EA201000063A1 - Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе - Google Patents
Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основеInfo
- Publication number
- EA201000063A1 EA201000063A1 EA201000063A EA201000063A EA201000063A1 EA 201000063 A1 EA201000063 A1 EA 201000063A1 EA 201000063 A EA201000063 A EA 201000063A EA 201000063 A EA201000063 A EA 201000063A EA 201000063 A1 EA201000063 A1 EA 201000063A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical compositions
- compositions based
- basis
- functions
- thrombin inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Настоящее изобретение описывает новые химические соединения, применение этих соединений в качестве ингибиторов тромбина и фармацевтические композиции на их основе и может быть использовано для лечения и профилактики тромбинзависящих тромбоэмболических событий, а также в научно-исследовательских целях.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2007124201/04A RU2354647C2 (ru) | 2007-06-28 | 2007-06-28 | Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе |
PCT/RU2008/000400 WO2009002228A2 (en) | 2007-06-28 | 2008-06-27 | New thrombin function compounds and pharmaceutical compositions based on them |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201000063A1 true EA201000063A1 (ru) | 2010-06-30 |
Family
ID=40186195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000063A EA201000063A1 (ru) | 2007-06-28 | 2008-06-27 | Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе |
Country Status (11)
Country | Link |
---|---|
US (1) | US20100324058A1 (ru) |
EP (1) | EP2178838A2 (ru) |
JP (1) | JP2010531352A (ru) |
KR (1) | KR20100039867A (ru) |
CN (1) | CN101861304A (ru) |
AU (1) | AU2008269712B2 (ru) |
CA (1) | CA2693226A1 (ru) |
EA (1) | EA201000063A1 (ru) |
RU (1) | RU2354647C2 (ru) |
UA (1) | UA98970C2 (ru) |
WO (1) | WO2009002228A2 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2353619C2 (ru) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
WO2013048787A1 (en) | 2011-09-26 | 2013-04-04 | Yes, Inc. | Novel hemostatic compositions and dressings for bleeding |
WO2013056116A1 (en) * | 2011-10-12 | 2013-04-18 | The Trustees Of Columbia University In The City Of New York | Hemostatic dressing for arterial bleeding |
FR3030516B1 (fr) * | 2014-12-19 | 2019-12-27 | Galderma Research & Development | Derives sulfonamides bicycles en tant qu'agonistes inverses du recepteur gamma orphelin associe aux retinoides ror gamma (t) |
RU2685261C1 (ru) * | 2018-04-05 | 2019-04-17 | Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" | Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1469906A (en) | 1921-08-26 | 1923-10-09 | Augie L Hansen | Tufting needle |
DE1245937B (ru) * | 1964-09-09 | 1967-08-03 | ||
US5089634A (en) * | 1984-08-20 | 1992-02-18 | Georgia Tech Research Corporation | Isocoumarins with cationic substituents |
US5214052A (en) | 1987-07-28 | 1993-05-25 | Mitsubishi Kasei Corporation | Method for dissolving arginineamides and pharmaceutical compositions containing them |
JPH0341065A (ja) * | 1989-07-06 | 1991-02-21 | Morishita Pharmaceut Co Ltd | アリールオキシアルキルイソチオウレア臭化水素酸塩類 |
JP3084458B2 (ja) * | 1991-11-08 | 2000-09-04 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
TW257757B (ru) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
IL109319A0 (en) * | 1993-04-27 | 1994-07-31 | Du Pont Merck Pharma | Amidino and guanidino substituted boronic acid compounds |
US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
DE4430757A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
SE9404196D0 (sv) | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
US5792769A (en) * | 1995-09-29 | 1998-08-11 | 3-Dimensional Pharmaceuticals, Inc. | Guanidino protease inhibitors |
ATE341317T1 (de) * | 1996-03-29 | 2006-10-15 | Ortho Mcneil Pharm Inc | Amidinohydrazone als protease-inhibitoren |
EP0927035A4 (en) * | 1996-09-13 | 2002-11-13 | Merck & Co Inc | THROMBIN INHIBITORS |
US5792779A (en) | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
US5886191A (en) * | 1997-08-18 | 1999-03-23 | Dupont Pharmaceuticals Company | Amidinoindoles, amidinoazoles, and analogs thereof |
UA75093C2 (en) * | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
JP4896387B2 (ja) * | 2003-09-30 | 2012-03-14 | 武田薬品工業株式会社 | チアゾリン誘導体およびその用途 |
DE602005001696T2 (de) * | 2004-03-02 | 2008-04-10 | F. Hoffmann-La Roche Ag | 4-(sulfanylpyrimidin-4-ylmethyl)morpholin-derivate und verwandte verbindungen als gaba-rezeptorliganden zur behandlung von angst, depression und epilepsie |
US8546583B2 (en) * | 2006-05-31 | 2013-10-01 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
RU2353619C2 (ru) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
-
2007
- 2007-06-28 RU RU2007124201/04A patent/RU2354647C2/ru not_active IP Right Cessation
-
2008
- 2008-06-27 CA CA2693226A patent/CA2693226A1/en not_active Abandoned
- 2008-06-27 CN CN200880104825A patent/CN101861304A/zh active Pending
- 2008-06-27 EA EA201000063A patent/EA201000063A1/ru unknown
- 2008-06-27 JP JP2010514671A patent/JP2010531352A/ja active Pending
- 2008-06-27 US US12/666,221 patent/US20100324058A1/en not_active Abandoned
- 2008-06-27 UA UAA201000792A patent/UA98970C2/ru unknown
- 2008-06-27 WO PCT/RU2008/000400 patent/WO2009002228A2/en active Application Filing
- 2008-06-27 EP EP08794028A patent/EP2178838A2/en not_active Withdrawn
- 2008-06-27 KR KR1020107002057A patent/KR20100039867A/ko not_active Application Discontinuation
- 2008-06-27 AU AU2008269712A patent/AU2008269712B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP2178838A2 (en) | 2010-04-28 |
JP2010531352A (ja) | 2010-09-24 |
UA98970C2 (ru) | 2012-07-10 |
CN101861304A (zh) | 2010-10-13 |
RU2007124201A (ru) | 2009-01-10 |
CA2693226A1 (en) | 2008-12-31 |
KR20100039867A (ko) | 2010-04-16 |
AU2008269712A8 (en) | 2010-04-15 |
AU2008269712B2 (en) | 2013-01-17 |
WO2009002228A3 (en) | 2009-03-12 |
US20100324058A1 (en) | 2010-12-23 |
WO2009002228A2 (en) | 2008-12-31 |
RU2354647C2 (ru) | 2009-05-10 |
AU2008269712A1 (en) | 2008-12-31 |
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