CA2855347C - In-situ cross-linkable polymeric compositions and methods thereof - Google Patents
In-situ cross-linkable polymeric compositions and methods thereof Download PDFInfo
- Publication number
- CA2855347C CA2855347C CA2855347A CA2855347A CA2855347C CA 2855347 C CA2855347 C CA 2855347C CA 2855347 A CA2855347 A CA 2855347A CA 2855347 A CA2855347 A CA 2855347A CA 2855347 C CA2855347 C CA 2855347C
- Authority
- CA
- Canada
- Prior art keywords
- polymer
- composition
- bleed
- wound
- cross
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title abstract description 21
- 238000011065 in-situ storage Methods 0.000 title abstract description 4
- 239000011159 matrix material Substances 0.000 claims abstract description 27
- 229920001661 Chitosan Polymers 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 8
- 235000010413 sodium alginate Nutrition 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 3
- 230000002439 hemostatic effect Effects 0.000 claims description 3
- 229920000447 polyanionic polymer Polymers 0.000 abstract description 31
- 229920002851 polycationic polymer Polymers 0.000 abstract description 21
- 238000004132 cross linking Methods 0.000 abstract description 8
- 230000008569 process Effects 0.000 abstract description 8
- 235000010443 alginic acid Nutrition 0.000 abstract description 6
- 229920000615 alginic acid Polymers 0.000 abstract description 6
- 229920002307 Dextran Polymers 0.000 abstract description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract description 3
- 239000001110 calcium chloride Substances 0.000 abstract description 3
- 229910001628 calcium chloride Inorganic materials 0.000 abstract description 3
- 230000023597 hemostasis Effects 0.000 abstract description 3
- 238000007711 solidification Methods 0.000 abstract description 3
- 230000008023 solidification Effects 0.000 abstract description 3
- 239000003431 cross linking reagent Substances 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 41
- 208000027418 Wounds and injury Diseases 0.000 description 40
- 229920000642 polymer Polymers 0.000 description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
- 239000002904 solvent Substances 0.000 description 13
- 230000029663 wound healing Effects 0.000 description 13
- 150000001768 cations Chemical class 0.000 description 12
- 210000001519 tissue Anatomy 0.000 description 12
- 230000006870 function Effects 0.000 description 11
- 230000001681 protective effect Effects 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 239000000499 gel Substances 0.000 description 9
- 230000035876 healing Effects 0.000 description 8
- 102000016359 Fibronectins Human genes 0.000 description 7
- 108010067306 Fibronectins Proteins 0.000 description 7
- -1 chitosun Chemical compound 0.000 description 7
- 230000001684 chronic effect Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 229920001600 hydrophobic polymer Polymers 0.000 description 6
- 229940124597 therapeutic agent Drugs 0.000 description 6
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 229940010747 sodium hyaluronate Drugs 0.000 description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 208000034693 Laceration Diseases 0.000 description 4
- 229940072056 alginate Drugs 0.000 description 4
- 125000002091 cationic group Chemical group 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 206010072170 Skin wound Diseases 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 229940072049 amyl acetate Drugs 0.000 description 3
- PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 230000023555 blood coagulation Effects 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108010054218 Factor VIII Proteins 0.000 description 2
- 102000001690 Factor VIII Human genes 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 208000004210 Pressure Ulcer Diseases 0.000 description 2
- 108010094028 Prothrombin Proteins 0.000 description 2
- 102100027378 Prothrombin Human genes 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 208000002847 Surgical Wound Diseases 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- 230000001010 compromised effect Effects 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 229960000301 factor viii Drugs 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 2
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
- 229920000193 polymethacrylate Polymers 0.000 description 2
- 229940039716 prothrombin Drugs 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910021653 sulphate ion Inorganic materials 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000037816 tissue injury Diseases 0.000 description 2
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
- JVIPLYCGEZUBIO-UHFFFAOYSA-N 2-(4-fluorophenyl)-1,3-dioxoisoindole-5-carboxylic acid Chemical compound O=C1C2=CC(C(=O)O)=CC=C2C(=O)N1C1=CC=C(F)C=C1 JVIPLYCGEZUBIO-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000004082 Calreticulin Human genes 0.000 description 1
- 108090000549 Calreticulin Proteins 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241001125840 Coryphaenidae Species 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 229920001425 Diethylaminoethyl cellulose Polymers 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 241000428198 Lutrinae Species 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 241000283216 Phocidae Species 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000270666 Testudines Species 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 description 1
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000010393 epithelial cell migration Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 102000013373 fibrillar collagen Human genes 0.000 description 1
- 108060002894 fibrillar collagen Proteins 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000019305 fibroblast migration Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000004738 parenchymal cell Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229960002796 polystyrene sulfonate Drugs 0.000 description 1
- 239000011970 polystyrene sulfonate Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000035752 proliferative phase Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000037309 reepithelialization Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 229940006186 sodium polystyrene sulfonate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0052—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/04—Alginic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Surgery (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559110P | 2011-11-13 | 2011-11-13 | |
| US61/559,110 | 2011-11-13 | ||
| PCT/US2012/064670 WO2013071235A1 (en) | 2011-11-13 | 2012-11-12 | In-situ cross-linkable polymeric compositions and methods thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2855347A1 CA2855347A1 (en) | 2013-05-16 |
