CA2854264A1 - 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives - Google Patents
2-oxo-oxazolidin-3,5-diyl antibiotic derivatives Download PDFInfo
- Publication number
- CA2854264A1 CA2854264A1 CA2854264A CA2854264A CA2854264A1 CA 2854264 A1 CA2854264 A1 CA 2854264A1 CA 2854264 A CA2854264 A CA 2854264A CA 2854264 A CA2854264 A CA 2854264A CA 2854264 A1 CA2854264 A1 CA 2854264A1
- Authority
- CA
- Canada
- Prior art keywords
- oxo
- dihydro
- oxazolidin
- cndot
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB2011/054968 | 2011-11-08 | ||
| IB2011054968 | 2011-11-08 | ||
| PCT/IB2012/056236 WO2013068948A1 (en) | 2011-11-08 | 2012-11-07 | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2854264A1 true CA2854264A1 (en) | 2013-05-16 |
Family
ID=47258051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2854264A Abandoned CA2854264A1 (en) | 2011-11-08 | 2012-11-07 | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
Country Status (21)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20150370T1 (hr) | 2008-10-07 | 2015-05-08 | Actelion Pharmaceuticals Ltd. | Antibiotiäśki spojevi tricikliäśkog oksazolidinona |
| WO2014170821A1 (en) | 2013-04-16 | 2014-10-23 | Actelion Pharmaceuticals Ltd | Antibacterial biaromatic derivatives |
| AR096135A1 (es) | 2013-05-02 | 2015-12-09 | Actelion Pharmaceuticals Ltd | Derivados de la quinolona |
| AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| MA41168A (fr) | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
| MA41169A (fr) | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
| CA3012569A1 (en) * | 2016-02-08 | 2017-08-17 | Redx Pharma Plc | Antibacterial compounds |
| GB201602235D0 (en) * | 2016-02-08 | 2016-03-23 | Redx Pharma Plc | Antibacterial compounds |
| SG11201806166WA (en) * | 2016-02-08 | 2018-08-30 | Redx Pharma Plc | Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds |
| JP2019517546A (ja) | 2016-06-08 | 2019-06-24 | アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニＡｚｉｅｎｄｅ Ｃｈｉｍｉｃｈｅ Ｒｉｕｎｉｔｅ Ａｎｇｅｌｉｎｉ Ｆｒａｎｃｅｓｃｏ Ａ．Ｃ．Ｒ．Ａ．Ｆ．Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ | 新しい抗菌性化合物 |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| PT3634968T (pt) * | 2017-06-08 | 2023-04-14 | Bugworks Res Inc | Compostos heterocíclicos úteis como agentes anti-bacterianos e método para a sua produção |
| ES2952989T3 (es) * | 2017-11-29 | 2023-11-07 | Bugworks Res Inc | Compuestos heterocíclicos antibacterianos y su síntesis |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3149104A (en) | 1961-01-03 | 1964-09-15 | Sterling Drug Inc | 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters |
| HU168497B (cg-RX-API-DMAC7.html) | 1972-12-18 | 1976-05-28 | ||
| GB1598915A (en) | 1977-09-20 | 1981-09-23 | Bellon Labor Sa Roger | 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them |
| SE444566B (sv) | 1977-09-20 | 1986-04-21 | Bellon Labor Sa Roger | 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav |
| CS274601B2 (en) | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| JPS62205060A (ja) | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | ８位置換キノロンカルボン酸誘導体 |
| DK164287A (da) | 1986-03-31 | 1987-10-01 | Sankyo Co | Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse |
| JP2631854B2 (ja) | 1987-12-23 | 1997-07-16 | 藤本製薬株式会社 | 新規な１，８−ナフチリジン誘導体 |
| DE4301246A1 (de) | 1993-01-19 | 1994-07-21 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäurederivate |
| AU2003244235A1 (en) | 2002-06-28 | 2004-01-19 | Kaneka Corporation | Process for preparation of optically active 1-substituted amino-2,3-epoxypropanes, intermediates for the synthesis thereof and process for preparation of the intermediates |
| ATE397930T1 (de) * | 2003-04-30 | 2008-07-15 | Morphochem Ag Komb Chemie | Verwendung von oxazolidinon-chinolin-hybrid- antibiotika zur behandlung von anthrax und anderen infektionen |
| DK1709044T4 (da) * | 2003-12-18 | 2014-01-20 | Morphochem Ag Komb Chemie | Oxazolidinon-quinolon-hybridantibiotika |
| CA2572442A1 (fr) | 2004-07-30 | 2006-03-09 | Palumed S.A. | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| CN101043921B (zh) | 2004-09-01 | 2011-05-11 | 乌比特拉克公司 | 用于游戏筹码的识别与计数的系统 |
