US20050079548A1
(en)
|
2003-07-07 |
2005-04-14 |
Plexxikon, Inc. |
Ligand development using PDE4B crystal structures
|
|
US7348338B2
(en)
|
2003-07-17 |
2008-03-25 |
Plexxikon, Inc. |
PPAR active compounds
|
|
KR20130023381A
(ko)
|
2003-07-17 |
2013-03-07 |
플렉시콘, 인코퍼레이티드 |
Ppar 활성 화합물
|
|
WO2005028624A2
(en)
|
2003-09-15 |
2005-03-31 |
Plexxikon, Inc. |
Molecular scaffolds for kinase ligand development
|
|
US20070066641A1
(en)
|
2003-12-19 |
2007-03-22 |
Prabha Ibrahim |
Compounds and methods for development of RET modulators
|
|
JP5138938B2
(ja)
|
2003-12-19 |
2013-02-06 |
プレキシコン インコーポレーテッド |
Ret調節剤の開発のための化合物および方法
|
|
US7517970B2
(en)
|
2003-12-19 |
2009-04-14 |
Plexxikon, Inc. |
Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same
|
|
JP2008503446A
(ja)
|
2004-05-06 |
2008-02-07 |
プレキシコン,インコーポレーテッド |
Pde4b阻害剤及びその使用
|
|
WO2006009755A2
(en)
|
2004-06-17 |
2006-01-26 |
Plexxikon, Inc. |
Azaindoles modulating c-kit activity and uses therefor
|
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
|
WO2006015123A1
(en)
|
2004-07-27 |
2006-02-09 |
Sgx Pharmaceuticals, Inc. |
Pyrrolo-pyridine kinase modulators
|
|
CA2583428A1
(en)
|
2004-09-03 |
2006-03-09 |
Plexxikon, Inc. |
Bicyclic heteroaryl pde4b inhibitors
|
|
AU2005311925A1
(en)
|
2004-11-30 |
2006-06-08 |
Plexxikon, Inc. |
Indole derivatives for use as PPAR PPAR active compounds
|
|
US20060135540A1
(en)
|
2004-11-30 |
2006-06-22 |
Jack Lin |
PPAR active compounds
|
|
US20060160135A1
(en)
|
2004-12-08 |
2006-07-20 |
Weiru Wang |
SF-1 and LRH-1 modulator development
|
|
US20060183758A1
(en)
|
2005-02-17 |
2006-08-17 |
Cb Research And Development, Inc. |
Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
|
|
CA2608733A1
(en)
|
2005-05-17 |
2007-02-01 |
Plexxikon, Inc. |
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
|
|
CN102603581B
(zh)
|
2005-06-22 |
2015-06-24 |
普莱希科公司 |
作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物
|
|
ES2372701T3
(es)
|
2005-07-22 |
2012-01-25 |
Shionogi & Co., Ltd. |
Derivado de indol que tiene actividad antagonista del receptor de pgd2.
|
|
JP2009509932A
(ja)
|
2005-09-07 |
2009-03-12 |
プレキシコン,インコーポレーテッド |
Ppar活性化合物
|
|
WO2007030567A2
(en)
|
2005-09-07 |
2007-03-15 |
Plexxikon, Inc. |
Pparactive compounds
|
|
NZ567162A
(en)
|
2005-09-07 |
2011-06-30 |
Plexxikon Inc |
1, 3-disubstituted indole derivatives for use as PPAR modulators
|
|
WO2007098418A1
(en)
|
2006-02-17 |
2007-08-30 |
Memory Pharmaceuticals Corporation |
Compounds having 5-ht6 receptor affinity
|
|
EA016527B1
(ru)
|
2006-10-23 |
2012-05-30 |
ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. |
Триазолопиридазиновые модуляторы протеинкиназ
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
PE20081581A1
(es)
|
2006-12-21 |
2008-11-12 |
Plexxikon Inc |
COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
|
|
BRPI0720695A2
(pt)
|
2006-12-21 |
2014-02-18 |
Plexxikon Inc |
Compostos e métodos para modulação de cinase, e indicações para estes
|
|
WO2008079909A1
(en)
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
US8524917B2
(en)
|
2007-01-11 |
2013-09-03 |
Allergan, Inc. |
6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
|
|
ES2397292T3
(es)
|
2007-01-15 |
2013-03-06 |
Santen Pharmaceutical Co., Ltd |
Nuevo derivado de indol que tiene actividad inhibidora de cinasa I B
|
|
CA2676906A1
(en)
|
2007-02-12 |
2008-08-21 |
Intermune, Inc. |
Novel inhibitors hepatitis c virus replication
|
|
JP2010520303A
(ja)
|
2007-03-08 |
2010-06-10 |
プレキシコン,インコーポレーテッド |
Ppar活性化合物
|
|
PE20090159A1
(es)
|
2007-03-08 |
2009-02-21 |
Plexxikon Inc |
COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
|
|
WO2008110508A1
(en)
|
2007-03-09 |
2008-09-18 |
Glaxo Group Limited |
Pyrrolo-pyridine derivatives for the treatment of disorders associated with inappropriate ikk1 activity
|
|
DE102007028515A1
(de)
|
2007-06-21 |
2008-12-24 |
Merck Patent Gmbh |
6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate
|
|
SG183036A1
(en)
|
2007-07-17 |
2012-08-30 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
KR20100038119A
(ko)
|
2007-08-01 |
2010-04-12 |
화이자 인코포레이티드 |
피라졸 화합물 및 raf 억제제로서 이의 용도
|
|
WO2009143018A2
(en)
|
2008-05-19 |
2009-11-26 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
US20090298820A1
(en)
|
2008-05-28 |
2009-12-03 |
Wyeth |
3-substituted-1h-pyrrolo[2,3-b]pyridine and 3-substituted-1h-pyrrolo[3,2-b]pyridine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
|
|
US8110576B2
(en)
|
2008-06-10 |
2012-02-07 |
Plexxikon Inc. |
Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications
|
|
CN104530052A
(zh)
|
2008-06-10 |
2015-04-22 |
普莱希科公司 |
用于激酶调节的5h-吡咯[2,3-b]吡嗪衍生物和其适应症
|
|
AR072008A1
(es)
|
2008-06-13 |
2010-07-28 |
Merck & Co Inc |
Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38
|
|
US8012992B2
(en)
|
2008-06-30 |
2011-09-06 |
Allergan, Inc. |
Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
|
|
DE102008031517A1
(de)
|
2008-07-03 |
2010-01-07 |
Merck Patent Gmbh |
Pyrrolopyridinyl-pyrimidin-2-yl-amin-derivate
|
|
US8912330B2
(en)
|
2008-12-12 |
2014-12-16 |
Ariad Pharmaceuticals, Inc. |
Azaindole derivatives as kinase inhibitors
|
|
TW201036972A
(en)
|
2009-03-11 |
2010-10-16 |
Plexxikon Inc |
Compounds and uses thereof
|
|
RU2011141123A
(ru)
|
2009-03-11 |
2013-04-20 |
Плексксикон, Инк. |
ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-b]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ RAF-КИНАЗ
|
|
WO2010111527A1
(en)
|
2009-03-26 |
2010-09-30 |
Plexxikon, Inc. |
Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
|
|
AU2010232670B2
(en)
|
2009-04-03 |
2015-07-09 |
F. Hoffmann-La Roche Ag |
Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
|
|
SG175877A1
(en)
|
2009-05-04 |
2011-12-29 |
Plexxikon Inc |
Compounds and methods for inhibition of renin, and indications therefor
|
|
TW201041888A
(en)
|
2009-05-06 |
2010-12-01 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
KR101256018B1
(ko)
|
2009-08-20 |
2013-04-18 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
|
|
PH12012500900A1
(en)
|
2009-11-06 |
2012-11-12 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
RU2012125070A
(ru)
|
2009-11-18 |
2013-12-27 |
Плексксикон, Инк. |
Соединения и способы модулирования киназы и показания к их применению
|
|
BR112012015745A2
(pt)
|
2009-12-23 |
2016-05-17 |
Plexxikon Inc |
compostos e métodos para a modulação de quinase, e indicações dos mesmos
|
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
|
AR081039A1
(es)
|
2010-05-14 |
2012-05-30 |
Osi Pharmaceuticals Llc |
Inhibidores biciclicos fusionados de quinasa
|
|
US8642606B2
(en)
|
2010-09-29 |
2014-02-04 |
Plexxikon Inc. |
ZAP-70 active compounds
|
|
US9000175B2
(en)
|
2010-11-26 |
2015-04-07 |
Lupin Limited |
Bicyclic GPR119 modulators
|
|
DE102011009961A1
(de)
|
2011-02-01 |
2012-08-02 |
Merck Patent Gmbh |
7-Azaindolderivate
|
|
LT2672967T
(lt)
|
2011-02-07 |
2018-12-10 |
Plexxikon Inc. |
Junginiai ir būdai skirti kinazės moduliavimui, ir jų indikacijos
|
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
|
CN103917235A
(zh)
|
2011-05-17 |
2014-07-09 |
普莱希科公司 |
激酶调节及其适应症
|
|
ES2601788T3
(es)
|
2011-10-25 |
2017-02-16 |
Shionogi & Co., Ltd. |
Derivados heterocíclicos que tienen actividad antagonista del receptor de PGD2
|
|
WO2013078254A1
(en)
|
2011-11-22 |
2013-05-30 |
Array Biopharma Inc. |
Bicyclic heteroaryl derivatives as kinase inhibitors
|
|
FR2984325A1
(fr)
|
2011-12-14 |
2013-06-21 |
Sanofi Sa |
Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique
|
|
US20130158066A1
(en)
|
2011-12-20 |
2013-06-20 |
Hoffmann-La Roche Inc. |
4-azaindole inhibitors of crac
|
|
US9358235B2
(en)
|
2012-03-19 |
2016-06-07 |
Plexxikon Inc. |
Kinase modulation, and indications therefor
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
MX2015002887A
(es)
|
2012-09-06 |
2015-07-06 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello.