| CA2855347C true CA2855347C (en) | 2019-03-05 |
Family
ID=48290658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2855347A Active CA2855347C (en) | 2011-11-13 | 2012-11-12 | In-situ cross-linkable polymeric compositions and methods thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US20140287061A1 (OSRAM) |
| EP (1) | EP2776068A4 (OSRAM) |
| JP (3) | JP2014533181A (OSRAM) |
| KR (1) | KR20140090670A (OSRAM) |
| CN (2) | CN103930133A (OSRAM) |
| AU (2) | AU2012334982A1 (OSRAM) |
| BR (1) | BR112014011442A8 (OSRAM) |
| CA (1) | CA2855347C (OSRAM) |
| HK (1) | HK1201734A1 (OSRAM) |
| IL (1) | IL232330B (OSRAM) |
| IN (1) | IN2014CN03524A (OSRAM) |
| MX (2) | MX366366B (OSRAM) |
| RU (2) | RU2640084C2 (OSRAM) |
| SG (2) | SG11201402279SA (OSRAM) |
| WO (1) | WO2013071235A1 (OSRAM) |
| ZA (1) | ZA201403166B (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110157010A (zh) * | 2019-05-05 | 2019-08-23 | 上海交通大学 | 一种基于多糖/聚肽的聚电解质复合物水凝胶止血剂 |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0822229A2 (pt) | 2008-01-24 | 2015-06-23 | Univ Utah Res Foudation | Coacervados de complexos adesivo e métodos de fabricação e uso dos mesmos |
| US8283384B2 (en) | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| CN103025360A (zh) | 2010-05-24 | 2013-04-03 | 犹他大学研究基金会 | 增强的粘合剂复合物凝聚层和其制备和使用方法 |
| WO2012065148A2 (en) | 2010-11-12 | 2012-05-18 | University Of Utah Research Foundation | Simple adhesive coacervates and methods of making and using thereof |
| WO2013071235A1 (en) | 2011-11-13 | 2013-05-16 | Suneris Inc. | In-situ cross-linkable polymeric compositions and methods thereof |
| WO2014123665A1 (en) | 2013-02-06 | 2014-08-14 | Kci Licensing, Inc. | Polymers, preparation and use thereof |
| ITTO20130375A1 (it) * | 2013-05-10 | 2014-11-11 | Marco Benzi | Prodotto per l'uso per il trattamento terapeutico di parodontopatie e perimplantiti |
| CN103611180B (zh) * | 2013-11-21 | 2015-02-18 | 无锡中科光远生物材料有限公司 | 一种自粘止血防粘连纤维体的制备方法 |
| WO2016007852A1 (en) * | 2014-07-11 | 2016-01-14 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Surgical tool and method for ocular tissue transplantation |
| JP6742297B2 (ja) | 2014-07-14 | 2020-08-19 | ユニヴァーシティ オブ ユタ リサーチ ファンデーション | その場凝固複合コアセルベートならびにその製造および使用方法 |
| CN107708750A (zh) * | 2015-06-22 | 2018-02-16 | 克里斯伦公司 | 高度有效的止血粘附性聚合物支架 |
| JP7493961B2 (ja) * | 2015-06-22 | 2024-06-03 | クレシロン， インコーポレイテッド | 高度に有用な止血用接着性ポリマー足場 |
| US10751444B2 (en) | 2015-08-07 | 2020-08-25 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
| US10660945B2 (en) | 2015-08-07 | 2020-05-26 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
| CN105030815B (zh) * | 2015-08-10 | 2019-03-15 | 贵州扬生医用器材有限公司 | 一种手术冲洗液及其制法 |
| WO2017106333A1 (en) | 2015-12-14 | 2017-06-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Complex coacervate for controlled release and related methods |
| KR101666792B1 (ko) | 2016-02-05 | 2016-10-17 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물 |
| US11298423B2 (en) * | 2016-03-04 | 2022-04-12 | University of Pittsburgh—of the Commonwealth System of Higher Education | Protection and delivery of multiple therapeutic proteins |
| CN105860107B (zh) * | 2016-04-26 | 2018-02-09 | 中南大学 | 一种过氧化氢响应及具有电化学活性的壳聚糖水凝胶的制备方法 |
| KR101916193B1 (ko) * | 2016-08-25 | 2018-11-07 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 관절강 주사용 조성물 |
