MXPA05011654A - Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones. - Google Patents

Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.

Info

Publication number
MXPA05011654A
MXPA05011654A MXPA05011654A MXPA05011654A MXPA05011654A MX PA05011654 A MXPA05011654 A MX PA05011654A MX PA05011654 A MXPA05011654 A MX PA05011654A MX PA05011654 A MXPA05011654 A MX PA05011654A MX PA05011654 A MXPA05011654 A MX PA05011654A
Authority
MX
Mexico
Prior art keywords
oxazolidinone
anthrax
infections
treatment
hybrid antibiotics
Prior art date
Application number
MXPA05011654A
Other languages
English (en)
Inventor
Christine Sigwalt
Original Assignee
Morphochem Ag Komb Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem Ag Komb Chemie filed Critical Morphochem Ag Komb Chemie
Publication of MXPA05011654A publication Critical patent/MXPA05011654A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invencion se refiere al uso de compuestos, en los cuales los farmacoforos de la quinolina y la oxazolidinona estan quimicamente enlazados juntos a traves de un enlazador que es estable bajo condiciones fisiologicas, para el tratamiento del antrax y de otras infecciones.
MXPA05011654A 2003-04-30 2004-04-06 Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones. MXPA05011654A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46694503P 2003-04-30 2003-04-30
US53082203P 2003-12-18 2003-12-18
PCT/EP2004/003650 WO2004096221A1 (en) 2003-04-30 2004-04-06 Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections

Publications (1)

Publication Number Publication Date
MXPA05011654A true MXPA05011654A (es) 2005-12-15

Family

ID=33423632

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011654A MXPA05011654A (es) 2003-04-30 2004-04-06 Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.

Country Status (16)

Country Link
US (3) US20070155714A1 (es)
EP (1) EP1620098B1 (es)
JP (2) JP4805139B2 (es)
KR (1) KR101101982B1 (es)
AT (1) ATE397930T1 (es)
AU (2) AU2004233557B2 (es)
BR (1) BRPI0409955A (es)
CA (1) CA2529347C (es)
DE (1) DE602004014361D1 (es)
ES (1) ES2308171T3 (es)
HK (1) HK1078806A1 (es)
IL (1) IL171546A (es)
MX (1) MXPA05011654A (es)
NZ (1) NZ543757A (es)
RU (1) RU2351335C2 (es)
WO (1) WO2004096221A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
KR101101982B1 (ko) 2003-04-30 2012-01-02 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 옥사졸리디논-퀴놀린 하이브리드 항생제의 탄저병 및 기타감염증의 치료용의 용도
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
WO2005058888A2 (en) 2003-12-18 2005-06-30 Morphochem Aktiengesellschaft für kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
AU2007225088B2 (en) 2006-03-13 2012-09-13 Kyorin Pharmaceutical Co., Ltd Aminoquinolones as GSK-3 inhibitors
US8148362B2 (en) 2006-03-31 2012-04-03 Research Foundation Itsuu Laboratory Compound having heterocyclic ring
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
EP2086968B1 (en) * 2006-11-10 2012-02-08 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one derivatives
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
CA2699151A1 (en) 2007-09-11 2009-03-19 Activx Biosciences, Inc. Cyanoaminoquinolones and tetrazoloaminoquinolones as gsk-3 inhibitors
MX2010002662A (es) 2007-09-12 2010-04-09 Activx Biosciences Inc Aminoquinolonas espirociclicas como inhibidores de gsk-3.
JPWO2009044777A1 (ja) 2007-10-02 2011-02-10 財団法人乙卯研究所 ７員ヘテロ環を有するオキサゾリジノン誘導体
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
WO2009120789A1 (en) * 2008-03-26 2009-10-01 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
DK2296651T3 (da) * 2008-05-09 2012-09-24 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-on-derivater til behandling af bakterielle intestinale sygdomme
EP2145891A1 (en) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
PT2364975E (pt) * 2008-10-27 2013-09-09 Mitsubishi Tanabe Pharma Corp Novo derivado de amida e sua utilização como medicamento
EP2406266B1 (en) 2009-03-11 2013-12-25 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminoquinolones as gsk-3 inhibitors
JP5796412B2 (ja) 2011-08-26 2015-10-21 三菱電機株式会社 半導体素子の製造方法
PL2776431T3 (pl) * 2011-11-08 2016-11-30 Stanowiące antybiotyki pochodne 2-okso-oksazolidyno-3,5-diylu
WO2014138437A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Steroid conjugates
AU2014225743A1 (en) 2013-03-08 2015-09-24 Allergan, Inc. Antibiotic conjugates directly linked with steroid drugs
CA2912590C (en) * 2013-05-28 2022-11-29 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibacterials for the parenteral treatment or prophylaxis of bacterial diseases
CN105246476B (zh) * 2013-05-28 2019-11-15 莫弗凯姆联合化学股份公司 含噁唑烷酮-喹诺酮的联合疗法在治疗细菌感染中的应用
CN104725330B (zh) * 2013-12-18 2017-06-13 四川好医生药业集团有限公司 噁唑烷酮类化合物及其制备方法和用途
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840956A (en) 1986-02-18 1989-06-20 Warner-Lambert Company Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH0269478A (ja) 1988-09-05 1990-03-08 Sagami Chem Res Center キノロンカルボン酸誘導体
US5491139A (en) 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5153203A (en) 1989-03-30 1992-10-06 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivatives and salts thereof, preparation processes thereof, and antibacterial agents containing the same
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
JP3176626B2 (ja) 1991-11-01 2001-06-18 ファルマシア・アンド・アップジョン・カンパニー 抗菌剤として有用な置換アリール−およびヘテロアリールフェニルオキサゾリジノン類
US5221676A (en) 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
EP0911327B1 (en) 1995-09-22 2001-12-05 Wakunaga Pharmaceutical Co., Ltd. Novel pyridonecarboxylic acid derivatives or their salts and antibacterial agent comprising the same as the active ingredient
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
DE19633480A1 (de) * 1996-08-20 1998-02-26 Bayer Ag Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6239152B1 (en) 1998-01-23 2001-05-29 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
TW572757B (en) 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
MXPA02000985A (es) 1999-07-28 2002-07-30 Upjohn Co Oxazolidinonas y su uso como antiinfecciosos.
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
ES2256331T3 (es) * 2000-12-21 2006-07-16 PHARMACIA & UPJOHN COMPANY LLC Derivados de quinolina antimicrobianos y uso de los mismos para tratar infecciones bacterianas.
ES2186550B2 (es) 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
WO2003031443A1 (en) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
WO2003031441A1 (en) * 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
AU2003202753A1 (en) 2003-02-07 2004-08-30 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
KR101101982B1 (ko) * 2003-04-30 2012-01-02 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 옥사졸리디논-퀴놀린 하이브리드 항생제의 탄저병 및 기타감염증의 치료용의 용도
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
WO2005058888A2 (en) 2003-12-18 2005-06-30 Morphochem Aktiengesellschaft für kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR200430712Y1 (ko) 2006-08-30 2006-11-13 명 식 신 천장등
EP2086968B1 (en) 2006-11-10 2012-02-08 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one derivatives
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
DK2296651T3 (da) 2008-05-09 2012-09-24 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-on-derivater til behandling af bakterielle intestinale sygdomme

