CA3007412C - The use of 1,4-disubstituted pyridazine compounds to treat huntington's disease - Google Patents

The use of 1,4-disubstituted pyridazine compounds to treat huntington's disease Download PDF

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Publication number
CA3007412C
CA3007412C CA3007412A CA3007412A CA3007412C CA 3007412 C CA3007412 C CA 3007412C CA 3007412 A CA3007412 A CA 3007412A CA 3007412 A CA3007412 A CA 3007412A CA 3007412 C CA3007412 C CA 3007412C
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Prior art keywords
pyridazin
tetramethylpiperidin
methyl
amino
phenol
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CA3007412A
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English (en)
French (fr)
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CA3007412A1 (en
Inventor
Suresh Babu
Anuradha Bhattacharyya
Seongwoo Hwang
Minakshi JANI
Young-Choon Moon
Nadiya Sydorenko
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PTC Therapeutics Inc
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PTC Therapeutics Inc
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Application filed by PTC Therapeutics Inc filed Critical PTC Therapeutics Inc
Priority to CA3119019A priority Critical patent/CA3119019C/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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