| US20090156577A1 (en) | 2004-09-09 | 2009-06-18 | Benjamin Davis | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| JP2009532504A (ja) | 2006-04-06 | 2009-09-10 | グラクソ グループ リミテッド | 抗菌薬 |
| ES2380388T3 (es) * | 2006-11-10 | 2012-05-11 | Actelion Pharmaceuticals Ltd. | Derivados de 5-hidroximetil-oxazolidin-2-ona |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001003A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| ES2380398T3 (es) * | 2007-12-18 | 2012-05-11 | Actelion Pharmaceuticals Ltd. | Derivados 5-aminociclilmetil-oxazolidin-2-ona |
| KR101592046B1 (ko) * | 2008-02-22 | 2016-02-05 | 액테리온 파마슈티칼 리미티드 | 옥사졸리디논 유도체 |
| HRP20150370T1 (hr) | 2008-10-07 | 2015-05-08 | Actelion Pharmaceuticals Ltd. | Antibiotiäśki spojevi tricikliäśkog oksazolidinona |
| JP2012505201A (ja) * | 2008-10-10 | 2012-03-01 | アクテリオン ファーマシューティカルズ リミテッド | ２−ベンゾチオフェニル−及び２−ナフチル−オキサゾリジノン、並びにそれらのアザアイソスター（ａｚａｉｓｏｓｔｅｒｅ）類似体 |
| WO2010041218A2 (en) | 2008-10-10 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Oxazolidinyl antibiotics |
| TW201121965A (en) | 2009-09-28 | 2011-07-01 | Lg Life Sciences Ltd | Use of a quinolone derivative containing 7-(4-aminomethyl-3-oxime)pyrrolidine group that is capable of inducing granulocyte colony stimulating factor for treatment of neutropenia and recovery of hematopoiesis |
| CN101792443A (zh) | 2010-03-09 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | 氟代喹诺酮衍生物及其制备方法和用途 |
-
2012
- 2012-11-07 RU RU2014123109A patent/RU2616609C2/ru not_active IP Right Cessation
- 2012-11-07 IN IN4126CHN2014 patent/IN2014CN04126A/en unknown
- 2012-11-07 KR KR1020147014957A patent/KR20140096337A/ko not_active Abandoned
- 2012-11-07 ES ES12791863.9T patent/ES2581056T3/es active Active
- 2012-11-07 JP JP2014540612A patent/JP6030146B2/ja not_active Expired - Fee Related
- 2012-11-07 HK HK15102622.5A patent/HK1202288A1/xx unknown
- 2012-11-07 US US14/356,896 patent/US9079922B2/en not_active Expired - Fee Related
- 2012-11-07 BR BR112014011064A patent/BR112014011064A8/pt not_active Application Discontinuation
- 2012-11-07 CA CA2854264A patent/CA2854264A1/en not_active Abandoned
- 2012-11-07 PH PH1/2014/500831A patent/PH12014500831A1/en unknown
- 2012-11-07 EP EP12791863.9A patent/EP2776431B1/en not_active Not-in-force
- 2012-11-07 MX MX2014005637A patent/MX344529B/es active IP Right Grant
- 2012-11-07 TW TW101141423A patent/TWI594996B/zh not_active IP Right Cessation
- 2012-11-07 PL PL12791863.9T patent/PL2776431T3/pl unknown
- 2012-11-07 AR ARP120104192A patent/AR088691A1/es unknown
- 2012-11-07 AU AU2012335207A patent/AU2012335207B2/en not_active Ceased
- 2012-11-07 SG SG11201401710PA patent/SG11201401710PA/en unknown
- 2012-11-07 WO PCT/IB2012/056236 patent/WO2013068948A1/en not_active Ceased
-
2014
- 2014-04-30 CL CL2014001154A patent/CL2014001154A1/es unknown
- 2014-05-05 IL IL232463A patent/IL232463A0/en unknown
- 2014-06-06 ZA ZA2014/04176A patent/ZA201404176B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2014001154A1 (es) | 2014-09-12 |
| US9079922B2 (en) | 2015-07-14 |
| AU2012335207B2 (en) | 2017-05-25 |
| RU2014123109A (ru) | 2015-12-20 |
| BR112014011064A8 (pt) | 2017-12-26 |
| ES2581056T3 (es) | 2016-08-31 |
| TWI594996B (zh) | 2017-08-11 |
| AU2012335207A1 (en) | 2014-07-03 |
| JP6030146B2 (ja) | 2016-11-24 |
| TW201326166A (zh) | 2013-07-01 |
| KR20140096337A (ko) | 2014-08-05 |
| RU2616609C2 (ru) | 2017-04-18 |
| IL232463A0 (en) | 2014-06-30 |
| AR088691A1 (es) | 2014-06-25 |
| IN2014CN04126A (cg-RX-API-DMAC7.html) | 2015-07-10 |
| WO2013068948A1 (en) | 2013-05-16 |
| MX2014005637A (es) | 2014-06-23 |
| US20150051188A1 (en) | 2015-02-19 |
| ZA201404176B (en) | 2016-05-25 |
| HK1202288A1 (en) | 2015-09-25 |
| BR112014011064A2 (pt) | 2017-06-13 |
| PH12014500831A1 (en) | 2019-08-07 |
| JP2014532754A (ja) | 2014-12-08 |
| SG11201401710PA (en) | 2014-09-26 |
| CN103917539A (zh) | 2014-07-09 |
| EP2776431B1 (en) | 2016-05-04 |
| PL2776431T3 (pl) | 2016-11-30 |
| EP2776431A1 (en) | 2014-09-17 |
| MX344529B (es) | 2016-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170920 |
|
| FZDE | Discontinued |
Effective date: 20200831 |