Also Published As

Publication number Publication date
RU2351335C2 (ru) 2009-04-10
AU2004233557A1 (en) 2004-11-11
ES2308171T3 (es) 2008-12-01
HK1078806A1 (en) 2006-03-24
IL171546A (en) 2014-06-30
KR101101982B1 (ko) 2012-01-02
EP1620098B1 (en) 2008-06-11
US8268812B2 (en) 2012-09-18
DE602004014361D1 (de) 2008-07-24
AU2004233557B2 (en) 2010-02-18
RU2005137032A (ru) 2007-06-10
AU2010201659A1 (en) 2010-05-20
JP2011184441A (ja) 2011-09-22
JP4805139B2 (ja) 2011-11-02
ATE397930T1 (de) 2008-07-15
CA2529347C (en) 2011-09-06
BRPI0409955A (pt) 2006-04-25
WO2004096221A1 (en) 2004-11-11
US20120135961A1 (en) 2012-05-31
EP1620098A1 (en) 2006-02-01
CA2529347A1 (en) 2004-11-11
US20120322766A1 (en) 2012-12-20
US8513231B2 (en) 2013-08-20
NZ543757A (en) 2009-02-28
JP2006526577A (ja) 2006-11-24
US20070155714A1 (en) 2007-07-05
JP5536706B2 (ja) 2014-07-02
KR20060025525A (ko) 2006-03-21

Similar Documents

Publication Publication Date Title
HK1078806A1 (en) Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
MY145647A (en) (4-hydroxy-2-oxo-3h-benzothiazol-7-yl)ethylamine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy (for example in the treatment of respiratory disease states)
TW200640908A (en) Chemical compounds
MX351590B (es) Antibioticos de oxazolidinona.
ES2422557T3 (es) Compuestos y composiciones como moduladores de la ruta Hedgehog
GB0625648D0 (en) Compounds
TNSN08283A1 (en) Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use
TW200508214A (en) Novel compounds
IL187904A (en) Use of quinoline derivatives for the preparation of bacterial preparations for the treatment of bacteria caused by bacteria
GEP20094834B (en) Macrolides, pharmaceutical compositions containing them and their use for treatment of bacterial infections
TW200630367A (en) Substituted adenines and the uses thereof
TW200734334A (en) Treatment of substance abuse
CY1112167T1 (el) Νεα χρηση αντιβιοτικων κινολονης
ES2186550A1 (es) Nuevos derivados de oxazolidinonas como antibacterianos.
YU102503A (sh) Kondenzovani pirimidinski dhfr inhibitori kao antibakterijska sredstva
SG162614A1 (en) Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors
MX2009006325A (es) Compuestos de heteroaril-heteroarilo como inhibidores de cdk para el tratamiento de cancer, inflamacion e infecciones virales.
ATE495186T1 (de) Antibakterielle amid-makrozyklen iv
RS20050649A (en) Antibacterial indolone oxazolidinones,intermediates for their preparation and pharmaceutical compositions containing them
EP2161037A3 (en) Camptothecin-Somatostatin conjugates
SG170778A1 (en) Antitumoral compounds
HK1106246A1 (en) S-tenatoprazole monohydrated sodium salt and the use thereof in therapy s-
UA91988C2 (ru) Фармацевтическая композиция на основе антагонистов nk2 для применения в педиатрии
IL185807A0 (en) Use of amino-substituted benzimidazoles
TW200637826A (en) Chemical compounds

Legal Events

Date Code Title Description
FG Grant or registration