ATE397930T1 - Verwendung von oxazolidinon-chinolin-hybrid- antibiotika zur behandlung von anthrax und anderen infektionen - Google Patents

Verwendung von oxazolidinon-chinolin-hybrid- antibiotika zur behandlung von anthrax und anderen infektionen

Info

Publication number
ATE397930T1
ATE397930T1 AT04725909T AT04725909T ATE397930T1 AT E397930 T1 ATE397930 T1 AT E397930T1 AT 04725909 T AT04725909 T AT 04725909T AT 04725909 T AT04725909 T AT 04725909T AT E397930 T1 ATE397930 T1 AT E397930T1
Authority
AT
Austria
Prior art keywords
oxazolidinone
infections
hybrid antibiotics
anthrax
quinoline
Prior art date
Application number
AT04725909T
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Luc Specklin
Daniel Baeschlin
Hans Locher
Christine Sigwalt
Original Assignee
Morphochem Ag Komb Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem Ag Komb Chemie filed Critical Morphochem Ag Komb Chemie
Application granted granted Critical
Publication of ATE397930T1 publication Critical patent/ATE397930T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT04725909T 2003-04-30 2004-04-06 Verwendung von oxazolidinon-chinolin-hybrid- antibiotika zur behandlung von anthrax und anderen infektionen ATE397930T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46694503P 2003-04-30 2003-04-30
US53082203P 2003-12-18 2003-12-18

Publications (1)

Publication Number Publication Date
ATE397930T1 true ATE397930T1 (de) 2008-07-15

Family

ID=33423632

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04725909T ATE397930T1 (de) 2003-04-30 2004-04-06 Verwendung von oxazolidinon-chinolin-hybrid- antibiotika zur behandlung von anthrax und anderen infektionen

Country Status (16)

Country Link
US (3) US20070155714A1 (de)
EP (1) EP1620098B1 (de)
JP (2) JP4805139B2 (de)
KR (1) KR101101982B1 (de)
AT (1) ATE397930T1 (de)
AU (2) AU2004233557B2 (de)
BR (1) BRPI0409955A (de)
CA (1) CA2529347C (de)
DE (1) DE602004014361D1 (de)
ES (1) ES2308171T3 (de)
HK (1) HK1078806A1 (de)
IL (1) IL171546A (de)
MX (1) MXPA05011654A (de)
NZ (1) NZ543757A (de)
RU (1) RU2351335C2 (de)
WO (1) WO2004096221A1 (de)

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DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
PL1709044T5 (pl) 2003-12-18 2014-03-31 Morphochem Aktiengesellschaft Fuer Komb Chemie Antybiotyki hybrydowe oksazolidynon-chinolon
CN102816194A (zh) 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
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US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
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FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
CA2712613C (en) * 2008-03-26 2017-02-28 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
ES2390405T3 (es) 2008-05-09 2012-11-12 Actelion Pharmaceuticals Ltd. Derivados de 5-hidroximetil-oxazolidin-2-ona para el tratamiento de enfermedades intestinales bacterianas
EP2145891A1 (de) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substierte 5-Carboxy-Oxadiazin-Chinolon-Derivate, ihre Herstellung und ihre Anwendung als antibakterielle Mittel
MX2011004372A (es) * 2008-10-27 2011-05-23 Mitsubishi Tanabe Pharma Corp Derivado de amida novedoso y uso del mismo como medicina.
EP2406266B1 (de) 2009-03-11 2013-12-25 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminochinolone als gsk-3-hemmer
JP5796412B2 (ja) 2011-08-26 2015-10-21 三菱電機株式会社 半導体素子の製造方法
ES2581056T3 (es) * 2011-11-08 2016-08-31 Actelion Pharmaceuticals Ltd. Derivados de 2-oxo-oxazolidin-3,5-diilo antibióticos
US9402913B2 (en) 2013-03-08 2016-08-02 Allergan, Inc. Cyclosporine A steroid conjugates
JP2016510750A (ja) 2013-03-08 2016-04-11 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ステロイド薬と直接結合した抗生物質共役体
RU2675847C2 (ru) * 2013-05-28 2018-12-25 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Комбинированные терапевтические средства, содержащие оксазолидинон-хинолоны, предназначенные для лечения бактериальных инфекций
PL3003289T3 (pl) * 2013-05-28 2019-09-30 Morphochem Gmbh Podawanie hybrydowych środków przeciwbakteryjnych oksazolidynon-chinolon
CN104725330B (zh) * 2013-12-18 2017-06-13 四川好医生药业集团有限公司 噁唑烷酮类化合物及其制备方法和用途
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid

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WO2003031443A1 (de) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
WO2003031441A1 (en) * 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
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DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
PL1709044T5 (pl) 2003-12-18 2014-03-31 Morphochem Aktiengesellschaft Fuer Komb Chemie Antybiotyki hybrydowe oksazolidynon-chinolon
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR200430712Y1 (ko) 2006-08-30 2006-11-13 명 식 신 천장등
JP4484965B2 (ja) 2006-11-10 2010-06-16 アクテリオン ファーマシューティカルズ リミテッド ５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
ES2390405T3 (es) 2008-05-09 2012-11-12 Actelion Pharmaceuticals Ltd. Derivados de 5-hidroximetil-oxazolidin-2-ona para el tratamiento de enfermedades intestinales bacterianas

Also Published As

Publication number Publication date
US20120135961A1 (en) 2012-05-31
AU2010201659A1 (en) 2010-05-20
NZ543757A (en) 2009-02-28
WO2004096221A1 (en) 2004-11-11
US8513231B2 (en) 2013-08-20
IL171546A (en) 2014-06-30
US20120322766A1 (en) 2012-12-20
EP1620098B1 (de) 2008-06-11
CA2529347A1 (en) 2004-11-11
JP5536706B2 (ja) 2014-07-02
US20070155714A1 (en) 2007-07-05
MXPA05011654A (es) 2005-12-15
KR20060025525A (ko) 2006-03-21
RU2351335C2 (ru) 2009-04-10
AU2004233557B2 (en) 2010-02-18
JP2011184441A (ja) 2011-09-22
DE602004014361D1 (de) 2008-07-24
EP1620098A1 (de) 2006-02-01
BRPI0409955A (pt) 2006-04-25
JP4805139B2 (ja) 2011-11-02
HK1078806A1 (en) 2006-03-24
ES2308171T3 (es) 2008-12-01
KR101101982B1 (ko) 2012-01-02
CA2529347C (en) 2011-09-06
AU2004233557A1 (en) 2004-11-11
US8268812B2 (en) 2012-09-18
RU2005137032A (ru) 2007-06-10
JP2006526577A (ja) 2006-11-24

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