| EP3534867B1 (en) | 2016-11-07 | 2025-06-04 | Solventum Intellectual Properties Company | Medical composition containing guanidinyl-containing polymer(s) and carrageenane(s) |
| WO2018119320A1 (en) * | 2016-12-21 | 2018-06-28 | Cresilon, Inc. | Hemostatic compositions with antifibrinolytic agents |
| BR112019012531A2 (pt) * | 2016-12-22 | 2019-11-19 | Omrix Biopharmaceuticals Ltd | composição hemostática compreendendo um trocador de ânions e um sal de cálcio |
| IL249725A0 (en) * | 2016-12-22 | 2017-03-30 | Omrix Biopharmaceuticals Ltd | A hemostatic preparation containing an anion exchanger and a calcium salt |
| JP6939607B2 (ja) * | 2017-03-27 | 2021-09-22 | Jsr株式会社 | 組成物およびその用途 |
| CN108926490B (zh) * | 2017-05-25 | 2021-01-26 | 南方医科大学南方医院 | 一种抗凝胃管的制作方法 |
| KR102218427B1 (ko) | 2017-09-20 | 2021-02-22 | 차의과학대학교 산학협력단 | 단백질 약물을 포함하는 코아세르베이트 조성물 및 이를 포함하는 창상 치료제 |
| AU2019212513B2 (en) | 2018-01-26 | 2024-10-31 | Fluidx Medical Technology, Llc | Apparatus and method of using in situ solidifying complex coacervates for vascular occlusion |
| CN111629765A (zh) * | 2018-01-26 | 2020-09-04 | 两极组织工程公司 | 复合界面生物材料促进剂基质 |
| RU2675631C1 (ru) * | 2018-10-02 | 2018-12-21 | Общество с ограниченной ответственностью "Новые Биомедицинские Решения" | Местное гемостатическое средство с повышенной антимикробной активностью |
| JP2022527348A (ja) * | 2019-04-03 | 2022-06-01 | ドテク－ソシエテ ア リスポンサビリタ リミタータ | 皮膚病変の治療的処置のための二成分系組成物およびその生成方法 |
| CN111303453B (zh) * | 2020-03-09 | 2021-06-04 | 中国海洋大学 | 一种多重敏感型水凝胶聚合物的制备方法和应用 |
| EP3925636A1 (en) | 2020-06-17 | 2021-12-22 | Centre Of Experimental Medicine Slovak Academy Of Sciences Institute Of Experimental Pharmacology | Composite membranes containing a smart-released cytoprotectant targeting the inflamed tissue and use thereof |
| JP2023092390A (ja) * | 2021-12-21 | 2023-07-03 | 富士フイルム株式会社 | 止血材組成物 |
| CN115887738B (zh) * | 2022-12-16 | 2024-05-10 | 湖南师范大学 | 一种聚丙烯酰胺-壳聚糖/高岭土多孔材料及其制备方法 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58206751A (ja) | 1982-05-26 | 1983-12-02 | 日石三菱株式会社 | 創傷被覆材 |
| JPS59139310A (ja) | 1983-01-31 | 1984-08-10 | Shiseido Co Ltd | 乳化組成物 |
| JPH0612993B2 (ja) | 1987-08-10 | 1994-02-23 | 株式会社クラレ | 球状の微生物固定化成形物の製造法 |
| US4956350A (en) * | 1988-08-18 | 1990-09-11 | Minnesota Mining And Manufacturing Company | Wound filling compositions |
| FI95207C (fi) | 1992-09-14 | 1996-01-10 | Novasso Oy | Haavansuojaside |
| JP3411602B2 (ja) * | 1992-10-22 | 2003-06-03 | グンゼ株式会社 | キトサンの溶解方法 |
| DE4337152A1 (de) | 1993-10-30 | 1995-05-04 | Merck Patent Gmbh | Verfahren zur Herstellung von wäßrigen Chitosan-Lösungen und -Gelen |
| US5670169A (en) | 1993-12-20 | 1997-09-23 | E.R. Squibb & Sons, Inc. | Wound hydrating gel with novel preservative system and low cytotoxicity |
| US20020032488A1 (en) | 1994-05-13 | 2002-03-14 | Brekke John H. | Device for regeneration of articular cartilage and other tissue |
| US6150581A (en) * | 1995-06-07 | 2000-11-21 | United States Surgical Corporation | Chitosan/alginate anti-adhesion barrier |
| US5836970A (en) * | 1996-08-02 | 1998-11-17 | The Kendall Company | Hemostatic wound dressing |
| GB2328443B (en) * | 1997-08-21 | 2001-09-05 | Reckitt & Colmann Prod Ltd | In situ formation of pharmaceutically acceptable polymeric material |
| WO1999034751A1 (en) | 1998-01-06 | 1999-07-15 | Sceusa Nicholas A | A drug dosage form based on the teorell-meyer gradient |
| US6200595B1 (en) | 1998-04-24 | 2001-03-13 | Kuraray Co., Ltd. | Medical adhesive |
