CA3007955A1 - Lipid nanoparticles for delivery of therapeutic agents - Google Patents

Lipid nanoparticles for delivery of therapeutic agents Download PDF

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Publication number
CA3007955A1
CA3007955A1 CA3007955A CA3007955A CA3007955A1 CA 3007955 A1 CA3007955 A1 CA 3007955A1 CA 3007955 A CA3007955 A CA 3007955A CA 3007955 A CA3007955 A CA 3007955A CA 3007955 A1 CA3007955 A1 CA 3007955A1
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CA
Canada
Prior art keywords
lipid
lnp
lnps
peg
group
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Pending
Application number
CA3007955A
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English (en)
French (fr)
Inventor
Gilles BESIN
Stephen Hoge
Joseph Senn
Kerry BENENATO
Staci SABNIS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ModernaTx Inc
Original Assignee
ModernaTx Inc
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Publication of CA3007955A1 publication Critical patent/CA3007955A1/en
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    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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