CN113754656A - 杂环化合物及其应用 - Google Patents
杂环化合物及其应用 Download PDFInfo
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- CN113754656A CN113754656A CN202111102799.1A CN202111102799A CN113754656A CN 113754656 A CN113754656 A CN 113754656A CN 202111102799 A CN202111102799 A CN 202111102799A CN 113754656 A CN113754656 A CN 113754656A
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Abstract
Description
组 | 处理 | 肿瘤大小(第27天,mm<sup>3</sup>) | TGI(%) |
1 | 载体对照 | 336.5±48.4 | - |
2 | 化合物Z(10mg/kg) | 141.5±16.3 | 92 |
3 | 化合物P-001(10mg/kg) | 99.2±13.5 | 112 |
试验名称 | BRD蛋白(nM) | 肽(nM) |
BRD2-BD1 | 6 | 41 |
BRD3-BD1 | 4 | 41 |
BRD4-BD1 | 6 | 41 |
BRD2-BD12 | 1 | 10 |
BRD4-BD12 | 3.7 | 37 |
Claims (7)
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US201562221508P | 2015-09-21 | 2015-09-21 | |
US62/221,508 | 2015-09-21 | ||
CN201680061129.0A CN108137585B (zh) | 2015-09-21 | 2016-09-19 | 杂环化合物及其应用 |
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JP (2) | JP6863970B2 (zh) |
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CN (2) | CN113754656A (zh) |
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