| JP4241985B2 (ja) * | 1998-04-24 | 2009-03-18 | 株式会社クラレ | 医療用接着材 |
| JPH11318407A (ja) * | 1998-05-19 | 1999-11-24 | Lion Corp | 加工食品 |
| WO2000012144A1 (en) | 1998-08-31 | 2000-03-09 | Coloplast A/S | A composition capable of absorbing fluid |
| JP4267106B2 (ja) * | 1998-10-15 | 2009-05-27 | 株式会社クラレ | 癒着防止用材料 |
| JP4159682B2 (ja) * | 1998-12-22 | 2008-10-01 | 株式会社クラレ | 止血材 |
| JP4149098B2 (ja) | 1999-09-13 | 2008-09-10 | 株式会社クラレ | 水膨潤性医療用高分子ゲルの製造法及び水膨潤性医療用高分子ゲル |
| US20030206958A1 (en) | 2000-12-22 | 2003-11-06 | Cattaneo Maurizio V. | Chitosan biopolymer for the topical delivery of active agents |
| CA2476656C (en) * | 2002-02-21 | 2008-11-25 | Encelle, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
| US7217426B1 (en) * | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
| JP2004041586A (ja) | 2002-07-15 | 2004-02-12 | Fujimori Kogyo Co Ltd | 生体適合性材料およびその製造方法 |
| US7112713B2 (en) | 2003-03-12 | 2006-09-26 | Gelsus Research And Consulting, Inc. | Dressing based on the Teorell-Meyer gradient |
| US7641643B2 (en) | 2003-04-15 | 2010-01-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| AU2005216094B2 (en) * | 2004-02-23 | 2010-12-23 | Loma Linda University Medical Center | Hemostatic agent for topical and internal use |
| US20050203058A1 (en) | 2004-03-11 | 2005-09-15 | Johnson Edwin L. | Compositions of alpha- and beta-chitosan and methods of preparing them |
| RU2369408C2 (ru) * | 2004-07-09 | 2009-10-10 | Ферросан А/С | Гемостатическая композиция, включающая гиалуроновую кислоту |
| CA2574773A1 (en) | 2004-07-22 | 2006-02-02 | Allan D. Pronovost | Compositions and methods for treating excessive bleeding |
| JP2009513182A (ja) * | 2005-07-21 | 2009-04-02 | エフエムシー バイオポリマー エイエス | 急速溶解する生体適合性被覆物で被覆した医療用部材 |
| CA2628272A1 (en) * | 2005-11-02 | 2007-05-18 | Aeris Therapeutics, Inc. | Polycation-polyanion complexes, compositions and methods of use thereof |
| CN100411690C (zh) * | 2006-01-17 | 2008-08-20 | 武汉理工大学 | 一种抑菌聚电解质多孔材料的制备方法 |
| WO2007112446A2 (en) | 2006-03-28 | 2007-10-04 | University Of Washington | Alginate-based nanofibers and related scaffolds |
| US20070237811A1 (en) * | 2006-04-10 | 2007-10-11 | Scherr George H | Chitosan wound dressing |
| ITPD20060203A1 (it) * | 2006-05-22 | 2007-11-23 | Univ Degli Studi Trieste | Idrogeli di miscele di polisaccaridi per l'ingegneria tissutale e la veicolazione di composti attivi |
| CN1883721A (zh) * | 2006-06-21 | 2006-12-27 | 哈尔滨工业大学 | 共价交联凝胶改性人工植入体的方法 |
| US7935363B2 (en) * | 2006-12-12 | 2011-05-03 | Synthasome, Inc. | Composite material for tissue repair |
| ES2552842T3 (es) | 2007-02-19 | 2015-12-02 | Marine Polymer Technologies, Inc. | Composiciones hemostáticas y regímenes terapéuticos |
| JP4997650B2 (ja) | 2007-06-11 | 2012-08-08 | 国立大学法人京都工芸繊維大学 | 植物の加工方法 |
| US20090041858A1 (en) | 2007-08-06 | 2009-02-12 | Cao Group, Inc. | Haemostatic Compositions Thickened by Polymers Containing Nitrogen Moieties |
| JP5489999B2 (ja) * | 2007-08-28 | 2014-05-14 | アデレード リサーチ アンド イノベーション ピーティーワイ リミテッド | 外科用ハイドロゲル |
| US20090123509A1 (en) | 2007-11-08 | 2009-05-14 | Cory Berkland | Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds |
| US8283384B2 (en) * | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| US8530632B2 (en) * | 2008-04-24 | 2013-09-10 | Medtronic Xomed, Inc. | Chitosan-containing protective composition |
