SG11201804915RA - Methods for treating huntington's disease - Google Patents

Methods for treating huntington's disease

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Publication number
SG11201804915RA
SG11201804915RA SG11201804915RA SG11201804915RA SG11201804915RA SG 11201804915R A SG11201804915R A SG 11201804915RA SG 11201804915R A SG11201804915R A SG 11201804915RA SG 11201804915R A SG11201804915R A SG 11201804915RA SG 11201804915R A SG11201804915R A SG 11201804915RA
Authority
SG
Singapore
Prior art keywords
international
disease
forms
compounds
methods
Prior art date
Application number
SG11201804915RA
Inventor
Suresh Babu
Anuradha Bhattacharyya
Seongwoo Hwang
Minakshi Jani
Young-Choon Moon
Nadiya Sydorenko
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201562265652P priority Critical
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Priority to PCT/US2016/066042 priority patent/WO2017100726A1/en
Publication of SG11201804915RA publication Critical patent/SG11201804915RA/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization MD 1111101110101011111 HO 11111 011101011101110111 OH III 111110 ill OEN International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/100726 Al 15 June 2017(15.06.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/506 (2006.01) A61P 25/00 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 405/12 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2016/066042 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 11 December 2016 (11.12.2016) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/265,652 10 December 2015 (10.12.2015) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: PTC THERAPEUTICS, INC. [US/US]; 100 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Corporate Court, South Plainfield, NJ 07080 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) TJ, TM), Inventors: BABU, Suresh; 225 Concord Place, Penning- European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, ton, NJ 08534 (US). BHATTACHARYYA, Anuradha; EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 115 Inverness Drive, Edison, NJ 08820 (US). HWANG, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Seongwoo; 227 Suttons Lane, Edison, NJ 08817 (US). SM, GW, KM, ML, MR, NE, SN, TD, TG). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, JANE Minakshi; 29 Kiva Street, Iselin, NJ 08830 (US). MOON, Young-choon; 11 Edgewood Drive, Belle Mead, Published: NJ 08502 (US). SYDORENKO, Nadiya; 37 Sycamore with Place, Princento, NJ 08540 (US). international search report (Art. 21(3)) (74) Agents: SCOLA, Daniel, A., Jr. et al.; Hoffmann & Bar- on, LLP, 6900 Jericho Turnpike, Syosset, NY 11791 (US). (54) Title: METHODS FOR TREATNG HUNTINGTON'S DISEASE W A 41111.1.1CP , \"s r .- X....... / N — N (I) ,tD ei IN © © ,-1 IN 1-1 (57) : The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using 0 such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present descrip - N tion relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and 0 methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
SG11201804915RA 2015-12-10 2016-12-11 Methods for treating huntington's disease SG11201804915RA (en)

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US201562265652P true 2015-12-10 2015-12-10
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