UA98970C2 - Соединения с функцией ингибирования тромбина и фармацевтические композиции на их основе - Google Patents
Соединения с функцией ингибирования тромбина и фармацевтические композиции на их основеInfo
- Publication number
- UA98970C2 UA98970C2 UAA201000792A UAA201000792A UA98970C2 UA 98970 C2 UA98970 C2 UA 98970C2 UA A201000792 A UAA201000792 A UA A201000792A UA A201000792 A UAA201000792 A UA A201000792A UA 98970 C2 UA98970 C2 UA 98970C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pharmaceutical compositions
- compositions based
- thrombin
- function compounds
- thrombin function
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Данное изобретение касается новых химических соединений, применения этих соединений как ингибиторов тромбина, а также фармацевтических композиций на их основе, и может использоваться для лечения и профилактики тромбинзависимых тромбоэмболических реакций, а также для исследовательских целей.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2007124201/04A RU2354647C2 (ru) | 2007-06-28 | 2007-06-28 | Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе |
Publications (1)
Publication Number | Publication Date |
---|---|
UA98970C2 true UA98970C2 (ru) | 2012-07-10 |
Family
ID=40186195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201000792A UA98970C2 (ru) | 2007-06-28 | 2008-06-27 | Соединения с функцией ингибирования тромбина и фармацевтические композиции на их основе |
Country Status (11)
Country | Link |
---|---|
US (1) | US20100324058A1 (ru) |
EP (1) | EP2178838A2 (ru) |
JP (1) | JP2010531352A (ru) |
KR (1) | KR20100039867A (ru) |
CN (1) | CN101861304A (ru) |
AU (1) | AU2008269712B2 (ru) |
CA (1) | CA2693226A1 (ru) |
EA (1) | EA201000063A1 (ru) |
RU (1) | RU2354647C2 (ru) |
UA (1) | UA98970C2 (ru) |
WO (1) | WO2009002228A2 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2353619C2 (ru) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
WO2013048787A1 (en) | 2011-09-26 | 2013-04-04 | Yes, Inc. | Novel hemostatic compositions and dressings for bleeding |
WO2013056116A1 (en) * | 2011-10-12 | 2013-04-18 | The Trustees Of Columbia University In The City Of New York | Hemostatic dressing for arterial bleeding |
FR3030516B1 (fr) * | 2014-12-19 | 2019-12-27 | Galderma Research & Development | Derives sulfonamides bicycles en tant qu'agonistes inverses du recepteur gamma orphelin associe aux retinoides ror gamma (t) |
RU2685261C1 (ru) * | 2018-04-05 | 2019-04-17 | Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" | Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1469906A (en) | 1921-08-26 | 1923-10-09 | Augie L Hansen | Tufting needle |
DE1245937B (ru) * | 1964-09-09 | 1967-08-03 | ||
US5089634A (en) * | 1984-08-20 | 1992-02-18 | Georgia Tech Research Corporation | Isocoumarins with cationic substituents |
US5214052A (en) | 1987-07-28 | 1993-05-25 | Mitsubishi Kasei Corporation | Method for dissolving arginineamides and pharmaceutical compositions containing them |
JPH0341065A (ja) * | 1989-07-06 | 1991-02-21 | Morishita Pharmaceut Co Ltd | アリールオキシアルキルイソチオウレア臭化水素酸塩類 |
JP3084458B2 (ja) * | 1991-11-08 | 2000-09-04 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
TW257757B (ru) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
IL109319A0 (en) * | 1993-04-27 | 1994-07-31 | Du Pont Merck Pharma | Amidino and guanidino substituted boronic acid compounds |
US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
DE4430757A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
SE9404196D0 (sv) | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
US5792769A (en) * | 1995-09-29 | 1998-08-11 | 3-Dimensional Pharmaceuticals, Inc. | Guanidino protease inhibitors |
US5891909A (en) * | 1996-03-29 | 1999-04-06 | 3-Dimensional Pharmaceuticals, Inc. | Amidinohydrazones as protease inhibitors |
WO1998010763A1 (en) * | 1996-09-13 | 1998-03-19 | Merck & Co., Inc. | Thrombin inhibitors |
US5792779A (en) | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
US5886191A (en) * | 1997-08-18 | 1999-03-23 | Dupont Pharmaceuticals Company | Amidinoindoles, amidinoazoles, and analogs thereof |
UA75093C2 (en) * | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
JP4896387B2 (ja) * | 2003-09-30 | 2012-03-14 | 武田薬品工業株式会社 | チアゾリン誘導体およびその用途 |
BRPI0508310A (pt) * | 2004-03-02 | 2007-07-24 | Hoffmann La Roche | derivados de 4-(sulfanil-pirimidin-4-ilmetil)-morfolina e compostos relacionados como ligandos do receptor gaba, para o tratamento de ansiedade, depressão e epilepsia |
BRPI0712720A2 (pt) * | 2006-05-31 | 2012-11-20 | Abbott Lab | compostos tiazàis como ligantes do receptor canabinàide e usos dos mesmos |
RU2353619C2 (ru) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
-
2007
- 2007-06-28 RU RU2007124201/04A patent/RU2354647C2/ru not_active IP Right Cessation
-
2008
- 2008-06-27 EP EP08794028A patent/EP2178838A2/en not_active Withdrawn
- 2008-06-27 US US12/666,221 patent/US20100324058A1/en not_active Abandoned
- 2008-06-27 WO PCT/RU2008/000400 patent/WO2009002228A2/en active Application Filing
- 2008-06-27 AU AU2008269712A patent/AU2008269712B2/en not_active Ceased
- 2008-06-27 UA UAA201000792A patent/UA98970C2/ru unknown
- 2008-06-27 EA EA201000063A patent/EA201000063A1/ru unknown
- 2008-06-27 CA CA2693226A patent/CA2693226A1/en not_active Abandoned
- 2008-06-27 KR KR1020107002057A patent/KR20100039867A/ko not_active Application Discontinuation
- 2008-06-27 CN CN200880104825A patent/CN101861304A/zh active Pending
- 2008-06-27 JP JP2010514671A patent/JP2010531352A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2009002228A3 (en) | 2009-03-12 |
RU2007124201A (ru) | 2009-01-10 |
CN101861304A (zh) | 2010-10-13 |
EA201000063A1 (ru) | 2010-06-30 |
AU2008269712A8 (en) | 2010-04-15 |
RU2354647C2 (ru) | 2009-05-10 |
CA2693226A1 (en) | 2008-12-31 |
AU2008269712B2 (en) | 2013-01-17 |
JP2010531352A (ja) | 2010-09-24 |
US20100324058A1 (en) | 2010-12-23 |
AU2008269712A1 (en) | 2008-12-31 |
KR20100039867A (ko) | 2010-04-16 |
EP2178838A2 (en) | 2010-04-28 |
WO2009002228A2 (en) | 2008-12-31 |
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