| US8697771B2 (en) * | 2008-08-19 | 2014-04-15 | The Regents Of The University Of Michigan | Biocompatible coatings, and methods of making and using the same |
| CN101463145A (zh) * | 2009-01-12 | 2009-06-24 | 武汉理工大学 | 羧甲基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料 |
| CN101463144B (zh) * | 2009-01-12 | 2010-12-29 | 武汉理工大学 | 羟丙基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料的制备方法 |
| WO2010117266A1 (en) | 2009-04-06 | 2010-10-14 | Broockeville Corporation N.V. | In situ gelling alginate systems |
| KR101103423B1 (ko) * | 2009-09-04 | 2012-01-06 | 아주대학교산학협력단 | 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도 |
| US8623274B2 (en) | 2009-11-25 | 2014-01-07 | Loma Linda University Medical Center | Chitosan-based hemostatic textile |
| EP2512588A4 (en) * | 2009-12-16 | 2014-06-04 | Univ Columbia | METHODS, DEVICES AND SYSTEMS FOR ULTRASOUND-RELEASED ON-DEMAND AGGREGATE FREEZING |
| US8389498B2 (en) | 2010-03-26 | 2013-03-05 | Taiwan Textile Research Institute | Spinning solution and method for manufacturing biomaterial fibers |
| US8968362B2 (en) * | 2010-04-08 | 2015-03-03 | Covidien Lp | Coated looped suture |
| CN103025360A (zh) * | 2010-05-24 | 2013-04-03 | 犹他大学研究基金会 | 增强的粘合剂复合物凝聚层和其制备和使用方法 |
| EP2600910B1 (en) * | 2010-08-05 | 2016-01-20 | Lifebond Ltd | Dry composition wound dressings and adhesives |
| CN102475691B (zh) | 2010-11-30 | 2014-04-16 | 中国科学院大连化学物理研究所 | 海藻酸盐-壳聚糖酰基衍生物微胶囊及其制备和应用 |
| EA023546B1 (ru) | 2011-03-17 | 2016-06-30 | Перма-Фикс Энвайронментал Сервисез, Инк. | Получение микропористого композитного материала на основе хитозана и его применения |
| JP5835751B2 (ja) | 2011-04-01 | 2015-12-24 | 珠海奥托沙医薬科技有限公司 | 医療用吸収性骨創傷止血材及びその調製方法 |
| GB2499359B (en) | 2011-10-05 | 2016-12-28 | Univ Of Bolton | Polysaccharide fibres for wound dressings |
| WO2013071235A1 (en) | 2011-11-13 | 2013-05-16 | Suneris Inc. | In-situ cross-linkable polymeric compositions and methods thereof |
| JP5902827B2 (ja) | 2011-12-09 | 2016-04-13 | アセル，インコーポレイテッド | 止血装置 |
| EP3459522B1 (en) | 2012-12-10 | 2021-02-17 | Regenics AS | Use of egg cellular extracts for wound treatment |
| WO2014169111A1 (en) | 2013-04-11 | 2014-10-16 | University Of Vermont And State Agricultural College | Decellularization and recellularization of whole organs |
| CN107708750A (zh) | 2015-06-22 | 2018-02-16 | 克里斯伦公司 | 高度有效的止血粘附性聚合物支架 |
-
2012
- 2012-11-12 WO PCT/US2012/064670 patent/WO2013071235A1/en not_active Ceased
- 2012-11-12 RU RU2014124157A patent/RU2640084C2/ru active
- 2012-11-12 JP JP2014541368A patent/JP2014533181A/ja active Pending
- 2012-11-12 KR KR1020147015600A patent/KR20140090670A/ko not_active Ceased
- 2012-11-12 CN CN201280055699.0A patent/CN103930133A/zh active Pending
- 2012-11-12 SG SG11201402279SA patent/SG11201402279SA/en unknown
- 2012-11-12 US US14/357,342 patent/US20140287061A1/en not_active Abandoned
- 2012-11-12 MX MX2014005738A patent/MX366366B/es active IP Right Grant
- 2012-11-12 BR BR112014011442A patent/BR112014011442A8/pt not_active Application Discontinuation
- 2012-11-12 EP EP12848403.7A patent/EP2776068A4/en not_active Withdrawn
- 2012-11-12 AU AU2012334982A patent/AU2012334982A1/en not_active Abandoned
- 2012-11-12 CN CN201811325132.6A patent/CN109602944A/zh active Pending
- 2012-11-12 RU RU2017144044A patent/RU2017144044A/ru not_active Application Discontinuation
- 2012-11-12 IN IN3524CHN2014 patent/IN2014CN03524A/en unknown
- 2012-11-12 HK HK15102296.0A patent/HK1201734A1/xx unknown