|
|
PL2935248T3
(pl)
|
2012-12-21 |
2018-07-31 |
Plexxikon Inc |
Związki i sposoby modulacji kinaz i wskazania dla nich
|
|
RU2680100C9
(ru)
*
|
2013-03-15 |
2019-04-18 |
Плексксикон Инк. |
Гетероциклические соединения и их применения
|
|
US20140303121A1
(en)
*
|
2013-03-15 |
2014-10-09 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
|
RU2015149937A
(ru)
|
2013-05-30 |
2017-07-06 |
Плексксикон Инк. |
Соединения для модулирования киназы и показания к их применению
|
|
HRP20200854T1
(hr)
|
2013-06-21 |
2020-08-21 |
Zenith Epigenetics Ltd. |
Novi biciklički inhibitori bromodomene
|
|
WO2015004534A2
(en)
|
2013-06-21 |
2015-01-15 |
Zenith Epigenetics Corp. |
Novel substituted bicyclic compounds as bromodomain inhibitors
|
|
US9771369B2
(en)
|
2014-03-04 |
2017-09-26 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
WO2016044067A1
(en)
|
2014-09-15 |
2016-03-24 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
|
ES2774178T3
(es)
|
2015-05-06 |
2020-07-17 |
Plexxikon Inc |
Síntesis de derivados de 1h-pirrolo[2,3-B] piridina que modulan cinasas
|
|
TWI727949B
(zh)
|
2015-05-06 |
2021-05-21 |
美商普雷辛肯公司 |
調節蛋白質激酶之化合物的固態形式
|
|
ES2825202T3
(es)
|
2015-05-22 |
2021-05-14 |
Plexxikon Inc |
Síntesis de compuestos heterocíclicos
|
|
CN113893253A
(zh)
|
2015-05-22 |
2022-01-07 |
普莱希科公司 |
用于治疗braf-v600相关的疾病的plx-8394或plx-7904
|
|
US10829484B2
(en)
|
2015-07-28 |
2020-11-10 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CN113754656A
(zh)
|
2015-09-21 |
2021-12-07 |
普莱希科公司 |
杂环化合物及其应用
|
|
RU2018123825A
(ru)
|
2015-12-07 |
2020-01-15 |
Плексксикон Инк. |
Соединения и способы для модуляции киназ, и показания для этого
|
|
ES2904615T3
(es)
|
2016-03-16 |
2022-04-05 |
Plexxikon Inc |
Compuestos y métodos para la modulación de quinasas e indicaciones al respecto
|
|
TW201815766A
(zh)
|
2016-09-22 |
2018-05-01 |
美商普雷辛肯公司 |
用於ido及tdo調節之化合物及方法以及其適應症
|
|
EP3558991A2
(en)
|
2016-12-23 |
2019-10-30 |
Plexxikon Inc. |
Compounds and methods for cdk8 modulation and indications therefor
|
|
ES2896502T3
(es)
|
2017-03-20 |
2022-02-24 |
Plexxikon Inc |
Formas cristalinas de ácido 4-(1-(1,1-di(piridin-2-il) etil)-6-(3,5-dimetilisoxazol-4-il)-1H-pirrolo[3,2-b]piridin-3- il)benzoico que inhiben el bromodominio
|
|
US10428067B2
(en)
|
2017-06-07 |
2019-10-01 |
Plexxikon Inc. |
Compounds and methods for kinase modulation
|
|
AU2018307910B2
(en)
|
2017-07-25 |
2024-07-25 |
Daiichi Sankyo Company, Limited |
Formulations of a compound modulating kinases
|
|
JP7675519B2
(ja)
|
2017-10-13 |
2025-05-13 |
オプナ バイオ ソシエテ アノニム |
キナーゼを調節するための化合物の固体形態
|
|
KR102849779B1
(ko)
|
2017-10-27 |
2025-08-25 |
플렉시콘 인코퍼레이티드 |
키나제를 조정하는 화합물의 제제
|