- 2012-11-12 SG SG10201610469QA patent/SG10201610469QA/en unknown
- 2012-11-12 CA CA2855347A patent/CA2855347C/en active Active
-
2014
- 2014-04-29 IL IL232330A patent/IL232330B/en active IP Right Grant
- 2014-05-02 ZA ZA2014/03166A patent/ZA201403166B/en unknown
- 2014-05-12 MX MX2019008051A patent/MX2019008051A/es unknown
-
2016
- 2016-09-15 US US15/266,813 patent/US9687584B1/en active Active
-
2017
- 2017-06-01 US US15/611,418 patent/US10850003B2/en active Active
- 2017-08-23 AU AU2017219007A patent/AU2017219007A1/en not_active Abandoned
-
2018
- 2018-06-26 JP JP2018120864A patent/JP7013336B2/ja active Active
-
2020
- 2020-09-14 JP JP2020153716A patent/JP2021007754A/ja not_active Withdrawn
- 2020-10-29 US US17/084,518 patent/US11383005B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110157010A (zh) * | 2019-05-05 | 2019-08-23 | 上海交通大学 | 一种基于多糖/聚肽的聚电解质复合物水凝胶止血剂 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11383005B2 (en) | In-situ cross-linkable polymeric compositions and methods thereof | |
| Sheokand et al. | Natural polymers used in the dressing materials for wound healing: Past, present and future | |
| Shi et al. | Recent progresses of collagen dressings for chronic skin wound healing | |
| Koehler et al. | Hydrogel wound dressings for bioactive treatment of acute and chronic wounds | |
| Sezer et al. | Biopolymers as wound healing materials: challenges and new strategies | |
| Ghadi et al. | Microparticulate polymers and hydrogels for wound healing | |
| CA2808454A1 (en) | Method and system for reversal of interactions between hydrophobically modified biopolymers and vesicles or cell membranes | |
| Yang et al. | Effect of natural polymer materials on skin healing based on internal wound microenvironment: a review | |
| Zamani et al. | Natural and synthetic polymers in burn wound healing | |
| De et al. | Insights into multifunctional smart hydrogels in wound healing applications | |
| Mercy et al. | Chitosan-derivatives as hemostatic agents: Their role in tissue regeneration | |
| Islam et al. | Chitosan and chitosan-based biomaterials for wound management | |
| HK40007228A (en) | In-situ cross-linkable polymeric compositions and methods thereof | |
| Khalid et al. | Polysaccharide composites as a wound-healing sponge | |
| NZ723969A (en) | In-situ cross-linkable polymeric compositions and methods thereof | |
| NZ723969B2 (en) | In-situ cross-linkable polymeric compositions and methods thereof | |
| Nisar et al. | Recent advances in natural polymer based hydrogels for wound healing applications | |
| Aderibigbe | Hybrid-based wound dressings: combination of synthetic and biopolymers. Polymers. 2022; 14: 3806 | |
| Kebria et al. | Polymers in wound repair and skin regeneration | |
| Susrutha et al. | Types of Wound Dressings and Materials used in Mild to Moderately Exuding Wounds: A Review | |
| RU2827960C1 (ru) | Гемостатический раствор, гемостатическое изделие и способ его изготовления | |
| Wahid | Polysaccharide Composites as a Wound-Healing Sponge | |
| Wiśniewska-Wrona et al. | Chitosan-based materials for wound healing and regeneration | |
| Choudhury et al. | Film: A Miscellaneous Drug Delivery with its Current Application in Diabetic Wound Healing | |
| Uddin et al. | Natural Biomaterials Used in Wound Healing and Diabetic Foot |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20151113 |